María Pérez-Alonso, Ismael Calero-Paniagua, Ricardo Usategui-Martin, Laisa-Socorro Briongos, Marta Ruiz-Mambrilla, José-Manuel Olmos, Manuel González-Sagrado, Daniel De Luis, Antonio Dueñas-Laita, José-Luis Pérez-Castrillón
{"title":"补充染料木素对西班牙绝经后健康妇女的维生素 D 水平没有影响。","authors":"María Pérez-Alonso, Ismael Calero-Paniagua, Ricardo Usategui-Martin, Laisa-Socorro Briongos, Marta Ruiz-Mambrilla, José-Manuel Olmos, Manuel González-Sagrado, Daniel De Luis, Antonio Dueñas-Laita, José-Luis Pérez-Castrillón","doi":"10.1024/0300-9831/a000781","DOIUrl":null,"url":null,"abstract":"<p><p><b></b> <i>Background:</i> In vitro studies have shown that genistein inhibits the CYP240 enzyme, which is involved in the degradation of 1,25-dihydroxycholecalciferol and its precursor 25-hydroxycholecalciferol, and increases their plasma levels. However, no clinical studies have primarily assessed the synergistic effect of isoflavones on vitamin D levels. The aim of this study was to evaluate the possible additive effect of genistein supplementation on vitamin D levels, calcium metabolism and bone remodeling markers in healthy postmenopausal women during the spring-summer months. <i>Patients and methods:</i> We made a prospective, double-blind study with 150 healthy postmenopausal women that were randomized to three groups. One received placebo, another received calcium (1000 mg/day) and vitamin D (cholecalciferol, 800 U/day) and the third received calcium (1000 mg/day), vitamin D (cholecalciferol, 800 U/day) and genistein (90 mg/day). The study period was from May to September (spring-summer). Vitamin D, PTH, CTX and P1NP were determined by electrochemiluminescence at baseline and after 12 weeks. <i>Results:</i> Vitamin D levels increased in all groups: placebo (23±9 ng/ml vs. 29±10 ng/ml, p<0.05), calcium+vitamin D (26±10 ng/ml vs. 33±8 ng/ml, p<0.05) and calcium+vitamin D+genistein (24±9 ng/ml vs. 31±8 ng/l, p<0.05) without between-group differences. At study end, the percentage of women with vitamin D <20 ng/ml (11%) and <30 ng/ml (39%) had fallen without between-group differences. The effects on calcium metabolism and bone remodeling markers were similar between groups: rises in vitamin D were significantly linked to reductions in PTH, CTX and P1NP. <i>Conclusion:</i> Adding genistein to supplementation with calcium and vitamin D provided not additional changes in vitamin D levels, calcium metabolism or bone remodeling markers in healthy Spanish postmenopausal women during the spring-summer months.</p>","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":" ","pages":"171-176"},"PeriodicalIF":2.0000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Genistein supplementation has no effects on vitamin D levels in healthy Spanish postmenopausal women.\",\"authors\":\"María Pérez-Alonso, Ismael Calero-Paniagua, Ricardo Usategui-Martin, Laisa-Socorro Briongos, Marta Ruiz-Mambrilla, José-Manuel Olmos, Manuel González-Sagrado, Daniel De Luis, Antonio Dueñas-Laita, José-Luis Pérez-Castrillón\",\"doi\":\"10.1024/0300-9831/a000781\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b></b> <i>Background:</i> In vitro studies have shown that genistein inhibits the CYP240 enzyme, which is involved in the degradation of 1,25-dihydroxycholecalciferol and its precursor 25-hydroxycholecalciferol, and increases their plasma levels. However, no clinical studies have primarily assessed the synergistic effect of isoflavones on vitamin D levels. The aim of this study was to evaluate the possible additive effect of genistein supplementation on vitamin D levels, calcium metabolism and bone remodeling markers in healthy postmenopausal women during the spring-summer months. <i>Patients and methods:</i> We made a prospective, double-blind study with 