International archives of allergy and applied immunology最新文献

T cells and asthma. II. Regulation of the eosinophilia of asthma by T cell cytokines. T细胞和哮喘。2T细胞因子对哮喘嗜酸性粒细胞的调节。

International archives of allergy and applied immunology Pub Date : 1991-07-01 DOI: 10.1159/000235373

C. Walker, J. Virchow, P. Bruijnzeel, K. Blaser

引用次数: 28

Potential implication of endothelial cells in bronchial asthma. 内皮细胞在支气管哮喘中的潜在意义。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235368

P Lassalle, Y Delneste, P Gosset, A B Tonnel, A Capron

{"title":"Potential implication of endothelial cells in bronchial asthma.","authors":"P Lassalle, Y Delneste, P Gosset, A B Tonnel, A Capron","doi":"10.1159/000235368","DOIUrl":"https://doi.org/10.1159/000235368","url":null,"abstract":"Inflammatory cells like eosinophils, neutrophils or mononuclear phagocytes have long been recognized as essential components in the pathophysiology of asthma. After recruitment in situ and subsequent activation, they are considered as responsible for epithelial and submucosal bronchial alterations. However, to access to the inflammatory site, these cells have to cross the endothelial wall, suggesting so a potential implication of endothelial cells (EC) in bronchial asthma. To test this hypothesis, we studied in a first step the modulation of vascular adhesions like intercellular adhesion molecule-1 (ICAM-1) on EC: supernatants of alveolar macrophages (AM) recovered by bronchoalveolar lavage in patients exhibiting a late asthmatic reaction, induced an enhanced expression of ICAM-1 on EC preparations; increase of ICAM-1 was clearly correlated to amounts of tumor necrosis factor-alpha (TNF alpha) present in AM supernatants, as shown by inhibition experiments with anti-TNF alpha antiserum. The second way to explore the possible role of EC in asthma was the detection of autoantibodies to EC in various allergic disorders: antibodies against a 120-kD EC antigen in patients with allergic granulomatosis and angiitis, antibodies towards a 55-kD component, common to human EC and platelets in patients with severe asthma, namely characterized by their corticosteroid dependence or by aspirin-induced intolerance. So our data suggest that bronchial asthma might result from either EC activation, through the induction of surface adhesion molecules or from an autoimmune process involving EC antigens.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"94 1-4","pages":"233-8"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235368","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12847002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Effect of neutral endopeptidase inhibition on substance-P-induced increase in short-circuit current of canine cultured tracheal epithelium. 中性内肽酶抑制对p物质诱导的犬气管上皮短路电流增加的影响。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235424

J Tamaoki, N Sakai, K Isono, T Kanemura, A Chiyotani, F Yamauchi, T Takizawa, K Konno

{"title":"Effect of neutral endopeptidase inhibition on substance-P-induced increase in short-circuit current of canine cultured tracheal epithelium.","authors":"J Tamaoki, N Sakai, K Isono, T Kanemura, A Chiyotani, F Yamauchi, T Takizawa, K Konno","doi":"10.1159/000235424","DOIUrl":"https://doi.org/10.1159/000235424","url":null,"abstract":"We studied the effect of substance P (SP) on the electric properties of cultured canine tracheal epithelium and its possible modulation by neutral endopeptidase (NEP) by Ussing's short-circuited technique in vitro. Addition of SP (5 x 10(-6) M) to the mucosal side increased short-circuit current (SCC) from 5.1 +/- 0.9 to 10.3 +/- 2.2 microA/cm2 (mean +/- SE; p less than 0.01), which was accompanied by increases in transepithelial potential difference and conductance. The effect of the mucosal SP on SCC was dose-dependent, with the maximal increase from the baseline value being 5.8 +/- 1.0 microA/cm2 observed at 5 x 10(-5) M. The NEP inhibitor phosphoramidon (10(-5) M) did not affect these responses. On the other hand, SCC was not altered by the addition of SP to the submucosal side. However, it was increased dose-dependently in the presence of phosphoramidon (10(-5) M) but not in the presence of captopril, bestatin or leupeptin. This stimulatory effect of submucosal SP was abolished by furosemide, diphenylamine-2-carboxylate and Cl-free medium, but not by amiloride. These results suggest that SP may selectively stimulate Cl secretion across the airway epithelium and that this effect may be modulated by submucosal NEP.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"95 2-3","pages":"169-73"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12882603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Neurogenic inflammation in airways. 气道神经源性炎症。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235392

