International Journal for Vitamin and Nutrition Research最新文献_第5页

Assessing mean corpuscular volume as a screening tool for gestational vitamin B12 deficiency based on NHANES. 根据 NHANES 评估作为妊娠维生素 B12 缺乏症筛查工具的平均血球容积。

IF 2.3 4区医学

International Journal for Vitamin and Nutrition Research Pub Date : 2024-06-01 Epub Date: 2023-07-20 DOI: 10.1024/0300-9831/a000788

Ülgen S Fideli, Ann I Scher, Cara Olsen, Elizabeth Hisle-Gorman

{"title":"Assessing mean corpuscular volume as a screening tool for gestational vitamin B12 deficiency based on NHANES.","authors":"Ülgen S Fideli, Ann I Scher, Cara Olsen, Elizabeth Hisle-Gorman","doi":"10.1024/0300-9831/a000788","DOIUrl":"10.1024/0300-9831/a000788","url":null,"abstract":" Vitamin B12 can lead to neurological deficits. We assessed whether the mean corpuscular volume (MCV) could be a sufficiently sensitive measurement for abnormal serum methylmalonic Acid (MMA) and total plasma homocysteine (tHCY) (biomarkers of vitamin B12 or folate deficiency) and if so, at what cutoff value. A total of 26,397 participants (12,730 males and 13,667 females) were included in the analysis. Weighted analysis was performed using NHANES data to calculate crude/adjusted associations between MCV-MMA/tHCY, using linear regression. Unadjusted odds ratios (OR) 95% CIs were estimated from logistic regression models. Receiver Operating Curve and the Youden Index were used to identify the MCV level that most accurately distinguished those with abnormal MMA and tHCY (dependent variables) from those without. A positive and significant correlation between MCV-MMA/tHCY was found in the general population between ages 18-85, 0.95 (95% C.I. 0.75-1.17) and 2.61 (95% C.I. 2.15-3.08). In pregnant women, for every unit increase in MCV there was a 19% increase in odds of abnormal MMA, OR 1.19 (95% C.I. 1.08-1.31), p=0.001 and the Area Under the Curve for MCV as a test for abnormal MMA was 78%. An MCV cutoff of 93.1 correctly identified abnormal MMA in pregnant women with 81% sensitivity and 77% specificity. In the general population the MCV test performed poorly in identifying abnormal MMA/tHCY. MCV is an inexpensive measurement that may be useful to screen asymptomatic pregnant women for vitamin B12 abnormalities. This may have a significant impact on reducing adverse neurological outcomes in their children.","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":" ","pages":"198-209"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9828267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could polyphenols be an effective treatment in the management of polycystic ovary syndrome? 多酚能否有效治疗多囊卵巢综合症？

IF 2 4区医学

International Journal for Vitamin and Nutrition Research Pub Date : 2024-06-01 Epub Date: 2024-01-17 DOI: 10.1024/0300-9831/a000802

Esra Irmak, Nazli Tunca Sanlier, Nevin Sanlier

{"title":"Could polyphenols be an effective treatment in the management of polycystic ovary syndrome?","authors":"Esra Irmak, Nazli Tunca Sanlier, Nevin Sanlier","doi":"10.1024/0300-9831/a000802","DOIUrl":"10.1024/0300-9831/a000802","url":null,"abstract":" Polycystic ovary syndrome (PCOS), is a health problem observed in women of reproductive age. Different diets, physical activity recommendations and lifestyle changes can be effective in dealing with the symptoms of PCOS. Nutrition is indeed an essential part of the treatment of the disease as it directly affects body weight loss, insulin resistance, lipid profile, hormones, and dermatological complaints such as acne. Polyphenols, simply classified as flavonoids and non-flavonoids, are bioactive components found in plant-based foods. The most common polyphenols in the diet are flavanols, flavonols, flavanone, anthocyanins. In particular, polyphenols which are compounds naturally found in foods, have antioxidant, anticancer, anti-inflammatory, antimutagenic benefits along with many other ones. In the treatment of PCOS, polyphenols may help reduce the symptoms, improve insulin resistance and poor lipid profile, and cure hormonal disorders. It has been reported that polyphenols are influential in menstrual cycle disorders and enable a decrease in body weight, hyperandrogenism, estrogen, testosterone, luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratios and LH. For adequate daily intake of polyphenols, which are found in high amounts in fruits and vegetables, at least 5 portions of fruits and vegetables should be consumed in addition to a healthy nutrition pattern. In this review, the effects of various polyphenols on polycystic ovary syndrome are discussed.","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":" ","pages":"422-433"},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139477831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary iron and the risk of lung cancer. 膳食中的铁与肺癌风险。

