International Journal of Dentistry最新文献

{"title":"Effects of Music Therapy on Pain, Anxiety, and Quality of Life During Lower Third Molar Extraction: A Randomized Double-Blind Clinical Trial.","authors":"Antônio Asriel Dos Santos Almeida, Bárbara Albuquerque Azevedo, Giselly Dos Santos Gomes, Mara Bianca Campos de Araújo, Maria Cecília Dantas Gadelha, Bruna Larissa Dos Santos Pinto, Isadora Idelfonso Monteiro Rodrigues, Rebeca Freitas Lima, Ana Rebeca Fernandes da Silveira, Marina Gurgel Tavares Guerra, Milena Alves Coutinho, Julianne Coelho da Silva, Rosária Emanuelly Oliveiras Bonfim, Paulo Goberlânio de Barros Silva, Edson Luiz Cetira Filho","doi":"10.1155/ijod/2182937","DOIUrl":"https://doi.org/10.1155/ijod/2182937","url":null,"abstract":"<p><p>Third molar extractions are commonly associated with anxiety, pain, and a negative impact on oral health-related quality of life, potentially compromising patient recovery and overall well-being. Nonpharmacological approaches, such as music therapy, have been investigated as adjunctive strategies to improve perioperative outcomes. This randomized, blinded, controlled clinical trial evaluated the effects of music therapy in 42 patients undergoing third molar extraction, who were allocated into two groups: with and without music therapy. The primary outcomes were pain, assessed using the visual analog scale, and anxiety, measured using the <i>Dental Anxiety Scale</i>, while oral health-related quality of life, evaluated using the <i>Oral Health Impact Profile</i> (OHIP-14), was considered a secondary outcome. The control group showed higher systolic blood pressure and respiratory rate. Pain levels increased intraoperatively and decreased postoperatively in both groups, with lower immediate postoperative pain scores observed in the music therapy group. No significant differences were found regarding anxiety levels or quality-of-life outcomes. These findings suggest that music therapy may contribute to the reduction of physiological parameters, such as blood pressure and respiratory rate, as well as participants pain perception, supporting its use as a complementary nonpharmacological strategy in third molar extraction procedures.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2026 ","pages":"2182937"},"PeriodicalIF":2.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Airborne Particle Abrasion and Nitric-Hydrofluoric Acid Etching on the Mechanical and Structural Properties of 3Y- and 5Y-TZP Zirconia.","authors":"Yasser M Aly, Magued H Fahmy, Ghada Ayash, Ola Taha","doi":"10.1155/ijod/3811328","DOIUrl":"https://doi.org/10.1155/ijod/3811328","url":null,"abstract":"<p><strong>Introduction: </strong>Surface treatment is essential for optimizing zirconia bonding, but conventional airborne-particle abrasion (APA) may compromise its mechanical properties, particularly in highly translucent materials. Nitric-hydrofluoric acid (HF) etching has recently emerged as a potential alternative, yet its influence on the surface characteristics and mechanical performance of different zirconia generations remains inadequately understood. Therefore, this study evaluated the effects of APA and nitric-HF etching on the surface roughness, crystalline structure, and biaxial flexural strength (BFS) of 3 mol% yttria-stabilized tetragonal zirconia polycrystal (3Y-TZP) and 5 mol% Y-TZP (5Y-TZP) zirconia.</p><p><strong>Methods: </strong>Ninety-six disc-shaped specimens (10 mm diameter × 1.5 mm thickness) were milled from 3Y-TZP (ZI) (<i>n</i> = 48) and 5Y-TZP (FX) (<i>n</i> = 48). Each zirconia type was randomly allocated into four treatment subgroups (<i>n</i> = 12 per subgroup; 8 subgroups in total): (1) untreated control, (2) APA-50, (3) APA-120, and (4) Zircos E etching. Surface roughness (Ra) was measured using a Marsurf Ps10 surface roughness analyzer, while the crystalline structure was assessed by X-ray diffraction (XRD) diffraction and BFS was evaluated using a universal testing machine according to ISO 6872. Data were statistically analyzed using ANOVA (<i>α</i> = 0.05), followed by posthoc tests.</p><p><strong>Results: </strong>APA-120 showed the highest Ra values (ZI = 1.09 ± 0.29 µm; FX = 0.69 ± 0.12 µm), significantly higher than those of all other treatments (<i>p</i>  < 0.001). Acid etching produced Ra values comparable to the controls (ZI = 0.38 ± 0.06 µm; FX = 0.47 ± 0.03 µm; <i>p</i>  > 0.05). for XRD, 5Y zirconia remained stable across all treatments, while 3Y zirconia showed slight peak intensity changes and minor tetragonal-to-monoclinic transformation after APA, with no change after acid etching. BFS was consistently higher in ZI than in FX (<i>p</i>  < 0.001). The highest strength was recorded for untreated ZI (1059 ± 103 MPa), whereas the lowest was observed for FX after APA-120 (420 ± 80 MPa). Zircos-E preserved 84.7% of the control strength in ZI (897 ± 153 MPa) and 96% in FX (479 ± 97 MPa), whereas APA-120 reduced strength by ~20% in 3Y-TZP and 16% in 5Y-TZP.