A. Shetti, Jay Manojkumar Bhensdadia, M.K. Chaitanya Krishna, Bhavika Singla, Rachita G Mustilwar
{"title":"Serum albumin level as a marker to predict morbidity in post COVID-19 patients admitted in a rural critical care unit","authors":"A. Shetti, Jay Manojkumar Bhensdadia, M.K. Chaitanya Krishna, Bhavika Singla, Rachita G Mustilwar","doi":"10.18231/j.ijpca.2022.026","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.026","url":null,"abstract":"Covid-19 raged for more than two years in almost all parts of the world including India and the long term effects are yet to be studied. Presently with the availability of vaccine has reduced the suffering even after covid-19 infection. This study is aimed to understand the patient with past history of covid-19 infection and serum albumin levels and the outcome. A total of 52 patients admitted to intensive care unit with past history of COVID-19 infection, between 01.11.2021 and 31.01.2022, were enrolled in this study. The required data were collected from the records. Of the total 52 patients included in the study, 41 (78.85%) were males and 11 (21.15%) were females. Amongst these 52 patients, 18 (34.6%) were detected with hypoalbuminemia. Higher association of co-morbidities (22.22% patients) was seen in patients with hypoalbuminemia. Death rate in hypoalbuminemia group was 11.11% while that in those with normal albumin levels was only 2.94%.Patients with hypoalbuminemia and previous covid 19 infection were having higher mortality rate as compared to normoalbuminemia.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78343355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Feeding jejunostomy and its implications among critical care patients - A review","authors":"A. Shetti, Joshna Kanipakam, Rachita G Mustilwar","doi":"10.18231/j.ijpca.2022.022","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.022","url":null,"abstract":"Jejunostomy is a surgical procedure where in a tube is placed in the lumen of proximal part of jejunum. This technique is mainly used to administer nutrition in case of patients with obstructive or operative area related to upper gastrointestinal system. This is one of the type to feed the nutrition and or medications by enteral means.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"425 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74128255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An innovative way of keeping epidural hub in sterile condition for cost effective epidural catheters","authors":"A. Shetti, Rachita G Mustilwar","doi":"10.18231/j.ijpca.2022.019","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.019","url":null,"abstract":"","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78062821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chiragkumar J. Gohil, K. Parmar, Priyanka R. Patel, Jignakumari J. Gohil
{"title":"Mechanism and management of antibiotic drug resistance tuberculosis","authors":"Chiragkumar J. Gohil, K. Parmar, Priyanka R. Patel, Jignakumari J. Gohil","doi":"10.18231/j.ijpca.2022.020","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.020","url":null,"abstract":"Drug resistance in tuberculosis has been shown to result from spontaneous mutation in several chromosomal genes of M.Tuberculosis. Mutation may reduce the medications' capacity to bind to the target genes. In many patients polydrug resistance, multidrug resistance, rifampicin resistance (RR) and extensive drug resistance (XDR) were seen. The diagnosis of drug-resistant TB in HIV-positive persons is more difficult and may be confused with other pulmonary or systemic infections. Management of patients with mono- or poly-resistant TB will be done with standard first line chemotherapy. Treatment of latent infection for people suffering from multidrug resistant bacilli is problematic because the only cure by isoniazid and rifampicin. In the recent cases of severe hepatotoxicity associated with preventive treatment comprising either pyrazinamide and rifampicin or pyrazinamide and fluoroquinolone. The use of dilatory fluoroquinolones, such as moxifloxacin, remarkable improved treatment outcomes of XDR-TB.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90772056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Elkhateeb, Amtul Noor, A. Rashid, A. Bilal, Ghulam Musharaf, Muhammad Akram, Kainat Zafar, G. Daba
{"title":"Current awareness and knowledge of olive oil","authors":"W. Elkhateeb, Amtul Noor, A. Rashid, A. Bilal, Ghulam Musharaf, Muhammad Akram, Kainat Zafar, G. Daba","doi":"10.18231/j.ijpca.2022.011","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.011","url":null,"abstract":"The olive tree is an unpredictable formed tree, which grows up to 10 m in stature. The olive leaves are inverse and elongated molded. The leaves are dim green above and gleaming beneath. The white and relatively little olive blossoms are shaped on a year ago's wood. The run of the mill natural products or olives are ovoid formed and regularly pointed. This study aimed to see if health signals influenced consumers' decisions of olive oil with varying levels of information about the oil's beneficial characteristics. In order to accomplish this, a direct poll on the use of olive oil was conducted by looking at the expressed preferences of a sample of users. Two economically measured examinations were conducted to determine the factors that influence the use of high-polyphenol olive oil. Furthermore, the data demonstrate that varying levels of personal knowledge have a role in shaping olive oil customers' health perceptions. Finally, this study confirmed that consumers' selections are heavily influenced by their sense of self-coherence, even with healthful foods. As a result, different reasons and traits impact customers' knowledge or beliefs that shape their attitudes.