IF 2 4区医学

International Journal for Vitamin and Nutrition Research Pub Date : 2024-06-01 Epub Date: 2023-07-20 DOI: 10.1024/0300-9831/a000789

Milad Mohammadzadeh, Alireza Bahrami, Fatemeh Ghafouri-Taleghani, Saman Khalesi, Fatemeh Abdi, Ehsan Hejazi

{"title":"Dietary iron and the risk of lung cancer.","authors":"Milad Mohammadzadeh, Alireza Bahrami, Fatemeh Ghafouri-Taleghani, Saman Khalesi, Fatemeh Abdi, Ehsan Hejazi","doi":"10.1024/0300-9831/a000789","DOIUrl":"10.1024/0300-9831/a000789","url":null,"abstract":" Animal models have suggested the carcinogenic effect of iron due to its oxidative potential. The lung is particularly vulnerable to oxidative stress. However, epidemiological studies investigating the association between dietary iron and the risk of lung cancer have reported inconclusive results. In this systematic review and meta-analysis, we aimed to clarify this association. Methods: We searched PubMed, Web of Science, Scopus and Google scholar for eligible articles published through May 2023 reporting the Relative Risk (RR), Hazard Ratio (HR) or Odds Ratio (OR) with 95% confidence interval (95% CI). Case-control and cohort studies that examined the relationship between dietary iron and lung cancer risk were included and review and meta-analyses articles, experimental studies, abstracts, letters to editor and studies with insufficient data were excluded. Finally, three case-control studies and 6 cohort studies were included. Random effect models were used to calculate the pooled results. Results: Nine studies (cases n=21,943, participants n=1,542,993) were included. There were no significant associations between the highest dietary total iron (heme and non-heme) (RR: 1.09, 95% CI: 0.78 to 1.51) or heme iron (RR: 1.01, 95% CI: 0.73 to 1.38) intake compared to the lowest intake with lung cancer risk. Null-associations were also observed in the subgroup analysis based on smoking status and lung cancer histology. However, in the subgroup of women (cases n=5074), heme iron was associated with a 14% increase in the risk of lung cancer (RR: 1.14, 95% CI: 1.01 to 1.29). Conclusions: The current results demonstrated that there is no significant relationship between dietary iron intake and the risk of lung cancer. However, a positive association was observed between dietary heme iron and the risk of lung cancer in women, which may require further investigation.","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":" ","pages":"264-274"},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9837414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astaxanthin could regulate the gut-kidney axis to mitigate kidney injury in high-fat diet/streptozotocin-induced diabetic mice. 虾青素可调节肠道-肾轴，减轻高脂饮食/链脲佐菌素诱导的糖尿病小鼠的肾损伤。

IF 2 4区医学

International Journal for Vitamin and Nutrition Research Pub Date : 2024-06-01 Epub Date: 2023-07-12 DOI: 10.1024/0300-9831/a000786