</p><p><strong>Conclusions: </strong>APA with 120 µm Al₂O₃ maximizes microroughness but compromises the flexural strength. Zircos E etching produced limited surface roughness changes while preserving crystalline stability and flexural strength in both zirconia generations.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2026 ","pages":"3811328"},"PeriodicalIF":2.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Assessment of Observed Dentinal Defects Following Root Canal Preparation With TruNatomy, ProTaper Next, and Dia-X Nickel-Titanium Rotary Systems: An In Vitro Study.","authors":"Shakhawan Kadir Kadir, Khanda Ali Kareem","doi":"10.1155/ijod/2003578","DOIUrl":"https://doi.org/10.1155/ijod/2003578","url":null,"abstract":"<p><p>Endodontic treatment relies on effective root canal preparation using nickel-titanium (NiTi) rotary instruments; however, dentinal defects may be observed following mechanical canal preparation. A total of 40 extracted human mandibular premolars with single roots and single straight canals were randomly allocated into four groups (<i>n</i> = 10), control (unprepared), TruNatomy (TRN), ProTaper Next (PTN), and Dia-X. Root canal was prepared using an ENDO-MATE DT endodontic motor (NSK, Japan), and horizontally sectioned from the apex using a low-speed diamond disc, corresponding to apical, middle, and coronal root thirds, respectively. Dentinal microcracks were evaluated under a stereomicroscope at ×20 magnification. Dentinal defects were observed in all instrumented groups, while the unprepared control group showed the lowest incidence, with defects detected at the apical and coronal thirds (10% each). No statistically significant differences were found among the three rotary systems at the apical (<i>p</i> = 0.211), middle (<i>p</i> = 0.069), or coronal (<i>p</i> = 0.600) levels. However, overall comparison showed a statistically significant difference among groups (<i>p</i> = 0.043), with significant differences between the control group and TRN (<i>p</i> = 0.045), PTN (<i>p</i> = 0.045), and Dia-X (<i>p</i> = 0.010). Dentinal defects were detected at different root levels following preparation with all three rotary systems, with higher overall defect incidence than in the unprepared control group; however, the present methodology does not allow definitive attribution of these defects to instrumentation.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2026 ","pages":"2003578"},"PeriodicalIF":2.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Aging: The Relationship Between Gerotranscendence and Oral Health-Related Quality of Life-A Scoping Review.","authors":"Mithun B H Pai, Shweta Yellapurkar, Sampada Suresh Kulkarni, Shushma B Rao, Kumar Gaurav Chhabra","doi":"10.1155/ijod/3541650","DOIUrl":"https://doi.org/10.1155/ijod/3541650","url":null,"abstract":"<p><strong>Background: </strong>\"Aging India\" is an important public health issue given the various multifactorial physical, psychological, and social aspects of old age. In 2000, the elderly population (≥60 years) in India accounted for 7.7% (77 million) of the total population; this percentage increased to 8.6% (104 million) in 2011 and increased again to 9.4% (125 million) in 2017. Oral health-related quality of life (OHRQoL) is a multidimensional construct that impacts every aspect of daily activities. Gerotranscendence has been suggested to be an ability that enables adaptation and coping strategies from despair, found in Erikson's eighth developmental task. The study aimed to systematically map and synthesize the existing literature on the relationship between gerotranscendence and OHRQoL among older adults and map any evidence gap on the topic.</p><p><strong>Methodology: </strong>This scoping review was conducted using Arksey O'Malley's framework, reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) ScR guidelines. The research question for this scoping review was: \"What is the available evidence on the relation between gerotranscendence and oral health-related quality of life (OHRQoL)?