International Journal of Dentistry最新文献

{"title":"A Novel 3-Dimensional Printed Nanoceramic Hybrid Resin Fixed Lingual Retainer: Characterization and Mechanical Tests.","authors":"Noor Salam Alnuaimy, Akram Faisal Alhuwaizi","doi":"10.1155/2024/3540846","DOIUrl":"https://doi.org/10.1155/2024/3540846","url":null,"abstract":"<p><p><b>Introduction:</b> An innovative retention protocol was developed to create a new 3D-printed fixed retainer employing SprintRay OnX nanoceramic hybrid resin. The feasibility and usability of the retainer were subsequently evaluated. <b>Methods:</b> Identification and characterization of SprintRay OnX was done using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy with energy dispersive X-ray (SEM-EDX), field emission scanning electron microscope (FE-SEM), X-ray diffraction (XRD), and flexural strength. Load-deflection and pull-out tests were conducted on the 3D-printed straight wires, with three distinct cross-sectional geometries: round (1 mm), oval (1 mm × 1.5 mm) and semielliptical (1 mm × 1.5 mm). Twisted G&H and coaxial Respond stainless steel multistrand retainers were used for comparison. In the load-deflection test, a three-point bending test (3PBT) was employed. For the pull-out test, the retainer wire was inserted into the composite, which was placed in a centrally located hole of an acrylic block; the retainer wire was subjected to a tensile force along its long axis. <b>Results:</b> Characteristic bands close to those of PMMA were observed in the FTIR spectra. SEM-EDX and XRD revealed a crystalline material with homogeneously distributed Yb element signals (19.4%). On FE-SEM micrographs, small clumps were displayed on smooth surfaces. The flexural strength and the flexural modulus were, respectively, 142.48 MPa and 7.842 GPa. All groups of 3D-printed wires exhibited significantly higher load-deflection levels than the multistrand wires (MSWs). Concerning pull-out forces, they fell in between twisted G&H (96 N) and coaxial Respond (48.09 N) retainer wires. The 3D-printed wires fractured cohesively without detachment from the adhesive, suggesting that the chemical bond was adequate for satisfactory wire integration, yet the wire's strength was compromised. Concerning the cross-sectional geometry, the load-deflection and the pull-out forces of 3D-printed oval and semielliptical wires were significantly higher than that of 3D-printed round wires, which was attributed to the larger cross-sections of the wires. <b>Conclusion:</b> Oval and semielliptical 3D-printed wires offered favorable features as lingual retainers.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2024 ","pages":"3540846"},"PeriodicalIF":1.9,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11496588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In Vitro</i> Aging and Fracture Tests on Differently Veneered Partially Stabilized Zirconia Anterior Crowns.","authors":"Andreas Zenthöfer, Ali Ilani, Stefan Rues","doi":"10.1155/2024/2037792","DOIUrl":"https://doi.org/10.1155/2024/2037792","url":null,"abstract":"<p><p><b>Objectives:</b> To evaluate the fracture resistance of veneered incisor crowns made from highly translucent zirconia frameworks. <b>Materials and Methods:</b> Ninety-six all-ceramic single crowns were based on either a coping with minimum wall thickness or a cutback framework fabricated from highly translucent zirconia (5Y-PSZ). Each one-third of the specimens was finalized with different veneering ceramics using standardizations and glaze firing. Crowns were luted to cobalt-chromium dies with MDP-containing composite cement. Half of the entire sample underwent artificial aging (chewing simulation and thermocycling) before fracture load tests were conducted using a 6 mm steel sphere applied in a 90° angle to the oral aspect of the crowns with 1.3 mm distance to the incisal edge. Besides descriptive presentation of recorded forces at first damage (F_1d) and fracture (F_u), Kruskal Wallis and Mann-Whitney <i>U</i> tests were used to analyze data at <i>α</i> = 0.05. <b>Results:</b> Directly after manufacturing, incisor crowns of all test groups showed sufficient mean fracture resistances. After artificial aging, crack formation was observed in a high percentage for fully veneered crowns of all test groups, but only for one veneering ceramics with cutback crowns. Mean test forces of unaged crowns were F_1d,mean ≥ 422 N | F_u,mean ≥ 749 N (fully veneered) and F_1d,mean ≥ 644 N | F_u,mean ≥ 706 N (cutback) dropped significantly to F_1d,mean ≥ 131 N | F_u,mean ≥ 223 N (fully veneered) and F_1d,mean ≥ 324 N | F_u,mean ≥ 524 N (cutback) . <b>Conclusions:</b> Within the limitations of this laboratory study, 5Y-PSZ based anterior crowns can be a viable treatment option. Framework design, choice of the veneering ceramics and artificial aging show relevant effects on the fracture resistances. Concerted veneering ceramics should be used and partially veneering of the zirconia frameworks should be favored over full veneers.