International Journal of Dentistry最新文献

{"title":"Tanzanian Population's Perspective on Facial Profile Esthetic Preferences.","authors":"Ali Khamis Hamad, Ferdinand Mabula Machibya, Matilda M Mlangwa, David N Ngassapa","doi":"10.1155/ijod/2937725","DOIUrl":"10.1155/ijod/2937725","url":null,"abstract":"<p><p><b>Background:</b> The perception of facial profile attractiveness varies among individuals and may influence clinical decision-making in orthodontic dentofacial treatment goals. <b>Objective:</b> The aim of the study was to evaluate the facial profile preferences of Tanzanian individuals. <b>Materials and Methods:</b> This cross-sectional study was conducted at Muhimbili University Dental Clinic in Dar es Salaam, Tanzania. A total of 387 participants, including 146 females and 241 males, were selected based on their lack of technical awareness of the facial profiles. The mean age of the male and female participants was 27.94 ± 7.67 and 28.98 ± 7.76 years, respectively. The participants were asked to evaluate male and female facial profiles and score them on a scale of 1-4, with no score being assigned to more than one profile. The relative frequency of the profile scores was calculated, and a <i>t</i>-test and analysis of variance (ANOVA) were used to compare the preferences across different groups. A statistical significance was set at a 95% confidence interval (CI), with a <i>p</i>-value of <i>p</i> < 0.05 considered significant. <b>Results:</b> Among the male profiles, 48.3% (187) of the participants ranked profile M1, \"normal maxilla, retruded mandible\", as the most attractive, while 48.1% (186) ranked profile M2, \"retruded maxilla, protruded mandible\", as the least preferred. Statistically significant differences were observed between age groups and income groups (<i>p</i> < 0.05) in the ratings of each male profile. For the female profiles, 56.6% (219) of the raters preferred profile F4, \"straight\", while profile F3, \"protruded maxilla, normal mandible\", was ranked as the least preferred by 51.7% (200) of the participants. Significant differences were observed in the ratings of profile F4, \"straight\", between groups (<i>p</i> < 0.05), except when comparing ratings between genders, where no significant difference was found. No statistically significant differences on age or income were observed for profile F3, \"protruded maxilla, normal mandible\". <b>Conclusions:</b> The most preferred profiles among the Tanzanian population were the male profile with a mandibular retrusion (M1) and the female straight profile (F4).</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"2937725"},"PeriodicalIF":1.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cephalometric Characteristics of Various Ethnic Groups in Tanzania.","authors":"Ali Khamis Hamad, Ferdinand Mabula Machibya, Matilda M Mlangwa, David N Ngassapa","doi":"10.1155/ijod/6685596","DOIUrl":"10.1155/ijod/6685596","url":null,"abstract":"<p><p><b>Objective:</b> The aim of this study is to investigate the craniofacial skeletal profile features of the Tanzanian population with normal occlusion using lateral skull cephalograms, to determine the differences in craniofacial characteristics among various Tanzanian ethnic groups, and to compare the cephalometric norms of Caucasians with those of Tanzanians. <b>Materials and Methods:</b> Lateral cephalograms were taken from 142 male and 167 female Tanzanians, aged 18-30 years, all with acceptable and pleasing profiles and Class I occlusion, and no history of previous orthodontic treatments. Six linear and 14 angular cephalometric measurements were selected for analysis. A Student <i>t</i>-test was used to compare the mean cephalometric values between Tanzanians and Caucasians, while a one-way analysis of variance was applied to assess the inter-ethnic differences within the Tanzanian group. <b>Results:</b> No significant differences were found between the Tanzanian ethnic groups, except for the ANB and NA-APog angles, which were increased in the Cushite group, and the Md1-ML angle, which was found to be reduced in the Bantu sample. Significant differences were observed between Tanzanians and Caucasians in all measurements (<i>p</i> < 0.05) except for the Wits appraisal in sagittal relationships and the S-Go:N-Me and SN-OcP measurements in vertical relationships. <b>Conclusion:</b> The findings indicate that Tanzanian adults display distinct craniofacial characteristics, including a more convex facial profile, increased lower lip protrusion, dental proclination, and notable ethnic and intergroup variations.