\" The databases searched were PubMed, Embase, Scopus, and Web of Science. Grey literature was not included in this scoping review because it was poorly indexed and unstructured, and the effort required to structure it outweighed the benefits of rapid scoping. The search was conducted by one researcher, with the last search carried out in November 2025.</p><p><strong>Results: </strong>The search of various databases yielded 95 records. After removing the duplicates and completing the title abstract screening, a total of six articles were identified for the full-text review. Based on the inclusion and exclusion criteria, four articles were excluded, and two were included in this scoping review; both were cross-sectional studies and were conducted on a total of 2369 participants aged between 60-81 years.</p><p><strong>Conclusion: </strong>This scoping review shows an intersection between psychosocial aging theory and oral health research. Gerotranscendence seems to modulate the way older adults perceive and respond to challenges presented by their oral health, which suggests that well-being later in life is not explained by clinical parameters alone.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2026 ","pages":"3541650"},"PeriodicalIF":2.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Tooth Discoloration Induced by Mineral Trioxide Aggregate and Polycarboxylate Cement Containing Potassium Nitrate in the Presence and Absence of Blood: An Ex Vivo Study.","authors":"Alireza Adl, Fereshte Sobhnamayan, Maziyar Ghani Kolahloo","doi":"10.1155/ijod/1663827","DOIUrl":"10.1155/ijod/1663827","url":null,"abstract":"<p><strong>Purpose: </strong>Most materials used in endodontic procedures may cause tooth discoloration. This study aimed to compare coronal tooth discoloration after application of mineral trioxide aggregate (MTA) and polycarboxylate cement containing 5 wt% potassium nitrate (PCPN) as vital pulp therapy materials in the presence and absence of blood.</p><p><strong>Methods: </strong>Sixty-eight extracted human single-rooted anterior and premolar teeth were selected, prepared, and standardized to 5 mm root length. After access cavity preparation and enlargement of canals up to Glidden drills #6, cylindrical pieces of white sponge were placed into the canals up to the cementoenamel junction. Specimens were then randomly assigned into two experimental groups (<i>n</i> = 30 each) in which the sponge was saturated with blood or saline solution. In each group, the pulp chambers were filled with 3-mm thickness of MTA or PCPN (<i>n</i> = 15 each) and cavities were sealed with composite after 24 h. Eight additional teeth (four in each of the blood and saline groups) were prepared without placement of any pulp capping material. All samples were incubated at 37°C and 100% humidity. Color changes (Δ<i>E</i>) were measured using a spectrophotometer at baseline, 1 day, 1 month, 3 months, and 6 months. Data were analyzed using repeated measures ANOVA, one-way ANOVA, Tukey post hoc, and paired <i>t</i>-tests (<i>α</i> = 0.05).</p><p><strong>Results: </strong>A significant interaction was observed between time and groups (<i>p</i> < 0.001). In the absence of blood, there was no significant difference in discoloration between MTA and PCPN. In the presence of blood, MTA showed greater discoloration at 3 and 6 months compared with PCPN (<i>p</i> < 0.05). Tooth color change in both experimental groups increased after 1 month (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>MTA exhibited more severe tooth discoloration than PCPN when used in the presence of blood. Both materials showed increased discoloration after 1 month.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2026 ","pages":"1663827"},"PeriodicalIF":2.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Oral Health Into Occupational Therapy: Knowledge, Practices, Barriers and Facilitators-A Systematic Review.","authors":"Ming Nam Tse, Kristy Coxon, Navira Chandio, Kh Shafiur Rahaman, Shruti Nair, Ajesh George, Kanchana Ekanayake, Rosalind Bye, Grace Wong, Carol Tran, Maria O'Reilly, Amit Arora","doi":"10.1155/ijod/2007891","DOIUrl":"https://doi.org/10.1155/ijod/2007891","url":null,"abstract":"<p><strong>Background: </strong>Oral health is essential for overall wellbeing and daily functioning, yet its integration into occupational therapy remains limited. Despite the profession's potential to promote oral health through person-centred, occupation-based approaches, evidence of this integration is scarce. This systematic review explores occupational therapists' (OTs) knowledge and practices in oral health care and examines the barriers and facilitators to incorporating oral health care into their clinical practice.