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2024 ","pages":"2037792"},"PeriodicalIF":1.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11483650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Matrix Metalloproteinase-3 for Dental Caries Prevention Using Herbal Isolates: MMP3 Inhibition by Cinnamic Acids.","authors":"Mahdieh Salman, Bahareh Asgartooran, Amir Taherkhani","doi":"10.1155/2024/9970824","DOIUrl":"https://doi.org/10.1155/2024/9970824","url":null,"abstract":"<p><p><b>Objectives:</b> Dental caries, a prevalent infectious disease affecting teeth, ranks highest among 328 diseases, according to a 2017 Lancet study. In demineralized human dentin, matrix metalloproteinase-3 (MMP3) functions as a proteoglycanase, contributing to the degradation of proteoglycan components. This process exposes collagen fibrils, thereby facilitating the demineralization of the dentin matrix. Inhibiting MMP3 shows potential for preventing dental caries. <b>Methods:</b> The binding affinity of 20 cinnamic acid derivatives, namely cynarin, chlorogenic acid, rosmarinic acid, cinnamyl caffeate, phenethyl caffeate, N-p-coumaroyltyramine, caffeic acid 3-glucoside, caffeic acid phenethyl ester, roscovitine, benzyl caffeate, o-coumaric acid, artepillin C, caffeic acid, methyl caffeate, 2-methylcinnamic acid, ferulic acid, drupanin, p-coumaric acid, cinnamic acid, and sinapinic acid, to the MMP3 catalytic cleft, was assessed utilizing AutoDock 4.0. Molecular dynamics simulation was then employed to analyze the stability of backbone atoms in free MMP3, MMP3-positive control inhibitor, and MMP3 complexed with the top-ranked cinnamic acid over a 100 ns computer simulation. <b>Results:</b> Four cinnamic acids demonstrated <i>ΔG</i> _binding scores below -10 kcal/mol, with cynarin emerging as the most potent MMP3 inhibitor, featuring a <i>ΔG</i> _binding score and inhibition constant value of -15.57 kcal/mol and 3.83 pM, respectively. The MMP3-cynarin complex exhibited stability after a 50 ns computer simulation, showing a root-mean-square deviation of 8 Å. <b>Conclusions:</b> The inhibition of MMP3 by cynarin, chlorogenic acid, rosmarinic acid, and cinnamyl caffeate holds promise as a potential preventive strategy for dental caries.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2024 ","pages":"9970824"},"PeriodicalIF":1.9,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Analysis of Concordance Between Clinical and Histopathologic Diagnoses and Completeness of Oral Biopsy Forms at a Tertiary Dental Hospital in Eastern Nepal.","authors":"Shashi Keshwar, Neetu Jain, Toniya Raut, Vimmi Singh, Ashish Shrestha","doi":"10.1155/2024/2528353","DOIUrl":"10.1155/2024/2528353","url":null,"abstract":"<p><p><b>Introduction:</b> Histopathological diagnosis remains the gold standard tool for the diagnosis, yet accurate and detailed clinical descriptions are necessary to facilitate the final diagnosis. Histopathologists believe that clinicians are unaware of how histopathology departments operate, partly because of the less information on requisition forms. The objective of the present study is to assess the concordance of clinical and histological diagnoses of all oral and maxillofacial biopsy samples, along with the completion of the requisition form provided with the biopsy sample. <b>Methods:</b> A retrospective study was conducted at the Department of Oral Pathology. The biopsy request forms of year 2018-2019 were retrieved from the archive of the department and were analyzed for clinicopathological concordance. Descriptive and analytical statistics were performed using SPSS. <b>Results:</b> Of 338 forms, 243 (71.89%) forms had total concordance between clinical and histopathologic diagnosis; 20 forms (5.92%) had concordance with the histopathological diagnosis, but only after the clinical diagnosis had been refined. Of all the forms analyzed, 36 (10.65%) forms lack habit history in cases suspected of oral cancer and oral potentially malignant disorder, and 24 (7.10%) cases lack radiographic details. The categories of clinicohistopathological concordance and the different clinical information groups showed a statistically significant relationship. We also found that the sign-out time for histopathological reports depend on the extent of clinical information provided which was statistically significant too. <b>Conclusions:</b> The current study concluded a sufficient level of concordance between clinical and histopathological diagnosis. A high completion rate of biopsy forms indicated that the clinicians/operating surgeons perceive the significance of clinical information in histopathological diagnosis. We also recommend, irrespective of the type of suspected oral lesions, submitted for biopsy, a detailed clinical information is the backbone for accurate and timely reporting of the histopathological diagnosis.