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"6685596"},"PeriodicalIF":1.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional Facial Imaging: A Comparative Assessment of the Clinical Applicability of State-of-the-Art Technologies for Three-Dimensional Facial Imaging.","authors":"Thanatchaporn Jindanil, Ranida Ponbuddhichai, Céline Massant, Lianyi Xu, Rocharles Cavalcante Fontenele, Maria Cadenas de Llano-Pérula, Reinhilde Jacobs","doi":"10.1155/ijod/8822293","DOIUrl":"10.1155/ijod/8822293","url":null,"abstract":"<p><p><b>Objective:</b> To compare the clinical applicability in terms of observer perception, patient perception, and clinical usability of stereophotogrammetry (SPG) and both static and portable structured light (SL) three-dimensional (3D) face scanners. This comparison was based on the perception of medical observers, nonmedical observers, and patients themselves, using two-dimensional (2D) photographs as clinical reference. <b>Material and Methods:</b> Facial images of 20 patients (12 females and eight males) were obtained using a professional camera (clinical reference) and three facial scanners: Vectra H1 (SPG), RAYFace RFS200 (static SL), and iReal 2E (portable SL). Instant similarity rank (ISR) and similarity score (SS) were evaluated by seven medical and six nonmedical observers, and intra- and interobserver reliability were calculated. Patients rated the overall SS (OSS) and comfort. Scanning time, processing time, need for image retake, and user-friendliness were rated by two operators who captured the images. <b>Results:</b> SPG obtained the best ISR, followed by static and portable SL. All scanners showed overall good SS and OSS. Static SL was the fastest, whereas SPG and portable SL recorded same total time. Retake rates for SPG, static SL, and portable SL were 10%, 15%, and 35%, respectively. User-friendliness and comfort ranged from moderate to good for all scanners. <b>Conclusion:</b> All tested scanners show a good clinical applicability, even though each scanner came with specific advantages and drawbacks for clinical use. SPG excelled in instant similarity, but had slower processing times. Static SL offered a balance of speed, comfort, and user-friendliness, though not always the best in similarity. Portable SL had higher retake rates and moderate comfort and user-friendliness. Similarity perception across scanners was comparable for both medical and non-medical observers, highlighting the need for clinicians to consider all scanner features to best meet clinical requirements.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"8822293"},"PeriodicalIF":1.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Fascin Expression in Oral Verrucous Carcinoma and Oral Squamous Cell Carcinoma.","authors":"Nima Mohammadi, Shadi Saghafi Khadem, Saghar Emami Ardestani, Mohammad Hossein Nikbakht","doi":"10.1155/ijod/5530533","DOIUrl":"https://doi.org/10.1155/ijod/5530533","url":null,"abstract":"<p><p><b>Introduction:</b> One of the diagnostic problems of pathology is to differentiate between oral verrucous carcinoma (OVC) and oral squamous cell carcinoma (OSCC). Fascin increases the invasion of normal and neoplastic cells by stabilizing cytoplasmic filamentous actin. The present study aimed to investigate the expression of fascin in OSCC and OVC. <b>Methods:</b> This descriptive-analytical cross-sectional was conducted on 25 blocks of OSCC, 22 blocks of OVC, and 10 blocks of healthy mucosa as a control group. After immunohistochemical staining, samples were observed by two maxillofacial pathologists simultaneously, and the percentage of stained cells, intensity of staining, and the location of stained cells were obtained. <b>Results:</b> There was no significant difference in the gender (<i>p</i>=0.123) and age (<i>p</i>=0.276) distribution of participants in the groups. There was a significant difference in the distribution of the involved area in the patients of the studied groups (<i>p</i> < 0.001). There was a significant difference in the intensity of staining and the percentage of stained cells between the studied groups (<i>p</i> < 0.001). <b>Conclusions:</b> The percentage and intensity of staining were higher in the OSCC, OVC and, control groups, respectively. It seems that Fascin expression has an important role in predicting OVC and OSCC.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"5530533"},"PeriodicalIF":1.