International Journal for Vitamin and Nutrition Research最新文献

{"title":"Inflammatory-Driven Vitamin A Transport Dysfunction in Ulcerative Colitis.","authors":"Zhe Zhou, Junming Miao, Yang Jing, Xiaojing Shi, Yifei Liu, Xinyue Wei, Zelin Feng, Huizhen Li, Qiuyue Tu, Hetong Zhang, Qinghua Yi, Mo Yang, Xue Li, Xiaocang Cao","doi":"10.31083/IJVNR37353","DOIUrl":"https://doi.org/10.31083/IJVNR37353","url":null,"abstract":"<p><strong>Background: </strong>Retinol-binding protein 4 (RBP4) is a vitamin A transport protein synthesized in the liver and also plays a crucial role in inflammation and immune regulation. Low serum vitamin A levels have been observed in both pediatric and adult patients with ulcerative colitis (UC). The association between serum vitamin A levels and serum RBP4 levels, as well as the underlying mechanism involved inimpaired vitamin A transport during inflammation in UC patients, has yet to been investigated.</p><p><strong>Methods: </strong>A validation cohort comprising 103 UC patients and 22 controls was analyzed. Serum RBP4 levels were measured using anenzyme-linked immunosorbent assay (ELISA), and correlations with vitamin A levels and disease severity wereassessed. A dextran sulfate sodium (DSS)-induced colitis mouse model was used to valuatehepatic RBP4 expression and inflammatory changes. Primary hepatocytes from C57BL/6 mice were exposed to inflammatory cytokines to assess the impact of these cytokines on RBP4 expression.</p><p><strong>Results: </strong>Serum vitamin A (<i>p</i> < 0.001) and RBP4 levels (<i>p</i> < 0.001) were significantly lower in UC patients compared to controls, exhibiting a pronounced decreasing trend as disease severity increased (vitamin A: <i>p</i> < 0.001; RBP4: <i>p</i> < 0.001), while vitamin A levels increased after effective treatment (<i>p</i> < 0.001). Hepatic <i>RBP4</i> expression was reduced in the DSS-induced colitis model and negatively correlated with <i>TNF-α</i>, <i>IL-6</i>, and <i>IL-17</i>.</p><p><strong>Conclusions: </strong>Serum RBP4 levels are decreased in UC patients and negatively correlate with disease severity, possibly due to proinflammatory cytokine-induced suppression which might contribute to inflammation-driven vitamin A transport dysfunction.</p>","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":"95 4","pages":"37353"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-protein Calorie-restriction Mitigates Diabetic Mice Kidney Injury via the Gut-Kidney Axis.","authors":"Ruixiang Zhang, Xiao Wei, Yijiao Xu, Chunrong Han, Xiangzeng Cai, Yinling Wu, Yan Geng, Chao Liu","doi":"10.31083/IJVNR37311","DOIUrl":"https://doi.org/10.31083/IJVNR37311","url":null,"abstract":"<p><strong>Background: </strong>Dietary interventions have exhibited promise in restoring microbial balance in chronic kidney disease. A low-protein calorie-restricted diet can reduce kidney injury in diabetic rodents. However, whether the renoprotective effects of this dietary intervention in murine diabetic kidney disease models are linked to gut microbiota modulation remains to be determined.</p><p><strong>Methods: </strong>Diabetic mice (induced by high-fat diet and streptozotocin) were randomized into four groups (n = 8/group): normal protein (20% protein), caloric restriction (30% restriction), low-protein (13% protein), and low-protein calorie-restricted (13% protein + 30% restriction). After a 5-week intervention, blood and urine samples were collected for relevant analyses, fecal samples for gut microbiota analysis, and kidney tissues for histological, immunohistochemical, and Western immunoblotting assays.