Mei Ha, Yuhui Yang, Mingzhu Wu, Ting Gong, Zongyue Chen, Luo Yu

{"title":"Astaxanthin could regulate the gut-kidney axis to mitigate kidney injury in high-fat diet/streptozotocin-induced diabetic mice.","authors":"Mei Ha, Yuhui Yang, Mingzhu Wu, Ting Gong, Zongyue Chen, Luo Yu","doi":"10.1024/0300-9831/a000786","DOIUrl":"10.1024/0300-9831/a000786","url":null,"abstract":" Accumulating evidences have shown the beneficial effects of astaxanthin (AST) supplementation on metabolic diseases prevention and treatment. The goal of present study was to reveal the favorable interactions among AST supplementation, gut microbiota, and kidneys in vivo, so as to attenuate kidney impairment in diabetic mice. Twenty C57BL/6J mice were assigned to a normal control group and a diabetic model group induced by a high-fat diet plus low-dose streptozotocin, and then the diabetic mice were fed with a high-fat diet without or with AST [0.01% (AST_a) or 0.02% (AST_b)] for 12 weeks. When compared to the diabetes kidney disease (DKD) group, AST supplementation delayed the renal pathological progression, reduced fasting blood glucose (AST_b: 1.53-fold, p<0.05), repressed levels of lipopolysaccharide (LPS; AST_a: 1.24-fold, p=0.008; AST_b: 1.43-fold, p<0.001) and TMAO (AST_a: 1.51-fold, p=0.001; AST_b: 1.40-fold, p=0.003), inhibited IL-6 (AST_a: 1.40-fold, p=0.004; AST_b: 1.57-fold, p=0.001) and reactive oxygen species (ROS; AST_a: 1.30-fold, p=0.004; AST_b: 1.53-fold, p<0.001), as well as regulated the Sirt1/PGC-1α/NFκB p65 signaling pathway. Moreover, the results of 16S rRNA gene-based Illumina deep sequencing in each group revealed that dietary AST supplementation also favorably modulated the gut microbiota compared with the DKD group, as evidenced by the inhibition of the harmful bacteria Clostridium_sensu_stricto_1, Romboutsia, and Coriobacteriaceae_UCG-002, and the enhancement of the probiotics such as Lachnospiraceae_NK4A136_group, Roseburia, and Ruminococcaceae. Taken together, dietary AST supplementation could protect kidneys against inflammation and oxidative stress by adjusting the gut-kidney axis in diabetic mice.","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":" ","pages":"187-197"},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10129016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The anti-infective effect of β-glucans in children. β-葡聚糖对儿童的抗感染作用。

IF 2.3 4区医学

International Journal for Vitamin and Nutrition Research Pub Date : 2024-06-01 Epub Date: 2023-10-02 DOI: 10.1024/0300-9831/a000793

Katarzyna Wzorek-Łyczko, Weronika Woźniak, Anna Piwowarczyk, Ernest Kuchar

{"title":"The anti-infective effect of β-glucans in children.","authors":"Katarzyna Wzorek-Łyczko, Weronika Woźniak, Anna Piwowarczyk, Ernest Kuchar","doi":"10.1024/0300-9831/a000793","DOIUrl":"10.1024/0300-9831/a000793","url":null,"abstract":" Background: β-glucans are bioactive β-D-glucose polysaccharides of natural origin, presenting antimicrobial and immunomodulation properties, with a low risk of toxicity. Objectives: This scoping review aims to present the current knowledge on the anti-infective properties of β-glucans in the pediatric population. Methods: We used the PRISMA Extension for Scoping Reviews Checklist to prepare this review. Studies were identified by electronic searches of Pubmed, Embase, and Cochrane databases up to May 2021. Results: The primary search allowed us to find 6232 studies, twelve of which were finally included in the analysis. Eight studies were designed as randomized, placebo-controlled trials, while in four studies the intervention outcome was compared with the pre-intervention period in the same group. The type of preparation and doses varied between studies: in five trials pleuran was administered (in dose 10 mg/5 kg of body weight/day), and in one study baker's yeast β-glucan was used (in two doses: 35 mg/day and 75 mg/day). In six other studies, the analyzed preparation comprised β-glucan and other substances. The shortest study lasted seven days, while the most prolonged intervention lasted six months, followed by six months of follow-up. Ten out of twelve trials demonstrated the effectiveness of β-glucans in reducing respiratory tract infection incidence or alleviation of upper respiratory tract infection symptoms. Ten out of twelve studies have reported a good tolerance and safety profile. Conclusions: Good tolerance of β-glucans shows a favorable benefit-risk ratio of this type of intervention. Nevertheless, further monitoring of their efficacy and safety in high-quality research is necessary.","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":" ","pages":"296-307"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41110610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selenium and children's cognition. 硒与儿童的认知能力

