International archives of allergy and applied immunology最新文献_第2页

Glomerulonephritis in NZW kidneys grafted into NZB/W mice. NZB/W小鼠肾移植后的肾小球肾炎。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235521

K Inoue, N Niesen, F Milgrom, B Albini

引用次数: 1

Platelet-derived growth factor can activate purified primate, phorbol myristate acetate-primed eosinophils. 血小板衍生的生长因子可以激活纯化的灵长类动物肉豆蔻酸酯引发的嗜酸性粒细胞。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235352

M K Bach, J R Brashler, B K Stout, H G Johnson, M E Sanders

引用次数: 6

A new method of the measurement of nasal secretion in guinea pigs. 豚鼠鼻分泌物测定的新方法。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235450

A Namimatsu, S Yamaura, K Go, H Tanimoto, M Okuda

{"title":"A new method of the measurement of nasal secretion in guinea pigs.","authors":"A Namimatsu, S Yamaura, K Go, H Tanimoto, M Okuda","doi":"10.1159/000235450","DOIUrl":"https://doi.org/10.1159/000235450","url":null,"abstract":"A simple quantitative method to measure nasal secretion in guinea pigs is described. Nasal secretion was measured with a piece of cotton thread dyed with fluorescein at one end which was inserted into an anterior naris and kept there for 60 s. The stretch of color of a thread dyed with fluorescein was proportional to fluid volume and to increase in weight of a thread due to absorbed nasal secretion induced by nasal provocation. In addition, the stretch of color due to nasal secretion was associated with the score of rhinorrhea. Thus, it is considered that the amount of nasal secretion can be reflected to the length of the stretch of color. Each secretion on the ipsilateral and the contralateral sides induced by nasal provocation could be separately measured by this method. The amount of nasal secretion induced by allergen in passively sensitized guinea pigs could be reduced by pretreatment with ketotifen or flutropium. These results suggest that our method may serve as a quantitative test for nasal secretion in guinea pigs, which would be useful in the study of hypersecretory response in the allergic model or in evaluating the effect of antiallergic drugs on nasal allergy.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"95 1","pages":"29-34"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235450","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13077375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

T lymphocytes and their products in atopic allergy and asthma. T淋巴细胞及其产物在特应性过敏和哮喘中的作用。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235360

A B Kay

{"title":"T lymphocytes and their products in atopic allergy and asthma.","authors":"A B Kay","doi":"10.1159/000235360","DOIUrl":"https://doi.org/10.1159/000235360","url":null,"abstract":"Various cells are associated with inflammatory events characteristic of atopic allergy and asthma. As well as T cells and eosinophils, mast cells, basophils, mononuclear phagocytes and platelets have all to be considered particularly as their mediators have potential for contributing directly to the features of bronchial asthma. Nevertheless, mast cell/T lymphocyte/eosinophil interactions may be of particular significance. For instance, the acute symptoms of allergy and asthma such as sneezing, bronchospasm and hives are believed to be largely the result of mediator release from mast cells whereas chronic symptoms (the result of allergic inflammation) can be explained on the basis of eosinophil-mediated tissue damage. Allergen is recognized directly by T cells. Specialized T cell subsets, possibly the Th2 equivalent, predominate in allergy and elaborate IL-4 (an essential co-factor for IgE production) and IL-5 which brings about terminal differentiation and activation of the eosinophil. Basic proteins derived from the crystalloid granule together with PAF and leukotrienes produce chronic wheeze, bronchial irritability, and might also be involved in permanent nasal blockage in chronic rhinitis. This general hypothesis is continually being tested. It is clearly important to identify precise molecular targets in allergy and asthma in order to construct therapeutic strategies.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"94 1-4","pages":"189-93"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235360","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13095785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 87

Complement in inflammation: induction of nephritides and progress to chronicity. 炎症中的补体:肾肽的诱导和慢性进展。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235320

K Rother, G M Hänsch, E W Rauterberg

引用次数: 25

Functional heterogeneity of human mast cells. 人肥大细胞的功能异质性。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235369

F L Pearce, P B Boulos, H Y Lau, W L Liu, K R Tainsh

引用次数: 44

Structural cell-derived cytokines in allergic inflammation. 结构细胞源性细胞因子在过敏性炎症中的作用。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235343