</p><p><strong>Results: </strong>The low-protein calorie-restricted diet significantly improved glycemic control (fasting blood glucose: <i>p</i> < 0.01), ameliorated dyslipidemia (all <i>p</i> < 0.01), and mitigated kidney damage in diabetic mice. Additionally, the low-protein calorie-restricted diet ameliorated gut microbiota dysbiosis, significantly suppressing the increase in Firmicutes/Bacteroidetes ratio (<i>p</i> = 0.02) and decreasing serum trimethylamine oxide levels (67.51 ± 1.47 ng/mL vs. 56.58 ± 5.75 ng/mL; <i>p</i> < 0.01). Compared to the normal protein group, the low-protein calorie-restricted group exhibited significant reductions in serum tumor necrosis factor-α (TNF-α) levels (20.75 ± 7.83 μmol/L vs. 5.37 ± 2.45 μmol/L; <i>p</i> < 0.01) and apoptosis-associated speck-like protein containing a CARD (ASC), NOD-like receptor family pyrin domain containing 3 (NLRP3), and interleukin-1β (IL-1β) expression in kidney tissue (all <i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>The low-protein calorie-restricted diet exerts renoprotective effects in mice with diabetic kidney disease, possibly by modulating the gut-kidney axis to reduce circulating trimethylamine oxide levels, suggesting a potential link to NLRP3 inflammasome suppression in kidney tissue.</p>","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":"95 4","pages":"37311"},"PeriodicalIF":2.5,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Ginkgo biloba</i> L. as a Potential Alternative Therapy to Improve the Management of Diabetes: An Overview on Phytochemical Insights, Mechanisms, and Therapeutic Applications.","authors":"Nawfal Hasan Siam, Nishat Anjum Talukder Eti, Afsana Akter Mim, Md Delwar Hossen, Tasnim Tabassum, Prottya Sarker, Taniza Tasnim, Irin Parvin, Jakir Ahmed Chowdhury","doi":"10.31083/IJVNR38103","DOIUrl":"https://doi.org/10.31083/IJVNR38103","url":null,"abstract":"<p><p>Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia and associated with severe complications, including cardiovascular diseases, neuropathy, nephropathy, and retinopathy. Although synthetic antidiabetic drugs are available, the side effects and limited long-term effectiveness of these medications highlight the urgent need for safer, more potent alternative therapies. <i>Ginkgo biloba</i> L., a traditional medicinal plant rich in flavonoids, terpenoids, and bilobalide, has attracted attention for its potential role in diabetes management. This review critically evaluates the antidiabetic potential of <i>G. biloba</i> by analyzing evidence from <i>in vitro</i>, <i>in vivo</i>, and clinical studies. Moreover, this review highlights the pharmacological actions of <i>G. biloba</i> and its key bioactive compounds, focusing on their mechanisms of action, including the activation of adenosine monophosphate-activated protein kinase (AMPK), the translocation of glucose transporter type 4 (GLUT4), and the inhibition of protein tyrosine phosphatases. The review also discusses the therapeutic implications of <i>G. biloba</i> supplementation and identifies gaps in clinical validation, optimal dosing, and safety profiling. Preclinical studies have demonstrated that <i>G. biloba</i> improves glycemic control by enhancing glucose uptake, regulating insulin secretion, inhibiting α-glucosidase activity, and exerting antioxidant and anti-inflammatory effects. Additionally, clinical trials suggest that supplementation with <i>G. biloba</i> can reduce oxidative stress, improve lipid profiles, and mitigate diabetes-related complications. However, despite these promising outcomes, inconsistencies remain in present study designs, dosages, and patient populations, which question the validity of results. Furthermore, studies related to the antidiabetic effect and underlying mechanisms of <i>G. biloba</i>, such as modulation of AMPK pathways and GLUT4 expression, also remain inadequate and warrant further systematic investigation. <i>G. biloba</i> may still be considered a complementary treatment approach in managing diabetes due to its broad pharmacological activities and favorable safety profile. However, well-designed, large-scale clinical trials are crucial for establishing standardized dosing regimens, confirming long-term safety, and fully elucidating the mechanisms of action. Integrating <i>G. biloba</i> into therapeutic strategies could offer a natural, and effective adjunct for enhancing glycemic control and reducing diabetes-related complications.</p>","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":"95 4","pages":"38103"},"PeriodicalIF":2.