International journal of clinical and experimental medicine最新文献_第10页

Promising potency of retinoic acid-poly(ethylene glycol)-thiol gold nanoparticle conjugates for cervical cancer treatment. 维甲酸-聚乙二醇-硫醇金纳米颗粒偶联物治疗宫颈癌的前景看好。

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Li Ye, Qian Song

{"title":"Promising potency of retinoic acid-poly(ethylene glycol)-thiol gold nanoparticle conjugates for cervical cancer treatment.","authors":"Li Ye, Qian Song","doi":"","DOIUrl":"","url":null,"abstract":"We investigated the effect of synthesized retinoic acid-poly(ethylene glycol)-thiol gold nanoparticle conjugates on cervical carcinoma cells. Cervical cancer is the major cause of deaths for the women of reproductive age in the developing countries. Compared to retinoic acid, the nanoparticle conjugates exhibited better activity against cervical carcinoma. Selective delivery of gold nanoparticle conjugates to estrogen receptor positive cervical cancer cells with 6-fold enhanced drug potency was observed. Transfer of gold nanoparticles was found to be dominated by estrogen ligand and receptor. It appeared that retinoic acid nanoparticle conjugates were selectively taken and retained by the estrogen receptor alpha present in the plasma membrane. Thus IC50 values for RA-PEG-SH were significantly improvedon nanoparticle ligation. Cells on treatment with RA-PEG-SH-AuNPsshowed growth inhibition at 12 and 24 h after incubation. The IC50 for RA in RA-PEG-SH-AuNPs after 12 and 24 h were 3 and 1 μM, respectively. Thus, the use of RA nanoparticle conjugates can be a better strategy for cervical carcinoma treatment. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 7","pages":"10501-7"},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565223/pdf/ijcem0008-10501.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34183648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil-lymphocyte ratio in systemic lupus erythematosus disease: a retrospective study. 系统性红斑狼疮中性粒细胞-淋巴细胞比率的回顾性研究。

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Lixiu Li, Yuncheng Xia, Chunmei Chen, Ping Cheng, Canhui Peng

{"title":"Neutrophil-lymphocyte ratio in systemic lupus erythematosus disease: a retrospective study.","authors":"Lixiu Li, Yuncheng Xia, Chunmei Chen, Ping Cheng, Canhui Peng","doi":"","DOIUrl":"","url":null,"abstract":"Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Lupus nephritis (LN) is an important cause of morbidity and even mortality in patients with SLE. Some evidences suggest that neutrophil-lymphocyte ratio (NLR) associated with different inflammatory malignancies, ischemic injury and cardiovascular disease. Few scholars have investigated the relationship between NLR and SLE. This study aims to evaluate the role of NLR in SLE without nephritis and LN patients.Methods: A total of 228 subjects were participated in this study. 79 diagnosed with SLE in patients group and 149 healthy age-and sex-matched in control group. In patient team, 20 of them were diagnosed with LN.Results: The SLE without nephritis group showed significantly higher NLR than control group (control=2.00±0.76, SLE=4.26±3.38, P<0.001), and the NLR values of the patients with LN were higher than those of the patients without LN (SLE=4.26±3.38, LN=7.21±6.01, P<0.001). Receiver-operating characteristics analysis (ROC) of NLR to predict SLE showed that the area under the curve (AUC) was 0.757. The cutoff value using the ROC curve was 3.13 (sensitivity, 0.574; specificity, 0.926; 95% confidence interval (CI), 0.668-0.845; P<0.001). While ROC analysis of NLR to predict LN showed that the AUC was 0.828). Logistic regression analysis showed that SLE without nephritis and LN were independently related to NLR.Conclusion: NLR is independently associated with SLE, and it may be a promising marker that reflects renal involvement in patients with SLE.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 7","pages":"11026-31"},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565283/pdf/ijcem0008-11026.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34183652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid prototyping for tissue-engineered bone scaffold by 3D printing and biocompatibility study. 组织工程骨支架的3D打印快速成型及生物相容性研究。

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Hui-Yu He, Jia-Yu Zhang, Xue Mi, Yang Hu, Xiao-Yu Gu

