International archives of allergy and applied immunology最新文献_第5页

Bradykinin induces eosinophil accumulation in the rat pleural cavity. 缓激肽诱导大鼠胸膜腔内嗜酸性粒细胞积聚。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235436

C P Pasquale, M A Martins, P T Bozza, P M Silva, H C Faria Neto, A L Pires, R S Cordeiro

引用次数: 21

Platelet aggregation in allergic reactions. 过敏反应中的血小板聚集。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235374

A G Palma-Carlos, M L Palma-Carlos, M C Santos, J R de Sousa

引用次数: 14

Fibroblast proliferation factors in pulmonary granuloma induced by Trichosporon cutaneum in rabbits: presence of a lymphocyte-derived fibroblast proliferation factor and its functional specificity. 兔皮毛霉诱导的肺肉芽肿中的成纤维细胞增殖因子:淋巴细胞源性成纤维细胞增殖因子的存在及其功能特异性

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235464

N Saita, M Ando, S Araki, M Yoshinaga

{"title":"Fibroblast proliferation factors in pulmonary granuloma induced by Trichosporon cutaneum in rabbits: presence of a lymphocyte-derived fibroblast proliferation factor and its functional specificity.","authors":"N Saita, M Ando, S Araki, M Yoshinaga","doi":"10.1159/000235464","DOIUrl":"https://doi.org/10.1159/000235464","url":null,"abstract":"The fibroblast proliferation activity (FPA) in pulmonary granulomatous lesions in rabbits which were exposed once (primary response) or twice (secondary response) to Trichosporon cutaneum was examined using R9ab, a rabbit fibroblast cell line cell, and fibroblasts from the lesions of the primary and secondary responses. The FPA in lung extracts and cell-free culture supernatants of bronchoalveolar lavage cells from the secondary response was more evident than that from the primary response. FPA from the primary response were recovered at about 60, 18, and 4.5 kD and those from secondary response at about 60, 26, 18, and 4.5 kD on Sephadex G-75 gel filtration. Among the FPA, the activity with a molecular weight of 26 kD and a pI of 7.0 was derived from lymphocytes, whereas the other activities were derived from macrophages. The macrophage-derived fibroblast proliferation factors (FPF) enhanced proliferation of fibroblasts from the lesions of both primary and secondary responses, while the lymphocyte-derived FPF enhanced only proliferation from the secondary response. It was further found that lymphocyte-derived FPF could chemotactically attract fibroblasts from the secondary but not the primary response, indicating functional specificity of lymphocyte-derived FPF on fibroblasts in the secondary response. The present results suggest that this lymphokine with fibroblast proliferation and chemotactic activity plays an important role in the granuloma formation in the secondary response to T. cutaneum.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"95 4","pages":"294-302"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235464","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13117859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Stimulation of human peripheral blood lymphocytes with chironomid hemoglobin allergen (Chi t I). 拟手性血红蛋白过敏原对人外周血淋巴细胞的刺激作用。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235423

V Liebers, S Schalbaba, G Mazur, X Baur

引用次数: 8

IgE-dependent histamine-releasing factors. A brief review. ige依赖性组胺释放因子。简单回顾一下。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235347

S M MacDonald, J M Langdon, B M Greenlee, A Kagey-Sobotka, L M Lichtenstein

引用次数: 11

Histamine-releasing factors. Histamine-releasing因素。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235348

A P Kaplan, M Baeza, S Reddigari, P Kuna

{"title":"Histamine-releasing factors.","authors":"A P Kaplan, M Baeza, S Reddigari, P Kuna","doi":"10.1159/000235348","DOIUrl":"https://doi.org/10.1159/000235348","url":null,"abstract":"Histamine-releasing factors (HRF) are cell-derived products which cause histamine release from basophils and/or mast cells. We have isolated HRF from human mononuclear cells and platelets and have purified 3 molecular species having molecular weights of 8-10, 15-17 and 35-41 kilodaltons (kDa). We prepared monoclonal antibodies to the 8- to 10-kDa form and have isolated it by affinity chromatography. A broad band was seen upon sodium dodecyl sulfate gel electrophoresis in 15% gels as well as immunoblotting, and the band was divided into an upper and a lower half. Amino acid sequence analysis of the upper half indicated that it is closely homologous to connective-tissue activating peptide III (CTAP III). The lower half also aligned with CTAP III beginning with amino acid 16; thus, proteolysis and occurred removing the N-terminal 15 amino acids. This corresponds to neutrophil-activating peptide 2. Both appear to be active on basophils with a dose-response between 250 ng up to 10 micrograms. Although interleukin-3 and granulocyte/macrophage-colony-stimulating factor have similar histamine-releasing capability at lower effective concentrations, they do not account for HRF activity in mononuclear cell/platelet supernatants, and the 15- to 17 and 40- to 41-kDa moieties appear to be unique gene products unrelated to previously described cytokines.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"94 1-4","pages":"148-53"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12882752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Regulation of mediator release by human basophils: importance of the sequence and time of addition in the combined action of different agonists. 人嗜碱性细胞释放介质的调节:不同激动剂联合作用中加入顺序和时间的重要性。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235350

