International journal of clinical and experimental medicine最新文献

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Application of MSCTA combined with VRT in the operation of cervical dumbbell tumors. MSCTA 联合 VRT 在颈椎哑铃状肿瘤手术中的应用。
IF 0.1
International journal of clinical and experimental medicine Pub Date : 2015-08-15 eCollection Date: 2015-01-01
Wan Wang, Jia Lin, Engelbert Knosp, Yuanzheng Zhao, Dianhui Xiu, Yongchuan Guo
{"title":"Application of MSCTA combined with VRT in the operation of cervical dumbbell tumors.","authors":"Wan Wang, Jia Lin, Engelbert Knosp, Yuanzheng Zhao, Dianhui Xiu, Yongchuan Guo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cervical dumbbell tumor poses great difficulties for neurosurgical treatment and incurs remarkable local recurrence rate as the formidable problem for neurosurgery. However, as the routine preoperative evaluation scheme, MRI and CT failed to reveal the mutual three-dimensional relationships between tumor and adjacent structures. Here, we report the clinical application of MSCTA and VRT in three-dimensional reconstruction of cervical dumbbell tumors. From January 2012 to July 2014, 24 patients diagnosed with cervical dumbbell tumor were retrospectively analyzed. All patients enrolled were indicated for preoperative MSCTA/VRT image reconstruction to explore the three-dimensional stereoscopic anatomical relationships among neuroma, spinal cord and vertebral artery to achieve optimal surgical approach from multiple configurations and surgical practice. Three-dimensional mutual anatomical relationships among tumor, adjacent vessels and vertebrae were vividly reconstructed by MSCTA/VRT in all patients in accordance with intraoperative findings. Multiple configurations for optimal surgical approach contribute to total resection of tumor, minimal damage to vessels and nerves, and maximal maintenance of cervical spine stability. Preoperative MSCTA/VRT contributes to reconstruction of three-dimensional stereoscopic anatomical relationships between cervical dumbbell tumor and adjacent structures for optimal surgical approach by multiple configurations and reduction of intraoperative damages and postoperative complications. </p>","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 8","pages":"14140-9"},"PeriodicalIF":0.1,"publicationDate":"2015-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retaining of PTCA guide wire in the left ventricular lead and subsequent application of epicardial electrode when CRT-D implantation in a patient with severe heart failure and persistent left superior vena cava: a case report. 在严重心力衰竭和左上腔静脉持续存在的患者中植入 CRT-D 时,在左心室导联中保留 PTCA 导丝并随后应用心外膜电极:病例报告。
IF 0.1
International journal of clinical and experimental medicine Pub Date : 2015-08-15 eCollection Date: 2015-01-01
Pei-Pei Hou, Yu-Hong Liu, Hai-Bo Qu, Jin Meng, Qiang Li, Zhi-Lin Miao
{"title":"Retaining of PTCA guide wire in the left ventricular lead and subsequent application of epicardial electrode when CRT-D implantation in a patient with severe heart failure and persistent left superior vena cava: a case report.","authors":"Pei-Pei Hou, Yu-Hong Liu, Hai-Bo Qu, Jin Meng, Qiang Li, Zhi-Lin Miao","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>One patient with severe heart failure (LV 92 mm, EF 28%) was treated by cardiac resynchronization therapy (CRT).</p><p><strong>Method: </strong>During the operation, it was found that double superior vena cava coexisted, and selective coronary venography cannot clearly show every branch. It was difficult to push ventriculus sinister electrode to sideward vein, so the electrode was released to far end of frontal septal branch along great cardiac vein.</p><p><strong>Result: </strong>However, because of insufficient braced force of ventriculus sinister electrode, 0.014 PTCA guide wire was detained in the electrode. 2 years later, two spots of PTCA guide wire retained in ventriculus sinister electrode broke in atrium dextrum, so the implantation of epicardial electrode was conducted.</p><p><strong>Conclusion: </strong>After the operation, heart failure was relieved. After 43 months, the battery of pacemaker depleted, so the pacemaker was changed. The effect since follow-up visit was good, LV decreased to 86 mm, EF increased to 32%, and SPWMD time limit shortened from 147 ms to 45 ms. The therapeutic experience of this patient indicated that the effect of detaining PTCA guide wire to enhance braced force in implantation of ventriculus sinister is unreliable and inappropriate to be advocated.</p>","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 8","pages":"14472-8"},"PeriodicalIF":0.1,"publicationDate":"2015-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive accuracy comparison of MELD and Child-Turcotte-Pugh scores for survival in patients underwent TIPS placement: a systematic meta-analytic review. MELD和Child-Turcotte-Pugh评分对接受TIPS置管患者存活率的预测准确性比较:系统性荟萃分析综述。