P J Barnes

引用次数: 53

Neuropeptide-induced secretion from human skin mast cells. 神经肽诱导的人皮肤肥大细胞分泌。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235393

M K Church, S el-Lati, J P Caulfield

{"title":"Neuropeptide-induced secretion from human skin mast cells.","authors":"M K Church, S el-Lati, J P Caulfield","doi":"10.1159/000235393","DOIUrl":"https://doi.org/10.1159/000235393","url":null,"abstract":"Unlike human mast cells associated with mucosal surfaces such as lung, adenoids, tonsils and intestine, skin mast cells may be stimulated to release histamine by the neuropeptides substance P, vaso-active intestinal polypeptide and somatostatin or by other basic secretagogues such as morphine and compound 48/80. Release of histamine by neuropeptides is rapid and accompanied by minimal generation of the eicosanoids prostaglandin D2 and leukotriene C4. Transient elevations of intracellular calcium are associated with mediator secretion induced by both immunological and non-immunological stimulation, that induced by anti-IgE being derived from extracellular sources through channels in the plasma membrane while that stimulated by neuropeptides is mobilized intracellularly. Similarly, elevations of intracellular cyclic AMP induced by anti-IgE occur only in the presence of extracellular calcium, whereas with substance P elevations are apparent even in the absence of extracellular calcium. With the latter stimulus, histamine release is complete before the peak cyclic AMP is achieved. Despite these biochemical and temporal differences, degranulation induced by both secretagogues proceeds by compound exocytosis which is indistinguishable under the electron microscope. From these results we suggest that IgE-dependent and neuropeptide stimulation of human skin mast cells proceed by distinct biochemical pathways which eventually merge to produce exocytosis of their preformed granule-associated mediators.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"94 1-4","pages":"310-8"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235393","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12883217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 101

Peptidase modulation of the pulmonary effects of tachykinins. 速激肽对肺部作用的肽酶调节。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235395

M A Martins, S A Shore, J M Drazen

引用次数: 11

The possible role of substance P in the allergic reaction, based on two different provocation models. P物质在过敏反应中的可能作用，基于两种不同的激发模型。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235397

K Nieber, C Baumgarten, A Witzel, R Rathsack, P Oehme, T Brunnee, J Kleine-Tebbe, G Kunkel

引用次数: 37

Alpha-2-macroglobulin-kallikrein complex: a temperature-sensitive mediator in contact-system-induced inflammation with a potential role in late and delayed hypersensitivity responses. α -2巨球蛋白-钾激肽复合物:接触系统诱导炎症的温度敏感介质，在晚期和迟发性超敏反应中具有潜在作用。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235484

E C Lasser, S G Lyon, S Negrete

引用次数: 2

Humoral transplantation antibodies play a role in protracted rejection of murine renal allografts. 体液移植抗体在小鼠同种异体肾移植的长期排斥反应中起作用。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235503

K Inoue, N Niesen, F Milgrom, B Albini

引用次数: 4

Attenuation of antigen-induced bronchoconstriction in guinea pigs by a new xanthine derivative (HWA448). 一种新的黄嘌呤衍生物(HWA448)对抗原诱导的豚鼠支气管收缩的衰减作用。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235496

H Sugiyama, W Gang, V A Bergren, R Eda, D R Bergren, R J Hopp, A K Bewtra, R G Townley

引用次数: 2