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Applications of Vitamin B Complex in Plastic and Cosmetic Surgery: Mechanisms and Therapeutic Benefits.","authors":"Feiya Du, Ahmad Alhaskawi, Xiaodi Zou, Weijie Zhou, Hui Lu","doi":"10.31083/IJVNR39087","DOIUrl":"https://doi.org/10.31083/IJVNR39087","url":null,"abstract":"<p><p>The vitamin B complex, a group of water-soluble vitamins, is essential for various metabolic and cellular processes and critical for achieving optimal surgical outcomes in plastic and cosmetic procedures. This review examines the mechanistic contributions of this complex at the cellular level, including any roles in mitochondrial bioenergetics, redox balance, gene regulation, and cellular repair mechanisms. Niacinamide, as a precursor to NAD⁺, enhances mitochondrial efficiency and facilitates energy production, supporting tissue regeneration. Pyridoxine functions as a cofactor in neurotransmitter biosynthesis and amino acid metabolism, contributing to nerve recovery post-surgery. Furthermore, cobalamin is crucial for maintaining the myelin sheath and facilitating axonal repair, thereby ensuring neuronal integrity and minimizing nerve damage. Additionally, pantothenic acid, through its role in coenzyme A synthesis, regulates fatty acid metabolism and accelerates cellular repair, aiding in wound healing. Biotin is fundamental for keratin synthesis and follicular cell proliferation, promoting skin integrity and hair regeneration, which are vital in aesthetic and reconstructive treatments. Meanwhile, thiamine ensures a sufficient energy supply for neuronal recovery and cellular resilience through modulating carbohydrate metabolism. Thus, by integrating these cellular mechanisms, the vitamin B complex enhances tissue repair, minimizes inflammation, and improves both aesthetic and functional outcomes. Advances in precision supplementation, innovative drug delivery methods, and regenerative medicine continue to expand the therapeutic potential of B vitamins in plastic and reconstructive surgery. This comprehensive overview underscores the clinical significance of these vitamins in optimizing surgical recovery and promoting long-term tissue health.</p>","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":"95 4","pages":"39087"},"PeriodicalIF":2.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Generalized Association Between Niacin Intake and Cardiovascular Events in US Adults Living With Chronic Kidney Disease.","authors":"Dong Zhang, Hui Wu, Shengyu Gong, Gang Zhou, YanFang Liu, Yi Li, Xiaoting Yang","doi":"10.31083/IJVNR37256","DOIUrl":"https://doi.org/10.31083/IJVNR37256","url":null,"abstract":"<p><strong>Background: </strong>The effects of dietary niacin on the risk of cardiovascular disease (CVD) and mortality in patients with chronic kidney disease (CKD) remain unclear.</p><p><strong>Methods: </strong>CKD patients with estimated glomerular filtration rates (eGFRs) 20-59 mL/min/1.73 m² or urinary albumin/creatinine ratio ≥30 mg/g were identified in the National Health and Nutrition Examination Survey (NHANES) data from 2003 to 2018. Age, gender, race, education level, marital status, body mass index, blood pressure, and smoking and drinking history were considered as confounders.</p><p><strong>Results: </strong>The present study encompassed 3815 CKD patients eligible for inclusion based on the study criteria. Participants with a niacin intake of >27.7 mg/d (quartile 4) had a lower prevalent CVD risk than those with an intake of ≤14.67 mg (quartile 1) (odds ratio (OR), 0.710, 95% CI: 0.560-0.900; <i>p</i> for trend = 0.004). In the follow-up with a median of 7.0 years, 323 from CVD. After adjustment, a higher niacin intake (>27.7 mg) reduced CVD mortality compared to a lower intake (≤14.67 mg) (hazard ratio (HR), 0.610, 95% CI: 0.480-0.770; <i>p</i> for trend <0.001). Adding dietary niacin to clinical variables increased the C-index from 0.746 to 0.749 for CVD prevalence and from 0.659 to 0.682 for mortality. The net reclassification improvement increased by 9.0% and 13.1% for CVD and mortality, respectively, and the integrated discrimination improvement increased by 0.3% and 1%, respectively.</p><p><strong>Conclusions: </strong>Higher dietary niacin intake may reduce CVD and its mortality in individuals with CKD.</p>","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":"95 4","pages":"37256"},"PeriodicalIF":2.