{"title":"Rapid prototyping for tissue-engineered bone scaffold by 3D printing and biocompatibility study.","authors":"Hui-Yu He, Jia-Yu Zhang, Xue Mi, Yang Hu, Xiao-Yu Gu","doi":"","DOIUrl":"","url":null,"abstract":"The prototyping of tissue-engineered bone scaffold (calcined goat spongy bone-biphasic ceramic composite/PVA gel) by 3D printing was performed, and the biocompatibility of the fabricated bone scaffold was studied. Pre-designed STL file was imported into the GXYZ303010-XYLE 3D printing system, and the tissue-engineered bone scaffold was fabricated by 3D printing using gel extrusion. Rabbit bone marrow stromal cells (BMSCs) were cultured in vitro and then inoculated to the sterilized bone scaffold obtained by 3D printing. The growth of rabbit BMSCs on the bone scaffold was observed under the scanning electron microscope (SEM). The effect of the tissue-engineered bone scaffold on the proliferation and differentiation of rabbit BMSCs using MTT assay. Universal testing machine was adopted to test the tensile strength of the bone scaffold. The leachate of the bone scaffold was prepared and injected into the New Zealand rabbits. Cytotoxicity test, acute toxicity test, pyrogenic test and intracutaneous stimulation test were performed to assess the biocompatibility of the bone scaffold. Bone scaffold manufactured by 3D printing had uniform pore size with the porosity of about 68.3%. The pores were well interconnected, and the bone scaffold showed excellent mechanical property. Rabbit BMSCs grew and proliferated on the surface of the bone scaffold after adherence. MTT assay indicated that the proliferation and differentiation of rabbit BMSCs on the bone scaffold did not differ significantly from that of the cells in the control. In vivo experiments proved that the bone scaffold fabricated by 3D printing had no acute toxicity, pyrogenic reaction or stimulation. Bone scaffold manufactured by 3D printing allows the rabbit BMSCs to adhere, grow and proliferate and exhibits excellent biomechanical property and high biocompatibility. 3D printing has a good application prospect in the prototyping of tissue-engineered bone scaffold. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 7","pages":"11777-85"},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565401/pdf/ijcem0008-11777.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34013955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LMNA gene single nucleotide polymorphisms in dilated cardiomyopathy of Han children. 汉族儿童扩张型心肌病的LMNA基因单核苷酸多态性。

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Li-Jian Xie, Ting-Ting Xiao, Min Huang, Jie Shen

{"title":"LMNA gene single nucleotide polymorphisms in dilated cardiomyopathy of Han children.","authors":"Li-Jian Xie, Ting-Ting Xiao, Min Huang, Jie Shen","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To investigate whether LMNA gene mutation is associated with dilated cardiomyopathy (DCM) in Chinese Han Race children.Methods: DNA was isolated from 78 patients with DCM and 100 healthy Chinese children who served as controls. 12 exons in the functional regions and the adjacent part of introns of the LMNA gene were amplified with polymerase chain reactions (PCR) and the PCR products were sequenced with DNA sequencer. We compared the DNA sequence with Blast software online PubMed website. The differences of allele and genotype between the groups were detected by χ(2) test.Results: No disease-causing mutation in LMNA gene was found in all DCM patients. Three nonsense single nucleotide polymorphisms (SNPs) were identified. ① The first is c.1908C>T (H566H, rs4641) which was located at exon 10 of LMNA gene. It was found in 29 DCM cases and 15 control subjects. Compared to healthy controls, the frequency of TT and TC genotypes, and the C allele were significantly increased in DCM patients (P<0.05). ② The second was c.861C>T (A287A, rs5380) which was located at exon 5 of LMNA gene. It was found in 9 DCM cases and 2 control subjects. The frequency of TC genotype was significantly increased in DCM patients (P<0.05). ③ The third was c.1338C>T (D446D, rs5058) which located at exon 7 of LMNA gene. It was found in 8 DCM cases and 3 control subjects. The frequency of TC genotype was significantly increased in DCM patients (P<0.05).Conclusion: The SNP of LMNA gene may be associated with the susceptivity of DCM in Chinese Han children.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 7","pages":"11230-4"},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565312/pdf/ijcem0008-11230.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34079627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-hospital clinical outcomes of elderly patients (≥60 years) undergoing primary percutaneous coronary intervention. 老年患者(≥60岁)初次经皮冠状动脉介入治疗的住院临床结果