IF 0.1
International journal of clinical and experimental medicine Pub Date : 2015-08-15 eCollection Date: 2015-01-01
Chunze Zhou, Changlong Hou, Delei Cheng, Wenjing Tang, Weifu Lv
{"title":"Predictive accuracy comparison of MELD and Child-Turcotte-Pugh scores for survival in patients underwent TIPS placement: a systematic meta-analytic review.","authors":"Chunze Zhou, Changlong Hou, Delei Cheng, Wenjing Tang, Weifu Lv","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Child-Turcotte-Pugh (CTP) and the model for end-stage liver disease (MELD) scores have been used commonly to predict the survival in the patients with liver diseases underwent transjugular intrahepatic portosystemic shunt (TIPS). However, a debate has continued for years whether CTP could be replaced by MELD score. We performed a systematic meta-analytic review to compare the prediction capability of both scores in survival among patients with TIPS.</p><p><strong>Methods: </strong>Retrospective cohort studies among patients with TIPS were published as of May 2013 were identified by systematically searching four electronic literature database, such as Ovid Medline, PubMed, EMBASE, and ISI Web of Science. The difference of standardized mean difference (SMD) of c-statistics for the predictive accuracy of 1-, 3-, 6-, and 12-month survival for both MELD and CP scores, defined as effect size (ES), was calculated for each individual study and then pooled across studies using standard meta-analyses with a random effects model. Publication bias was evaluated using funnel plots and Kendall's rank correlation tests.</p><p><strong>Results: </strong>174 researches articles or conference abstracts were searched and reviewed using the combination of relevant terms in the articles. Finally, 11 articles were defined as eligible studies to evaluate simultaneously the predictive accuracy of MELD and CTP scores. In the meta-analyses, MELD score was superior to CP score in predicting 3-month survival after TIPS (mean ES, 0.63; 95% confidence interval [CI], 0.13-1.14; P=0.01), but the predictive capability in 1-month, 6-month, and 12-month survival was not significant (1-month: mean ES, 0.79; 95% CI, -0.24-1.83; P=0.13; 6-month: mean ES, 0.46; 95% CI, -2.46-3.37; P=0.76; 12-month: mean ES, 0.36; 95% CI, -0.25-0.96; P=0.25).</p><p><strong>Conclusions: </strong>No enough evidence are confirmed so far that MELD score is better than CTP score to assess the overall prognosis after TIPS, especially long-term predictions, but 3-month predictive capability of MELD score significantly outperform CTP score.</p>","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 8","pages":"13464-72"},"PeriodicalIF":0.1,"publicationDate":"2015-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduction of α1GABAA receptor mediated by tyrosine kinase C (PKC) phosphorylation in a mouse model of fragile X syndrome. 在脆性 X 综合征小鼠模型中,酪氨酸激酶 C (PKC) 磷酸化介导的 α1GABAA 受体减少。
IF 0.1
International journal of clinical and experimental medicine Pub Date : 2015-08-15 eCollection Date: 2015-01-01
Weidong Zhao, Jiaqin Wang, Shunyi Song, Fang Li, Fangfang Yuan
{"title":"Reduction of α1GABAA receptor mediated by tyrosine kinase C (PKC) phosphorylation in a mouse model of fragile X syndrome.","authors":"Weidong Zhao, Jiaqin Wang, Shunyi Song, Fang Li, Fangfang Yuan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fragile X syndrome (FXS) caused by lack of fragile X mental retardation protein (Fmr1) is the most common cause of inherited intellectual disability and characterized by many cognitive disturbances like attention deficit, autistic behavior, and audiogenic seizure and have region-specific altered expression of some gamma-aminobutyric acid (GABAA) receptor subunits. Quantitative real-time polymerase chain reaction and western blot experiments were performed in the cultured cortical neurons and forebrain obtained from wild-type (WT) and Fmr1 KO mice demonstrate the reduction in the expression of α1 gamma-aminobutyric acid (α1GABAA) receptor, phospho-α1GABAA receptor, PKC and phosphor-PKC in Fmr1 KO mice comparing with WT mice, both in vivo and in vitro. Furthermore, we found that the phosphorylation of the α1GABAA receptor was mediated by PKC. Our results elucidate that the lower phosphorylation of the α1GABAA receptor mediated by PKC neutralizes the seizure-promoting effects in Fmr1 KO mice and point to the potential therapeutic targets of α1GABAA agonists for the treatment of fragile X syndrome. </p>","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 8","pages":"13219-26"},"PeriodicalIF":0.1,"publicationDate":"2015-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic effects and complications of simplified pericardial devascularization for patients with portal hypertension. 门静脉高压症患者简化心包血管切断术的治疗效果和并发症。