</p><p><strong>Methods: </strong>A comprehensive search was conducted across four databases: MEDLINE (Ovid), CINAHL (EBSCO), SCOPUS and EMBASE (Ovid). Studies were deemed eligible if they reported on OTs' knowledge and practices, as well as the barriers and facilitators to incorporating oral health into clinical practice. Two reviewers independently screened studies, extracted data and resolved discrepancies through team consultation. We assessed methodological quality using the Joanna Briggs Institute Critical Appraisal Checklist for Qualitative Research. We performed thematic analysis and reported the results in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.</p><p><strong>Results: </strong>Of the 14,138 records screened, three qualitative studies met the inclusion criteria. While these studies highlighted OTs' recognition of oral health's impact on daily living and their awareness of person-related challenges to oral hygiene, the relatively small number of included studies limits the generalisability of these findings. Reported practices included assessment, education, environmental modifications, and sensory strategies. Facilitators included prior therapist training, family-centred care and access to resources for oral health intervention. Barriers included limited oral health knowledge, insufficient training, systemic service gaps, lack of oral healthcare supplies and other resource constraints.</p><p><strong>Conclusion: </strong>This review suggests preliminary insights that OTs could potentially play a meaningful role in promoting oral health but are constrained by barriers at individual, organisational and systemic levels. Strengthening workforce training, interprofessional collaboration and policy support may help address oral health needs within occupational therapy practice.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2026 ","pages":"2007891"},"PeriodicalIF":2.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary Classification and Diagnostic Pathways for Common Gingival and Alveolar Ridge Lesions.","authors":"Hamed Mortazavi, Aida Kheiri, Shaghayegh Khoshgou, Ehsan Chegeni, Hamidreza Eghbalikhosro, Amirsalar Mofid, Zahra Karami","doi":"10.1155/ijod/7197720","DOIUrl":"https://doi.org/10.1155/ijod/7197720","url":null,"abstract":"<p><p>Oral lesions can be observed in different locations in the oral cavity, including periodontal supporting structures, gingiva, and alveolar ridge. Ranging from benign to potentially malignant lesions, these lesions can be described from various perspectives, including duration, size, origin, number, and clinical characteristics. Early diagnosis of these lesions can highly affect treatment procedures and outcomes, while preserving tooth-supporting tissues. This review aimed to introduce a decision tree for gingival and alveolar ridge lesions. According to the search strategy, a thorough electronic search was conducted in Web of Science, MEDLINE/PubMed, Google Scholar, EMBASE, and Scopus to identify English-language studies published from January 2000 to June 2026. All clinical studies, including case reports and series, clinical trials and cohorts, and reviews, were considered eligible for inclusion. Initial search led to 6472 findings. Following screening and full-text assessment, 129 studies were finally included. According to clinical manifestations, four main groups of gingival and alveolar ridge lesions, named ulcers and erosions, exophytic lesions, white lesions, and pigmented lesions, were introduced. Based on the clinical characteristics of lesions in each group, certain entities were identified for each category. This review presented a clinically based decision tree to enhance the diagnostic accuracy of gingival and alveolar ridge lesions. Applying this decision tree in clinical practice can help with precise diagnosis and appropriate treatment selection, thereby further improving therapeutic outcomes and preserving the integrity of periodontal structures around teeth.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2026 ","pages":"7197720"},"PeriodicalIF":2.