IF 2.5 4区医学

International Journal for Vitamin and Nutrition Research Pub Date : 2024-06-01 Epub Date: 2023-07-07 DOI: 10.1024/0300-9831/a000787

Ya-Zhi Bai, Shuang-Qing Zhang

引用次数: 0

Aloe Barbadensis Miller (Aloe Vera). 芦荟（芦荟）。

IF 2.3 4区医学

International Journal for Vitamin and Nutrition Research Pub Date : 2024-06-01 Epub Date: 2023-11-02 DOI: 10.1024/0300-9831/a000797

Sukhdeep Kaur, Kiran Bains

{"title":"Aloe Barbadensis Miller (Aloe Vera).","authors":"Sukhdeep Kaur, Kiran Bains","doi":"10.1024/0300-9831/a000797","DOIUrl":"10.1024/0300-9831/a000797","url":null,"abstract":" Aloe Barbadensis Miller (Aloe Vera, AV) is a widely recognized for its diverse health-promoting, skin care, and medicinal properties. This narrative review provides a comprehensive overview of AV's bioactive compounds, pharmacological activities, potential applications, its toxic and adverse effects, as well as the clinical evidence supporting AV's efficacy in disease prevention. AV contains over 200 bioactive compounds, with the inner clear gel of the leaves containing the majority of these compounds. These include phenolic acids (274.5-307.5 mg/100 g), flavonoids. (3.63-4.70 g/kg), polysaccharides (3.82-6.55 g/kg), saponins, alkaloids, terpenoids, and anthraquinone derivatives. Findings from clinical studies involving both humans and animals highlight the therapeutic potential of AV across diverse health domains. The studies demonstrate AV's efficacy in reducing blood glucose levels, exhibiting antioxidant and immunomodulatory effects, inducing apoptosis in cancer cells, protecting the liver from damage, and displaying antimicrobial properties. In the fields of dermatology and dentistry, AV has also been observed to promote skin and oral health. However, it is imperative to acknowledge potential risks, adhere to recommended dosages, and seek guidance from healthcare experts before employing AV as a natural therapeutic option. Moreover, considering safety concerns, further well-designed randomized controlled trials are necessary to substantiate the potential benefits of AV and comprehensively assess any associated risks.","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":" ","pages":"308-321"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71423372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The anti-obesity effects of resveratrol on the 3T3-L1 adipocytes. 白藜芦醇对 3T3-L1 脂肪细胞的抗肥胖作用

IF 2.3 4区医学

International Journal for Vitamin and Nutrition Research Pub Date : 2024-06-01 Epub Date: 2023-05-30 DOI: 10.1024/0300-9831/a000784

