维生素 A5/X 缺乏症的定义--维生素 A5/X 是影响心理健康的关键饮食因素。

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Diána Bánáti, Julian Hellman-Regen, Isabelle Mack, Hayley A Young, David Benton, Manfred Eggersdorfer, Sascha Rohn, Joanna Dulińska-Litewka, Wojciech Krężel, Ralph Rühl
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引用次数: 0

摘要

健康均衡的饮食是确保中枢和周围神经系统良好运作的重要因素。视黄醇 X 受体(RXR)介导的信号被认为是一种重要的机制,可传递依赖于饮食的主要生理和营养信号,如控制髓鞘化和多巴胺信号。最近,维生素 A5/X (主要以维生素 A5/X 的形式存在于蔬菜中)被认为是一种新概念的维生素,它作为一种营养前体,可促成 RXR 介导的信号传导。维生素 A5/X 的活性形式--9-顺式-13,14-脱氢维甲酸(9CDHRA)--可诱导 RXR 激活,从而成为启动各种异二聚体-RXR-信号级联的中心开关,这些级联涉及各种伙伴异二聚体,如脂肪酸受体和二十烷受体/过氧化物酶体增殖激活受体(PPARs)、胆固醇受体/肝 X 受体(LXRs)、维生素 D 受体(VDR)和维生素 A(1)受体/维甲酸受体(RARs)。因此,维生素 A5/X 的营养供应可能是一个总体营养依赖性开关,可启动这一庞大的激素信号通路级联,因此对于保证整个生物体的稳态十分重要。研究表明,RXR 介导的信号转导依赖于维生素 A5/X,其直接作用是通过系统或直接在大脑中介导有益的生理和神经保护功能。总之,通过控制多巴胺信号、淀粉样蛋白 β 清除、神经保护和神经炎症,维生素 A5/X - RXR - RAR - 维生素 A(1)信号可能是良好的心理健康、健康的大脑衰老以及防止吸毒成瘾和预防一系列神经系统疾病所必需的 "关键因素 "之一,甚至是 "关键因素"。同样,维生素 A5/X - RXR - 非 RAR 依赖性信号传导与髓鞘化/再髓鞘化和吞噬/脑清理相关,也将有助于此类调节。在这篇综述中,我们将讨论神经系统的基本科学背景、逻辑联系和营养/药物专家建议,特别是考虑到大脑的老化问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Defining a vitamin A5/X specific deficiency - vitamin A5/X as a critical dietary factor for mental health.

A healthy and balanced diet is an important factor to assure a good functioning of the central and peripheral nervous system. Retinoid X receptor (RXR)-mediated signaling was identified as an important mechanism of transmitting major diet-dependent physiological and nutritional signaling such as the control of myelination and dopamine signalling. Recently, vitamin A5/X, mainly present in vegetables as provitamin A5/X, was identified as a new concept of a vitamin which functions as the nutritional precursor for enabling RXR-mediated signaling. The active form of vitamin A5/X, 9-cis-13,14-dehydroretinoic acid (9CDHRA), induces RXR-activation, thereby acting as the central switch for enabling various heterodimer-RXR-signaling cascades involving various partner heterodimers like the fatty acid and eicosanoid receptors/peroxisome proliferator-activated receptors (PPARs), the cholesterol receptors/liver X receptors (LXRs), the vitamin D receptor (VDR), and the vitamin A(1) receptors/retinoic acid receptors (RARs). Thus, nutritional supply of vitamin A5/X might be a general nutritional-dependent switch for enabling this large cascade of hormonal signaling pathways and thus appears important to guarantee an overall organism homeostasis. RXR-mediated signaling was shown to be dependent on vitamin A5/X with direct effects for beneficial physiological and neuro-protective functions mediated systemically or directly in the brain. In summary, through control of dopamine signaling, amyloid β-clearance, neuro-protection and neuro-inflammation, the vitamin A5/X - RXR - RAR - vitamin A(1)-signaling might be "one of" or even "the" critical factor(s) necessary for good mental health, healthy brain aging, as well as for preventing drug addiction and prevention of a large array of nervous system diseases. Likewise, vitamin A5/X - RXR - non-RAR-dependent signaling relevant for myelination/re-myelination and phagocytosis/brain cleanup will contribute to such regulations too. In this review we discuss the basic scientific background, logical connections and nutritional/pharmacological expert recommendations for the nervous system especially considering the ageing brain.

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来源期刊
CiteScore
5.00
自引率
4.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds. The editorial and advisory boards include many of the leading persons currently working in this area. The journal is of particular interest to: - Nutritionists - Vitaminologists - Biochemists - Physicians - Engineers of human and animal nutrition - Food scientists
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