血浆同型半胱氨酸与2型糖尿病患者早期肾病进展的关系

IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
International journal of clinical and experimental medicine Pub Date : 2015-07-15 eCollection Date: 2015-01-01
Huan Wang, Kai Cui, Ke Xu, Shixin Xu
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引用次数: 0

摘要

现在有越来越多的证据支持肾功能不全和血浆同型半胱氨酸(Hcy)积累之间的关联。然而,Hcy在2型糖尿病患者糖尿病肾病(DN)发展中的作用尚不清楚。为此,我们对208名患者和49名对照组进行了前瞻性观察性研究。我们发现,Hcy的基线水平在DN患者中显著升高,并且与疾病的严重程度相关。针对早期DN患者(n = 157),经过4年随访,我们发现血浆Hcy水平升高与肾功能衰竭加重相关,其特征是肾小球滤过率(eGFR)下降更快。使用多元线性回归模型,我们发现在控制其他进展促进因子后,血浆Hcy仍然与eGFR下降显著相关。我们的研究结果支持血浆Hcy是一个独立的危险因素,也是2型糖尿病患者DN进展的早期预测因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between plasma homocysteine and progression of early nephropathy in type 2 diabetic patients.

There is now growing evidence supporting the association between renal insufficiency and accumulation of plasma homocysteine (Hcy). However, the role of Hcy in the development of diabetic nephropathy (DN) in type 2 diabetic patients is not clearly elucidated. To this end, we performed a prospective observational study in 208 patients and 49 controls. We show that baseline level of Hcy is significantly enhanced in patients with DN and is associated with the severity of the disease. Focusing on patients at early DN stage (n = 157), after four-year follow-up, we find that increase in plasma Hcy level correlates with greater renal failure characterized by faster decline in estimated glomerular filtration rate (eGFR). Using a multivariate linear regression model, we show that plasma Hcy remains significantly associated with eGFR decline after controlling for other progression promoters. Our results support that plasma Hcy is an independent risk factor as well as an early predictor for DN progression in type 2 diabetic patients.

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