International Journal of Biomedical and Advance Research最新文献_第5页

Study of histopathological pattern of thyroid lesions 甲状腺病变的组织病理学模式研究

International Journal of Biomedical and Advance Research Pub Date : 2018-01-30 DOI: 10.7439/IJBAR.V9I1.4592

M. Modi, M. Daveshwar

{"title":"Study of histopathological pattern of thyroid lesions","authors":"M. Modi, M. Daveshwar","doi":"10.7439/IJBAR.V9I1.4592","DOIUrl":"https://doi.org/10.7439/IJBAR.V9I1.4592","url":null,"abstract":"Aim: To study histopathological features and to find out the frequency of various lesions of thyroid and to distribute thyroid lesions according to age, sex and benign and malignant behaviour. Material and methods: The test population comprised of patients with thyroid pathology, between July 2014 to August 2016, evaluated by light microscopy and immunohistochemistry. Results: In our study, Age group of patients ranged from 6-70 years, with a mean age of 37.4 years and Male to Female ratio was 1:4.9. Among total 100 cases, 54 non-neoplastic masses and 44 neoplastic masses. Incidence rate of inflammatory lesions was 8%. The most common type of inflammatory lesion was lymphocytic thyroiditis (50% of total inflammatory lesion). Incidence rate of hyperplastic lesions was 46%. It was most common thyroid lesion in our study. Most of the cases presented at the age group of 21-60 years. The most common histopathological sub type of hyperplastic lesion was colloid goiter (58.7% of the total hyperplastic lesion). Incidence rate of benign lesion was 27%. The most common presenting age group for benign thyroid lesion was 21-50 years. Benign thyroid lesion was represented exclusively in this study by follicular adenoma only. One case of well differentiated tumor of uncertain malignant potential was found. Incidence rate of malignant lesions was 16%. Most of the malignant cases presented at the age group of 21-40 years. The most common histopathological sub type of thyroid malignancy was papillary thyroid carcinoma (81.3% of the total malignant lesion). Five cases were analyzed immunohistochemically, wherever light microscopy was inconclusive. Conclusion: Neoplastic and non-neonlastic disorders affect thyroid gland. Non-neoplastic disorders outnumber the neoplastic disorders. Most common non-neoplastic lesion was colloid goiter. The most common benign tumor was Follicular adenoma and the most common malignant tumor was papillary carcinoma.","PeriodicalId":13848,"journal":{"name":"International Journal of Biomedical and Advance Research","volume":"7 1","pages":"27-36"},"PeriodicalIF":0.0,"publicationDate":"2018-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87520674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Association between thyroid hormone disorders and renal dysfunction 甲状腺激素紊乱与肾功能障碍的关系

International Journal of Biomedical and Advance Research Pub Date : 2018-01-30 DOI: 10.7439/IJBAR.V9I1.4580

Mushir Ahmad, A. Sharma, S. Iqbal, S. Nagtilak, Naved Ahmad

{"title":"Association between thyroid hormone disorders and renal dysfunction","authors":"Mushir Ahmad, A. Sharma, S. Iqbal, S. Nagtilak, Naved Ahmad","doi":"10.7439/IJBAR.V9I1.4580","DOIUrl":"https://doi.org/10.7439/IJBAR.V9I1.4580","url":null,"abstract":"Background: Thyroid hormones perform a wide range of metabolic functions. Relationship between thyroid diseases and kidney function initially described were clinically subtle. It has been suggested that patients of thyroid disorder can be associated with increased risk of renal diseases. Aims and Objectives: To understand the effects of thyroid disorders on renal function and carbohydrate metabolism, we estimated and compared blood sugar, serum urea and serum creatinine levels with T3, T4 and TSH in thyroid dysfunction patients and euthyroid subjects. Materials and Method: Case control study was done on 78 newly diagnosed thyroid disorder cases and 78 age and sex matched healthy controls, attending medicine OPD within the age group of 18 to 59 years. Result: There is significant positive correlation between TSH and serum creatinine levels with p<0.001, and there is positive correlation between TSH and serum urea levels and also with TSH and blood sugar levels. Conclusion: It is evident from the study that there is an association between fasting blood glucose levels, creatinine levels and thyroid disorder. Larger epidemiological research is required to find out the incidence of renal dysfunction in thyroid disorders.","PeriodicalId":13848,"journal":{"name":"International Journal of Biomedical and Advance Research","volume":"12 1","pages":"23-26"},"PeriodicalIF":0.0,"publicationDate":"2018-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73311637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Formulation and in vitro evaluation of Metformin HCl mucoadhesive tablets for NIDDM 盐酸二甲双胍黏合剂片的处方及体外评价

