白藜芦醇对 3T3-L1 脂肪细胞的抗肥胖作用

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Roghayeh Molani-Gol, Maryam Rafraf
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引用次数: 0

摘要

由于肥胖与各种不良健康后果相关联,因此肥胖是全球严重的健康问题。本研究旨在评估白藜芦醇这种天然多酚对 3T3-L1 脂肪细胞的抗肥胖作用。截至 2022 年 3 月,我们使用相关关键词在 PubMed、Scopus、ScienceDirect、Web of Sciences 和 Google Scholar 数据库中进行了检索。所有评估白藜芦醇对3T3-L1脂肪细胞抗肥胖作用的英文原创文章均符合本综述的要求。最初在电子检索数据库中发现了 4361 条记录。根据标题和摘要去除重复和无关的研究后,对 51 篇文章的全文进行了严格筛选,38 项体外研究被纳入本综述。除一例研究外,所有这些研究都报道了不同剂量(1-200 μM)的白藜芦醇通过诱导细胞凋亡、减少脂肪堆积和脂肪生成等不同机制对 3T3L1 脂肪细胞产生抗肥胖作用、白藜芦醇通过多种机制对 3T3L1 脂肪细胞产生抗肥胖作用,如诱导细胞凋亡、减少脂肪堆积和脂肪生成、促进白色脂肪细胞褐变、抑制前脂肪细胞增殖和随后的分化,以及上调参与白色脂肪组织中抗脂肪生成和三酰甘油代谢的 miRNA。研究结果表明,白藜芦醇具有抗肥胖作用。因此,白藜芦醇治疗可用于预防和治疗肥胖及其相关疾病。建议对肥胖者进行设计良好的随机临床试验,使用不同剂量的白藜芦醇。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The anti-obesity effects of resveratrol on the 3T3-L1 adipocytes.

Obesity is a severe health problem worldwide due to its association with various adverse health consequences. The present study aims to evaluate the anti-obesity effects of resveratrol, as a natural polyphenol, on the 3T3-L1 adipocytes. PubMed, Scopus, ScienceDirect, Web of Sciences, and Google Scholar databases were searched up to March 2022 using relevant keywords. All original articles, written in English, evaluating the anti-obesity effects of resveratrol on the 3T3-L1 adipocytes were eligible for this review. Initially, 4361 records were found in the electronic search databases. After removing duplicates and irrelevant studies according to the title and abstract, the full text of the 51 articles was critically screened and 38 in vitro studies were included in this review. Except for one case, all of these studies reported that different doses (ranged 1-200 μM) of resveratrol treatment have anti-obesity effects on 3T3L1 adipocytes through various mechanisms such as induction of apoptosis, a decrease of fat accumulation and adipogenesis, promotion of white adipocytes browning, inhibition of preadipocyte proliferation and consequent differentiation, and up-regulation of miRNA that involved in the antiadipogenic and triacylglycerol metabolism in white adipose tissue. The findings indicate that resveratrol has anti-obesity effects. Therefore, resveratrol treatment could be used to prevent and treat obesity and its related disorders. Well-designed randomized clinical trials with different doses of resveratrol are recommended to be performed on obese subjects.

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来源期刊
CiteScore
5.00
自引率
4.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds. The editorial and advisory boards include many of the leading persons currently working in this area. The journal is of particular interest to: - Nutritionists - Vitaminologists - Biochemists - Physicians - Engineers of human and animal nutrition - Food scientists
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