Association between thyroid hormone disorders and renal dysfunction

Background: Thyroid hormones perform a wide range of metabolic functions. Relationship between thyroid diseases and kidney function initially described were clinically subtle. It has been suggested that patients of thyroid disorder can be associated with increased risk of renal diseases. Aims and Objectives: To understand the effects of thyroid disorders on renal function and carbohydrate metabolism, we estimated and compared blood sugar, serum urea and serum creatinine levels with T3, T4 and TSH in thyroid dysfunction patients and euthyroid subjects. Materials and Method: Case control study was done on 78 newly diagnosed thyroid disorder cases and 78 age and sex matched healthy controls, attending medicine OPD within the age group of 18 to 59 years. Result: There is significant positive correlation between TSH and serum creatinine levels with p<0.001, and there is positive correlation between TSH and serum urea levels and also with TSH and blood sugar levels. Conclusion: It is evident from the study that there is an association between fasting blood glucose levels, creatinine levels and  thyroid disorder. Larger epidemiological research is required to find out the incidence of renal dysfunction in thyroid disorders.