International Journal of Biomedical and Advance Research Pub Date : 2018-01-30 DOI: 10.7439/IJBAR.V9I1.4533

H. Kouser, Santosh kumar Chinnaiyan

{"title":"Formulation and in vitro evaluation of Metformin HCl mucoadhesive tablets for NIDDM","authors":"H. Kouser, Santosh kumar Chinnaiyan","doi":"10.7439/IJBAR.V9I1.4533","DOIUrl":"https://doi.org/10.7439/IJBAR.V9I1.4533","url":null,"abstract":"The objective of the present work was to develop an oral Mucoadhesive Metformin hydrochloride tablet for the sustained-release. Metformin hydrochloride (HCl), a biguanide, has a relatively short plasma half-life and low absolute bioavailability. The tablets were prepared by the Wet Granulation method, using biodegradable mucoadhesive polymer Xanthan gum and pectin at different concentrations. All the batches were evaluated for thickness, weight variation, hardness, drug content uniformity, in vitro drug release and mucoadhesion strength. Mean dissolution time is used to characterize the drug release rate from a dosage form, and indicates the drug release-retarding efficiency of the polymer. The in vitro studies the formulations containing Pectin showed less retardation than the formulation with Xanthan gum. The Metformin release effectively controlled for 12 h with Xanthan gum, thus, can be successfully employed for formulating mucoadhesive tablets. Fitting the data to the Zero order and Higuchi equation indicated the mechanism of drug release. The study reveals that Xanthan gum highest mucoadhesive strength compared with pectin.","PeriodicalId":13848,"journal":{"name":"International Journal of Biomedical and Advance Research","volume":"357 1","pages":"06-12"},"PeriodicalIF":0.0,"publicationDate":"2018-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82626991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of Video Assisted learning (VAL) on slow learners 视频辅助学习(VAL)对慢学习者的影响

International Journal of Biomedical and Advance Research Pub Date : 2018-01-30 DOI: 10.7439/IJBAR.V9I1.4536

A. Tayade, S. Tayade, Anita Chalak, Tripti K Srivastava

{"title":"The impact of Video Assisted learning (VAL) on slow learners","authors":"A. Tayade, S. Tayade, Anita Chalak, Tripti K Srivastava","doi":"10.7439/IJBAR.V9I1.4536","DOIUrl":"https://doi.org/10.7439/IJBAR.V9I1.4536","url":null,"abstract":"Background: Every medical graduate after completion of his course is posted in the emergency room where he/she faces many chest emergencies. In some chest emergencies a small intervention can be life-saving. In view of evidence based clinical practice every medical graduate should be confident to diagnose chest emergencies (e.g. Tension pneumothorax, massive pleural effusion, periodical effusion etc.) on radiographs, where an immediate intervention is necessary. Video Assisted learning (VAL) improves the performance of learners as it addresses a variety of learning styles. Video can be as good as an instructor in communicating facts or demonstrating procedures to assist in mastery learning where a student can view complex clinical or mechanical procedures as many times as they need to. In this study the advantages of video assisted learning would be used to enhance the academic output of learners. Method : 60 medical students of 6th semester were exposed to video assisted learning after traditional didactic lecture teaching on chest emergencies in the discipline of Radiology. Pretest OSCE was conducted in the form of interpretation of chest radiographs and post test OSCE was conducted after the intervention (VAL) Results: The average pretest score was 25.2 (31.5%) and average post test score was 48.15(60.18%). Based on the pretest scores, students were divided into three groups, i.e. Top one-third students, Middle one-third students and Bottom one-third students (i.e. slow learners). The pretest and post test results were compared as mean scores of the groups, with Paired t test. The difference in the scores was found to be statistically significant in all the groups (p value less than 0.001). The students perceived VAL as a good instructor which improves the understanding of complex case scenarios. Conclusion: Video assisted learning is an effective medium for teaching learning in graduate medical education.","PeriodicalId":13848,"journal":{"name":"International Journal of Biomedical and Advance Research","volume":"100 1","pages":"13-18"},"PeriodicalIF":0.0,"publicationDate":"2018-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80944008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparison of Blackboard and PowerPoint Presentation in Teaching Biochemistry For MBBS Students 板书与ppt在生物化学教学中的比较

