The Effect of the L-Carnitine Supplementation on Obesity Indices: An Umbrella Meta-Analysis.

IF 2 4区医学 Q3 NUTRITION & DIETETICS

International Journal for Vitamin and Nutrition Research Pub Date : 2025-04-28 DOI:10.31083/IJVNR40033

Fatemeh Hamedi-Kalajahi, Meysam Zarezadeh, Mahsa Malekahmadi, Parsa Jamilian, Parmida Jamilian, Roghayeh Molani-Gol, Alireza Ostadrahimi

{"title":"The Effect of the L-Carnitine Supplementation on Obesity Indices: An Umbrella Meta-Analysis.","authors":"Fatemeh Hamedi-Kalajahi, Meysam Zarezadeh, Mahsa Malekahmadi, Parsa Jamilian, Parmida Jamilian, Roghayeh Molani-Gol, Alireza Ostadrahimi","doi":"10.31083/IJVNR40033","DOIUrl":null,"url":null,"abstract":"Aims: Obesity, one of the most frequent health risks, represents a global public health problem. The potential impact of L-carnitine, a vital nutrient for energy metabolism, on weight loss is worth considering. However, given the inconclusive results from recent meta-analyses on L-carnitine, we conducted an umbrella meta-analysis of placebo-controlled and controlled trials to evaluate the effect of L-carnitine on anthropometric indices.Methods: Data synthesis: A comprehensive search approach using the relevant keywords was performed in PubMed, Web of Science, Scopus databases, and Google Scholar up to March 2023. Meta-analyses published in English that provided quantitative statistical analyses regarding the effects of L-carnitine on body weight, waist circumference (WC), and body mass index (BMI) were included. A random-effects model and subgroup analysis were performed based on the L-carnitine dosage and study population.Results: A total of 16,352 participants were included. Intervention durations ranged from 8 to 30 weeks, with L-carnitine dosages ranging between 150 and 4000 mg/day. The pooled results of the eight included meta-analyses indicated that L-carnitine supplementation can significantly decrease weight (effect size (ES) = -1.11; 95% confidence intervals (CIs): -1.90, -0.33, p = 0.005; I2 = 90.6%, p < 0.001), BMI (ES = -0.33; 95% CI: -0.61, -0.04, p = 0.026; I2 = 89.8%, p < 0.001), and WC (ES = -1.34; 95% CI: -1.83, -0.85, p < 0.001; I2 = 00.0%, p = 0.442).Conclusion: The findings of this umbrella meta-analysis support that supplementation of L-carnitine supplementation can successfully manage weight, BMI, and WC reduction. Therefore, L-carnitine might help treat obesity. PROSPERO Registration Number: CRD42022307951.","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":"95 2","pages":"40033"},"PeriodicalIF":2.0000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal for Vitamin and Nutrition Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.31083/IJVNR40033","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Aims: Obesity, one of the most frequent health risks, represents a global public health problem. The potential impact of L-carnitine, a vital nutrient for energy metabolism, on weight loss is worth considering. However, given the inconclusive results from recent meta-analyses on L-carnitine, we conducted an umbrella meta-analysis of placebo-controlled and controlled trials to evaluate the effect of L-carnitine on anthropometric indices.

Methods: Data synthesis: A comprehensive search approach using the relevant keywords was performed in PubMed, Web of Science, Scopus databases, and Google Scholar up to March 2023. Meta-analyses published in English that provided quantitative statistical analyses regarding the effects of L-carnitine on body weight, waist circumference (WC), and body mass index (BMI) were included. A random-effects model and subgroup analysis were performed based on the L-carnitine dosage and study population.

Results: A total of 16,352 participants were included. Intervention durations ranged from 8 to 30 weeks, with L-carnitine dosages ranging between 150 and 4000 mg/day. The pooled results of the eight included meta-analyses indicated that L-carnitine supplementation can significantly decrease weight (effect size (ES) = -1.11; 95% confidence intervals (CIs): -1.90, -0.33, p = 0.005; I² = 90.6%, p < 0.001), BMI (ES = -0.33; 95% CI: -0.61, -0.04, p = 0.026; I² = 89.8%, p < 0.001), and WC (ES = -1.34; 95% CI: -1.83, -0.85, p < 0.001; I² = 00.0%, p = 0.442).

Conclusion: The findings of this umbrella meta-analysis support that supplementation of L-carnitine supplementation can successfully manage weight, BMI, and WC reduction. Therefore, L-carnitine might help treat obesity. PROSPERO Registration Number: CRD42022307951.

查看原文本刊更多论文

补充左旋肉碱对肥胖指标的影响：一项综合荟萃分析。

目的：肥胖是最常见的健康风险之一，是一个全球性的公共卫生问题。左旋肉碱是能量代谢的重要营养物质，它对减肥的潜在影响值得考虑。然而，鉴于最近关于左旋肉碱的荟萃分析结果不确定，我们对安慰剂对照和对照试验进行了综合荟萃分析，以评估左旋肉碱对人体测量指标的影响。方法：数据综合：利用相关关键词在PubMed、Web of Science、Scopus、谷歌Scholar等数据库中进行综合检索，检索截止至2023年3月。发表在英文上的荟萃分析提供了关于左旋肉碱对体重、腰围（WC）和身体质量指数（BMI）影响的定量统计分析。根据左旋肉碱剂量和研究人群进行随机效应模型和亚组分析。结果：共纳入16352名受试者。干预持续时间为8至30周，左旋肉碱剂量为150至4000毫克/天。8项纳入的荟萃分析的汇总结果表明，补充左旋肉碱可以显著降低体重(效应值(ES) = -1.11；95%置信区间（ci）： -1.90, -0.33, p = 0.005；I2 = 90.6%, p < 0.001), BMI (ES = -0.33；95% CI: -0.61, -0.04, p = 0.026；I2 = 89.8%, p < 0.001), WC (ES = -1.34；95% CI: -1.83, -0.85, p < 0.001；I2 = 0.000%, p = 0.442)。结论：这项综合荟萃分析的结果支持补充左旋肉碱可以成功地控制体重、BMI和WC的降低。因此，左旋肉碱可能有助于治疗肥胖。普洛斯彼罗注册号：CRD42022307951。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal for Vitamin and Nutrition Research 医学-营养学

CiteScore

5.00

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds. The editorial and advisory boards include many of the leading persons currently working in this area. The journal is of particular interest to: - Nutritionists - Vitaminologists - Biochemists - Physicians - Engineers of human and animal nutrition - Food scientists