Effects of theophylline compared with prednisolone on late phase airway leukocyte infiltration in guinea pigs.

R W Gristwood, J Llupiá, A G Fernández, P Berga
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引用次数: 22

Abstract

The effects of prednisolone, theophylline or salbutamol treatment were studied on leukocyte numbers in bronchoalveolar lavage (BAL) fluid taken 72 h after ovalbumin challenge in sensitized guinea pigs. Ovalbumin challenge resulted in an approximate 3-fold increase in the number of eosinophils in BAL fluid. This increase was significantly reduced by oral administration of prednisolone (59% inhibition with 10 mg/kg x 2) theophylline (56% with 50 mg/kg x 2) but not by salbutamol (10 mg/kg x 2). A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.

茶碱与强的松龙对豚鼠晚期气道白细胞浸润的影响。
研究了强的松龙、茶碱和沙丁胺醇对致敏豚鼠卵清蛋白激发后72 h支气管肺泡灌洗液中白细胞数量的影响。卵清蛋白激发导致BAL液中嗜酸性粒细胞数量增加约3倍。口服强的松龙(10 mg/kg × 2时抑制59%)和茶碱(50 mg/kg × 2时抑制56%)显著降低了这种增加,但沙丁胺醇(10 mg/kg × 2)则没有。与上述药物的支气管扩张剂药效比较表明,在豚鼠中,沙丁胺醇作为支气管扩张剂表现出相对选择性,强的松龙作为嗜酸性粒细胞抑制剂具有选择性,而茶碱表现出两种活性的平衡。
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