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2024 ","pages":"2528353"},"PeriodicalIF":1.9,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11466534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the Ability of Senior Dental Students to Detect Interproximal Caries Using Different Radiographic Techniques.","authors":"Muzan Abdalla, Saadika B Khan","doi":"10.1155/2024/9877819","DOIUrl":"https://doi.org/10.1155/2024/9877819","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the diagnostic capability of 5th-year students using digital imaging, conventional bitewing (BW) radiographs, and printed film on paper to detect interproximal caries lesions. <b>Methods:</b> A cross-sectional study was conducted with senior dental students. Three different radiographs: digital, BW, and printed films on paper were used; thus, nine radiographs, each with a 2-min viewing time, were considered by students along with a questionnaire. A control group of specialists from Prosthodontics and Radiology had finalized the answers prior to conducting the study. The appropriate responses were divided into five categories: R0: Intact surface, R1: Radiolucency in the outer half of enamel, R2: Radiolucency in the inner half of enamel, R3: Radiolucency in the outer half of dentin, and R4: Radiolucency in the inner half of dentin. Students' responses were analyzed using a one-way analysis of variance (ANOVA) test and a <i>t</i>-test. <b>Results:</b> Ethics for the study was obtained from the institutional committee (Reg No: BM19/9/8). When compared with the control group using ANOVA testing, the results showed good <i>detection accuracy</i> with a success rate of ~64 accuracy. There was a significant difference in the outcomes when detecting the presence of the caries lesion between the three diagnostic techniques (<i>p</i>  > 0.001). In detecting the <i>size</i> of the carious lesion, the students' ability was recorded as poor. The highest average for detecting the presence of the carious lesion was correspondent to the printed film on paper method. <b>Conclusions:</b> Senior dental students have shown good accuracy in detecting the presence but not the size of interproximal caries on all radiographs viewed. <b>Clinical Significance</b>: Teachings and availability of diverse radiological diagnostic techniques ensured a reasonable level of understanding and use of the diagnostic caries risk assessment methodologies as required in restorative treatment planning.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2024 ","pages":"9877819"},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphology of Roots and Canals of Maxillary First Premolars: A CBCT Study in a Peruvian Sample.","authors":"Juan Salvador Yanqui-Gómez, Julissa Amparo Dulanto-Vargas, Kilder Maynor Carranza-Samanez","doi":"10.1155/2024/2341041","DOIUrl":"https://doi.org/10.1155/2024/2341041","url":null,"abstract":"<p><p><b>Introduction:</b> It is important to take into account variations in structures related to dental pulp for planning the most adequate endodontic treatment management. The objective of this study was to determine the morphology of roots and canals of maxillary first premolars (MFPs) using cone-beam computed tomography (CBCT). <b>Materials and Methods:</b> This retrospective study included a sample of 392 CBCTs of Peruvian adults proportionally selected by sex, age, and quadrant. One MFP per individual was selected for evaluation by a calibrated evaluator based on the number of roots and canal configuration according to the Vertucci classification (VC; Cohen's <i>κ</i> ≥ 0.834). Pearson's <i>χ</i> ² and Kruskal-Wallis tests were used with a significance level of <i>P</i> < 0.05. <b>Results:</b> Most MFP presented double roots (59.9%) and were VC type IV (52%). Morphology showed a nonsignificant difference by quadrants (<i>P</i>=0.994). A significant positive association was found between the presence of double roots and type IV in men and with older age, while single roots and type I and II were associated with women and younger age (<i>P</i> < 0.05). Double roots were associated with VC type IV (86%) and single roots with types III (34%), II (32%), and I (26%; <i>P</i> < 0.001). <b>Conclusions:</b> MFPs in a Peruvian sample presented a higher frequency of double roots with two separate canals. The morphology of root and canals was associated with age and sex.