Comparative evaluation of the presence of serum antibodies SMA, Anti DNA, ANA and RF in the oral lichen planus and oral lichenoid drug and contact reactions

Introduction: Oral lichenoid reactions (OLR) are referred to a group of diseases that clinically and histologically could not be differentiated from the oral lichen planus (OLP) diseases. In the recent years, the two groups of diseases have been considered as T-Cell mediated inflammatory diseases. The aim of this study was to gather more information to help better distinguish these two lesions. Method and Materials: In this descriptive-analytical study, blood samples were taken from 80 patients (59 females and 29 males) and sent to the laboratory for histopathological diagnosis based on WHO criteria. After separating the blood sera of the samples, the sera were evaluated by enzyme linked immunosorbent assay (ELISA) for the presence of ANA, anti-DNA, RF, and SMA auto-antibodies. Data statistically was analyzed with SPSS using the chi-squared test and t-test (a = 0.05). Results: The mean ages were 48.62 and 49.38 for OLP and OLR patients, respectively. There were no significant differences in ANA and RF blood levels (p value g 0.05). Anti-DNA and SMA antibodies were not detected in the blood samples. No significant differences were noted in the blood levels of these antibodies (p value g 0.05). Conclusion: According to the results of the present study, no significant differences were observed between the OLP and OLR patients in relation to the presence or absence of ANA, anti-DNA, RF, and SMA auto-antibodies in the blood samples.