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Antimicrobial Properties of Mesoporous Zinc Oxide Nanoparticles Against <i>Streptococcus mutans</i>: An In Vitro Investigation.","authors":"Zahra Jowkar, Shima Askarzadeh, Seyed Ahmadreza Hamidi, Zahra Fattah, Ali Moaddeli","doi":"10.1155/ijod/4438269","DOIUrl":"10.1155/ijod/4438269","url":null,"abstract":"<p><p><b>Background:</b> This study focused on synthesizing and characterizing mesoporous zinc oxide nanoparticles (ZnO NPs) while evaluating their antibacterial effectiveness against <i>Streptococcus mutans</i>. Their antimicrobial properties were compared to conventional ZnO NPs using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests. <b>Methods:</b> Mesoporous ZnO NPs were produced and analyzed for structural properties. Their antibacterial potential was assessed through MIC and MBC determinations, along with inhibition zone measurements. The test groups included calcined and noncalcined mesoporous ZnO NP solutions (10 mg/mL), standard ZnO NP solution (10 mg/mL), normal saline, and chlorhexidine (CHX) solution (2 mg/mL). <b>Results:</b> All ZnO NP solutions exhibited an MIC of 5 mg/mL, with lower concentrations (2.5 mg/mL and below) showing no inhibition against <i>S. mutans</i>. The MIC for CHX (2 mg/mL) was found to be 0.156 mg/mL. MBC values matched MIC results for all NP solutions (5 mg/mL), whereas CHX had an MBC of 0.312 mg/mL. Among the tested solutions, the calcined mesoporous ZnO NP solution produced the largest inhibition zone (19 ± 0.02 mm), followed by the noncalcined version (17.2 ± 0.03 mm). CHX (14.9 ± 0.02 mm) and ZnO NP solution (15.2 ± 0.13 mm) showed similar inhibitory effects. <b>Conclusion:</b> The study suggests that mesoporous ZnO NP solution possesses strong antibacterial properties against <i>S. mutans</i>, offering a promising alternative to CHX, which is widely used in dental disinfection. These findings highlight the potential application of mesoporous ZnO NPs in various dental procedures, including endodontics, restorative treatments, and periodontal therapy.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"4438269"},"PeriodicalIF":1.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Genetic Polymorphisms of <i>IL33</i> and <i>IL1RL1</i> Genes on the Immunopathogenesis of Periodontitis.","authors":"Aléia Harumi Uchibaba Yamanaka, Josiane Bazzo de Alencar, Victor Hugo de Souza, Joana Maiara Valentini Zacarias, Larissa Danielle Bahls-Pinto, Cléverson O Silva, Ana Maria Sell, Quirino Alves de Lima Neto","doi":"10.1155/ijod/7599713","DOIUrl":"https://doi.org/10.1155/ijod/7599713","url":null,"abstract":"<p><p>Periodontitis (PD) is an inflammatory disease that affects the protective and supporting tissues of teeth. Mutations in cytokines and their receptors may influence the immunopathogenesis of PD, but the role of interleukin-33 (IL-33) and IL1RL1 is not clear. Thus, this study aimed to analyze the polymorphisms in <i>IL33</i> (rs1929992 and rs7025417) and <i>IL1RL1</i> (rs11685424 and rs3821204) genes and the IL-33 serum levels in PD patients. A case-control study was performed with 186 PD patients and 189 controls. Genotyping was performed by polymerase chain reaction using sequence-specific primer (PCR-SSP) technique. Serum levels of IL-33 were determined using the immunoenzymatic method. Statistical analyses were performed using SNPStats and OpenEpi. <i>p</i> > 0.05 was considered statistically significant. The <i>IL33</i> rs7025417 C/C genotype was a risk factor for PD in nonsmokers (<i>p</i>=0.0015) regardless of smoking status and gender. In the general population, the <i>IL1RL1</i> rs3821204 G/G genotype was protective for PD (<i>p</i>=0.006), regardless of gender. Nevertheless, the IL-33 serum levels were increased in patients compared to controls (<i>p</i> < 0.0001); however, no difference was observed among PD patients. The polymorphisms <i>IL33</i> rs7025417 and <i>IL1RL1</i> rs3821204 were associated with risk and protection, respectively, and the production of IL-33 was higher in PD patients than in controls, independent of the extent or severity of the disease.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"7599713"},"PeriodicalIF":1.