International Journal of Clinical Practice最新文献

{"title":"The Effect of a Three-Month Aquatic Training Program on Physical Functioning in Elderly Men: A Randomized Controlled Trial","authors":"Yaser Alikhajeh,&nbsp;Roghayyeh Afroundeh,&nbsp;Mohamad Motevalli,&nbsp;Gholam Rasul Mohammad Rahimi,&nbsp;Ozkan Isik","doi":"10.1155/ijcp/9157147","DOIUrl":"https://doi.org/10.1155/ijcp/9157147","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Aquatic training is emerging as a multifaceted therapy for enhancing health parameters, particularly among elderly populations. This study aimed to investigate the effects of a three-month aquatic training on physical functioning, including balance, muscular strength, and flexibility, among healthy older men.</p>\u0000 <p><b>Methods:</b> From an initial sample of 80 elderly men, 45 healthy participants (mean age: 75.5 years) were randomly assigned to either the intervention (<i>n</i> = 23) or control group (<i>n</i> = 22). The intervention group participated in three 60-min sessions per week for 12 weeks. Functional fitness variables, encompassing upper and lower body flexibility and muscular strength, along with dynamic and static balance, were assessed using multiple tests at both baseline and postintervention. The training load increased gradually over the 12-week program, ranging between 50% and 70% of heart rate reserve (HRR). Exercise intensity was controlled using the rate of perceived exertion (RPE) scale, aiming for a targeted range of 12–15 on the Borg scale. The control group maintained their usual daily activities throughout the study period, providing a basis for comparison with the exercise intervention group.</p>\u0000 <p><b>Results:</b> No significant baseline differences in demographic characteristics were observed between the study groups (<i>p</i> &gt; 0.05). Compared to the control group, the intervention group demonstrated significant improvements across all outcome measures, including static balance, dynamic balance, upper and lower body flexibility, and upper and lower body muscular strength (<i>p</i> &lt; 0.001).</p>\u0000 <p><b>Conclusion:</b> The study findings highlight the efficacy of aquatic training in enhancing various aspects of physical functioning among older men, supporting the growing recognition of aquatic training as an effective therapeutic approach for promoting vitality and independence in elderly populations.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9157147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitudes, and Practices Toward Orthostatic Intolerance Among Surgical Medical Staff in Chongqing, China: A Web-Based Cross-Sectional Study","authors":"Hongjie Yi,&nbsp;Wenfeng Tang","doi":"10.1155/ijcp/6622089","DOIUrl":"https://doi.org/10.1155/ijcp/6622089","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> To explore the knowledge, attitudes, and practices (KAPs) toward orthostatic intolerance (OI) among surgical medical staff in Chongqing, China.</p>\u0000 <p><b>Methods:</b> Surgical medical staff of the First Affiliated Hospital of Chongqing Medical University were recruited in this cross-sectional study between March and April 2023. The data were collected using a self-administered questionnaire. Statistical analyses, including tests of relationships such as Spearman correlation analysis and structural equation modeling (SEM), were performed using SPSS 22 and AMOS software.</p>\u0000 <p><b>Results:</b> A total of 392 valid questionnaires were analyzed, including 24 (6.12%) filled out by doctors and 368 (93.88%) filled out by nurses. Among the participants, there were 345 females (88.01%) and 47 males (11.99%), mostly aged between 20 and 40 years (86.7%). The average KAPs scores were 10.02 ± 2.08, 40.48 ± 6.87, and 43.27 ± 8.67, respectively. Positive correlations were found between knowledge and attitudes (<i>r</i> = 0.0289, <i>p</i> &lt; 0.001), knowledge and practices (<i>r</i> = 0.028, <i>p</i> &lt; 0.001), and attitudes and practices (<i>r</i> = 0.594, <i>p</i> &lt; 0.001). SEM revealed direct effects of knowledge on attitudes (Estimate = 0.625, <i>p</i> &lt; 0.001) and attitudes on practices (Estimate = 0.700, <i>p</i> &lt; 0.001), suggesting an indirect effect of knowledge on practices, with knowledge also directly influencing practices (Estimate = 0.375, <i>p</i> = 0.033).</p>\u0000 <p><b>Conclusion:</b> Surgical medical staff in Chongqing demonstrated moderate knowledge, positive attitudes, and moderate practices regarding OI. Targeted interventions to enhance knowledge and attitudes may improve practices and optimize patient outcomes.