International journal of clinical and experimental medicine最新文献_第10页

Rapid prototyping for tissue-engineered bone scaffold by 3D printing and biocompatibility study. 组织工程骨支架的3D打印快速成型及生物相容性研究。

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Hui-Yu He, Jia-Yu Zhang, Xue Mi, Yang Hu, Xiao-Yu Gu

{"title":"Rapid prototyping for tissue-engineered bone scaffold by 3D printing and biocompatibility study.","authors":"Hui-Yu He, Jia-Yu Zhang, Xue Mi, Yang Hu, Xiao-Yu Gu","doi":"","DOIUrl":"","url":null,"abstract":"The prototyping of tissue-engineered bone scaffold (calcined goat spongy bone-biphasic ceramic composite/PVA gel) by 3D printing was performed, and the biocompatibility of the fabricated bone scaffold was studied. Pre-designed STL file was imported into the GXYZ303010-XYLE 3D printing system, and the tissue-engineered bone scaffold was fabricated by 3D printing using gel extrusion. Rabbit bone marrow stromal cells (BMSCs) were cultured in vitro and then inoculated to the sterilized bone scaffold obtained by 3D printing. The growth of rabbit BMSCs on the bone scaffold was observed under the scanning electron microscope (SEM). The effect of the tissue-engineered bone scaffold on the proliferation and differentiation of rabbit BMSCs using MTT assay. Universal testing machine was adopted to test the tensile strength of the bone scaffold. The leachate of the bone scaffold was prepared and injected into the New Zealand rabbits. Cytotoxicity test, acute toxicity test, pyrogenic test and intracutaneous stimulation test were performed to assess the biocompatibility of the bone scaffold. Bone scaffold manufactured by 3D printing had uniform pore size with the porosity of about 68.3%. The pores were well interconnected, and the bone scaffold showed excellent mechanical property. Rabbit BMSCs grew and proliferated on the surface of the bone scaffold after adherence. MTT assay indicated that the proliferation and differentiation of rabbit BMSCs on the bone scaffold did not differ significantly from that of the cells in the control. In vivo experiments proved that the bone scaffold fabricated by 3D printing had no acute toxicity, pyrogenic reaction or stimulation. Bone scaffold manufactured by 3D printing allows the rabbit BMSCs to adhere, grow and proliferate and exhibits excellent biomechanical property and high biocompatibility. 3D printing has a good application prospect in the prototyping of tissue-engineered bone scaffold. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565401/pdf/ijcem0008-11777.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34013955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

XRCC1 Arg399Gln polymorphism is not associated with breast cancer in Chinese. 中国人乳腺癌与XRCC1 Arg399Gln多态性无关

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Shuren Guo, Xiaohuan Mao, Liang Ming

{"title":"XRCC1 Arg399Gln polymorphism is not associated with breast cancer in Chinese.","authors":"Shuren Guo, Xiaohuan Mao, Liang Ming","doi":"","DOIUrl":"","url":null,"abstract":"Background: A number of studies have been conducted to explore the association of XRCC1 polymorphisms with Breast cancer (BC) risk in Asians, but the results have been inconsistent. We therefore performed the present meta-analysis to explore the relationship in detail.Materials and methods: Reported studies were searched from 1990 to October 15, 2014 in PubMed and Wan fang Med Online. We performed a meta-analysis of 13 published case-control studies fitting our eligibility criteria. These studies involved XRCC1 Arg399Gln polymorphisms in 4984 BC cases and 5744 controls in dominant (ArgArg vs. GlnGln+ArgGln), recessive (ArgGln+ArgArg vs. GlnGln), and co-dominant (ArgArg vs. GlnGln) inheritance models. The total odds Ratio (OR) and 95% CI were calculated and analyzed by Review Manager 5.2 and STATE 12.Results: Overall, significantly increased BC risk was observed in any genetic model (dominant model: odds ration [OR] = 1.31, 95% confidence interval [CI] = [1.08, 1.58]; recessive model: OR = 0.63, 95% CI = [0.50, 0.81]; codominant model: OR = 2.52, 95% CI: [1.38, 4.60]) when all eligible studies were pooled into the meta-analysis. In further stratified analyses, no association was found between Arg399Gln polymorphism and BC risk in Chinese fewer than three hereditary models.Conclusions: Our results suggest that the XRCC1 Arg399Gln polymorphism may be associated with increased Breast cancer risk among Asians, except Chinese population.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565216/pdf/ijcem0008-10429.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34182131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Folic acid in combination with adult neural stem cells for the treatment of spinal cord injury in rats. 叶酸联合成体神经干细胞治疗大鼠脊髓损伤。

