International journal of clinical and experimental medicine最新文献

A case report of moderate COVID-19 with an extremely long-term viral shedding period in China 中国中度新冠肺炎病毒脱落期极长病例报告

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International journal of clinical and experimental medicine Pub Date : 2020-04-20 DOI: 10.21203/rs.3.rs-23009/v1

Yonghong Wang, Chao-Nan Liu, Qinghui Meng, Shuang Gui, Yu Wu, P. Cheng, Peng Wang, Xiu-Yun Liao

{"title":"A case report of moderate COVID-19 with an extremely long-term viral shedding period in China","authors":"Yonghong Wang, Chao-Nan Liu, Qinghui Meng, Shuang Gui, Yu Wu, P. Cheng, Peng Wang, Xiu-Yun Liao","doi":"10.21203/rs.3.rs-23009/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-23009/v1","url":null,"abstract":"\u0000 Background: An ongoing outbreak of novel coronavirus disease 2019 (COVID-19) from Wuhan, China, is currently recognized as a global public health emergency, which has subsequently spread to the rest of China and other countries. The WHO raised the COVID-19 alert to the highest level. The virus is a new highly contagious via human-to-human transmission. The median duration of viral shedding is 20.0 days. We report that the longest duration of viral shedding was 32.0 days from illness onset in a patient with moderate COVID-19 admitted to QianJiang Central Hospital.Case presentation: A 37-year-old male sought medical advice while suffering from fever, dry cough, fatigue, dizziness, runny nose and diarrhoea. Five days before the visit, he had a history of travel from affected geographic areas. The patient had a positive RT-PCR test, and chest CT images showed multiple nodules and mixed ground-glass opacification with consolidation in both lungs. Laboratory findings showed that his lymphocyte and CD4+ counts were below the normal range. The patient was given antiviral treatment, including arbidol, lopinavir, IFN-α, and traditional Chinese medicine, and other necessary support care. All clinical symptoms and CT imaging manifestation abnormalities resolved during the course of therapy.Conclusion: Although the positive RT-PCR tests were verified in consecutive upper respiratory specimens, the clinical symptoms, CT imaging findings, CD4+ lymphocyte counts, and IgG antibody levels had obviously improved. Positive tests may be detecting pieces of inactive viruses, which would not be transmissible in individual cases.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2020-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43533437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lentivirus-Mediated knockdown of tectonic family member 1 inhibits medulloblastoma cell proliferation [Retraction]. 慢病毒介导的构造家族成员1的敲低抑制成神经管细胞瘤细胞增殖[撤回]。

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International journal of clinical and experimental medicine Pub Date : 2018-03-15 eCollection Date: 2018-01-01

引用次数: 0

Classification of MRI and psychological testing data based on support vector machine. 基于支持向量机的核磁共振成像和心理测试数据分类。

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International journal of clinical and experimental medicine Pub Date : 2017-12-01

Wenlu Yang, Xinyun Chen, David S Cohen, Eric R Rosin, Arthur W Toga, Paul M Thompson, Xudong Huang

{"title":"Classification of MRI and psychological testing data based on support vector machine.","authors":"Wenlu Yang, Xinyun Chen, David S Cohen, Eric R Rosin, Arthur W Toga, Paul M Thompson, Xudong Huang","doi":"","DOIUrl":"","url":null,"abstract":"Alzheimer's disease (AD) is a progressive, and often fatal, brain disease that causes neurodegeneration, resulting in memory loss as well as other cognitive and behavioral problems. Here, we propose a novel multimodal method combining independent components from MRI measures and clinical assessments to distinguish Alzheimer's patients or mild cognitive impairment (MCI) subjects from healthy elderly controls. 70 AD subjects (mean age: 77.15 ± 6.2 years), 98 MCI subjects (mean age: 76.91 ± 5.7 years), and 150 HC subjects (mean age: 75.69 ± 3.8 years) were analyzed. Our method includes the following steps: pre-processing, estimating the number of independent components from the MR image data, extracting effective voxels for classification, and classification using a support vector machine (SVM)-based classifier. As a result, with regards to classifying AD from healthy controls, we achieved a classification accuracy of 97.7%, sensitivity of 99.2%, and specificity of 96.7%; for differentiating MCI from healthy controls, we achieved a classification accuracy of 87.8%, a sensitivity of 86.0%, and a specificity of 89.6; these results are better than those obtained with clinical measurements alone (accuracy of 79.5%, sensitivity of 74.0%, and specificity of 85.1%). We found that (1) both AD patients and MCI subjects showed brain tissue loss, but the volumes of gray matter loss in MCI subjects was far less, supporting the notion that MCI is a prodromal stage of AD; and (2) combining gray matter features from MRI and three commonly used measures of mental status, cognitive function improved classification accuracy, sensitivity, and specificity compared with classification using only independent components or clinical measurements.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808983/pdf/nihms939321.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35832873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of lipiodol and methylene blue on the thoracoscopic preoperative positioning [Retraction]. 脂醇和亚甲基蓝对胸腔镜术前定位的影响。