150 healthy postmenopausal women that were randomized to three groups. One received placebo, another received calcium (1000 mg/day) and vitamin D (cholecalciferol, 800 U/day) and the third received calcium (1000 mg/day), vitamin D (cholecalciferol, 800 U/day) and genistein (90 mg/day). The study period was from May to September (spring-summer). Vitamin D, PTH, CTX and P1NP were determined by electrochemiluminescence at baseline and after 12 weeks. <i>Results:</i> Vitamin D levels increased in all groups: placebo (23±9 ng/ml vs. 29±10 ng/ml, p<0.05), calcium+vitamin D (26±10 ng/ml vs. 33±8 ng/ml, p<0.05) and calcium+vitamin D+genistein (24±9 ng/ml vs. 31±8 ng/l, p<0.05) without between-group differences. At study end, the percentage of women with vitamin D <20 ng/ml (11%) and <30 ng/ml (39%) had fallen without between-group differences. 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引用次数: 0
摘要
背景:体外研究表明,染料木素可抑制参与 1,25- 二羟基胆钙化醇及其前体 25- 羟基胆钙化醇降解的 CYP240 酶,并提高其血浆水平。然而,目前还没有临床研究主要评估异黄酮对维生素 D 水平的协同作用。本研究的目的是评估在春夏季节补充染料木素对健康绝经后妇女的维生素 D 水平、钙代谢和骨重塑指标可能产生的增效作用。患者和方法我们进行了一项前瞻性双盲研究,将 150 名绝经后健康妇女随机分为三组。一组服用安慰剂,另一组服用钙剂(1000 毫克/天)和维生素 D(胆钙化醇,800 U/天),第三组服用钙剂(1000 毫克/天)、维生素 D(胆钙化醇,800 U/天)和染料木素(90 毫克/天)。研究时间为 5 月至 9 月(春夏季)。在基线期和 12 周后,通过电化学发光法测定维生素 D、PTH、CTX 和 P1NP。结果显示所有组的维生素 D 水平都有所上升:安慰剂组(23±9 ng/ml vs. 29±10 ng/ml,p)和非安慰剂组(29±10 ng/ml vs. 29±10 ng/ml,p):在补充钙和维生素 D 的基础上添加染料木素,不会对春夏季节健康的西班牙绝经后妇女的维生素 D 水平、钙代谢或骨重塑指标产生额外的影响。
Genistein supplementation has no effects on vitamin D levels in healthy Spanish postmenopausal women.
Background: In vitro studies have shown that genistein inhibits the CYP240 enzyme, which is involved in the degradation of 1,25-dihydroxycholecalciferol and its precursor 25-hydroxycholecalciferol, and increases their plasma levels. However, no clinical studies have primarily assessed the synergistic effect of isoflavones on vitamin D levels. The aim of this study was to evaluate the possible additive effect of genistein supplementation on vitamin D levels, calcium metabolism and bone remodeling markers in healthy postmenopausal women during the spring-summer months. Patients and methods: We made a prospective, double-blind study with 150 healthy postmenopausal women that were randomized to three groups. One received placebo, another received calcium (1000 mg/day) and vitamin D (cholecalciferol, 800 U/day) and the third received calcium (1000 mg/day), vitamin D (cholecalciferol, 800 U/day) and genistein (90 mg/day). The study period was from May to September (spring-summer). Vitamin D, PTH, CTX and P1NP were determined by electrochemiluminescence at baseline and after 12 weeks. Results: Vitamin D levels increased in all groups: placebo (23±9 ng/ml vs. 29±10 ng/ml, p<0.05), calcium+vitamin D (26±10 ng/ml vs. 33±8 ng/ml, p<0.05) and calcium+vitamin D+genistein (24±9 ng/ml vs. 31±8 ng/l, p<0.05) without between-group differences. At study end, the percentage of women with vitamin D <20 ng/ml (11%) and <30 ng/ml (39%) had fallen without between-group differences. The effects on calcium metabolism and bone remodeling markers were similar between groups: rises in vitamin D were significantly linked to reductions in PTH, CTX and P1NP. Conclusion: Adding genistein to supplementation with calcium and vitamin D provided not additional changes in vitamin D levels, calcium metabolism or bone remodeling markers in healthy Spanish postmenopausal women during the spring-summer months.
期刊介绍:
Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds.
The editorial and advisory boards include many of the leading persons currently working in this area.
The journal is of particular interest to:
- Nutritionists
- Vitaminologists
- Biochemists
- Physicians
- Engineers of human and animal nutrition
- Food scientists