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2024 ","pages":"2341041"},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Color of Zirconia in Different Substrates of Osseointegrated Implants, Thickness of Materials and Types of Resin Cements.","authors":"Aida Seyidaliyeva, Andreas Zenthöfer, Stefan Rues","doi":"10.1155/2024/8696008","DOIUrl":"https://doi.org/10.1155/2024/8696008","url":null,"abstract":"<p><p><b>Objectives:</b> To evaluate the impact of surface conditioning of titanium, zirconia thickness, and cement type on the final color of zirconia luted to the titanium. <b>Methods:</b> A total of 192 grade 5 titanium specimens with the final dimensions 10 mm × 10 mm × 2 mm were fabricated and subjected to four different surface conditioning including, that is, sandblasting, etching, and anodization. In addition, 192 zirconia specimens with the same dimensions as the titanium specimens but altered thicknesses of 0.7 (<i>n</i> = 96) and 1.0 (<i>n</i> = 96) mm were fabricated using 5Y-TZP zirconia. Color as expressed by <i>L</i> ^<i>∗</i> (lightness), <i>a</i> ^<i>∗</i> (red-green axis), and <i>b</i> ^<i>∗</i> (blue-yellow axis) of titanium and zirconia specimens as well as the joined titanium-zirconia complex, total assembly (Panavia V5 clear, PC; opaque, PO, each <i>n</i> = 96) were determined under standardized conditions using a spectroradiometer (SpectraScan P-650). Color differences were calculated using the <i>ΔE</i> ₀₀ formula. ANOVA supplemented with post hoc Tukey test for group comparisons was compiled to estimate possible effects of titanium conditioning, zirconia thickness, and type of cement used on the final zirconia color (SPSS Ver. 28; <i>α</i> = 0.05). <b>Results:</b> All investigated factors affected the zirconia color of the total assembly (<i>p</i>  < 0.001). Using PO mean values of all groups were still close to baseline colors (<i>ΔE</i> ₀₀ between 5.5 and 6.2). When using PC, the final color was significantly altered, irrespective of the other parameters. Specimens luted with PO appeared lighter, less reddish (<i>a</i> ^<i>∗</i> was affected predominately by sample thickness), and more bluish, while luting with PC resulted in reduced lightness combined with large shifts along the red and yellow axes. <b>Significance:</b> Color changes of zirconia luted to titanium are primarily affected by the color of the substrate if a translucent cement was used. Vice versa, the application of an opaque cement effectively masked the dark substrate color. Substrate color and choice of cement have to be taken into consideration when performing shade selection.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2024 ","pages":"8696008"},"PeriodicalIF":1.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Color Matching Ability of a Smart Chromatic Technology-Based Composite Resin for Premolar Teeth Restoration.","authors":"Kamyar Fathpour, Alaleh Salehi, Pouran Samimi, Amirhossein Fathi","doi":"10.1155/2024/5514821","DOIUrl":"10.1155/2024/5514821","url":null,"abstract":"<p><p><b>Objectives:</b> This study aims to evaluate the color-matching ability of OMNICHROMA composite, a single-shade composite, using the CIE L ^<i>∗</i> a ^<i>∗</i> b ^<i>∗</i> system and determining <i>Δ</i>E values. <b>Materials and Methods:</b> In this in vitro study, 30 intact premolar teeth were collected, cleaned, and disinfected with 0.5% thymol solution. The teeth were stored in distilled water at 37°C. A putty index calibrated the color assessment sites on buccal and lingual surfaces. Two cavities were prepared, one with 1.25 mm depth (enamel) and another with 2.25 mm depth (dentin), and restored using OMNICHROMA composite resin. The putty index measured the color of the cured composite, and <i>Δ</i>E between the composite and original tooth color was calculated. <b>Statistical analysis:</b> Data analysis included <i>t</i>-tests, correlation coefficients, and Fisher's exact test (<i>α</i> = 0.05). <b>Results:</b> The mean <i>Δ</i>E was 2.39 in enamel cavities and 2.32 in dentin cavities, both within the clinically acceptable range (<3.3). In enamel cavities, the composite color was darker than the tooth, shifting toward green and blue shades. In dentin cavities, the composite color was lighter than the tooth, with shifts toward green and yellow shades. Color matching was slightly better in dentin cavities, but the difference was not statistically significant (<i>p</i>=0.719). <b>Conclusion:</b> OMNICHROMA composite resin's color matching falls within the clinically acceptable range, unaffected by cavity depth.