International archives of allergy and applied immunology最新文献_第6页

Tumor necrosis factor production by human granulocytes. 人粒细胞产生肿瘤坏死因子。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235479

Y Mándi, V Endrész, L Krenács, K Régely, M Degré, I Béládi

引用次数: 17

Induction of auto-antibody formation in C3H/HeJ mice by cobra venom factor. 眼镜蛇毒因子诱导C3H/HeJ小鼠自身抗体的形成。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235481

P Bloembergen, C Hol, F M Hofhuis, H van Dijk

引用次数: 1

Faecally derived hydrolytic enzymes from Dermatophagoides pteronyssinus: physicochemical characterisation of potential allergens. 从翼状棘球绦虫粪便中提取的水解酶:潜在过敏原的理化特征。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235437

G A Stewart, F R Lake, P J Thompson

{"title":"Faecally derived hydrolytic enzymes from Dermatophagoides pteronyssinus: physicochemical characterisation of potential allergens.","authors":"G A Stewart, F R Lake, P J Thompson","doi":"10.1159/000235437","DOIUrl":"https://doi.org/10.1159/000235437","url":null,"abstract":"The previous findings that the group I and III mite allergens, and amylase present in mite faeces are hydrolytic enzymes has prompted a study to determine whether this material contains other enzymes which could be allergenic. Thus, spent growth medium devoid of whole Dermatophagoides pteronyssinus mites was shown to contain glucoamylase, lipase and lysozyme in addition to the cysteine protease, serine protease and amylase activities associated with the above allergens, respectively. All of these enzymes are probably associated with mite digestive processes. They were rapidly solubilised, heterogeneous with regard to charge (pI in the range 4-8) and demonstrated maximum biochemical activity in the neutral pH range. Three serine proteases were detected and comprised a chymotrypsin-like, a trypsin-like and an unclassified enzyme with pI of 4.1 and 5.3, 8.5 and 7.1, respectively. Only one cysteine protease was observed, which paralleled immunochemically identified Der p I in a variety of assays. It was shown to cleave at lysyl residues and could be inhibited by the specific cysteine protease inhibitor, E-64. The remaining serine proteases, glucoamylase, lipase and lysozyme represent potential allergens.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"95 2-3","pages":"248-56"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12882560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 77

Extracellular ATP stimulates interleukin-dependent cultured mast cells and eosinophils through calcium mobilization. 细胞外ATP通过钙动员刺激白细胞介素依赖性培养肥大细胞和嗜酸性粒细胞。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235327

H Saito, M Ebisawa, D C Reason, K Ohno, K Kurihara, N Sakaguchi, A Ohgimi, E Saito, A Akasawa, K Akimoto

{"title":"Extracellular ATP stimulates interleukin-dependent cultured mast cells and eosinophils through calcium mobilization.","authors":"H Saito, M Ebisawa, D C Reason, K Ohno, K Kurihara, N Sakaguchi, A Ohgimi, E Saito, A Akasawa, K Akimoto","doi":"10.1159/000235327","DOIUrl":"https://doi.org/10.1159/000235327","url":null,"abstract":"We examined the effect of ATP and related nucleotides on the changes in intracellular calcium ([Ca2+]i) in murine bone marrow-derived mast cells (BMMC) and human cord blood-derived eosinophils (EO) cultured in the presence of interleukins. ATP, ADP and AMP released a substantial amount of histamine and leukotriene C4 from BMMC, and EO showed locomotive activity in response to ATP, ADP and GTP. These reactions were accompanied with an increase in [Ca2+]i in BMMC and in EO. The rise in [Ca2+]i in BMMC induced by ATP or antigen at optimal concentrations was inclined to be persisting. On the other hand, these nucleotides induced a rapid and transient rise in [Ca2+]i in EO. Purified human peripheral EO also exhibited locomotive activity and an increase in [Ca2+]i in response to ATP. These results indicate that extracellular ATP activates interleukin-dependent cultured mast cells and EO through Ca2+ mobilization, and suggest that ATP, which is known to be released from activated platelets or autonomic nerves, may stimulate in vivo counterparts of these cultured inflammatory cells.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"94 1-4","pages":"68-70"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235327","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12882596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Antiasthmatic effects of Picrorhiza kurroa: androsin prevents allergen- and PAF-induced bronchial obstruction in guinea pigs. 黑纹小弧菌的平喘作用:雄激素可预防豚鼠变应原和paf诱导的支气管阻塞。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235416

W Dorsch, H Stuppner, H Wagner, M Gropp, S Demoulin, J Ring

引用次数: 78

Effects of geraniin on morphology and function of macrophages. 天竺葵苷对巨噬细胞形态和功能的影响。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235499

Y Ushio, T Okuda, H Abe

引用次数: 6

Effect of nitric oxide generators on ischemia-reperfusion injury and histamine release in isolated perfused guinea pig heart. 一氧化氮发生器对豚鼠离体心脏缺血再灌注损伤及组胺释放的影响。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235376

E Masini, F Gambassi, S Bianchi, L Mugnai, M Lupini, A Pistelli, P F Mannaioni

引用次数: 4

Early development of mast cells. 肥大细胞的早期发育。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235339

M Rottem, A S Kirshenbaum, D D Metcalfe

引用次数: 14

Endogenous regulation of rat brain mast cell serotonin release. 内源性调节大鼠脑肥大细胞血清素释放。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235470

K Marathias, M Lambracht-Hall, J Savala, T C Theoharides

{"title":"Endogenous regulation of rat brain mast cell serotonin release.","authors":"K Marathias, M Lambracht-Hall, J Savala, T C Theoharides","doi":"10.1159/000235470","DOIUrl":"https://doi.org/10.1159/000235470","url":null,"abstract":"Mast cells are involved in allergic reactions where they release numerous vasoactive and other mediators in response to IgE and antigen. They are also activated by neuropeptides and are found in close contact with neurons. Mast cell heterogeneity has now been documented for mucosal mast cells and connective tissue mast cells. Rat brain mast cells were studied in a perfusion system and were shown to release serotonin in response to the mast cell secretagogue compound 48/80 (C48/80). High-potassium neuronal depolarization also released serotonin, but this was calcium dependent, not associated with beta-hexosaminidase, and was unaffected by prior treatment with C48/80. Neuronal depolarization, however, was associated with somatostatin secretion and substantially reduced subsequent C48/80 stimulation, an effect abolished by neonatal treatment of the animals with capsaicin. Perfusion with somatostatin and substance P also induced brain mast cell serotonin release. C48/80 stimulation of combined thalamic and hypothalamic slices after neuronal depolarization substantially reduced the C48/80 effect, suggesting the possible presence of endogenous inhibitors released from the hypothalamus. Finally, the alpha 2-receptor agonist clonidine had a slight stimulatory effect. These results indicate that brain mast cell serotonin release may be regulated by endogenous neurotransmitters and/or neuromodulators.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"95 4","pages":"332-40"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235470","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12884091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

In vitro formation of complement activation products by lipopolysaccharide chemotypes of Salmonella minnesota. 明尼苏达沙门氏菌脂多糖化学型在体外形成补体活化产物的研究。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235534

J S Gardiner, L B Keil, V A DeBari

引用次数: 5