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Chen Zhang, Lin Shen

{"title":"Folic acid in combination with adult neural stem cells for the treatment of spinal cord injury in rats.","authors":"Chen Zhang, Lin Shen","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To observe the therapeutic effect of folic acid in combination with adult neural stem cells on spinal cord injury and to investigate the possible mechanism.Methods: A total of 120 Wistar rats were randomly assigned to six groups: normal, model, sham-surgery, folic acid injection, adult neural stem cell transplantation, and combination (folic acid injection + adult neural stem cells transplantation) groups. Morphology of neural stem cells was observed by inverted microscopy. Expression of CD105, CD45, CD44, and CD29 were detected by flow cytometry; expression of neuron-specific enolase and glial fibrillary acidic protein were determined by immunofluorescence. Motor coordination and integration capabilities were assessed using BBB scores; Morphology of spinal cord tissues was observed by hematoxylin-eosin staining and 5-bromodeoxyuridine immunohistochemistry. GDNF, BDNF and NT-3 expression in spinal cord tissues were determined by ELISA; while expression of the apoptosis-related proteins BCL-2, Bax and caspase-3 was detected using western blotting.Results: Flow cytometry showed that the isolated cells were positive for CD44 and CD29 and negative for CD105 and CD45. Combination treatment significantly improved the behavior of model rats with spinal cord injury, attenuated inflammatory reaction of spinal cord tissues, restored injured nerve cells, and increased expression of GDNF, BDNF and NT-3 in spinal cord tissues, up regulated BCL-2 expression, and down regulated Bax and caspase-3 expression.Conclusions: Folic acid in combination with adult neural stem cells significantly improved nerve function and plays a key role in maintaining microenvironment homeostasis in the neurons of rats with spinal cord injury.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565220/pdf/ijcem0008-10471.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34183645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promising potency of retinoic acid-poly(ethylene glycol)-thiol gold nanoparticle conjugates for cervical cancer treatment. 维甲酸-聚乙二醇-硫醇金纳米颗粒偶联物治疗宫颈癌的前景看好。

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Li Ye, Qian Song

{"title":"Promising potency of retinoic acid-poly(ethylene glycol)-thiol gold nanoparticle conjugates for cervical cancer treatment.","authors":"Li Ye, Qian Song","doi":"","DOIUrl":"","url":null,"abstract":"We investigated the effect of synthesized retinoic acid-poly(ethylene glycol)-thiol gold nanoparticle conjugates on cervical carcinoma cells. Cervical cancer is the major cause of deaths for the women of reproductive age in the developing countries. Compared to retinoic acid, the nanoparticle conjugates exhibited better activity against cervical carcinoma. Selective delivery of gold nanoparticle conjugates to estrogen receptor positive cervical cancer cells with 6-fold enhanced drug potency was observed. Transfer of gold nanoparticles was found to be dominated by estrogen ligand and receptor. It appeared that retinoic acid nanoparticle conjugates were selectively taken and retained by the estrogen receptor alpha present in the plasma membrane. Thus IC50 values for RA-PEG-SH were significantly improvedon nanoparticle ligation. Cells on treatment with RA-PEG-SH-AuNPsshowed growth inhibition at 12 and 24 h after incubation. The IC50 for RA in RA-PEG-SH-AuNPs after 12 and 24 h were 3 and 1 μM, respectively. Thus, the use of RA nanoparticle conjugates can be a better strategy for cervical carcinoma treatment. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565223/pdf/ijcem0008-10501.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34183648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil-lymphocyte ratio in systemic lupus erythematosus disease: a retrospective study. 系统性红斑狼疮中性粒细胞-淋巴细胞比率的回顾性研究。

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Lixiu Li, Yuncheng Xia, Chunmei Chen, Ping Cheng, Canhui Peng