IF 0.1
International journal of clinical and experimental medicine Pub Date : 2015-08-15 eCollection Date: 2015-01-01
Hongwei Lu, Sida Liu, Yafei Zhang, Hao Shang, Hong Ji, Yiming Li
{"title":"Therapeutic effects and complications of simplified pericardial devascularization for patients with portal hypertension.","authors":"Hongwei Lu, Sida Liu, Yafei Zhang, Hao Shang, Hong Ji, Yiming Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the therapeutic effects and complications of simplified pericardial devascularization for patients with portal hypertension.</p><p><strong>Methods: </strong>By means of prospective study, 212 patients who underwent simplified pericardial devascularization (Group A) and 309 patients who underwent traditional pericardial devascularization (Group B) were followed up from 2003' to 2011'. Results were performed with the general condition of the patients and the incidence of complications to assess the value of the two operating methods.</p><p><strong>Results: </strong>The operating time was 1.0-3.83 hours (mean 1.94 ± 0.32 hours) in Group A versus 1.67-4.50 hours (mean 2.86 ± 0.40 hours) in Group B. The amount of bleeding, postoperative hospital stay and hospitalization expenses were 110-500 ml (mean 224.81 ± 78.44 ml), 7-22 days (mean 10.41 ± 4.01 days) and 15700-27500 yuan with an average of 19300 ± 1600 yuan in Group A and 200-700 ml (mean 423.50 ± 85.19 ml), 9-32 days (mean 14.76 ± 4.52 days) and 18700-44500 yuan with an average of 23400 ± 2200 yuan in Group B. In September 2012', successful follow-up was completed for 438 patients, of which, 181 underwent the simplified devascularization with 31 patients lost (follow-up rate 85.4%). Meanwhile, 257 patients in Group B were followed up completely and 52 patients were lost (follow-up rate 83.2%). The follow-up time ranged from 1 to 9.5 years and the average time was 5.03 ± 2.13 years. The mortality, rebleeding rate, rate of hepatic encephalopathy, rate of ascites and the incidence of gastric fistula and (or) esophageal fistula were 6.1%, 6.1%, 1.7%, 8.3% and 0 in Group A versus 14.0%, 15.2%, 4.3%, 17.7% and 3.1% in Group B.</p><p><strong>Conclusions: </strong>The final results suggested that simplified pericardial devascularization performed more effectively and conveniently than the traditional method, depending on the mitigated operative wound and the shortened operation time. We concluded that simplified pericardial devascularization was better in treatment of portal hypertension compared than the traditional method.</p>","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 8","pages":"14036-41"},"PeriodicalIF":0.1,"publicationDate":"2015-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of relationship of visceral body fat and inflammatory markers with metabolic syndrome and its components among apparently healthy individuals. 内脏脂肪和炎症标志物与代谢综合征及其组成部分之间关系的调查。
IF 0.1
International journal of clinical and experimental medicine Pub Date : 2015-08-15 eCollection Date: 2015-01-01
Yasemin Turker, Davut Baltaci, Yasin Turker, Serkan Ozturk, Cemil Isik Sonmez, Mehmet Harun Deler, Yunus Cem Sariguzel, Feyza Sariguzel, Handan Ankarali
{"title":"Investigation of relationship of visceral body fat and inflammatory markers with metabolic syndrome and its components among apparently healthy individuals.","authors":"Yasemin Turker, Davut Baltaci, Yasin Turker, Serkan Ozturk, Cemil Isik Sonmez, Mehmet Harun Deler, Yunus Cem Sariguzel, Feyza Sariguzel, Handan Ankarali","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Metabolic syndrome is a cluster of disorders and great risk for cardiovascular diseases. We aimed to investigate association between severity of metabolic syndrome (MetS) and anthropometric measurements, and to evaluate correlation of MetS and its components with metabolic deterioration and inflammatory indexes. The cross-sectional study enrolled 1474 patients with obesity and overweight. The patients were grouped as MetS and Non-MetS, and were sub-grouped as group 1 (three criteria), 2 (four criteria) and 3 (≥ five criteria) according to NCEP ATP III. Mean age was 38.7 ± 11.9 years and BMI was 35.1 ± 6.3 kg/m(2). Lipid profile, anthropometric and blood pressure measurements, liver function tests, bioelectric impedance body fat compositions, insulin resistance and HbA1c, and spot urinary albumin-creatinine ratio were significantly different between groups of MetS and Non-MetS. Age, lipid profile, bioelectric impedance fat analyses, BMI, blood pressure values, glucose, insulin resistance, uric acid and hs-CRP