International Journal of Pharmaceutical Chemistry and Analysis最新文献

{"title":"Dapagliflozin: A molecule for type-2 diabetes mellitus","authors":"Ravinandan A P, H. N. Vishwas, Shashank S Hosur, Mohammed Mustafa G., Kavya H.B.","doi":"10.18231/j.ijpca.2022.029","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.029","url":null,"abstract":"Dapagliflozin which is also known as Farxiga in the US and Forxiga in the EU is a drug which was developed by Bristol-Myers Squibb in partnership with Astra Zeneca. It is also available in Oxra and it is marking by Sun Pharmaceutical Industries Ltd. It contains the active substance Dapagliflozin which is the second member of selective sodium glucose co-transporter-2 (SGLT-2) inhibitor and it is the first group among oral anti-diabetic agents which are independent of insulin secretion. The drug Dapagliflozin shows the action of reducing the blood glucose by preventing the reabsorption of glucose at the renal proximal tubule and avoids insulin resistance. It is a new molecule that helps in maintaining the glycemic control either in mono therapy or combinational therapy or add on therapy. This is a review article which summarizes the details of Dapagliflozin.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74435280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardization & evaluation of anti-oxidant, anti-inflammatory and antimicrobial potential of Panchnimba Churna","authors":"A. Meena, Sanjana Rajput, Sadhana Chaturvedi, Deepesh Parashar, Lavkush Sharma","doi":"10.18231/j.ijpca.2022.032","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.032","url":null,"abstract":": Ayurvedic medication pancha nimba choorna is a herbal powder. The panchanimba is a well-known medication stated in the old Ayurvedic texts used to cure kshudra kushtas (minor skin disorders), such as eczema, acne, and Maha kushtas (major skin ailments).It is used to treat a variety of skin conditions, including dermatitis, pruritis, psoriasis, sinus, non-healing wounds, headaches, uti, diabetes, toxins, and arthritis. It is employed to treat infections of the skin.The traditional use of the neem tree's leaves, blossoms, seeds, fruits, roots, and bark for the treatment of inflammation, infections, fever, skin conditions, and dental problems includes all of these parts. Neem leaf's therapeutic benefits have been specifically discussed. The immunomodulatory, anti-inflammatory, anti-hyperglycaemic, antiulcer, antimalarial, antifungal, antibacterial, antiviral, antioxidant, antimutagenic, and anticarcinogenic activities of neem leaf and its components have been proven. Protein, carbohydrates, flavonoids, phenol, saponin, glycosides, tannin, and alkaloids are all present according to phytochemical analysis, whereas terpenoids, sterols, and other substances are not present.To guarantee the quality of the product, standardization employing various parameters was used which was performed as per the Indian Pharmacopoeia, WHO guidelines and various literature reports. The antioxidant activity may be attributes to flavonoids and phenolics present in extracts of . In terms of gallic acid equivalent, Panchanimb Churna contained 105 mg/g of total phenols and the total flavonoid concentration was 43.8214 mg/g, which is the quercetin equivalent.Antioxidant property was evaluated using DPPH activity.According to a forementioned quality criterion, Panchanimb Churna was determined to be competent under every examined aspect. The current study strengthens belief in herbal remedies of natural origin to combat infectious diseases and other illnesses that may be included in medications in the future. Overall the product is very beneficicial in day to day life for humans as it possess various qualities and activities.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81488257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A COVID-19 complication of bilateral lower motor neuron facial palsy","authors":"Divya B M, Shylashree, Saikrupa B V","doi":"10.18231/j.ijpca.2022.036","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.036","url":null,"abstract":"COVID-19 caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), profoundly infectious disease which manifests as respiratory symptoms is potentially fatal due to multiorgan involvement and greatly of public health concern. However neurological symptoms could be the first or only symptom of the disease. Here, we report an unusual case of an international traveler who was diagnosed with COVID-19 after presenting with bilateral lower motor neuron (LMN) palsy, despite showing no respiratory manifestations at initial presentation.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82383365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction and characterization of opuntia stricta cladodes mucilage as pharmaceutical excipient","authors":"F. Tamboli, Asavari R. Rasam, S. S. Patil, Vishal T. Khade, Shubham S. Bavkar, Shivtej S. Gaikwad, S. Killedar","doi":"10.18231/j.ijpca.2022.025","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.025","url":null,"abstract":"This study deals with extraction and characterization of mucilage extracted from cladodes of Cactus () as pharmaceutical excipient. With the use Acetone based extraction method, the yield of mucilage was found to be 1.44%. Characterization of the extracted mucilage was done by various parameters such as micromeritic studies, flow behavior, organoleptic properties, surface tension and viscosity, loss on drying, ash value and swelling index. The result showed that extracted mucilage exhibited good flow properties (Angle of repose 25.30°), the surface tension of 2.85% w/v solutions of mucilage was found to be 70.20 N/m, total ash was 28.33% w/w, loss on drying was 13% and pH was found to be in the range of 7.2-7.4. Extracted mucilage was soluble in warm water and slightly soluble in cold water while insoluble in organic solvents except chloroform. Phytochemical screening and powder characteristics of extracted mucilage powder of cladodes showed that it can be safely used in dosage form without causing any adverse effect.