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Strategies for Peri-Implant Mucositis: The Final Stop for Preventing Peri-Implantitis.","authors":"Rafael Pereira, Hamoun Sabri, Paolo Nava, Abdusalam Alrmali, Hom-Lay Wang","doi":"10.1155/ijod/6901156","DOIUrl":"https://doi.org/10.1155/ijod/6901156","url":null,"abstract":"<p><p><b>Objectives:</b> This article aims to provide a comprehensive overview of peri-implant mucositis, covering its etiology, risk factors, clinical features, diagnosis, and available treatment modalities. <b>Methods:</b> A comprehensive electronic and manual search was performed on electronic databases. Studies with focus on peri-implant mucositis were included and reviewed comprehensively. Based on the latest evidence, decisional workflows and clinical recommendations were proposed. <b>Results:</b> The review highlights the multifactorial etiology of peri-implant mucositis, primarily driven by bacterial biofilm accumulation. Key risk factors identified include poor oral hygiene, smoking, uncontrolled diabetes, and local factors such as implant surface characteristics and prosthesis design. Diagnostic criteria are based on the presence of clinical signs (inflammation, redness, swelling, and bleeding on probing (BoP)) and the absence of radiographic bone changes. Nonsurgical treatments, including mechanical debridement and photodynamic therapy (PDT), have shown effectiveness in managing the condition. However, the efficacy of adjunctive therapies remains inconclusive. Regular maintenance and optimal oral hygiene are critical in preventing and managing peri-implant mucositis. <b>Conclusion:</b> Peri-implant mucositis remains a prevalent condition in implant dentistry, with nonsurgical treatment strategies showing promising outcomes in disease management. Further research is needed to establish the long-term effectiveness of adjunctive therapies and optimize preventive strategies for maintaining peri-implant health.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"6901156"},"PeriodicalIF":1.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexural Strength and Stress Analysis of CAD-CAM Milled Glass Fiber Post and Core.","authors":"Sergio Eduardo Ramos Dos Santos, Klíssia Romero Felizardo, Ricardo Danil Guiraldo, Sandrine Bittencourt Berger, Murilo Baena Lopes","doi":"10.1155/ijod/6298753","DOIUrl":"https://doi.org/10.1155/ijod/6298753","url":null,"abstract":"<p><p>Intraradicular posts have the potential to induce mechanical stresses within the root structure during masticatory activities, hence contributing to fatigue and ultimately resulting in the fracture of the remaining dental structure. The objective of this work was to compare the stress pattern generated on the root by a computer-aided design and computer-aided manufacturing (CAD-CAM) milled fiberglass post under occlusal load in a photoelastic simulation and to compare its flexural strength (FS) to other types of posts. A total of 15 simulated roots, produced from photoelastic resins, were created using human canine teeth. These specimens were then separated into three distinct groups: Fiber post conventional, which consisted of fiberglass posts; fiber post customizable, which involved prefabricated fiberglass posts anatomized with composite resin; and fiber post CAD-CAM, which utilized CAD-CAM milled fiberglass posts. Following the application of Relyx ARC cement, the posts underwent photoelastic testing using a polariscope and FS testing using a universal testing machine. The data were submitted to analysis of variance (ANOVA) and Tukey's test at 5% significance level. It was found that the stress was significantly greater (<i>p</i> < 0.05) for the customizable post (246.5 MPa ± 218.7) in comparison to both the conventional (135.8 MPa ± 99.3) and CAD-CAM (136.5 MPa ± 68.4) posts; the latter group exhibited the lowest flexural values (50.8 MPa ± 7.9), which were significantly different from both the conventional group (123.0 MPa ± 26.9) and the customized group (230.3 MPa ± 18.9), which also differed from each other. The modulus of elasticity showed statistical differences (<i>p</i>  < 0.05) among the three different methods: CAD-CAM (0.50 GPa ± 0.06), conventional (1.75 GPa ± 0.13), and custom (3.46 GPa ± 0.19). The FS and elasticity modulus of customized posts were significantly higher than those of CAD-CAM, that exhibited the lowest values. Intermediate values were demonstrated by conventional posts. In comparison, to the customized post, the stress study revealed that conventional and CAD-CAM posts had a lower stress in the apical area and a lower general root stress value; but the cervical stress from CAD-CAM posts were practically twice of conventional and customized posts.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"6298753"},"PeriodicalIF":1.