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Ya-Min Su, Xing-Xing Cai, Hai-Hua Geng, Hong-Zhuan Sheng, Meng-Kan Fan, Min Pan

{"title":"In-hospital clinical outcomes of elderly patients (≥60 years) undergoing primary percutaneous coronary intervention.","authors":"Ya-Min Su, Xing-Xing Cai, Hai-Hua Geng, Hong-Zhuan Sheng, Meng-Kan Fan, Min Pan","doi":"","DOIUrl":"","url":null,"abstract":"Elderly patients are at high risk of mortality when they present with ST-elevation myocardial infarction (STEMI). However, the clinical outcomes of this sub-group undergoing primary percutaneous coronary intervention (PPCI) have not been well established, despite recent advances in both devices and techniques. In the present retrospective cohort study from a Chinese single center, we assessed the clinical outcomes and predictors of mortality in elderly patients (≥60 years) underwent with PPCI. The primary endpoints were immediate angiographic success and in-hospital procedural success. The secondary endpoints were all-cause death in hospital. Between January 2011 and December 2013, a total of 184 consecutive patients with acute STEMI underwent PPCI were enrolled. 116 (63.04%) patients were in the elderly group. Despite the difference in lesion complexity between groups, the immediate angiographic success rate was similar (93.97% in the elderly group, and 94.12% in the non-elderly group, P=0.966). The procedural success rate were not significantly different between the two groups (90.52% in the elderly group, and 94.12% in the non-elderly group, P=0.389). However, in-hospital mortality was statistically higher in elderly group than in the non-elderly group (8.62% Vs 1.47%, P=0.048). The major causes of death were cardiac shock and malignant arrhythmias (ventricular tachycardia and fibrillation). Our results indicate that PPCI in the elderly is feasible and has a high likelihood of immediate angiographic and procedural success. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 7","pages":"11244-51"},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565314/pdf/ijcem0008-11244.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34079629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of leptin and soluble leptin receptor levels with anthropometric parameters in mother-newborn pairs. 母亲-新生儿对瘦素和可溶性瘦素受体水平与人体测量参数的相关性。

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Linda A Marino-Ortega, Adiel Molina-Bello, Julio C Polanco-García, José F Muñoz-Valle, Aralia B Salgado-Bernabé, Iris P Guzmán-Guzmán, Isela Parra-Rojas

{"title":"Correlation of leptin and soluble leptin receptor levels with anthropometric parameters in mother-newborn pairs.","authors":"Linda A Marino-Ortega, Adiel Molina-Bello, Julio C Polanco-García, José F Muñoz-Valle, Aralia B Salgado-Bernabé, Iris P Guzmán-Guzmán, Isela Parra-Rojas","doi":"","DOIUrl":"","url":null,"abstract":"The aim of this study was to investigate if anthropometric parameters are associated with both leptin and soluble leptin receptor (sLEPR) levels in newborns and their mothers. This cross-sectional study was performed in 118 mother-newborn pairs. The venous blood sample of mothers was taken before delivery and immediately after delivery an umbilical cord blood sample was collected. Levels of leptin and sLEPR in maternal and umbilical cord sera were assessed by ELISA. Maternal serum concentration of leptin and sLEPR (6.2 and 25.7 ng/ml, respectively) were higher than in umbilical cord blood (2.4 and 14.2 ng/ml, respectively). However, the newborns and their mothers had higher sLEPR levels than leptin levels. In mothers was observed that leptin levels increase with weight gain in pregnancy and decreased sLEPR levels. Cord leptin levels correlated with neonatal birth weight and length, the body circumferences, placental weight and maternal leptin levels. Cord sLEPR levels correlated with maternal sLEPR and leptin levels. Maternal serum concentration of leptin correlated with pre-pregnancy BMI, weight gain, cord sLEPR and leptin levels. Maternal sLEPR concentration correlated with cord sLEPR levels. The leptin and sLEPR levels in mother-newborn pairs are related with anthropometric parameters and an inverse correlation between leptin levels and sLEPR was observed in pairs. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 7","pages":"11260-7"},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565316/pdf/ijcem0008-11260.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34079631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