International Journal of Biomedical and Advance Research Pub Date : 2018-01-30 DOI: 10.7439/IJBAR.V9I1.4551

G. Saritha, M. RameshBabu

{"title":"Comparison of Blackboard and PowerPoint Presentation in Teaching Biochemistry For MBBS Students","authors":"G. Saritha, M. RameshBabu","doi":"10.7439/IJBAR.V9I1.4551","DOIUrl":"https://doi.org/10.7439/IJBAR.V9I1.4551","url":null,"abstract":"Background: Blackboard teaching is the traditional method of delivery of lecture for MBBS students. Power point presentation is the popular new tool in teaching the subject for the students. An effective teaching method helps to improve the academic performance of the student and also it is useful to implement the knowledge in the future. Aims and objectives: The aim of the study was to compare the student’s perception of blackboard teaching and power point presentation in learning Biochemistry among MBBS students. Material and methods: A total of 120 first year MBBS students participated in this study. The study was conducted by asking the students to fill a questionnaire regarding their perception about the blackboard teaching and power point presentation in learning Biochemistry. Results: In this study, the students preferred blackboard (70%) as the teaching method compared to power point presentation. In blackboard teaching there is better perception of the subject (77%) and there was more involvement in teaching (80%) compared to power point teaching. Whereas power point was preferred by the students to make notes (62%) compared to blackboard teaching. Conclusion: Blackboard still remains the preferred teaching aid to learn Biochemistry among the MBBS students. Power point presentation is helpful for the students to take down notes.","PeriodicalId":13848,"journal":{"name":"International Journal of Biomedical and Advance Research","volume":"2 1","pages":"19-22"},"PeriodicalIF":0.0,"publicationDate":"2018-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73081535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Synthesis And Biological Evaluation Of Benzimidazole Derivatives As An Antitubercular And Antimicrobial Agents 苯并咪唑类抗结核和抗菌药物的合成及生物学评价

International Journal of Biomedical and Advance Research Pub Date : 2018-01-30 DOI: 10.7439/IJBAR.V9I1.4585

S. Kale, M. Kale

{"title":"Synthesis And Biological Evaluation Of Benzimidazole Derivatives As An Antitubercular And Antimicrobial Agents","authors":"S. Kale, M. Kale","doi":"10.7439/IJBAR.V9I1.4585","DOIUrl":"https://doi.org/10.7439/IJBAR.V9I1.4585","url":null,"abstract":"Heterocyclic Compounds especially with Benzimidazole, Thiophene & Piperazine moieties were synthesized and investigated for their biological activities. The Increasing global tuberculosis burden due to the curse of HIV, MDR and XRD TB has led to the search of newer therapeutic agents to tackle the menance. The benzimidazole, Thiophene, Piperazine are an heterocyclic compounds. It is an important pharmacophore and privileged structure in medicinal chemistry. It plays a very important role with useful therapeutic activitiy such as antitubercular activity. literature shows that the benzimidazole, Thiophene, Piperazine derivatives are outstandingly effective compounds and a large number of reviews available for biochemical and pharmacological studies conformed that their molecules are useful against a wide variety of micro-organisms. Because of their importance, the methods for their synthesis have become a focus of synthetic organic chemists. Therefore in the present work study of chemistry of different derivative of substituted benzimidazole, Thiophene, Piperazine as well as various Antifungal, Antibacterial, Antitubercular activities).1 The structures of these compounds were established by means of IR, 1H-NMR,C13NMR and elemental analysis. All compounds were evaluated for antibacterial, antifungal and antitubercular activities. Most of the compounds have shown significant antibacterial, antifungal and antitubercular activity when compared with the standard drug. QSAR study were done by using Schrodinger software.","PeriodicalId":13848,"journal":{"name":"International Journal of Biomedical and Advance Research","volume":"46 1","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"2018-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88331909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Umbilical cord blood Erythropoietin as a biomarker of subacute and chronic hypoxia in deliveries complicated by meconium stained amniotic fluid 脐带血促红细胞生成素作为亚急性和慢性缺氧分娩合并胎粪染色羊水的生物标志物