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Occlusion Tracking by T-Scan Novus System in Bruxism Patients Treated With 3D Printed Occlusal Splints.","authors":"Dobromira Shopova","doi":"10.1155/ijod/8842498","DOIUrl":"https://doi.org/10.1155/ijod/8842498","url":null,"abstract":"<p><p><b>Background:</b> Bruxism is a chronic pathological condition with significant clinical implications, necessitating meticulous monitoring for comprehensive treatment. The primary aim of this study was to conduct a digital measurement-based comparative analysis of occlusal alterations in occlusal splints over a 3-month period. <b>Methods:</b> This investigation involved 32 patients with natural dentition, fixed dental restorations, implant treatments, and a minimum of second molars. Intraoral scanning was executed using the 3DISK OVO imaging system. Digital models generated from these scans were employed to design occlusal splints using the 3Shape design software in conjunction with its splint studio module. The splints were subsequently fabricated using 3D printing technology and a biocompatible resin, Ortho Rigid (Nextdent). The assessment of occlusion was carried out using the T-Scan Novus system (Tekscan, 2018) and subjected to analysis with licensed software version 10.0.40 (T-Scan 10). Student's <i>t</i>-test for independent samples and a paired-sample <i>t</i>-test were used to detect the statistically significant difference in the distribution of occlusal force. <b>Results:</b> Initial digital occlusal measurements revealed statistically significant disparities in two specific regions between male and female subjects-the right first molar (<i>t</i>(31) = 2.04, <i>p</i> < 0.05) and left second molar (<i>t</i>(31) = 1.95, <i>p</i> < 0.05). Following a 3-month follow-up, significant differences in occlusal splint wear were discerned among male subjects (<i>p</i> < 0.01), whereas such differences were not observed among female subjects (<i>p</i> > 0.01). <b>Conclusion:</b> The digital design of occlusal splints facilitates the development of uniform contact areas across the entire occlusal surface. Nonetheless, the examination with T-Scan Novus unveiled that uniformity in contact area does not necessarily correspond to uniformity in force distribution.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"8842498"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Cytoprotective Effect of <i>Morus alba L</i>. Fruits as a Means of Transporting the Avulsed Teeth.","authors":"Mihaela Chirilă, Ioana Suciu, Ecaterina Ionescu, Ionela Daniela Popescu, Eleonora Codorean, Elena Codrici, Lucian Chirilă, Oana Amza, Bogdan Dimitriu, Cornelia Nichita","doi":"10.1155/ijod/6661398","DOIUrl":"https://doi.org/10.1155/ijod/6661398","url":null,"abstract":"<p><p>This study aims to test the cytoprotective effect of <i>Morus alba</i> L. fruit extracts on cell viability and its suitability as a transport medium for avulsed teeth. <b>Materials and Methods</b>. Two <i>Morus alba</i> L. fruit extracts were synthesized, E1 and E2. The E1 extract was composed of fresh mulberry fruits, whereas the E2 extract was made from dehydrated fruits. The cytoprotective effect of the E1 and E2 extracts was determined using MTS testing over 5000 and 10,000 cells, after a 48 h incubation period, and sampling times of 1 h and 3 h. The concentrations tested were 50 μg/mL (E1A and E2A), 150 μg/mL (E1B and E2B), and 250 μg/mL (E1C and E2C). The data was analyzed using the one-way analysis of variance (ANOVA) test (<i>p</i> < 0.05) and post hoc LSD (least significant difference) analysis (<i>p</i> < 0.1). <b>Results.</b> The post hoc LSD analysis based on the concentration of the E1 extract showed statistically differences (<i>p</i> < 0.1), and for the E2 extract, the results were highly significant (<i>p</i> = 0.011). As a function of concentration between the populations, there are significant differences between E1A and E1B (<i>p</i> = 0.071) and between E1B and E1C (<i>p</i> = 0.084), and statistically insignificant differences between E1A and E1C (<i>p</i> = 0.919). Significant differences were also detected between the E2A and E2B extracts (<i>p</i> = 0.047) and between E2B and E2C (<i>p</i> = 0.004). <b>Conclusions</b>. Analyzing the preliminary results of our study, we can conclude that the <i>M. alba</i> L. extract can be considered a potential transport medium for avulsed teeth.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"6661398"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}