APOBEC3A possesses anticancer and antiviral effects by differential inhibition of HPV E6 and E7 expression on cervical cancer. APOBEC3A通过差异抑制HPV E6和E7在宫颈癌中的表达而具有抗癌和抗病毒作用。

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Shan Chen, Xiao Li, Junpu Qin, Yuan Chen, Longyang Liu, Dongqing Zhang, Minyi Wang, Maocai Wang, Dikai Zhang

{"title":"APOBEC3A possesses anticancer and antiviral effects by differential inhibition of HPV E6 and E7 expression on cervical cancer.","authors":"Shan Chen, Xiao Li, Junpu Qin, Yuan Chen, Longyang Liu, Dongqing Zhang, Minyi Wang, Maocai Wang, Dikai Zhang","doi":"","DOIUrl":"","url":null,"abstract":"Cervical cancer is the second most common cancer among women worldwide and is the leading cause of deaths in developing countries. Persistent infections with a subset of HPVs, called \"high-risk HPVs\", including HPV16 and HPV18, are the primary cause of cervical cancer. The apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) family of proteins is a group of cellular enzymes that catalyze the deamination of cytidine (C) to uracil (U) in single-stranded DNA/RNA, and functions as antiviral factors in the innate immune system of the host. Recent studies have shown that APOBEC3A could restrict certain DNA viruses, including HPVs. In this study, we confirmed that the expression of APOBEC3A was decreased in cervical cancer tissues. Furthermore, APOBEC3A inhibited the cervical cells proliferation, migration as well as invasion, and promoted apoptosis depend on cytidine deaminase. In addition, APOBEC3A decreased HPV16-E6, HPV16-E7 and HPV18-E6 depend on cytidine deaminase, but no effect on HPV18-E7. Therefore, we believe that, in cervical cancer cells, the expression of APOBEC3A possesses anticancer and antiviral effects by differential inhibition of HPV E6 and E7 expression depend on cytidine deaminase. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 7","pages":"10548-57"},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565227/pdf/ijcem0008-10548.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34080322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical significance of incidental FDG uptake in the prostate gland detected by PET/CT. PET/CT检测前列腺偶然摄取FDG的临床意义。

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Ertan Sahin, Umut Elboga, Ebuzer Kalender, Mustafa Basıbuyuk, Hasan Deniz Demir, Yusuf Zeki Celen

{"title":"Clinical significance of incidental FDG uptake in the prostate gland detected by PET/CT.","authors":"Ertan Sahin, Umut Elboga, Ebuzer Kalender, Mustafa Basıbuyuk, Hasan Deniz Demir, Yusuf Zeki Celen","doi":"","DOIUrl":"","url":null,"abstract":"The value of FDG-positron emission tomography/computed tomography (PET/CT) for detecting prostate cancer is unknown. We aimed to investigate the clinical value of incidental prostate FDG uptake on PET/CT scans. We reviewed 6128 male patients who underwent FDG-PET/CT scans and selected cases that reported hypermetabolic lesion in the prostate. The patients who have prior history of prostate carcinoma or prostate surgery were excluded from the study. We have analyzed the correlation between PET/CT findings and serum prostate-specific antigen (PSA) levels, imaging (USG), urological examinations and biopsy. Incidental 18F-FDG uptake of the prostate gland was observed in 79 patients (1.3%). While sixteen of them were excluded due to inadequate clinical data, the remaining 63 patients were included for further analysis. The patients were divided into two groups; 8 patients (12.7%) in the malignant group and 55 patients (87.3%) in the benign group. The SUVmax values were not significantly different between the two groups. In 6 (75%) patients with prostate cancer, FDG uptake was observed focally in the peripheral zone of the prostate glands. There was no significant correlation between the SUVmax and the PSA levels. Incidental 18F-FDG uptake in the prostate gland is a rare condition, but a substantial portion of it is associated with the cancer. Benign and malignant lesions of the prostate gland in FDG-PET/CT imaging could not be reliably distinguished. The peripheral focally FDG uptake of prostate glands should be further examined with the clinical and labaratory evaluations. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 7","pages":"10577-85"},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565230/pdf/ijcem0008-10577.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34080325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The predictive value of physical examination in the decision of laparotomy in penetrating anterior abdominal stab injury. 体格检查对腹前刺穿伤是否开腹的预测价值。