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6622089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Drug Susceptibility Profiling of Multidrug-Resistant Pseudomonas aeruginosa Infections","authors":"Mingxia Cai,&nbsp;Zhibin Zhou,&nbsp;Jiaming Huang,&nbsp;Yuxia Du","doi":"10.1155/ijcp/2755014","DOIUrl":"https://doi.org/10.1155/ijcp/2755014","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> To investigate the epidemiology of <i>Pseudomonas aeruginosa</i> (PA) in hospitalized patients with PA respiratory infections and to analyze the clinical characteristics and antibiotic resistance profiles of drug-resistant PA, providing valuable insights to inform clinical management strategies.</p>\u0000 <p><b>Methods:</b> A retrospective analysis of clinical data from hospitalized patients with PA respiratory infections was collected and analyzed to investigate the clinical features and their correlation with PA drug resistance.</p>\u0000 <p><b>Results:</b> In the study cohort, 34.1% (<i>n</i> = 93) of patients were classified as having multidrug-resistant <i>Pseudomonas aeruginosa</i> (MDR-PA), while 65.9% (<i>n</i> = 180) were non-MDR-PA. Logistic regression identified that male gender, ICU admission, hemiplegia, and mechanical ventilation were independent risk factors for MDR-PA infection (all <i>p</i> &lt; 0.05). Multivariate analysis showed male gender (OR 2.44, 95% CI 1.15–5.17) and hemiplegia (OR 2.99, 95% CI 1.02–8.82) as significant factors for MDR-PA infection. Both analyses also confirmed mechanical ventilation as an independent risk factor for difficult-to-treat <i>Pseudomonas aeruginosa</i> (DTR-PA) infections. MDR-PA exhibited low susceptibility to meropenem (32.3%) and imipenem (18.3%), whereas aminoglycosides showed higher effectiveness, with over 80% susceptibility against MDR-PA and more than 50% susceptibility against DTR-PA.</p>\u0000 <p><b>Conclusion:</b> Male patients with hemiplegia should be closely monitored for MDR-PA infections when PA is detected. Mechanical ventilation necessitates vigilance against DTR-PA. Aminoglycoside-based combination therapy offers an effective empirical option for resistant PA infections. These findings indicate the need for antimicrobial stewardship or infection control measures to address MDR-PA and DTR-PA infections.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/2755014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Narrative Review on Predictive Models for Bleeding Risk Associated With Anticoagulant Therapy in Venous Thromboembolism","authors":"Zuoyi Yao,&nbsp;Jichun Zhao","doi":"10.1155/ijcp/4109309","DOIUrl":"https://doi.org/10.1155/ijcp/4109309","url":null,"abstract":"<div>\u0000 <p>The prediction of bleeding risk is crucial for the standardized treatment of venous thromboembolism. This article introduces the definition and importance of predicting anticoagulant therapy–related bleeding in venous thromboembolism and reviews the latest research on existing anticoagulant therapy-related bleeding risk prediction models, especially HAS-BLED, RIETE, and VTE-BLEED models in recent years. It is found that existing clinical factor–based bleeding risk prediction models have certain predictive significance for bleeding events, but there is still a gap compared to ideal models, and dynamic evaluation is more important. This review also explores new models for predicting bleeding risk and provides a reference for clinical physicians to develop anticoagulant strategies.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/4109309","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Adverse Newborn Outcome Among Adolescent Pregnancy in Nigist Elleni Mohammed Memorial Referral Hospital, Central Ethiopia: A Case-Control Study","authors":"Lonsako Abute Woiloro,&nbsp;Amene Abebe Kerbo,&nbsp;Kasa Daka Gidebo,&nbsp;Bizuayehu Belete Erdedo,&nbsp;Belay Erchafo Lubego,&nbsp;Dawit Sulamo Erjino,&nbsp;Rediet Dessalegne Dayemo,&nbsp;Mengistu Meskele Koyra","doi":"10.1155/ijcp/5825053","DOIUrl":"https://doi.org/10.1155/ijcp/5825053","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Adolescent pregnancy remains a common healthcare problem in low- and middle-income countries, and it is associated with higher maternal and neonatal complications. Adverse neonatal outcomes among adolescents are one of the most common causes of maternal and neonatal mortality and morbidity. This study was carried out to evaluate the adverse neonatal outcomes associated with teenage pregnancy in Nigist Elleni Mohammed Memorial Referral Hospital, Central Ethiopia.