International Journal of Biomedical and Advance Research Pub Date : 2018-01-30 DOI: 10.7439/IJBAR.V9I1.4465

Shatha Abdulkareem Mahmoud, I. M. Saleh, D. Salman, Z. Mohammed

{"title":"Umbilical cord blood Erythropoietin as a biomarker of subacute and chronic hypoxia in deliveries complicated by meconium stained amniotic fluid","authors":"Shatha Abdulkareem Mahmoud, I. M. Saleh, D. Salman, Z. Mohammed","doi":"10.7439/IJBAR.V9I1.4465","DOIUrl":"https://doi.org/10.7439/IJBAR.V9I1.4465","url":null,"abstract":"Background: The presence of meconium stained amniotic fluid (MSAF) during labour is often associated with a lot of adverse outcomes and historically has been considered to be a predictor of bad neonatal outcome. It is associated with fetal hypoxia and leads to emergency C/S, instrumental vaginal delivery for fetal distress, low Apgar score at birth, meconium aspiration syndrome and neuro-developmental handicaps. Umbilical cord serum erythropoietin levels have been claimed to be elevated in response to fetal hypoxia. Objective: To evaluate the umbilical cord serum erythropoietin levels in neonates born through MSAF and to determine whether it is influenced by gestational age. Study Design: Prospective case control study. Materials & Methods: Women with term uncomplicated singlet on pregnancies at gestational age between (37-41 +6 ) weeks admitted to the labour room in the active phase of labour were enrolled to participate in this study. The studied population has been divided into two groups, women with thick meconium stained amniotic fluid (study group) and women with clear amniotic fluid (control group). Umbilical cord serum Erythropoietin levels will be measured for both groups by ELISA, after delivery and Apgar score will be assessed for neonates of both groups then statistical analysis will be performed. Results: A significant relationship was found between MSAF and elevated umbilical cord serum erythropoietin levels since the p value was P < 0.001. Apgar score was lower significantly after 1 minute in study group, but lower none significantly after 5 minutes, as P <0.001and 0.109 respectively. Conclusions: The elevated umbilical cord serum Erythropoietin levels in neonates born through MSAF suggest subacute or chronic fetal Hypoxia, independent of gestational age.","PeriodicalId":13848,"journal":{"name":"International Journal of Biomedical and Advance Research","volume":"172 1","pages":"01-05"},"PeriodicalIF":0.0,"publicationDate":"2018-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74879554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Homocysteine a silent marker for cardiovascular disease 同型半胱氨酸是心血管疾病的无声标志物吗

International Journal of Biomedical and Advance Research Pub Date : 2017-12-30 DOI: 10.7439/ijbar.v8i12.4515

N. Abraham, Priyanka S. Bannikoppa, P. Anand

引用次数: 0

Comparative evaluation of the presence of serum antibodies SMA, Anti DNA, ANA and RF in the oral lichen planus and oral lichenoid drug and contact reactions 血清抗体SMA、Anti DNA、ANA和RF在口腔扁平苔藓和口腔类地衣药物及接触反应中的存在比较评价

International Journal of Biomedical and Advance Research Pub Date : 2017-12-30 DOI: 10.7439/ijbar.v8i12.4520