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Metin Yucel, Gurhan Bas, Adnan Ozpek, Fatih Basak, Abdullah Sisik, Aylin Acar, Buket Altun Ozdemir, Sema Yuksekdag, Orhan Alimoglu

{"title":"The predictive value of physical examination in the decision of laparotomy in penetrating anterior abdominal stab injury.","authors":"Metin Yucel, Gurhan Bas, Adnan Ozpek, Fatih Basak, Abdullah Sisik, Aylin Acar, Buket Altun Ozdemir, Sema Yuksekdag, Orhan Alimoglu","doi":"","DOIUrl":"","url":null,"abstract":"A selective conservative treatment for penetrating anterior abdominal stab injuries is an increasingly recognized approach. We analyzed patients who followed-up and treated for penetrating anterior abdominal stab injuries. The anterior region was defined as the area between the arcus costa at the top and the mid-axillary lines at the laterals and the inguinal ligaments and symphysis pubis at the bottom. An emergency laparotomy was performed on patients who were hemodynamically unstable or had symptoms of peritonitis or organ evisceration; the remaining patients were followed-up selectively and conservatively. A total of 175 patients with purely anterior abdominal injuries were included in the study. One hundred and sixty-five of the patients (94.29%) were males and 10 (5.71%) were females; the mean age of the cohort was 30.85 years (range: 14-69 years). While 16 patients (9%) were made an emergency laparotomy due to hemodynamic instability, peritonitis or evisceration, the remaining patients were hospitalized for observation. During the selective conservative follow-up, an early laparotomy was performed in 20 patients (12%), and a late laparotomy was performed in 13 patients (7%); the remaining 126 patients (72%) were discharged after non-operative follow-up. A laparotomy was performed on 49 patients (28%); the laparotomy was therapeutic for 42 patients (86%), non-therapeutic for 4 patients (8%), and negative for 3 patients (6%). A selective conservative approach based on physical examination and clinical follow-up in penetrating anterior abdominal stab injuries is an effective treatment approach. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 7","pages":"11085-92"},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565291/pdf/ijcem0008-11085.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34080330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alcohol dehydrogenase 1C (ADH1C) gene polymorphism and alcoholic liver cirrhosis risk: a meta analysis. 酒精脱氢酶1C (ADH1C)基因多态性与酒精性肝硬化风险的meta分析

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Lei He, Tao Deng, He-Sheng Luo

{"title":"Alcohol dehydrogenase 1C (ADH1C) gene polymorphism and alcoholic liver cirrhosis risk: a meta analysis.","authors":"Lei He, Tao Deng, He-Sheng Luo","doi":"","DOIUrl":"","url":null,"abstract":"The association between alcohol dehydrogenase 1C (ADH1C) gene polymorphism and alcoholic liver cirrhosis (ALC) has been analyzed in several studies, but results have been conflicting. In this study, a meta-analysis was performed to assess the associations between the ADH1C polymorphism and risk of ALC. Relevant studies were identified using PubMed, Web of Science, CNKI and Wanfang databases up to January 10, 2015. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association using the fixed or random effect model. A total of 16 case-control studies, including 1375 cases and 1802 controls, were included. Overall, no significant association between the ADH1C polymorphism and ALC risk was found (dominant model: OR=0.87, 95% CI: 0.62-1.23; recessive model: OR=1.30, 95% CI: 0.84-1.99; *1/*2 vs. *1/*1: OR=0.87, 95% CI: 0.63-1.21; *2/*2 vs. *1/*1: OR=1.10, 95% CI: 0.71-1.70). In the subgroup analysis by ethnicity, we observed a significant association in Asian descent (*1/*2 vs. *1/*1: OR=1.63, 95% CI: 1.07-2.49), while a decreased risk was found among Caucasians (dominant model: OR=0.81, 95% CI: 0.66-0.99; *1/*2 vs. *1/*1: OR=0.76, 95% CI: 0.61-0.95). This meta-analysis demonstrated that the ADH1C polymorphism might increase the risk of ALC in Asians, while it may be a protective factor for ALC among Caucasians. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 7","pages":"11117-24"},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565295/pdf/ijcem0008-11117.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34080334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0