J A Denburg, J Gauldie, J Dolovich, T Ohtoshi, G Cox, M Jordana

{"title":"Structural cell-derived cytokines in allergic inflammation.","authors":"J A Denburg, J Gauldie, J Dolovich, T Ohtoshi, G Cox, M Jordana","doi":"10.1159/000235343","DOIUrl":"https://doi.org/10.1159/000235343","url":null,"abstract":"Based on observations of fluctuations in progenitors for inflammatory cells during allergic responses, we have proposed that a primary determinant of allergic inflammation involves microenvironmental influences on hemopoietic cell differentiation and phenotype; in addition, as a corollary of this, inflammatory cell burden is proposed as an important indicator of the severity and pattern of the inflammatory process in allergy. The studies outlined here focus on the effects of epithelial-cell- and fibroblast-derived cytokines on granulocytic and monocytic cell differentiation and activation in models involving allergic reactions in the upper and lower airways. Pure cultures of nasal or bronchial epithelial cells or fibroblasts are observed to give rise to cytokines important in inducing the differentiation of basophils, eosinophils, neutrophils and monocyte/macrophages. Gene expression, production and secretion of granulocyte/macrophage-colony-stimulating factor, interleukin-6 (IL-6) and IL-8 can be demonstrated in vitro and in vivo. Up-regulation of gene expression and production of these cytokines, which are important in inducing basophil, eosinophil and neutrophil/macrophage differentiation in several assays, is seen with IL-1 and the neuropeptide substance P; conversely, inhibition of cytokine production by structural cells is observed after pretreatment with corticosteroids in vitro, paralleling in vivo effects. Other modulatory effects also examined include: antiallergic compounds, which may affect posttranscriptional events in cytokine production, and heavy metal ions, which can also induce changes in gene expression. Structural-cell-derived extracellular matrices appear also to be important both in mast cell differentiation and in macrophage cytokine gene expression, both of which potentially feedback upon chronic allergic inflammatory processes, leading to their perpetuation.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"94 1-4","pages":"127-32"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235343","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13096609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Time course of cellular infiltration in the nasal mucosa during the immediate allergic reaction. 立即过敏反应时鼻黏膜细胞浸润的时间过程。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235441

S Lozewicz, E Gomez, S Chalstrey, D Gatland, R J Davies

引用次数: 19

Isolation and characterization of a 60-kDa IgE-binding component derived from sera of atopic patients (atopic dermatitis). 特应性皮炎患者血清中60 kda ige结合成分的分离与鉴定

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235336

J Bujanowski-Weber, I Knöller, W König

{"title":"Isolation and characterization of a 60-kDa IgE-binding component derived from sera of atopic patients (atopic dermatitis).","authors":"J Bujanowski-Weber, I Knöller, W König","doi":"10.1159/000235336","DOIUrl":"https://doi.org/10.1159/000235336","url":null,"abstract":"The low-affinity receptor for IgE (Fc epsilon RII, CD23) and the related soluble IgE-binding factors (IgE-BF; sCD23) play an important role in IgE regulation. Sera of patients suffering from atopic dermatitis (AD) were reported to contain an IgE-binding component with a molecular weight of 60 kD. The aim of our studies was the isolation and characterization of the 60 kD component. Sera of patients with AD were fractionated by ammonium sulfate precipitation (10-90%). The fractions were analyzed with regard to their IgE and their IgE-BF contents. Furthermore, sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis and subsequent autoradiography with 125I-labeled human IgE (PS) was performed to detect IgE-binding activity. The major amount of IgE as well as IgE-BF was obtained within the 30-50% ammonium sulfate precipitation. In addition, IgE-binding activity was precipitated at 60% saturation. Separation by gel filtration under physiological conditions indicated IgE-BF with molecular weight of greater than 100, 60, 25 and 15 kD. Rechromatography of the greater than 100-kD fraction led to IgE-binding activity with a molecular weight of 60 kD which is not present within normal sera. The data demonstrate that the 60-kD component is partially bound to serum IgE. One may suggest that the complex is involved in the induction and persistence of allergic disorders.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"94 1-4","pages":"96-8"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235336","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13096861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Selective impairment of T lymphocyte activation following contact sensitization with oxazolone. 接触恶唑酮致敏后T淋巴细胞活化的选择性损伤。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235419

I Kimber, J R Foster, D Baker, J L Turk

{"title":"Selective impairment of T lymphocyte activation following contact sensitization with oxazolone.","authors":"I Kimber, J R Foster, D Baker, J L Turk","doi":"10.1159/000235419","DOIUrl":"https://doi.org/10.1159/000235419","url":null,"abstract":"We have previously reported that topical exposure of mice to oxazolone results in the appearance of regulatory mechanisms which markedly depress lymph node cell (LNC) proliferative responses to subsequent challenge with the same chemical. In the present study, we have sought to identify the cellular targets for such immunoregulation. Autoradiographic analyses revealed that although pre-exposure to oxazolone caused a substantial reduction of paracortical hyperplasia following challenge, the frequency of proliferating cells in lymphoid follicles was slightly increased. That B lymphocyte responses are unaffected by oxazolone-induced immunoregulation was confirmed by investigation of anti-hapten antibody formation by draining LNC. Challenge with oxazolone resulted in an accelerated antibody response in mice previously exposed to the same chemical. These data reveal that the active immunoregulation induced following sensitization with oxazolone is selective for T lymphocytes. Evidence is presented that CD4+ and CD8+ T lymphocytes possess equivalent sensitivity to these mechanisms.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"95 2-3","pages":"142-8"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235419","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13096866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14