{"title":"Neutrophil-lymphocyte ratio in systemic lupus erythematosus disease: a retrospective study.","authors":"Lixiu Li, Yuncheng Xia, Chunmei Chen, Ping Cheng, Canhui Peng","doi":"","DOIUrl":"","url":null,"abstract":"Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Lupus nephritis (LN) is an important cause of morbidity and even mortality in patients with SLE. Some evidences suggest that neutrophil-lymphocyte ratio (NLR) associated with different inflammatory malignancies, ischemic injury and cardiovascular disease. Few scholars have investigated the relationship between NLR and SLE. This study aims to evaluate the role of NLR in SLE without nephritis and LN patients.Methods: A total of 228 subjects were participated in this study. 79 diagnosed with SLE in patients group and 149 healthy age-and sex-matched in control group. In patient team, 20 of them were diagnosed with LN.Results: The SLE without nephritis group showed significantly higher NLR than control group (control=2.00±0.76, SLE=4.26±3.38, P<0.001), and the NLR values of the patients with LN were higher than those of the patients without LN (SLE=4.26±3.38, LN=7.21±6.01, P<0.001). Receiver-operating characteristics analysis (ROC) of NLR to predict SLE showed that the area under the curve (AUC) was 0.757. The cutoff value using the ROC curve was 3.13 (sensitivity, 0.574; specificity, 0.926; 95% confidence interval (CI), 0.668-0.845; P<0.001). While ROC analysis of NLR to predict LN showed that the AUC was 0.828). Logistic regression analysis showed that SLE without nephritis and LN were independently related to NLR.Conclusion: NLR is independently associated with SLE, and it may be a promising marker that reflects renal involvement in patients with SLE.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565283/pdf/ijcem0008-11026.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34183652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gallstone disease founded by ultrasonography in functional dyspepsia: prevalence and associated factors. 功能性消化不良超声诊断胆囊结石:患病率及相关因素

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Yaser Froutan, Ahmad Alizadeh, Fariborz Mansour-Ghanaei, Farahnaz Joukar, Hossein Froutan, Faeze Berenji Bagheri, Mohammad Reza Naghipour, Seyed Ali Chavoshi

{"title":"Gallstone disease founded by ultrasonography in functional dyspepsia: prevalence and associated factors.","authors":"Yaser Froutan, Ahmad Alizadeh, Fariborz Mansour-Ghanaei, Farahnaz Joukar, Hossein Froutan, Faeze Berenji Bagheri, Mohammad Reza Naghipour, Seyed Ali Chavoshi","doi":"","DOIUrl":"","url":null,"abstract":"The aim of this study was to evaluate the frequency of gallbladder stone in functional dyspepsia (FD) by abdominal ultrasonography and to determine the factors associated with this frequency in Guilan province. A total of 195 subjects who referred to outpatient clinic of Razi Hospital, a tertiary referral center (Guilan, Iran) to evaluate FD were included in this study. They were interviewed by using a questionnaire and underwent ultrasonography. Among the 195 subjects were 18.5% male and 81.5% female. The overall frequency of Gallstones (GS) was 19% (37/195) with 17% males and 83% female. In patients with dyspepsia, the presence of fatty liver evidenced by ultrasonography was 67% (131/195). From 131 patients with fatty liver disease 24 (18.3%) have been reported GS. The most frequent symptom in all participants as well as patients with GS and patients with fatty liver was abdominal pain (69.7%, 81% and 66%, respectively) followed by excess flatus. Risk factor associated with increased odds ratios (ORs) for the development of gall stones was diabetes mellitus (OR = 2.63). It also showed that gallbladder wall thickening was more common in patients with GS (OR = 36.63). GS disease was not significantly related to the age, gender, fatty liver, renal stone, history of hypertension (HTN) and hyperlipidemia (HLP), alcohol consumption and smoking status. Patients with FD especially if they have diabetes should be referred for upper abdominal ultrasonography for screening and early detection of GS disease. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565319/pdf/ijcem0008-11283.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34079634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Image classification of liver cancer surrounding right hepatic pedicle and its guide to precise liver resection. 右肝蒂周围肝癌的影像分类及其对肝脏精确切除的指导。