</p>\u0000 <p><b>Methods:</b> This case-control study was carried out on 75 cases and 150 matched control adolescent pregnant women between June and November, 2021. A structured questionnaire that has been validated and considered credible was employed as a data collection technique. Consecutive sampling technique was used to select study participants. Descriptive statistics and logistic regression analysis were used to look at the relationship between the independent and dependent variables. A <i>p</i> value of less than 0.05 was used to declare significant threshold.</p>\u0000 <p><b>Result:</b> There were 150 controls and 75 patients in this study, with a 100% response rate. From the participants, 84% of cases and 76.7% of controls were in the age group of 15–19 years old. Out of the 75 cases, 38.3% had low birth weight children, 32.8% had preterm delivery, and 28.7% had poor Apgar scores. From the participants, 64.5% of the controls and 56% of the cases have good knowledge about the risks associated with low birth outcomes. Adverse newborn outcomes were independently predicted by mothers living in rural areas 3.04 (1.46–7.66), those with gestational diabetes 4.26 (2.65–2.34), and mothers experiencing any complication during pregnancy 4.02 (1.13–7.75).</p>\u0000 <p><b>Conclusion:</b> Adolescent pregnancies in rural areas, as well as those with complications and gestational diabetes, were the study’s predictive variables. In order to reduce the chance of an adverse newborn outcome, adolescent pregnant women living in rural areas and those who have gestational diabetes should be made aware of the dangers associated with their age and encouraged to consult with health professionals on a regular basis.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5825053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Transcatheter Arterial Embolization for Chronic Intractable Shoulder Pain: A Prospective Clinical Study","authors":"Kun Yung Kim,&nbsp;Young-Min Han,&nbsp;Myoung-Hwan Ko,&nbsp;Jeong-Hwan Seo,&nbsp;Sung-Hee Park,&nbsp;Yu Hui Won,&nbsp;Gi-Wook Kim","doi":"10.1155/ijcp/9964536","DOIUrl":"https://doi.org/10.1155/ijcp/9964536","url":null,"abstract":"<div>\u0000 <p><b>Objectives:</b> Based on the idea that the neovessels and nerves are a possible cause of pain, transcatheter arterial embolization (TAE) has been reported as a novel adjunctive treatment with good outcomes. Purpose of this was to examine the short-term outcomes of TAE including 1-day follow-up results in patients with chronic shoulder pain using patient-reported outcome measures.</p>\u0000 <p><b>Study Design:</b> Prospective study.</p>\u0000 <p><b>Methods:</b> TAE was performed with a suspension of imipenem/cilastatin sodium in contrast agent. Subjects were assessed before, 1 day after, and 1 month after the procedure using the visual analogue scale (VAS, 0–10), shoulder pain and disability index (SPADI, 0–100), and Constant–Murley score (CMS, 0–100).</p>\u0000 <p><b>Results:</b> A total of 10 patients were enrolled. All procedures were technically successful with the radial artery approach. Abnormal neovessels with angiographic blushes were identified in all cases, with a mean of 3.3 abnormal neovessels per patient (range, 2–4) and a total of 41 arteries embolized, averaging 4.1 vessels per patient (range, 3–5). Baseline VAS, SPADI, and CMS were 3.5, 50.0, and 47.4, respectively. The 1-day follow-up (VAS, 2.0; SPADI, 26.3; CMS, 68.1; <i>p</i> ≤ 0.001 compared to baseline) and 1-month follow-up (VAS, 1.7; SPADI, 24.3; CMS, 72.8; <i>p</i> ≤ 0.002 compared to baseline) demonstrated significant improvements. The 1-day and 1-month follow-up results were not significantly different.</p>\u0000 <p><b>Conclusions:</b> Substantial pain relief and functional scales improvement were observed both immediately and 1 month after TAE in chronic intractable shoulder pain. TAE may be an effective alternative treatment for patients with shoulder pain who do not respond to conservative or surgical treatment.</p>\u0000 <p><b>Trial Registration:</b> Korean Registry of Clinical Trials: KCT0004720</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9964536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Clinical Practices and Future Perspectives for Primary Healthcare Use of Point-of-Care Devices: A Scoping Review","authors":"Abdulaziz Alrubayyi,&nbsp;Reza Fahimi,&nbsp;Muntaha Hassan,&nbsp;Jason Madan,&nbsp;Olalekan A. Uthman","doi":"10.1155/ijcp/4742851","DOIUrl":"https://doi.org/10.1155/ijcp/4742851","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Expanding access to screening through primary care is essential to address changes in disease patterns, patients’ needs, and demographics. Point-of-care test (POCT) devices play a crucial role in providing primary care and have positive operational and economic impacts compared to central laboratories. Despite their importance, the implementation of POCT devices in primary care remains low. This scoping review aims to map the current evidence on POCT types and their current uses in primary care.