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Middle Mesial Canals and Additional Distal Root Canal Anatomy in Mandibular First Molars: A Cone-Beam Computed Tomography Study in an Iranian Population.","authors":"Tooba Aslanabadi, Tahmineh Razi, Saeedeh Galledar, Naghmeh Rahimi Darehchi, Parisa Jalali, Saeed Rahimi","doi":"10.1155/ijod/1262780","DOIUrl":"10.1155/ijod/1262780","url":null,"abstract":"<p><strong>Background: </strong>A comprehensive understanding of root canal morphology is essential for successful endodontic treatment. Anatomical variations such as middle mesial canals (MMCs), second distal canals, and additional distal roots may complicate canal identification and instrumentation. Although the prevalence of these anatomical features has been investigated in different populations, evidence regarding their potential coexistence within the same tooth remains limited. This study evaluated the prevalence of MMCs and their association with second distal canals and additional distal roots in mandibular first molars using cone-beam computed tomography (CBCT) in an Iranian population.</p><p><strong>Methods: </strong>This retrospective cross-sectional study analyzed 200 CBCT examinations obtained from patients referred to the Department of Oral and Maxillofacial Radiology, Tabriz University of Medical Sciences, between 2019 and 2021. The prevalence of MMCs, second distal canals, and additional distal roots was recorded. Associations among anatomical variables were evaluated using chi-square tests and multivariable logistic regression analyses adjusted for age and sex.</p><p><strong>Results: </strong>MMCs were identified in 26 of 200 mandibular first molars (13.0%), while second distal canals were observed in 64 cases (32.0%). Among teeth with a second distal canal, 15 cases (23.4%) also exhibited an additional distal root. In multivariable analysis, the presence of an MMC was associated with higher odds of a second distal canal (adjusted odds ratio [OR] = 2.62; 95% confidence interval [CI]: 1.11-6.20; <i>p</i> = 0.027). Among teeth with a second distal canal, an association was also observed between MMC presence and additional distal roots (adjusted OR = 6.00; 95% CI: 1.33-27.16; <i>p</i> = 0.020). However, the relatively small number of positive cases, particularly for additional distal roots, resulted in wide CIs and limited the precision of these effect estimates.</p><p><strong>Conclusions: </strong>Within the limitations of this retrospective CBCT-based study, MMCs were associated with the presence of additional distal canal anatomy in mandibular first molars. The findings suggest a possible relationship between mesial and distal anatomical complexity; however, the relatively small number of positive cases and wide CIs warrant cautious interpretation. These associations should be considered exploratory rather than definitive and require confirmation in larger, multicenter studies with greater statistical precision.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2026 ","pages":"1262780"},"PeriodicalIF":2.2,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophage-Marker Response and Exploratory Hepatorenal Safety of a Tricalcium Silicate-Biogenic Calcium Carbonate (<i>Achatina fulica</i>) Hybrid Pulp-Capping Material in a Mechanically Exposed Rat Molar Pulp Model: An In Vivo Study.","authors":"Endo Sadewa, Nurhayaty Natsir, Nurlindah Hamrun, Noor Hikmah, Nisrina Ekayani Nasrun, Kezia Rachellea Mustakim, Juni Jekti Nugroho","doi":"10.1155/ijod/8074092","DOIUrl":"https://doi.org/10.1155/ijod/8074092","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;This study aimed to evaluate, in vivo, the macrophage marker response and exploratory hepatorenal safety of a complete candidate formulation of 75% tricalcium silicate (TCS) and 25% biogenic calcium carbonate (CaCO&lt;sub&gt;3&lt;/sub&gt;) from &lt;i&gt;Achatina fulica&lt;/i&gt; shells, applied to mechanically exposed rat molar pulp, and compared with the manufacturer-prepared commercial calcium silicate standard.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;Forty-eight male Wistar rats underwent mechanical pulp exposure of the maxillary first molars and were randomly allocated to three groups (&lt;i&gt;n&lt;/i&gt; = 16): negative control (saline), positive control (undiluted commercial calcium silicate cement, manufacturer-hydrated, designated \"100% TCS\" for brevity), or the water-activated hybrid (75% TCS + 25% &lt;i&gt;A. fulica&lt;/i&gt; CaCO&lt;sub&gt;3&lt;/sub&gt;), with euthanasia on days 1, 3, 7, and 14 (&lt;i&gt;n&lt;/i&gt; = 4/subgroup). Characterization was performed using Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDX). The pulpal response was assessed by immunohistochemical cell counts for CD68 (pan-macrophage), inducible nitric oxide synthase (iNOS) (M1-associated), and CD163 (M2-associated), and systemic safety by hepatorenal biochemistry (AST, ALT, BUN, creatinine) and blinded liver/kidney histopathology. The prespecified significance threshold was set at &lt;i&gt;α&lt;/i&gt; = 0.05. Primary inference was drawn from