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between a Body Shape Index and Testosterone Among U.S. Adult Males: National Health and Nutrition Examination Survey (2011-2016).","authors":"Feng Gao, Chunhua Deng, Peng Luo","doi":"10.31083/IJVNR26559","DOIUrl":"https://doi.org/10.31083/IJVNR26559","url":null,"abstract":"<p><strong>Background: </strong>Obesity, a prevalent global health issue, is associated with testosterone deficiency (TD). A body shape index (ABSI) provides a more precise assessment of obesity and visceral fat, but its relationship with testosterone remains unclear. This study aimed to explore the association between ABSI and testosterone levels leading to TD.</p><p><strong>Methods: </strong>Data from 5256 adult males participating in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2016 were collected to analyze of the association between ABSI and TD. The data underwent analysis using multivariate linear regression, logistic regression, restricted cubic spline (RCS) analysis, subgroup analysis, and interaction testing. The predictive ability of ABSI based on weight, height, and waist circumference, as well as body mass index (BMI) based on weight and height, alongside a multiplicative combination of both metrics, BMI × ABSI, and optimal proportional combination O_{BMI + ABSI} for assessing TD risk, was valuated using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>Following adjustment for all confounding factors, ABSI exhibited a negative linear correlation with testosterone (β = -6.99, 95% confidence interval (CI): -8.25 to -5.73; <i>p</i> < 0.001) and a positive association with TD risk (odds ratio (OR) = 1.06, 95% CI: 1.04-1.08; <i>p</i> < 0.001). Notably, these associations remained consistent in the subgroup analysis. Additionally, age and hypertension demonstrated significant interactions between ABSI and TD (<i>p</i> < 0.05). Moreover, combining metrics, such as BMI × ABSI and O_{BMI + ABSI}, proved to be more reliable predictors of TD compared to BMI or ABSI alone.</p><p><strong>Conclusions: </strong>This study identified a negative linear correlation between ABSI and total testosterone levels in adult American males, as well as a positive linear correlation with TD prevalence. ABSI represents a valuable addition to BMI for assessing obesity and the association between obesity and TD.</p>","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":"95 4","pages":"26559"},"PeriodicalIF":2.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overall and Progression-Free Survival of Patients With Malignant Neoplasm Following Intravenous Vitamin C: A Systematic Review and Meta-Analysis.","authors":"Jinxiu Qu, Mingtao Yao, Shijie Yu, Yi Wang, Shuai Lu, Bing Wang, Jia He, Shiwan Wang, Yuan Zhao, Xin Wang, Xiaomei Tao, Xiaozhu Liu, Yizhong Rao, Yuru Li, Benqiang Rao","doi":"10.31083/IJVNR37372","DOIUrl":"10.31083/IJVNR37372","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to determine whether administering intravenous vitamin C in patients with malignant neoplasm is associated with increased survival outcomes compared to no intravenous vitamin C administration.</p><p><strong>Methods: </strong>The primary search was conducted using MEDLINE (via PubMed), Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) databases from inception to October 13, 2024. Results were collected from randomized clinical trials and cohort studies that compared intravenous vitamin C and blank controls or placebo in patients with malignant neoplasm. Two reviewers independently assessed the data extraction process and the risk of bias, while the certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation approach. A frequentist framework was used as the primary analysis approach.</p><p><strong>Results: </strong>A total of 8 studies with 2722 adult participants were included. The vitamin C dose ranged from 2.5 g/d to 1.5 g/kg of body weight per day, with the treatment duration ranging from 9 days to 1 year. The primary outcome was overall survival, with progression-free survival as a secondary measure. Intravenous vitamin C was associated with a significantly longer median overall survival (pooled estimated median survival ratio: 1.83; 95% confidence interval: 1.40-2.40; <i>p</i> < 0.001; moderate certainty), and a trend towards improved progression-free survival (pooled estimated median survival ratio: 1.80; 95% confidence interval: 0.95-3.41; <i>p</i> = 0.073). Subgroup analyses of overall survival showed higher median survival ratios with vitamin C doses <1 g/kg (<i>vs.