</p>\u0000 <p><b>Methods:</b> A scoping review was conducted using the framework proposed by Arksey and O’Malley, and further refined by Levac et al. and the Joanna Briggs Institute. Our process included five stages: identifying the research question, identifying relevant studies, study selection, charting the data, and collating, summarizing, and reporting the results. We searched MEDLINE (Ovid), CINAHL, Embase, Web of Science, Cochrane Library, and Google Scholar for studies published between 2018 and 2023 on the use of POCTs in primary care settings for adult populations. Our findings were summarized using descriptive statistics and thematic analysis.</p>\u0000 <p><b>Results:</b> The search yielded 43,913 publications, of which, 167 met the inclusion criteria. From these studies, biomarker detection tests were used in 33.5%, antibody tests in 21.6%, other POCTs in 17.4%, POC technologies in 11.4%, antigen tests in 8.4%, and POC molecular tests in 7.8%. Across studies, 46.7% targeted communicable diseases, 39.5% targeted noncommunicable diseases, and 13.8% for other diseases. POC devices are mainly used for communicable diseases in urban healthcare settings, particularly in low- and middle-income countries (LMIC). POC devices are used primarily for noncommunicable diseases in urban healthcare settings, particularly in high-income countries.</p>\u0000 <p><b>Conclusion:</b> This scoping review has mapped the evidence and highlighted gaps regarding POCTs used in primary care. The findings can be used to design and effectively implement sustainable patients’ healthcare journeys to accommodate the changes in patients’ demographics and healthcare needs.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/4742851","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns of Women Diagnosed With Polycystic Ovary Syndrome Regarding the Process and Having Children: A Qualitative Study","authors":"Handan Özcan,&nbsp;Sedanur Altın,&nbsp;Esra Şekercioğlu,&nbsp;Sümeyye Köse,&nbsp;Esra Güzel","doi":"10.1155/ijcp/4889905","DOIUrl":"https://doi.org/10.1155/ijcp/4889905","url":null,"abstract":"<div>\u0000 <p><b>Aim:</b> This study aims to examine the concerns of women diagnosed with PCOS regarding the process and childbearing using interpretative phenomenological analysis.</p>\u0000 <p><b>Methods:</b> This qualitative research was conducted between February and June 2024 with 17 women, aged 18–35 years, who had been diagnosed with PCOS within the past 1–12 months and had visited a Women’s Health Clinic at a Training and Research Hospital. The study data were collected through a personal information form and a semistructured interview form, using individual face-to-face structured interviews.</p>\u0000 <p><b>Results:</b> The emotions expressed in the interviews were categorized under three main themes: “Emotions Experienced Upon Diagnosis,” “Anxiety Regarding Childbearing,” and “Sources of Information.” During the interviews, participants narrated their emotions and experiences related to PCOS within a narrative flow. The study findings revealed that the most commonly experienced emotions were anxiety, sadness, and concerns about infertility. The majority of participants expressed significant anxiety about the possibility of not being able to conceive. The primary source of information about the disease was the Internet, followed by doctors, although it was noted that the participants felt that they did not receive sufficient information from their doctors about their condition.</p>\u0000 <p><b>Conclusion:</b> The study highlights that women with PCOS experience anxiety related to the disease and concerns about infertility after diagnosis, and it identifies the factors influencing these anxieties. The findings from this study may contribute to the development of supportive healthcare and emotion regulation strategies for women with PCOS.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/4889905","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Series of Adult and Pediatric Basidiobolomycosis in Saudi Arabia: An Emerging Rare Disease","authors":"Fahdah Al-Mutairi,&nbsp;Adel Almaymuni,&nbsp;Bayan Hafiz,&nbsp;Alanoud Alghanem,&nbsp;Nada Rabie,&nbsp;Mohammed Samannodi,&nbsp;Nabeel Khojah,&nbsp;Ishaq Mudawi,&nbsp;Abdulkareem Alshamrani,&nbsp;Tahani Almeleebia,&nbsp;Wala Felemban,&nbsp;Daliah Abdulhafeez,&nbsp;Rehab Fadaq,&nbsp;Khalid Al Johani,&nbsp;Sara Tayeb,&nbsp;Heba Jalloun","doi":"10.1155/ijcp/1747727","DOIUrl":"https://doi.org/10.1155/ijcp/1747727","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Basidiobolomycosis is a fungal infection caused by <i>Basidiobolus ranarum</i>. It is primarily located in the tropical areas. It is commonly affecting the gastrointestinal tract and rarely presents with systemic affection.