between-group comparisons pooled across the four time points (&lt;i&gt;n&lt;/i&gt; = 16 per group), with time-point-specific comparisons (&lt;i&gt;n&lt;/i&gt; = 4) reported descriptively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;FTIR confirmed the presence of characteristic carbonate functional groups, and EDX indicated a calcium fraction of 23.7% on the analyzed surfaces, while chlorine decreased from 13.9% to 4.7% after hydration-liquid substitution. Compared to the commercial standard, the hybrid was associated with lower pan-macrophage infiltration (CD68) and M1-associated marker (iNOS) counts at each timepoint and higher M2-associated marker (CD163) counts, peaking at day 14 (all omnibus comparisons &lt;i&gt;p&lt;/i&gt; &lt; 0.001). Hepatorenal parameters and organ histopathology in the hybrid group were milder than those in the commercial standard group, although all four biochemical parameters remained above those of the operated saline control group, and hepatic portal inflammation was modestly higher in the hybrid group (&lt;i&gt;p&lt;/i&gt; = 0.009).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Compared with the commercial standard, the water-activated 75:25 hybrid was associated with lower pro-inflammatory (M1-associated) and higher proresolving (M2-associated) macrophage-marker levels and with milder renal histopathology and minimal hepatic injury relative to the commercial standard. Because these associations reflect marker immunoreactivity in independent cross-sectional samples rather than tracking individual cells, they support further pre","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2026 ","pages":"8074092"},"PeriodicalIF":2.2,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial Colonization in Monofilament Sutures of Different Materials Following Periodontal Surgeries: A Microbial Analysis Study.","authors":"Abdulaziz Alsakr, Lamia Mohammed Alammar, Mohammed Nasser Alasqah, Abdullah Saad Alqahtani, Khalid Gufran","doi":"10.1155/ijod/6008407","DOIUrl":"https://doi.org/10.1155/ijod/6008407","url":null,"abstract":"<p><strong>Objective: </strong>This study sought to assess and compare the extent of bacterial colonization on various monofilament suture types, including polytetrafluoroethylene (PTFE), polyglycolide-co-caprolactone (PGCL Monocryl), triclosan-coated polydioxanone (Monocryl Plus), and polyamide (nylon). The investigation also aimed to identify predominant bacterial species colonizing these materials and evaluate their potential impact on wound healing and infection control.</p><p><strong>Methods: </strong>An in vitro experimental design combined with clinical sampling was employed. Sutures were retrieved from patients following periodontal surgery between days 7 and 10. Microbiological culture methods, colony-forming unit (CFU) quantification, bacterial identification through Vitek2, and scanning electron microscopy (SEM) were utilized to analyze both aerobic and anaerobic bacterial growth. Statistical analysis was performed to compare bacterial adhesion among the different suture types.</p><p><strong>Results: </strong>The results revealed that PTFE sutures exhibited the lowest bacterial colonization, recording mean aerobic and anaerobic counts of 9.8 × 10⁸ CFU/mL and 8.49 × 10⁸ CFU/mL, respectively, likely due to their smooth and hydrophobic surface characteristics. In contrast, PGCL Monocryl demonstrated the highest levels of colonization, with aerobic and anaerobic counts of 13.3 × 10⁸ and 13.68 × 10⁸ CFU/mL, and harbored bacteria such as <i>Lactococcus garvieae</i>, <i>Staphylococcus warneri</i>, and <i>Streptococcus sobrinus</i>. Monocryl Plus and nylon showed moderate colonization levels, with the triclosan coating on Monocryl Plus reducing but not preventing bacterial attachment.</p><p><strong>Conclusion: </strong>PTFE demonstrated the lowest numerical bacterial colonization among the evaluated suture materials. However, the differences between the groups were not statistically significant and should therefore be interpreted with caution. Further studies with larger sample sizes are needed to confirm these findings.</p><p><strong>Clinical relevance: </strong>The study provides preliminary evidence on bacterial colonization of different monofilament suture materials. These findings may assist clinicians in selecting suture materials, but larger clinical studies are required before definitive recommendations can be made.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2026 ","pages":"6008407"},"PeriodicalIF":2.2,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}