C A Dahinden, S C Bischoff, T Brunner, M Krieger, S Takafuji, A L de Weck

{"title":"Regulation of mediator release by human basophils: importance of the sequence and time of addition in the combined action of different agonists.","authors":"C A Dahinden, S C Bischoff, T Brunner, M Krieger, S Takafuji, A L de Weck","doi":"10.1159/000235350","DOIUrl":"https://doi.org/10.1159/000235350","url":null,"abstract":"Biologically active molecules affecting basophil function can be divided into 4 groups according to their capacity to induce basophil degranulation and/or leukotriene generation: (1) full agonists such as anti-IgE or fMLP, which induce both histamine and leukotriene release; (2) partial agonists such as C5a, which induces degranulation only; (3) incomplete agonists such as neutrophil-activating peptide-1, platelet-activating factor or C3a, which induce mediator release only after cytokine preincubation, and (4) basophil response modifiers, such as interleukin-3, interleukin-5 and granulocyte/macrophage- colony-stimulating factor, which (a) enhance the releasability to all basophil agonists, (b) change the mediator profile, (c) enhance the rate of mediator release, (d) render basophils responsive to lower agonist concentrations and (e) render basophils responsive to incomplete agonists. We demonstrated that histamine release and de novo synthesis of lipid mediators are clearly separately regulated, and that combined actions of different molecules are of importance. In particular, the type(s), the time interval and the sequence of action of basophil-activating molecules are crucial for the final outcome of the basophil release reaction.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"94 1-4","pages":"161-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235350","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12882754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Identification of reactive synthetic gliadin peptides specific for coeliac disease. 乳糜泻特异性反应性合成麦胶蛋白肽的鉴定。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235473

J M Devery, V Bender, I Penttila, J H Skerritt

{"title":"Identification of reactive synthetic gliadin peptides specific for coeliac disease.","authors":"J M Devery, V Bender, I Penttila, J H Skerritt","doi":"10.1159/000235473","DOIUrl":"https://doi.org/10.1159/000235473","url":null,"abstract":"Gluten intolerance (coeliac disease) is characterised by the development of a small intestinal lesion following exposure to the gliadin fraction after consumption of wheat and related cereals. Cellular immune mechanisms are thought to be responsible for gliadin toxicity, but the toxic sequence/s within gliadin have not been clearly established. A panel of synthetic gliadin peptides was tested using peripheral blood mononuclear cells from coeliac patients and two assays for cell-mediated immunity. Using the indirect leucocyte migration inhibition factor and the macrophage procoagulant activity assays, gliadin peptides which were located in the aminoterminal or the proline-rich domain of the alpha/beta gliadin molecule were coeliac-active. Peptides predicted by T cell algorithms or on the basis of homology to adenovirus Ad12 Elb protein and which were located in the proline-poor gliadin domains were inactive. Protein sequence studies which indicate significant homology in the proline-poor gliadin domains with a number of non-coeliac-toxic seed proteins also supported the hypothesis that the proline-rich domains may be more important in the pathogenesis of coeliac disease.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"95 4","pages":"356-62"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235473","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12884092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Possible role of macrophages in allergic rhinitis. 巨噬细胞在过敏性鼻炎中的可能作用。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235371

C Bachert, H Behrendt, K Nosbüsch, U Hauser, U Ganzer

引用次数: 13

Interleukin-4 induced IgE and IgG4 secretion by B cells from atopic dermatitis patients. 白细胞介素4诱导特应性皮炎患者B细胞分泌IgE和IgG4。

International archives of allergy and applied immunology Pub Date : 1991-01-01 DOI: 10.1159/000235357

H L Spiegelberg, R D O'Connor, R J Falkoff, L Beck

{"title":"Interleukin-4 induced IgE and IgG4 secretion by B cells from atopic dermatitis patients.","authors":"H L Spiegelberg, R D O'Connor, R J Falkoff, L Beck","doi":"10.1159/000235357","DOIUrl":"https://doi.org/10.1159/000235357","url":null,"abstract":"Peripheral blood mononuclear cells from 8 normals and 8 patients with atopic dermatitis (AD) were cultured with recombinant interleukin-4 (IL-4) and the IgE and IgG subclass levels in the culture supernatants measured by radioimmunoassays. IL-4 induced IgE and IgG4 secretion by B cells from both normals and AD patients whereas it has no consistent effect on IgG1, IgG2 and IgG3 secretion. The IL-4 dose response was similar for IgE and IgG4 secretion by cells from both normals and AD patients. On the average, the patients' cells secreted more IgE and less IgG4 than the cells from normals, but because of a large variation, the differences were not significant. However, the ratio of IgG4:IgE secretion was significantly greater for normals than AD patients (mean +/- SEM 7.1 +/- 1.6:1 vs. 1.5 +/- 0.4:1; p less than 0.01). The data demonstrate that IL-4 induces IgE and IgG4 secretion by B cells from both normals and AD patients and suggest that the IL-4 induced switch from IgM to IgG4 or IgE secretion may proceed preferentially to IgE in AD patients as compared to normals.","PeriodicalId":13810,"journal":{"name":"International archives of allergy and applied immunology","volume":"94 1-4","pages":"181-3"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000235357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13096614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18