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79004121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Method development and validation of ibuprofen obtained from the extraction of bougainvillea campanulata flowers by UV spectrophotometry, FTIR and TLC method","authors":"P. Paul, A. Monika","doi":"10.18231/j.ijpca.2022.015","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.015","url":null,"abstract":"The present study was aimed to develop and validate a simple, accurate, precise, reproducible UV-Visible spectrophotometric method and FTIR for the estimation of Ibuprofen present in extract. The solvent used in the experiment was m. Absorption maximum (λmax) of the drug was found to be 264 nm. The Beer’s law was obeyed in the range of 100-500 μg/ml. The method was shown linear in the mentioned concentrations having line equation y = 0.000023x with correlation coefficient r of 1 The amount of ibuprofen present in the extract was found to be 7 ug/ml. The recovery values for ibuprofen present in Bougainvillea Campanulata flowers extract ranged from 85.9%-87.6%. The percent relative standard deviation (RSD %) of interday precision was 51.35 % and intraday precision was 42.95 %. The limit of detection and limit of quantification was 0.9 μg/mL and 2.7 μg/mL. The percent relative standard deviation of robustness of the method was 37.43-45.86. Hence, proposed method was precise, accurate and cost effective. This method could be applicable for quantitative determination of the methanol present in Bougainvillea flowers extract.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90699846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"To study the efficacy of AG CUFFILL (Digital) compared to that of standard PORTEX cuff inflator/pressure analog gauge for the measurement of endotracheal tube cuff pressure","authors":"A. Shetti, Veena Vijayakumar, Bhavika Singla","doi":"10.18231/j.ijpca.2022.017","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.017","url":null,"abstract":"Endotracheal tube (ETT) is commonly used to provide positive pressure ventilation. ETT cuff pressure is maintained within a range of 20 to 30 cmH2O. High pressure affects micro-circulation and integrity of the tracheal mucosa, resulting in complications. The cuff pressure is measured by connecting a pressure gauge device to pilot balloon. Two variety devices are available; analog or digital manometers. Present study is used to study the efficacy of AG CUFFILLL (Digital) compared with standard PORTEX Cuff inflator/pressure gauge (Analog) for the measurement of ETT cuff pressure.This study was conducted after obtaining institutional ethical clearance and written informed consent.100 patients between the age of 18-70yrs who fulfilled inclusion criteria. We measured ETT cuff pressure using AG CUFFILL (Digital) and standard PORTEX Cuff inflator/pressure gauge and compared the pressure recording of the two equipment and we studied ease of use for both.Out of 100 patients between the age of 18-70yrs, 61 patients (61%) were male and 39 patients (39%) were female. Mean cuff pressure of ETT using AG CUFFILL was 36.29±6.36 cmH2O and in PORTEX was 33.97±6.16cm H2O. Mean difference in the values between the cuff pressure measured by AG CUFFILL and PORTEX was ± 2.67. Comparing the two devices, it was noticed that in 05 (5%) patients measuring ETT cuff pressure using AG CUFFILL was difficult as the values were fluctuating. Based on results, authors recommend AG CUFFILL for ETT cuff pressure measurement owing to its accuracy, non-bulky, and ease to carry.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73418943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Formulation of herbal ointment for assessment of wound healing activity from leaves","authors":"S. S. Shaikh","doi":"10.18231/j.ijpca.2022.013","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.013","url":null,"abstract":"has been extensively used as a nutrient herb in traditional Vietnamese remedies for the treatment of various diseases. (Wild.) are widely used plants in Asian folk and traditional medicines. In the present study, we have tried to find out the Phytoconstituents, wound healing activity of the Ethanolic extracts of these plants. It’s been showed that totally different a part of Launaea sarmentosa species as well as leaves, flowers, seed, root, and aerial half possess ethno botanic values could be a crawl herb, native to coastal areas in India, Africa (east coast, Mauritius, and South Asia etc.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78811499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hexaconazole poisoning - An uncommon poisoning incidence in rural tertiary care and our experience","authors":"A. Shetti, D. D. Patel, Bhavika Singla","doi":"10.18231/j.ijpca.2022.018","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.018","url":null,"abstract":"Acute pesticide poisoning is a very common in rural India. The pesticides used in the agriculture are major contributors in poisoning either intentiaonal or accidental. Poisoning itself is a major global concern. Hexaconazole is not as common poison in India and very few cases are reports. We report a rare case of hexaconazole poisoning and its successful management in rural tertiary care unit.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88872855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacognostical, phytochemical standardization and anticonvulsant activity study of sesbania grandiflora flowers","authors":"S. S. Shaikh","doi":"10.18231/j.ijpca.2022.016","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.016","url":null,"abstract":"In the India there is a good biodiversity in plants. Plants based medicinal products used as integrated part of treatment on most of traditional systems of medicines. Sesbania grandiflora is a plant which used traditionally for many medicinal used which belongs in family Fabaceae. Present study was about investigated the Physicochemical and Phytochemical studies on selected plant such as Sesbania grandiflora. For the study Soxhlet apparatus was used for extraction of plant materials with using water, ethanol and chloroform as extractive solvents. Standard chemicals and methods were used for the qualitative determination of plant S. grandiflora flowers extract. The study investigation was followed to determine the presence of chemical compound in flowers part of plant as well as to investigate the quality of drug. Result found that the different flower extract may presence of alkaloids, steroids, tannins, sterols, flavonoid etc. The pentylenetetrazol (PTZ) induced seizure model was used for testing anticonvulsant activity of ethanolic, aqueous and chloroform extracts(100mg/kg) of Sesbania grandiflora flowers. The extracts significantly (*p < 0.01) reduced the duration of convulsion and delay onset of seizure. The study results that Sesbania grandiflora flowers has anticonvulsant activity.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73804314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}