International archives of allergy and applied immunology最新文献_第3页

Ultrastructural localization of the allergen Der p I in the gut of the house dust mite Dermatophagoides pteronyssinus. 屋尘螨肠道变应原Der p I的超微结构定位。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235405

B Thomas, P Heap, F Carswell

引用次数: 38

Airway inflammation and atopic asthma: a comparative bronchoscopic investigation. 气道炎症和特应性哮喘:支气管镜比较研究。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235379

P H Howarth, J Wilson, R Djukanovic, S Wilson, K Britten, A Walls, W R Roche, S T Holgate

引用次数: 37

Exercise-induced asthma in adolescent gym class population. 青少年体育课人群的运动性哮喘。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235381

R P Bransford, G M McNutt, J N Fink

{"title":"Exercise-induced asthma in adolescent gym class population.","authors":"R P Bransford, G M McNutt, J N Fink","doi":"10.1159/000235381","DOIUrl":"https://doi.org/10.1159/000235381","url":null,"abstract":"The prevalence of exercise-induced asthma (EIA) was determined in a population of 12- and 13-year-old schoolchildren whose parents returned a questionnaire regarding a previous diagnosis of asthma, recent asthmatic symptoms and symptoms of allergic rhinitis. EIA was defined as a greater than 15% fall in peak expiratory flow rate (PEFR) following 6 min of free running in a gymnasium. Among the 201 children studied, 18 (8.9%) demonstrated EIA. Of 21 children with symptomatic asthma in the 6 months prior to study, 9 (43%) developed EIA compared to none of 6 children with asymptomatic asthma (p less than 0.0001). Among 48 children with a history of allergic rhinitis alone, 7 (14.6%) demonstrated EIA. The mean postexercise changes in PEFR were 14.9% for 16 children with both asthma and allergic rhinitis, 6.4% among 48 children with allergic rhinitis only, and 1.8% among 125 normal children. Recent symptoms of asthma and a history of allergic rhinitis appeared to be risk factors for EIA. EIA was readily demonstrated in a gym class setting; the use of such screening may facilitate its diagnosis and treatment.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"94 1-4","pages":"272-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235381","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13097767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Comparison of dermal and systemic application of glucocorticoids on the RM 3/1+ macrophage in human blood. 皮肤和全身应用糖皮质激素对人血液中RM 3/1+巨噬细胞的影响比较。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235383

G Zwadlo-Klarwasser, S Bent, W Schmutzler

引用次数: 2

Modulation of leukotriene formation by cellular composition and exogenous leukotriene A4. 细胞组成和外源性白三烯A4对白三烯形成的调节。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235375

R Hilger, J Knöller, W König

引用次数: 0

Characterization of a monoclonal antibody (RJ5) against the immunodominant 41-kD antigen of Candida albicans. 抗白色念珠菌41-kD抗原单克隆抗体(RJ5)的鉴定。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235485

H D Shen, K B Choo, K W Yu, W L Ling, F C Chang, S H Han

{"title":"Characterization of a monoclonal antibody (RJ5) against the immunodominant 41-kD antigen of Candida albicans.","authors":"H D Shen, K B Choo, K W Yu, W L Ling, F C Chang, S H Han","doi":"10.1159/000235485","DOIUrl":"https://doi.org/10.1159/000235485","url":null,"abstract":"A 41-kD component of Candida albicans was identified to be the major antigen radioimmunoprecipitated by antibodies with increased titers in the sera of patients with invasive candidiasis. A mouse monoclonal antibody (RJ5) was generated which, by immunoblotting, showed positive reactivity to the immunoprecipitated 41-kD component. By two-dimensional gel electrophoresis and immunoblotting, MoAb RJ5 was shown to react with different isoforms of the 41-kD component with pI values from 6.1 to 6.9. Furthermore, MoAb RJ5 showed positive reactivity to cytoplasmic antigens of C. albicans by frozen section and immunoperoxidase staining. By SDS-polyacrylamide gel electrophoresis and immunoblotting, MoAb RJ5 showed no cross-reactivity to antigens of Candida tropicalis and Candida parapsilosis. The epitope of the 41-kD molecule recognized by MoAb RJ5 was susceptible to treatment of proteinase K at concentrations of greater than or equal to 5 micrograms/ml, and was relatively resistant to periodate oxidation with concentration of NaIO4 up to 20 mM. This MoAb may be useful in the purification and characterization of the immunodominant 41-kD antigen of C. albicans, and as a probe in the detection of Candida antigens in the sera of patients with invasive candidiasis.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"96 2","pages":"142-8"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235485","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Immunocytochemical determination of the role of alveolar macrophages in endotoxin processing in vitro and in vivo. 免疫细胞化学测定肺泡巨噬细胞在体内和体外内毒素加工中的作用。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235486

G E Keller, R D Dey, R Burrell

引用次数: 2

Serum eosinophil cationic protein in patients with atopic dermatitis. 特应性皮炎患者血清嗜酸性阳离子蛋白的研究。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235490

R Paganelli, E Fanales-Belasio, D Carmini, E Scala, P Meglio, L Businco, F Aiuti

引用次数: 37

Effects of corticosteroids on cytokine generation and expression of activation antigens by monocytes in bronchial asthma. 皮质类固醇对支气管哮喘单核细胞细胞因子产生和活化抗原表达的影响。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235365

J R Wilkinson, S J Lane, T H Lee

{"title":"Effects of corticosteroids on cytokine generation and expression of activation antigens by monocytes in bronchial asthma.","authors":"J R Wilkinson, S J Lane, T H Lee","doi":"10.1159/000235365","DOIUrl":"https://doi.org/10.1159/000235365","url":null,"abstract":"The capacity of corticosteroids to inhibit the secretion of cytokines and the expression of selective antigens on monocytes has been studied in corticosteroid-sensitive (CS) and corticosteroid-resistant (CR) asthmatic patients. Incubation of monocytes derived from CS subjects with hydrocortisone inhibited the production of the enhancing activity, whereas in CR subjects hydrocortisone at concentrations of up to 10(-4) M did not suppress the release of enhancing activity. There was a rank order of potency for corticosteroid action: hydrocortisone less than methylprednisolone less than dexamethasone. The major activity was characterized as a heat-sensitive peptide of 3,000 daltons. The expression of CR1, CR3 and class II on asthmatic peripheral-blood mononuclear cells was increased relative to normal control donors. Culturing monocytes for 24 h in the presence of 10(-4) M hydrocortisone inhibited the expression of CR1, CR3 and class II in CS subjects but not in CR individuals. These results suggest that monocytes of CR asthmatic patients can increase the inflammatory potential of neutrophils and that they are hyperactive, as indicated by increased cytokine production and enhanced expression of activation markers, despite the presence of corticosteroids.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"94 1-4","pages":"220-1"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12996087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Platelet-activating factor-induced immediate and late cutaneous reactions. 血小板活化因子诱导的即时和晚期皮肤反应。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235390

J P Rihoux, R Fadel, L Juhlin

引用次数: 6