Mohammad Akhondzadeh

{"title":"Comparative evaluation of the presence of serum antibodies SMA, Anti DNA, ANA and RF in the oral lichen planus and oral lichenoid drug and contact reactions","authors":"Mohammad Akhondzadeh","doi":"10.7439/ijbar.v8i12.4520","DOIUrl":"https://doi.org/10.7439/ijbar.v8i12.4520","url":null,"abstract":"Introduction: Oral lichenoid reactions (OLR) are referred to a group of diseases that clinically and histologically could not be differentiated from the oral lichen planus (OLP) diseases. In the recent years, the two groups of diseases have been considered as T-Cell mediated inflammatory diseases. The aim of this study was to gather more information to help better distinguish these two lesions. Method and Materials: In this descriptive-analytical study, blood samples were taken from 80 patients (59 females and 29 males) and sent to the laboratory for histopathological diagnosis based on WHO criteria. After separating the blood sera of the samples, the sera were evaluated by enzyme linked immunosorbent assay (ELISA) for the presence of ANA, anti-DNA, RF, and SMA auto-antibodies. Data statistically was analyzed with SPSS using the chi-squared test and t-test (a = 0.05). Results: The mean ages were 48.62 and 49.38 for OLP and OLR patients, respectively. There were no significant differences in ANA and RF blood levels (p value g 0.05). Anti-DNA and SMA antibodies were not detected in the blood samples. No significant differences were noted in the blood levels of these antibodies (p value g 0.05). Conclusion: According to the results of the present study, no significant differences were observed between the OLP and OLR patients in relation to the presence or absence of ANA, anti-DNA, RF, and SMA auto-antibodies in the blood samples.","PeriodicalId":13848,"journal":{"name":"International Journal of Biomedical and Advance Research","volume":"40 1","pages":"460-464"},"PeriodicalIF":0.0,"publicationDate":"2017-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86078737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous estimation of Cetrizine hydrochloride and Phenylephrine hydrochloride in tablet dosage form by RP-HPLC 反相高效液相色谱法同时测定片剂剂型盐酸头孢嗪和盐酸苯肾上腺素的含量

International Journal of Biomedical and Advance Research Pub Date : 2017-12-30 DOI: 10.7439/IJBAR.V8I12.4542

T. Tonde, Halavath Ramesh, Sashank Bhandarkar, Trupti S. Bobade, Sachin M. Hiradeve

{"title":"Simultaneous estimation of Cetrizine hydrochloride and Phenylephrine hydrochloride in tablet dosage form by RP-HPLC","authors":"T. Tonde, Halavath Ramesh, Sashank Bhandarkar, Trupti S. Bobade, Sachin M. Hiradeve","doi":"10.7439/IJBAR.V8I12.4542","DOIUrl":"https://doi.org/10.7439/IJBAR.V8I12.4542","url":null,"abstract":"A simple, economical, specific, accurate, precise and validated Reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the simultaneous estimation of Cetrizine hydrochloride and Phenylephrine hydrochloride in synthetic mixture and its combined dosage form. The chromatographic separation was achieved on C18 column (Intersil, 220 mm 4.6 mm i.d., 10 ?m particle size) at ambient temperature using disodium hydrogen phosphate (Na 2 HPO 4 ) buffer; pH was adjusted to 6.50 using ortho-phosphoric acid and a mobile phase of Methanol: Acetonitrile: Disodium hydrogen phosphate (80: 4: 19, v/v) at flow rate 2.0 ml/min. Quantification was achieved with UV detector at wavelength 270 nm. The retention time was found to be 1.2 0.04 min and 3.1 0.06 min for cetirizine HCl and phenylephrine HCl respectively. The calibration curves were linear with correlation coefficient 0.998 and 0.999 in the range of 10-50 ?g/ml for Cetrizine hydrochloride and Phenylephrine hydrochloride. The methods were validated in terms of linearity, precision, accuracy, LOD, LOQ and ruggedness according to ICH guideline.","PeriodicalId":13848,"journal":{"name":"International Journal of Biomedical and Advance Research","volume":"28 1","pages":"465-472"},"PeriodicalIF":0.0,"publicationDate":"2017-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85201403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2