Roghayeh Molani-Gol, Maryam Rafraf

{"title":"The anti-obesity effects of resveratrol on the 3T3-L1 adipocytes.","authors":"Roghayeh Molani-Gol, Maryam Rafraf","doi":"10.1024/0300-9831/a000784","DOIUrl":"10.1024/0300-9831/a000784","url":null,"abstract":" Obesity is a severe health problem worldwide due to its association with various adverse health consequences. The present study aims to evaluate the anti-obesity effects of resveratrol, as a natural polyphenol, on the 3T3-L1 adipocytes. PubMed, Scopus, ScienceDirect, Web of Sciences, and Google Scholar databases were searched up to March 2022 using relevant keywords. All original articles, written in English, evaluating the anti-obesity effects of resveratrol on the 3T3-L1 adipocytes were eligible for this review. Initially, 4361 records were found in the electronic search databases. After removing duplicates and irrelevant studies according to the title and abstract, the full text of the 51 articles was critically screened and 38 in vitro studies were included in this review. Except for one case, all of these studies reported that different doses (ranged 1-200 μM) of resveratrol treatment have anti-obesity effects on 3T3L1 adipocytes through various mechanisms such as induction of apoptosis, a decrease of fat accumulation and adipogenesis, promotion of white adipocytes browning, inhibition of preadipocyte proliferation and consequent differentiation, and up-regulation of miRNA that involved in the antiadipogenic and triacylglycerol metabolism in white adipose tissue. The findings indicate that resveratrol has anti-obesity effects. Therefore, resveratrol treatment could be used to prevent and treat obesity and its related disorders. Well-designed randomized clinical trials with different doses of resveratrol are recommended to be performed on obese subjects.","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":" ","pages":"252-263"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9542217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial cell autofluorescence as a method for measuring the intracellular content of B2 and B6 vitamins. 微生物细胞自发荧光作为测量细胞内B2和B6维生素含量的方法。

IF 2 4区医学

International Journal for Vitamin and Nutrition Research Pub Date : 2024-06-01 Epub Date: 2023-10-18 DOI: 10.1024/0300-9831/a000796

Roman Maslanka, Michał Przywara, Agnieszka Janeczko, Renata Zadrag-Tecza

{"title":"Microbial cell autofluorescence as a method for measuring the intracellular content of B2 and B6 vitamins.","authors":"Roman Maslanka, Michał Przywara, Agnieszka Janeczko, Renata Zadrag-Tecza","doi":"10.1024/0300-9831/a000796","DOIUrl":"10.1024/0300-9831/a000796","url":null,"abstract":" Vitamins are important organic compound required for the proper functioning of cells and organisms. Vitamins of special industrial and pharmaceutical interests include riboflavin (vitamin B2) and pyridoxine (vitamin B6). Commercial production of those biological compounds has increasingly relied on microorganisms and requires simple methods for detecting and estimating their level of synthesis during the biotechnological process. In the case of yeast, methods based on autofluorescence, i.e. natural fluorescence emitted by several cellular compounds, including vitamins, may be useful. Considering that the intensity of emitted light is proportional to the intracellular concentration of riboflavin and pyridoxine, autofluorescence may be a convenient method for their quantification. In this report, we demonstrate a simple, rapid, and sufficiently trustworthy spectrofluorimetric method for determining the content of vitamins B2 and B6 in yeast cells which consists of cells growing, harvesting, washing, and resuspending in a buffer, and then measuring the emitted visible light using specific wavelength of excitation (λex=340 nm and λem=385 nm for pyridoxine; λex=460 nm and λem=535 nm for riboflavin). The limits of detection (LOD) and quantification (LOQ) estimated through measurements of vitamin fluorescence were below 0.005 μg/ml for riboflavin and below 0.05 μg/ml for pyridoxine, respectively. In turn, the smallest credible cell density for measuring autofluorescence was set at 1×108 yeast cells/ml. The relative level of the cell's autofluorescence can be expressed in mass units by applying proper calculation formulas. A comparison of the autofluorescence-based method with the reference HPLC-UV method shows that autofluorescence measurement can be used in the screening analysis of vitamin content (especially riboflavin) in microbial cells.","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":" ","pages":"334-341"},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49677200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soy isoflavones and inflammation in participants with chronic diseases. 大豆异黄酮与慢性病患者的炎症。

IF 2.5 4区医学

International Journal for Vitamin and Nutrition Research Pub Date : 2024-06-01 Epub Date: 2024-03-13 DOI: 10.1024/0300-9831/a000806

Tomoyuki Kawada

引用次数: 0