levels were significantly different between groups of MetS component groups. ROC analysis revealed that hs-CRP was found to be more predictive for severity of metabolic syndrome components 3 and 4 (P=0.030); uric acid and visceral fat were more actual to predict severity of metabolic syndrome between 3 and 5 MetS components, (P=0.006) and uric acid was detected as more actual to predict severity of MetS between 4 and 5 components (P=0.023). In conclusion, uric acid, hs-CRP and visceral body fat composition were useful to predict to severity of MetS in primary care. </p>","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 8","pages":"13067-77"},"PeriodicalIF":0.1,"publicationDate":"2015-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Different regulation of Toll-like receptor 4 expression on blood CD14(+) monocytes by simvastatin in patients with sepsis and severe sepsis. 辛伐他汀对脓毒症和严重脓毒症患者血液 CD14(+)单核细胞上 Toll 样受体 4 表达的不同调节作用
IF 0.1
International journal of clinical and experimental medicine Pub Date : 2015-08-15 eCollection Date: 2015-01-01
Huanzhang Shao, Cunzhen Wang, Wenliang Zhu, Xiaopei Huang, Zhisong Guo, Huifeng Zhang, Bingyu Qin
{"title":"Different regulation of Toll-like receptor 4 expression on blood CD14(+) monocytes by simvastatin in patients with sepsis and severe sepsis.","authors":"Huanzhang Shao, Cunzhen Wang, Wenliang Zhu, Xiaopei Huang, Zhisong Guo, Huifeng Zhang, Bingyu Qin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have demonstrated that regulation of Toll-like receptor 4 (TLR4) surface expression levels on blood CD14(+) monocytes by simvastatin treatment in patient with sepsis is different from that in patients with severe sepsis. In patients with sepsis simvastatin treatment statistically significantly decreased TLR4 surface expression level on blood CD14(+) monocytes, while in patients with severe sepsis simvastatin treatment had no significant influence on TLR4 surface expression level on blood CD14(+) monocytes. The changes of plasma interleukin-6 (IL-6) induced by simvastatin in patients with sepsis and severe sepsis were similar with that of TLR4. Our results indicated simvastatin treatment differently influenced inflammation process in patients with sepsis and severe sepsis, which might partially explain the discrepancy, presented by previous trials, about the therapeutic effects of simvastatin treatment in patients with sepsis and severe sepsis. </p>","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 8","pages":"13830-5"},"PeriodicalIF":0.1,"publicationDate":"2015-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decreased mean platelet volume is associated with the developing stage of fetoplacental unit in spontaneous abortion. 自然流产时平均血小板体积减少与胎胎盘单位发育阶段有关。
IF 0.1
International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01
Mustafa Kaplanoglu, Tuncay Yuce, Mehmet Bulbul
{"title":"Decreased mean platelet volume is associated with the developing stage of fetoplacental unit in spontaneous abortion.","authors":"Mustafa Kaplanoglu,&nbsp;Tuncay Yuce,&nbsp;Mehmet Bulbul","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>The aim was to evaluate the place of mean platelet volume (MPV) in predicting spontaneous miscarriage and to identify any differences in its values following miscarriage after biochemical and clinical pregnancy.</p><p><strong>Material and method: </strong>We retrospectively evaluated the data of 305 spontaneous miscarriages and 168 control subjects. The miscarriage subjects were evaluated in two groups: miscarriage after biochemical pregnancy (n=79) (BA group) and miscarriage after clinical pregnancy (n=226) (CA group). Demographic and laboratory data of all subjects were statistically compared.</p><p><strong>Results: </strong>No statistically significant difference was found between the miscarriage and control subjects in terms of demographic data and Hb, Htc, WBC, and Plt values. The mean platelet volume (MPV) value in the miscarriage group (8.99±1.47 fl) was statistically significantly lower than in the control group (9.66±1.64 fl) (P<0.001). A statistically significant difference was present between the BA, CA and control group, with the lowest MPV value in the BA group (8.64±1.34 fl, 9.11±1.49 fl, and 9.66±1.64 fl, respectively) (P<0.001).</p><p><strong>Discussion: </strong>MPV was significantly lower in patients with miscarriage than the control group, and this was correlated with the gestational stage when the miscarriage occurred.</p>","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 7","pages":"11301-6"},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565322/pdf/ijcem0008-11301.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34011195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
