W Dorsch, H Stuppner, H Wagner, M Gropp, S Demoulin, J Ring
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引用次数: 78
摘要
在阿育吠陀医学中，Picrorhiza kurroa Royle ex Benth。用于治疗肝脏和肺部疾病。采用不同的化学和药理学方法，在体内鉴定出酚甙雄激素是预防豚鼠变应原和血小板活化因子所致支气管阻塞的活性化合物(10 mg/kg p.o.;吸入刺激前1小时)。体外多形核白细胞的组胺释放受到其他化合物的抑制。
Antiasthmatic effects of Picrorhiza kurroa: androsin prevents allergen- and PAF-induced bronchial obstruction in guinea pigs.
In the Ayurvedic medicine, Picrorhiza kurroa Royle ex Benth. is used for the treatment of liver and lung diseases. Using different chemical and pharmacological methods, we could identify the phenol glycoside androsin as active compound preventing allergen and platelet-activating factor induced bronchial obstruction in guinea pigs in vivo (10 mg/kg p.o.; 1 h prior to the inhalation challenge). Histamine release from human polymorphonuclear leukocytes in vitro was inhibited by other compounds yet to be identified.
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