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73943348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative antioxidative potential of aqueous and ethanolic dalz root extracts","authors":"F. Tamboli, S. S. Patil, H. More, Asavari R. Rasam, Shreyash D. Tarlekar, K. Alaskar, Shabana A. Menon, Rahul J. Jadhav, Prasanna R. Rasal, P. G. Tandale","doi":"10.18231/j.ijpca.2022.024","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.024","url":null,"abstract":"The medicinal plant Barleria gibsoni Dalz, family Apocynaceae, is a well-known traditional medicinal plant used in various system of medicines. It is spread all over India. The present study provides antioxidant capacity of aqueous and ethanolic root extracts of Barleria gibsoni Dalz, 2,2'-diphenyl-1-picrylhydrazyl (DPPH), nitrous oxide and hydrogen peroxide scavenger assays were used.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84555965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scalp block: The forgotten technique –A review article","authors":"A. Shetti, Rachita G Mustilwar","doi":"10.18231/j.ijpca.2022.021","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.021","url":null,"abstract":"Majority of neurosurgical procedures are performed under general anaesthesia. It is still possible to perform some of the procedures under regional anaesthesia like scalp block. It involves blocking the nerves that innervate the scalp. The technique is easy to perform, but the practitioners should be aware of possible complications because of closer relation of blood vessels with nerves. Despite various advantages over general anaesthesia scalp block is not practiced routinely. This article reviews the relevant anatomy and technique of scalp block.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82155708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum albumin level as a marker to predict morbidity in post COVID-19 patients admitted in a rural critical care unit","authors":"A. Shetti, Jay Manojkumar Bhensdadia, M.K. Chaitanya Krishna, Bhavika Singla, Rachita G Mustilwar","doi":"10.18231/j.ijpca.2022.026","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.026","url":null,"abstract":"Covid-19 raged for more than two years in almost all parts of the world including India and the long term effects are yet to be studied. Presently with the availability of vaccine has reduced the suffering even after covid-19 infection. This study is aimed to understand the patient with past history of covid-19 infection and serum albumin levels and the outcome. A total of 52 patients admitted to intensive care unit with past history of COVID-19 infection, between 01.11.2021 and 31.01.2022, were enrolled in this study. The required data were collected from the records. Of the total 52 patients included in the study, 41 (78.85%) were males and 11 (21.15%) were females. Amongst these 52 patients, 18 (34.6%) were detected with hypoalbuminemia. Higher association of co-morbidities (22.22% patients) was seen in patients with hypoalbuminemia. Death rate in hypoalbuminemia group was 11.11% while that in those with normal albumin levels was only 2.94%.Patients with hypoalbuminemia and previous covid 19 infection were having higher mortality rate as compared to normoalbuminemia.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78343355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feeding jejunostomy and its implications among critical care patients - A review","authors":"A. Shetti, Joshna Kanipakam, Rachita G Mustilwar","doi":"10.18231/j.ijpca.2022.022","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.022","url":null,"abstract":"Jejunostomy is a surgical procedure where in a tube is placed in the lumen of proximal part of jejunum. This technique is mainly used to administer nutrition in case of patients with obstructive or operative area related to upper gastrointestinal system. This is one of the type to feed the nutrition and or medications by enteral means.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74128255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chromatographic estimation of cefetamet pivoxil in bulk and tablet dosage form: Development and validation approach","authors":"M. Palled, Mahesh Bhanusali, S. Suryawanshi","doi":"10.18231/j.ijpca.2022.023","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.023","url":null,"abstract":"Cefetamet pivoxil is an oral third generation cephalosporin class of antibiotic which is mainly used in the treatment and management of both upper and lower community acquired respiratory tract infection. Many branded and generic formulations are available in tablet dosage forms in market, hence the quality control of Cefetamet pivoxil play an important role in pharmaceutical industry. In the present research work an attempt has been made to develop and validate cost effective, simple, precise, robust and rugged chromatographic method for estimation of Cefetamet pivoxil in bulk and tablets. Chromatographic method was developed using HPLC instrument. The separation was based on isocratic reverse phase chromatographic mode using C-18 column as stationary phase and mobile phase composed of acetonitrile: water (80:20 v/v) at ambient temperature using UV detection at 251 nm. Developed method was validated by analyzing parameters such as specificity, selectivity, linearity, range, precision, robustness, ruggedness, detection limit, quantification limit and drug recovery. All the method validation reportwas found to be within the acceptance as per ICH guidelines. Linearity was found between the range of 10 – 50 mg/ml. The results obtained from the validation data showed that method was specific, selective, linear, precise, accurate, robust and rugged and hence can be used for estimation of Cefetamet pivoxil in bulk and tablets dosage forms.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84828605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An innovative way of keeping epidural hub in sterile condition for cost effective epidural catheters","authors":"A. Shetti, Rachita G Mustilwar","doi":"10.18231/j.ijpca.2022.019","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.019","url":null,"abstract":"","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78062821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}