</i> ≥1 g/kg), in non-Chinese regions (vs. Chinese regions), with non-chemotherapy combinations (<i>vs.</i> chemotherapy combinations), and in cohort studies (<i>vs.</i> randomized controlled trials).</p><p><strong>Conclusions: </strong>The administration of intravenous vitamin C to adults with malignant neoplasm was associated with a longer median overall survival compared to no vitamin C administration. The current evidence indicates a moderate degree of certainty for considering intravenous vitamin C as a standard of care in managing malignant neoplasms. The PROSPERO Registration: CRD42024600634, https://www.crd.york.ac.uk/PROSPERO/view/CRD42024600634.</p>","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":"95 3","pages":"37372"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Selenium Intake and All-Cause Mortality in Diabetic Kidney Disease: A Dose-Response Relationship Based on the NHANES Observational Study.","authors":"Xiaona Wang, Dongyan Wang, Shanshan Su","doi":"10.31083/IJVNR36782","DOIUrl":"10.31083/IJVNR36782","url":null,"abstract":"<p><strong>Objective: </strong>Substantial experimental evidence has demonstrated that selenium, an essential micronutrient with pleiotropic physiological effects, also promotes dual antioxidant and anti-inflammatory effects. Meanwhile, the epidemiological association between dietary selenium consumption and mortality risk in diabetic kidney disease (DKD) remains underexplored. This investigation demonstrated a significant association between selenium intake and all-cause mortality among adult populations with DKD.</p><p><strong>Methods: </strong>This study analyzed data from 2183 individuals diagnosed with DKD, obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2014. The mortality rate was determined through linkage to the National Death Index until December 31, 2015. The hazard ratios (HRs) and their corresponding 95% confidence intervals (95% CIs) were calculated using Cox proportional hazards regression models. Kaplan-Meier survival curves were generated to examine the association between survival probabilities and selenium intake.</p><p><strong>Results: </strong>A total of 1063 mortalities were recorded over an average follow-up period of 8 years. All-cause mortality decreased with higher selenium intake levels. Adjusted for demographic variables, dietary habits, lifestyle factors, glucose regulation, and significant comorbidities, higher selenium intake was associated with improved all-cause mortality among DKD patients (adjusted HR = 0.705, 95% CI: 0.551-0.901). A significant overall association was observed between selenium intake and all-cause mortality risk, as evidenced by restricted cubic spline (RCS) analysis (<i>p</i>_overall < 0.001; <i>p</i>_nonlinearity = 0.397).</p><p><strong>Conclusion: </strong>Higher dietary selenium intake was significantly associated with lower risk of all-cause mortality after multivariable adjustment for confounders among individuals with DKD.</p>","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":"95 3","pages":"36782"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Support for Prevention and Treatment of Pressure Injuries in Adults: An Integrative Narrative Literature Review.","authors":"Giovanni Cangelosi, Francesco Sacchini, Sara Morales Palomares, Marco Sguanci, Federico Biondini, Stefano Mancin, Antonella Amendola, Gaetano Ferrara, Gabriele Caggianelli, Fabio Petrelli","doi":"10.31083/IJVNR36342","DOIUrl":"https://doi.org/10.31083/IJVNR36342","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Pressure injuries (PIs) are a significant issue for international healthcare systems. Particularly common among older adults with reduced mobility, PIs represent a considerable socio-healthcare burden, which deeply impacts the psychological well-being of patients. Malnutrition is one of the main risk factors for the development of PIs, as malnutrition hinders healing and increases the risk of complications. For these reasons, implementing appropriate nutritional interventions, often underestimated in clinical practice, is crucial to manage PIs effectively. This study primarily aimed to identify and synthesize the best scientific evidence on nutritional interventions to prevent, facilitate, or improve the healing of PIs in an adult population. Additionally, both qualitative and quantitative outcomes were analyzed.