XRCC1 Arg399Gln polymorphism is not associated with breast cancer in Chinese. 中国人乳腺癌与XRCC1 Arg399Gln多态性无关
IF 0.1
International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01
Shuren Guo, Xiaohuan Mao, Liang Ming
{"title":"XRCC1 Arg399Gln polymorphism is not associated with breast cancer in Chinese.","authors":"Shuren Guo,&nbsp;Xiaohuan Mao,&nbsp;Liang Ming","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>A number of studies have been conducted to explore the association of XRCC1 polymorphisms with Breast cancer (BC) risk in Asians, but the results have been inconsistent. We therefore performed the present meta-analysis to explore the relationship in detail.</p><p><strong>Materials and methods: </strong>Reported studies were searched from 1990 to October 15, 2014 in PubMed and Wan fang Med Online. We performed a meta-analysis of 13 published case-control studies fitting our eligibility criteria. These studies involved XRCC1 Arg399Gln polymorphisms in 4984 BC cases and 5744 controls in dominant (ArgArg vs. GlnGln+ArgGln), recessive (ArgGln+ArgArg vs. GlnGln), and co-dominant (ArgArg vs. GlnGln) inheritance models. The total odds Ratio (OR) and 95% CI were calculated and analyzed by Review Manager 5.2 and STATE 12.</p><p><strong>Results: </strong>Overall, significantly increased BC risk was observed in any genetic model (dominant model: odds ration [OR] = 1.31, 95% confidence interval [CI] = [1.08, 1.58]; recessive model: OR = 0.63, 95% CI = [0.50, 0.81]; codominant model: OR = 2.52, 95% CI: [1.38, 4.60]) when all eligible studies were pooled into the meta-analysis. In further stratified analyses, no association was found between Arg399Gln polymorphism and BC risk in Chinese fewer than three hereditary models.</p><p><strong>Conclusions: </strong>Our results suggest that the XRCC1 Arg399Gln polymorphism may be associated with increased Breast cancer risk among Asians, except Chinese population.</p>","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 7","pages":"10429-36"},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565216/pdf/ijcem0008-10429.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34182131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Folic acid in combination with adult neural stem cells for the treatment of spinal cord injury in rats. 叶酸联合成体神经干细胞治疗大鼠脊髓损伤。
IF 0.1
International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01
Chen Zhang, Lin Shen
{"title":"Folic acid in combination with adult neural stem cells for the treatment of spinal cord injury in rats.","authors":"Chen Zhang,&nbsp;Lin Shen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To observe the therapeutic effect of folic acid in combination with adult neural stem cells on spinal cord injury and to investigate the possible mechanism.</p><p><strong>Methods: </strong>A total of 120 Wistar rats were randomly assigned to six groups: normal, model, sham-surgery, folic acid injection, adult neural stem cell transplantation, and combination (folic acid injection + adult neural stem cells transplantation) groups. Morphology of neural stem cells was observed by inverted microscopy. Expression of CD105, CD45, CD44, and CD29 were detected by flow cytometry; expression of neuron-specific enolase and glial fibrillary acidic protein were determined by immunofluorescence. Motor coordination and integration capabilities were assessed using BBB scores; Morphology of spinal cord tissues was observed by hematoxylin-eosin staining and 5-bromodeoxyuridine immunohistochemistry. GDNF, BDNF and NT-3 expression in spinal cord tissues were determined by ELISA; while expression of the apoptosis-related proteins BCL-2, Bax and caspase-3 was detected using western blotting.</p><p><strong>Results: </strong>Flow cytometry showed that the isolated cells were positive for CD44 and CD29 and negative for CD105 and CD45. Combination treatment significantly improved the behavior of model rats with spinal cord injury, attenuated inflammatory reaction of spinal cord tissues, restored injured nerve cells, and increased expression of GDNF, BDNF and NT-3 in spinal cord tissues, up regulated BCL-2 expression, and down regulated Bax and caspase-3 expression.</p><p><strong>Conclusions: </strong>Folic acid in combination with adult neural stem cells significantly improved nerve function and plays a key role in maintaining microenvironment homeostasis in the neurons of rats with spinal cord injury.</p>","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 7","pages":"10471-80"},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565220/pdf/ijcem0008-10471.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34183645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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