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International journal of clinical and experimental medicine Pub Date : 2017-11-15 eCollection Date: 2017-01-01

引用次数: 0

Nucleostemin regulates proliferation and migration of gastric cancer and correlates with its malignancy [Retraction]. 核干素调节胃癌的增殖和迁移，并与胃癌的恶性相关[撤回]。

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International journal of clinical and experimental medicine Pub Date : 2017-11-15 eCollection Date: 2017-01-01

引用次数: 0

Development of synthetic of peptide-functionalized liposome for enhanced targeted ovarian carcinoma therapy [Retraction]. 肽功能化脂质体用于卵巢癌靶向强化治疗的研究进展[撤回]。

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International journal of clinical and experimental medicine Pub Date : 2017-09-15 eCollection Date: 2017-01-01

引用次数: 0

Early molecular responses of bone to estrogen deficiency induced by ovariectomy in rats [Retraction]. 大鼠卵巢切除后雌激素缺乏对骨的早期分子反应[牵回]。

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International journal of clinical and experimental medicine Pub Date : 2017-02-15 eCollection Date: 2017-01-01

引用次数: 0

Correlation between expression of NF-E2-related factor 2 and progression of gastric cancer [Retraction]. nf - e2相关因子2的表达与胃癌进展的关系[牵回]。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2017-01-15 eCollection Date: 2017-01-01

引用次数: 0

Upregulation of autophagy genes and the unfolded protein response in human heart failure. 人类心力衰竭中自噬基因和未折叠蛋白反应的上调。

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International journal of clinical and experimental medicine Pub Date : 2017-01-01 Epub Date: 2017-01-30

Brian C Jensen, Scott J Bultman, Darcy Holley, Wei Tang, Gustaaf de Ridder, Salvatore Pizzo, Dawn Bowles, Monte S Willis

{"title":"Upregulation of autophagy genes and the unfolded protein response in human heart failure.","authors":"Brian C Jensen, Scott J Bultman, Darcy Holley, Wei Tang, Gustaaf de Ridder, Salvatore Pizzo, Dawn Bowles, Monte S Willis","doi":"","DOIUrl":"","url":null,"abstract":"The cellular environment of the mammalian heart constantly is challenged with environmental and intrinsic pathological insults, which affect the proper folding of proteins in heart failure. The effects of damaged or misfolded proteins on the cell can be profound and result in a process termed \"proteotoxicity\". While proteotoxicity is best known for its role in mediating the pathogenesis of neurodegenerative diseases such as Alzheimer's disease, its role in human heart failure also has been recognized. The UPR involves three branches, including PERK, ATF6, and IRE1. In the presence of a misfolded protein, the GRP78 molecular chaperone that normally interacts with the receptors PERK, ATF6, and IRE-1 in the endoplasmic reticulum detaches to attempt to stabilize the protein. Mouse models of cardiac hypertrophy, ischemia, and heart failure demonstrate increases in activity of all three branches after removing GRP78 from these internal receptors. Recent studies have linked elevated PERK and CHOP in vitro with regulation of ion channels linked with human systolic heart failure. With this in mind, we specifically investigated ventricular myocardium from 10 patients with a history of conduction system defects or arrhythmias for expression of UPR and autophagy genes compared to myocardium from non-failing controls. We identified elevated Chop, Atf3, and Grp78 mRNA, along with XBP-1-regulated Cebpa mRNA, indicative of activation of the UPR in human heart failure with arrhythmias.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546743/pdf/nihms888500.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35309348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparison study of immune-inflammatory response in electroacupuncture and transcutaneous electrical nerve stimulation for patients undergoing supratentorial craniotomy [Retraction]. 电针与经皮电神经刺激对幕上开颅患者免疫炎症反应的比较研究[回缩]。

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International journal of clinical and experimental medicine Pub Date : 2016-10-15 eCollection Date: 2016-01-01

引用次数: 0