International archives of allergy and applied immunology最新文献_第4页

Effects of theophylline compared with prednisolone on late phase airway leukocyte infiltration in guinea pigs. 茶碱与强的松龙对豚鼠晚期气道白细胞浸润的影响。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235388

R W Gristwood, J Llupiá, A G Fernández, P Berga

引用次数: 22

Mast cell heterogeneity: protein composition, biosynthesis and mRNA characterization. 肥大细胞异质性:蛋白质组成、生物合成和mRNA表征。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235364

R C Benyon, T Imai, T Abe, D Befus

引用次数: 8

Interleukin-4 gene expression and IgE responsiveness. 白细胞介素-4基因表达与IgE反应性。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235358

H Okudaira, A Mori, K Akiyoshi, K Yamamoto, M Suko, N Watanabe, M Ito, K Takahashi, T Juji

{"title":"Interleukin-4 gene expression and IgE responsiveness.","authors":"H Okudaira, A Mori, K Akiyoshi, K Yamamoto, M Suko, N Watanabe, M Ito, K Takahashi, T Juji","doi":"10.1159/000235358","DOIUrl":"https://doi.org/10.1159/000235358","url":null,"abstract":"Interleukin-4 (IL-4) gene expression by stimulation with concanavalin A (Con A) in murine spleen cells was examined. The amount of IL-4 mRNA induced by Con A was greatest in spleen cells obtained from IgE high responder strains of mice. A trace amount of IL-4 mRNA was induced in spleen cells from IgE low responder (SJL) mice. The amount of IL-4 mRNA induced in spleen cells from an IgE intermediate responder (C57BL/6) was smaller than that from high responders, but significantly greater than that from low responders. Spleen cells from IgE nonresponders (SJA/9) developed only a negligible amount of IL-4 mRNA. IL-4 mRNA was detected in human peripheral blood mononuclear cells (PBMC) stimulated with Con A. The IL-4 gene expression seemed to be greater in PBMC obtained from highly atopic patients and was decreased in PBMC from individuals showing hypo-IgE immunoglobulinemia (less than 10 IU/ml). The results obtained in the present study may indicate that high and low IgE responder traits are determined depending on their levels of IL-4 mRNA expression.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"94 1-4","pages":"184-6"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235358","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13096615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Role of CD8 T cells in rat IgE responses. CD8 T 细胞在大鼠 IgE 反应中的作用

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235337

D M Kemeny, D Diaz-Sanchez

{"title":"Role of CD8 T cells in rat IgE responses.","authors":"D M Kemeny, D Diaz-Sanchez","doi":"10.1159/000235337","DOIUrl":"10.1159/000235337","url":null,"abstract":"The role of the cytokines interleukin-4 and interferon-gamma in the regulation of IgE responses in the mouse and man have focused on the role of CD4 T cells. In the rat, antigen-specific CD8 T cells, generated following inhalation of antigen, have been shown to be capable of suppressing IgE responses. Repeated intraperitoneal injections of 1 ng ricin and 1 microgram antigen established a long-lived IgE response in both low- and high-IgE responder rat strains (Wistar and Brown Norway). The duration of the IgE antibody response was 204 and 248 days, respectively. Total IgE levels rose from 30 +/- 20 to 39,000 +/- 7,500 ng/ml in the Wistar rat and from 120 +/- 100 to 47,000 +/- 8,000 ng/ml in the Brown Norway rat. An even greater (10(4)-fold) increase was seen in antigen-specific IgE antibody levels. Ricin alone had no effect and concomitant or prior stimulation with antigen was required. The proportion of CD4+ and CD8+ cells present in the spleen at the peak of the IgE response was markedly increased compared with animals given ricin or antigen alone. Furthermore, CD8 T cells were approximately 100 times more sensitive to ricin than CD4 T cells. These data suggest that enhancement of IgE responses in ricin-treated animals results from the selective deletion of T cells which suppress IgE and are of the CD8 phenotype.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"94 1-4","pages":"99-101"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235337","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13096862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Experimental allergic encephalomyelitis-prophylactic and therapeutic treatment with the cyclooxygenase inhibitor piroxicam (Feldene). 实验性变应性脑脊髓炎:环氧化酶抑制剂吡罗康的预防和治疗。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235418

F Weber, R Meyermann, K Hempel

引用次数: 13

Characterization of eosinophils in a continuous ambulatory peritoneal dialysis patient with eosinophilic peritonitis. 嗜酸性腹膜炎患者连续动态腹膜透析中嗜酸性粒细胞的特征。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235425

J M Sligh, S J Gottlieb, D T Domoto, R G Slavin

引用次数: 6

Intracellular mechanisms regulating exocytotic secretion in mast cells. 肥大细胞胞外分泌调节的胞内机制。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235321

B D Gomperts, Y Churcher, A Koffer, T H Lillie, P E Tatham, T D Whalley

引用次数: 9

The Carl Prausnitz Lecture. Biographical sketch of Dr. Alec H. Sehon. 卡尔·普劳斯尼茨的讲座。亚历克·h·塞洪博士的传记。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235317

引用次数: 0

Appearance of macrophage migration inhibition factor in patients with systemic reactions to bee venom. 蜂毒系统反应患者巨噬细胞迁移抑制因子的出现。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235428

A Goldberg, E Livni, Y A Mekori

{"title":"Appearance of macrophage migration inhibition factor in patients with systemic reactions to bee venom.","authors":"A Goldberg, E Livni, Y A Mekori","doi":"10.1159/000235428","DOIUrl":"https://doi.org/10.1159/000235428","url":null,"abstract":"Cellular responses in bee venom (BV) allergy is a controversial issue. Previous studies could not reach an agreement whether this mechanism is activated as a result of allergic sensitization to bee venom. All previous works have used lymphocyte proliferation as their method to analyze cell-mediated immunity. In the present work, we tried to explore whether the production of macrophage migration inhibition factor (MIF), which is another in vitro correlate with cellular responses, is increased in these patients. We also examined which of the major antigenic components of BV played a significant role in the cellular response. Peripheral blood lymphocytes from 10 patients with systemic allergic reactions to bee sting and 9 healthy volunteers were examined for their ability to induce positive MIF responses. Macrophage inhibition was significantly increased in allergic patients when tested with BV, phospholipase A2 (PLA2) and with melittin. Positive MIF responses to other components were also more common in allergic patients than in the control group. Our results indicate that cellular response to BV is expressed in patients with systemic allergic reaction to BV. When major antigenic components of BV are examined, PLA2 seems to play the major role in inducing this response.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"95 2-3","pages":"191-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235428","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13097403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anaphylaxis is enhanced by increased absorption of antigen in postinflammatory state. 在炎症后状态下，抗原吸收增加会增强过敏反应。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235431

S Levine, A Saltzman

引用次数: 6