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Xiao-Peng Chen, Wei-Dong Zhang, Dong Wang, Wei Cui, Yuan-Lin Yu

{"title":"Image classification of liver cancer surrounding right hepatic pedicle and its guide to precise liver resection.","authors":"Xiao-Peng Chen, Wei-Dong Zhang, Dong Wang, Wei Cui, Yuan-Lin Yu","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: The aim of this study was to explore the feasibility of image classification of liver cancer surrounding right hepatic pedicle (RHP) and its guide to precise liver resection.Methods: Twenty-five patients with single liver cancer surrounding RHP were collected. According to the adjacent relationship between neoplasm and RHP shown in CT or MRI, the liver neoplasms were divided into the 4 types, type A neoplasm infiltrating or surrounding RHP, type B neoplasm locating in the anterior side of RHP, type C neoplasm locating in the dorsal side of RHP and type D neoplasm locating between the two branches. On the basis of image classification, operation project including hepatic vascular occlusion (HVO) and surgical resection procedure was designed. In the end, preoperative classification and surgical design was compared with operative results.Results: The locations of liver neoplasms were completely in line with preoperative classification. The methods of HVO and range of surgical resection were essentially coincident with preoperative plan. Pringle maneuver, total hepatic and hemihepatic vascular occlusion were applied. Four patients with type A neoplasms underwent right hemihepatectomy or extended right hepatectomy. Seven with type B received right anterior lobectomy or mesohepatectomy. Six with type C underwent segment V, VI resection, and eight with type D received right anterior or posterior lobectomy. All operations were smoothly finished.Conclusion: Preoperative classification guided by RHP can provide the accurate location information for liver cancer surrounding RHP, contribute to choosing suitable method of HVO and reasonable range of hepatic resection for precise surgery.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565292/pdf/ijcem0008-11093.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34080331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor markers CA19-9, CA242 and CEA in the diagnosis of pancreatic cancer: a meta-analysis. 肿瘤标志物CA19-9、CA242和CEA在胰腺癌诊断中的meta分析

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Yimin Zhang, Jun Yang, Hongjuan Li, Yihua Wu, Honghe Zhang, Wenhu Chen

{"title":"Tumor markers CA19-9, CA242 and CEA in the diagnosis of pancreatic cancer: a meta-analysis.","authors":"Yimin Zhang, Jun Yang, Hongjuan Li, Yihua Wu, Honghe Zhang, Wenhu Chen","doi":"","DOIUrl":"","url":null,"abstract":"Background: Pancreatic cancer has the worst prognosis and early detection is crucial for improving patient prognosis. Therefore, we performed a meta-analysis to evaluate and compare the sensitivity and specificity of single test of CA19-9, CA242, and CEA, as well as combination test in pancreatic cancer detection.Methods: We searched PubMed, Embase, Medline, and Wanfang databases for studies that evaluated the diagnostic validity of CA19-9, CA242, and CEA between January 1990 and September 2014. Data were analyzed by Meta-Disc and STATA software.Results: A total of 21 studies including 3497 participants, which fulfilled the inclusion criteria were considered for analysis. The pooled sensitivities for CA19-9, CA242, and CEA were 75.4 (95% CI: 73.4-77.4), 67.8 (95% CI: 65.5-70), and 39.5 (95% CI: 37.3-41.7), respectively. The pooled specificities of CA19-9, CA242, and CEA were 77.6 (95% CI: 75.4-79.7), 83 (95% CI: 81-85), and 81.3 (95% CI: 79.3-83.2), respectively. Parallel combination of CA19-9+CA242 has a higher sensitivity (89, 95% CI: 80-95) without impairing the specificity (75, 95% CI: 67-82).Conclusions: Our meta-analysis showed that CA242 and CA19-9 have better performance in the diagnosis of pancreatic cancer than CEA. Furthermore, parallel combination test of CA19-9+CA242 could be of better diagnostic value than individual CA242 or CA19-9 test.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565388/pdf/ijcem0008-11683.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34080338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The anti-leukemic effect of carnosic acid combined with adriamycin in a K562/A02/SCID leukemia mouse model. 鼠尾草酸联合阿霉素对K562/A02/SCID白血病小鼠模型的抗白血病作用。