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2024 ","pages":"5514821"},"PeriodicalIF":1.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Pattern of Oral and Maxillofacial Pathology in Al-Qassim Region, Saudi Arabia.","authors":"Faraj Alotaiby, Rahaf Alruhaimi, Norah Alzamil, Ezdyan Alsemanni, Areej Almutairi, Hala Elsaka","doi":"10.1155/2024/6611349","DOIUrl":"10.1155/2024/6611349","url":null,"abstract":"<p><p><b>Objective:</b> The purpose of this study is to determine the prevalence and features of oral and maxillofacial lesions found in the residents of Al-Qassim region, Saudi Arabia. <b>Methods:</b> A retrospective study was conducted at King Fahad Specialist Hospital, Buraidah, Qassim, KSA. The data for all biopsied oral and maxillofacial lesions were retrieved from January 2014 until August 2022. All patients' data including age, gender, location of the lesion, and histopathologic diagnosis were reviewed and analyzed using IBM SPSS version 23 and Microsoft Excel. <b>Results:</b> A total of 381 oral pathology biopsies for individuals aged 18 and above were included in a descriptive analysis. One hundred ninety five (51.18%) of patients were male, and 186 (48.82%) were female. The site most commonly biopsied was the oral mucosa (26%). The diagnosis was categorized according to the histopathological diagnosis into 13 categories including all pathological lesions in the oral and maxillofacial area. The frequently biopsied category was soft tissue pathological lesion category (26%), second to that is the odontogenic cyst category (22%), and third is the immunological-mediated lesion category (13%). The sub-diagnosis that was mostly observed was radicular cyst, lichen planus, and focal fibrous hyperplasia with the percentages of 13.6%, 10.8%, and 9.4%, respectively. <b>Conclusion:</b> The findings provide important information about the oral and maxillofacial pathology in Al-Qassim region, Saudi Arabia. This study found that biopsied oral lesions were more prevalent in males and in patients in the fourth decade of life. The oral mucosa was the most biopsied site, and the majority of the biopsies were soft tissue pathological lesions and radicular cyst was the most frequent diagnosis. Knowledge of such demographic and clinical features of oral and maxillofacial pathology cases helps in prediction of disease incidence and subsequent proper patient care in the region.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2024 ","pages":"6611349"},"PeriodicalIF":1.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Differentiation Potential of Apical Papilla Cells in Relation to Tenascin-C and Syndecan-1 Expression and Their Potential Role in Regeneration.","authors":"K Kodonas, A Fardi, S Papadimitriou, C Gogos","doi":"10.1155/2024/7295498","DOIUrl":"https://doi.org/10.1155/2024/7295498","url":null,"abstract":"<p><p><b>Introduction:</b> This study investigated the distribution pattern of tenascin-C and syndecan-1 in the dental mesenchyme during root development of immature swine teeth in order to define the differentiation dynamics of both pulp tissue progenitors and apical papilla cells, as well as to assess the adequacy criticize of the apical papilla to induce dentin-pulp regeneration. <b>Methods:</b> Three 7-month-old miniature swine were used in this study. A total of 12 teeth, including two immature permanent incisors and two premolar teeth of each case, were extracted and processed for histological and immunohistochemical analysis. Different populations of mesenchymal cells located at the root apex were morphologically evaluated in hematoxylin-eosin serial sections. Additionally, the distribution patterns of tenascin-C and syndecan-1 were assessed immunohistochemically. <b>Results:</b> Syndecan-1 was strongly expressed in the dental pulp, particularly along the odontoblasts of the root and the newly deposited predentin layer. Tenascin-C was intensely expressed in the dental pulp. The apical papilla and dental follicle showed no expression of either molecule. <b>Conclusions:</b> Cell differentiation potential in the developing swine apex is progressively restricted to the newly formed dental pulp, whereas phenotypic expression of apical papilla cells remains undetermined unless the new microenvironment triggers cell differentiation towards the odontoblastic lineage.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2024 ","pages":"7295498"},"PeriodicalIF":1.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}