</p><p><strong>Methods: </strong>A narrative literature review was conducted using the PubMed-Medline, Scopus, and Google Scholar databases to potentially include potential studies. The scientific validity of the study was ensured using the Scale for the Assessment of Narrative Review Articles (SANRA) and the pre-registration of the OSF database was performed using the PICOS method, which is employed in numerous studies of this type. Randomized controlled trials (RCTs) published within the last 10 years and in English were included.</p><p><strong>Results: </strong>Out of the 1507 records identified, 8 RCTs were included, published between May 2014 and May 2023. One study focused on patient education and self-care in nutrition related to PIs, while the remaining seven focused on intensive nutritional interventions or the administration of dietary supplements to treat PIs directly. Positive therapeutic effects were observed using collagen peptides, vitamin C, and arginine. Furthermore, the topical application of fish oil showed a protective effect.</p><p><strong>Conclusions: </strong>This study found that targeted nutritional interventions have a direct positive impact on PIs and an indirect effect on care, reducing complications and the duration of intensive care and healing times for PIs. Future systematic studies are recommended to broaden the understanding of the studied care framework.</p>","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":"95 3","pages":"36342"},"PeriodicalIF":2.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mean Corpuscular Volume and Risk of Autism Spectrum Disorder.","authors":"Ülgen S Fideli, Ann I Scher, William W Young, Cara H Olsen, Apryl Susi, Elizabeth Hisle-Gorman","doi":"10.31083/IJVNR26726","DOIUrl":"https://doi.org/10.31083/IJVNR26726","url":null,"abstract":"<p><strong>Background: </strong>Autism spectrum disorder (ASD) can be diagnosed as early as 18 months old, but more reliably after two years. Notably, no laboratory test exists to identify mothers at higher risk of having a child who will later be diagnosed with ASD or to identify at-risk infants before the manifestation of symptoms. One frequently described risk factor for neurodevelopmental disorders is vitamin B12 and folate deficiency, which results in macrocytic anemias.</p><p><strong>Methods: </strong>We evaluated whether increased mean corpuscular volume (MCV), an indicator of macrocytic anemias in the mother or child, is associated with increased odds of a subsequent ASD diagnosis. Maternal mean MCV (mMCV) was calculated from any value in the year before birth, and the mMCV for the child was calculated from any MCV value from birth until the end of the follow-up time. Odds ratios with 95% confidence intervals were estimated from logistic regression models.</p><p><strong>Results: </strong>A total of 3798 mothers (984 cases-ASD/2814 controls) and 9633 children (3206 cases-ASD/6427 controls) had at least one MCV value. The mMCV for the mother one year before birth was not associated with a later diagnosis of ASD in their children. In children, compared to the reference group (mMCV 76 femtoliters (fL)), an mMCV of 81 fL, 84 fL, and 91 fL was increased odds of ASD of 26%, 38%, and 32%, respectively.</p><p><strong>Conclusion: </strong>The MCV can be a potential inexpensive biomarker to identify a subset of children at risk of ASD or other developmental disorders; this exploratory study can inform larger studies to determine the clinical utility of MCV.</p>","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":"95 3","pages":"26726"},"PeriodicalIF":2.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}