</p>\u0000 <p><b>Patients and Methods:</b> The records of fifteen patients, including pediatrics, from various geographic regions (western and southern regions of the Kingdom of Saudi Arabia) who were diagnosed with basidiobolomycosis in two tertiary hospitals over the last fourteen consecutive years from January 2010 to February 2023 were included. A detailed history and data for each patient were reviewed and evaluated.</p>\u0000 <p><b>Results:</b> A total of fifteen patients were found to have basidiobolomycosis, of which fourteen were found to have gastrointestinal basidiobolomycosis (GIB). They presented with abdominal pain, fever, nausea, vomiting, diarrhea, and loss of weight. One of them with an orbital infection presented with periorbital swelling, hotness, and redness. The diagnosis was confirmed after histopathological examination with typical features of granulomatous reaction, dense infiltrate of eosinophils, and fungal structures. Seven patients were treated with antifungals alone, such as voriconazole or itraconazole. Eight patients were treated by surgical resection followed by antifungal medication. Ten patients demonstrated good clinical response and completed their treatment course, while one patient showed a slight improvement and is still receiving treatment and follow-up. There have been four reported cases of death. The length of the therapy was scheduled based on how the patients responded clinically to the intervention.</p>\u0000 <p><b>Conclusions:</b> We present the series with the most patients collected to date, and it is shown that GIB is often misdiagnosed as cancer or inflammatory bowel disease. Histological analysis confirms the diagnosis of basidiobolomycosis. The choice of therapy is still up for debate: medical intervention alone or surgical resection followed by antifungal medication.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/1747727","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Relationship Between Hypothyroidism and Multiple Cardiovascular Diseases: A Bidirectional Mendelian Randomization Study","authors":"Zhifeng Xu,&nbsp;Jian Peng,&nbsp;Wanjun Lu,&nbsp;Junwei Xu,&nbsp;Minglong Zhu,&nbsp;Mengxuan Yuan","doi":"10.1155/ijcp/8724692","DOIUrl":"https://doi.org/10.1155/ijcp/8724692","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> Hypothyroidism is associated with a variety of cardiovascular diseases, but whether they are causally related to each other is unclear. This study intends to explore the bidirectional causal relationship between hypothyroidism and four common cardiovascular diseases using Mendelian randomization (MR).</p>\u0000 <p><b>Methods:</b> Single-nucleotide polymorphisms (SNPs), the instrumental variable required for the study, were obtained from the public genome-wide association study (GWAS) database, and samples were obtained from European populations. Causal effects were assessed using three methods: inverse variance weighted (IVW), MR-Egger regression, and weighted median (WM), with IVW being the main method. Sensitivity analyses were conducted using MR-PRESSO, Cochran’s <i>Q</i> test, MR-Egger regression intercept term, and leave-one-out method to assess the reliability and stability of the study results.</p>\u0000 <p><b>Results:</b> The results of IVW method showed a causal effect of hypothyroidism on coronary heart disease (CHD) (OR: 2.313, 95% CI: 1.271 to 4.208, <i>p</i> = 0.006) and hypertension (OR: 2.293, 95% CI: 1.331 to 3.955, <i>p</i> = 0.003). In contrast, there was no causal effect of hypothyroidism on arrhythmias (OR: 1.448, 95% CI: 0.885 to 2.371, <i>p</i> = 0.141) and heart failure (OR: 1.512, 95% CI: 0.775 to 2.951, <i>p</i> = 0.226). The results of MR-PRESSO and Cochran’s <i>Q</i> test showed that there was no heterogeneity in the instrumental variables included to study the effect of hypothyroidism on CHD, while there was heterogeneity in the instrumental variables included to study the effect on hypertension; also, the results of the MR-Egger regression intercept term showed that none of the included instrumental variables were horizontally pleiotropic. The results of the reverse MR analysis showed no causal effect of any of the four cardiovascular diseases on hypothyroidism.</p>\u0000 <p><b>Conclusion:</b> Patients with hypothyroidism are more likely to develop CHD as well as hypertension.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8724692","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}