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Lu-Qun Wang, Ran Wang, Xiang-Xin Li, Xiao-Ning Yu, Xue-Liang Chen, Hao Li

{"title":"The anti-leukemic effect of carnosic acid combined with adriamycin in a K562/A02/SCID leukemia mouse model.","authors":"Lu-Qun Wang, Ran Wang, Xiang-Xin Li, Xiao-Ning Yu, Xue-Liang Chen, Hao Li","doi":"","DOIUrl":"","url":null,"abstract":"The effects of carnosic acid (CA) were investigated on the acute myeloid leukemia (AML) cell growth in vivo. A NOD/SCID AML mouse model, which was set up by inoculation with K562/A02 cells, was used to study whether tumor growth in vivo can be inhibited by CA combined with adriamycin. After being inoculated with K562/A02 cells, the NOD/SCID mice were expressed positive human mdr1 and bcr/abl genes. This result indicates that the K562/A02/SCID leukemia mouse model is successfully established. The mice treated with CA combined with adriamycin exhibit a significant lower number of leukemia cells (20%) than that of untreated animals (32.5%) (P<0.05), in particular with higher percentages of apoptotic cells than the mice treated by single adriamycin (control) group. The median of 95% CI survival time is 19 (10.0-44.2) and 33 (29.4-36.6) days for the control group and the CA-treated group, respectively. The difference is statistically significant (P<0.05). It is illustrated that the natural compound CA, combined with Adriamycin, has high potential to inhibit the growth of malignant cells in vivo, and is a promising adjuvant anti-cancer drug. Prospective studies should be conducted to understand the functional mechanism of CA at the molecular level. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565391/pdf/ijcem0008-11708.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34080341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acoustic radiation force impulse induced strain elastography and point shear wave elastography for evaluation of thyroid nodules. 声辐射力脉冲应变弹性成像和点剪切波弹性成像评价甲状腺结节。

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International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01

Xian Huang, Le-Hang Guo, Hui-Xiong Xu, Xue-Hao Gong, Bo-Ji Liu, Jun-Mei Xu, Yi-Feng Zhang, Xiao-Long Li, Dan-Dan Li, Shen Qu, Lin Fang

{"title":"Acoustic radiation force impulse induced strain elastography and point shear wave elastography for evaluation of thyroid nodules.","authors":"Xian Huang, Le-Hang Guo, Hui-Xiong Xu, Xue-Hao Gong, Bo-Ji Liu, Jun-Mei Xu, Yi-Feng Zhang, Xiao-Long Li, Dan-Dan Li, Shen Qu, Lin Fang","doi":"","DOIUrl":"","url":null,"abstract":"The aim of the study was to evaluate the diagnostic performance of acoustic radiation force impulse (ARFI) induced strain elastography (SE), point shear wave elastography (p-SWE), and their combined use in differentiating thyroid nodules. This retrospective study included 155 thyroid nodules (94 benign and 61 malignant) in 136 patients. Ultrasound, ARFI-induced SE and p-SWE were performed on each nodule. Receiver operating characteristic curve (ROC) analyses were performed to assess the diagnostic efficacy of ARFI-induced SE, p-SWE and their combined use to distinguish benign from malignant thyroid nodules with histological results used as the reference standard. The areas under the ROC for ARFI-induced SE, p-SWE, and their combined use were 0.828, 0.829, and 0.840, respectively (both P > 0.05). The specificity of ARFI-induced SE was higher than that of p-SWE as well as their combined use (both P < 0.05). The combination of the two methods significantly improved the diagnostic sensitivity and NPV compared with either ARFI-induced SE or p-SWE alone (both P < 0.05). For nodules ≤ 10 mm, the combination of the two methods significantly improved the diagnostic sensitivity only. For nodules > 10 mm, there were no significant differences in sensitivity and NPV among the three methods in differentiating thyroid nodules (all P > 0.05). In conclusions, ARFI-induced SE and p-SWE are both valuable tools for detecting malignant thyroid nodules. The combined use of ARFI-induced SE and p-SWE improves the diagnostic sensitivity and NPV significantly whereas ARFI-induced SE alone achieves the highest specificity. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565273/pdf/ijcem0008-10956.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34182133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0