International Archives of Otorhinolaryngology最新文献_第4页

Vocal Cord Paralysis after Tracheal Intubation: An Overview of the Etiology and Associated Risk Factors. 气管插管后声带麻痹：病因及相关危险因素综述。

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International Archives of Otorhinolaryngology Pub Date : 2025-07-07 eCollection Date: 2025-04-01 DOI: 10.1055/s-0045-1808244

Meerab Anwar, Komal Ashiq Hussain, Pervez Anwar

{"title":"Vocal Cord Paralysis after Tracheal Intubation: An Overview of the Etiology and Associated Risk Factors.","authors":"Meerab Anwar, Komal Ashiq Hussain, Pervez Anwar","doi":"10.1055/s-0045-1808244","DOIUrl":"10.1055/s-0045-1808244","url":null,"abstract":"Introduction: Vocal cord paralysis (VCP) is a deprivation of motility and the dysfunction of the vocal cords due to a defect in the vagal nerve or recurrent laryngeal nerve (RLN). It also occurs due to mutilation in the cricoarytenoid joint or posterior commissure scarring after prolonged tracheal intubation. It is a disorder with an extensive range of etiologies reliant on its laterality pattern.Objective: To discuss the laterality pattern of VCP due to endotracheal intubation and its respective treatments, the associated etiologies, and the risk factors, to provide a new direction to physicians for its treatment and to avoid its occurrence.Data synthesis: We conducted a peer review of many of the articles published to date on VCP. An analysis of 967 patients from 5 studies determined that unilateral VCP (UVCP) is three times more frequent than bilateral VCP (BVCP). Furthermore, we analyzed 2,232 patients from 6 different studies that concluded surgery was the most common cause, followed by neoplastic diseases or malignancies. Another important though highly uncommon etiology of VCP is endotracheal intubation; however, it is disturbing for doctors as endotracheal intubation is a common procedure for general anesthesia.Conclusion: A variety of factors may cause VCP, including age, comorbidities, body mass index BMI, the duration of the intubation, the handling of the apparatus, operative time, and tracheal tube sizes. Preventive measures should be prioritized to avoid severe consequences, and intubation must be performed carefully in elderly people and in subjects with lower BMIs. Knowledge of the risk factors will help physicians customize intubation procedures in the future.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 2","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12234165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hearing Loss and Middle Ear Effusion in Nasopharyngeal Carcinoma Following Radiotherapy: Dose-Response Relationship and Normal Tissue Complication Probability Modeling. 鼻咽癌放疗后听力损失和中耳积液：剂量-反应关系和正常组织并发症概率模型。

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International Archives of Otorhinolaryngology Pub Date : 2025-07-03 eCollection Date: 2025-04-01 DOI: 10.1055/s-0045-1805045

Prem Wungcharoen, Anussara Prayongrat, Napadon Tangjaturonrasme

{"title":"Hearing Loss and Middle Ear Effusion in Nasopharyngeal Carcinoma Following Radiotherapy: Dose-Response Relationship and Normal Tissue Complication Probability Modeling.","authors":"Prem Wungcharoen, Anussara Prayongrat, Napadon Tangjaturonrasme","doi":"10.1055/s-0045-1805045","DOIUrl":"10.1055/s-0045-1805045","url":null,"abstract":"Introduction Radiotherapy is the primary treatment for nasopharyngeal carcinoma. Radiation exposure to the cochlea and middle ear can cause hearing loss. Objective To develop a multivariable normal tissue complication probability (NTCP) model to predict the risk of hearing impairment in nasopharyngeal cancer patients based on clinical and radiation dosimetry features and to identify the key factors associated with hearing loss. Methods A retrospective review of 229 patients was conducted. We recorded the audiometry and presence of middle ear effusion (MEE) and compared findings before and after therapy. The factors included age, gender, signs and symptoms at presentation, tumor staging, prescribed dose at the tumor and high-risk nodal region, cochlea, and concurrent chemotherapy treatment. The model was formulated using multivariate logistic regression. Results Age of more than 50 years, high primary staging, and dose at the cochlea > 43 Gy were major risk factors for sensorineural hearing loss. The final NTCP model for hearing loss comprised age and cochlea dose with an area under the curve (AUC) of 0.644; the predicted risk ranged from 15.84 to 44.52%. Locally advanced disease and cochlea dose greater than 44 Gy were risk factors for MEE; the predicted risk ranged from 20.42 to 51.99%. Conclusion Age over 50, T stages 3 and 4, and > 43 Gy dose to the cochlea were significantly associated with an increased risk of sensorineural hearing loss and MEE. The developed NTCP model provides information to predict these risks, aiding in treatment planning and decision-making to avoid complications.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 2","pages":"1-9"},"PeriodicalIF":1.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auditory Processing in Stuttering Children: Behavioral and Electrophysiological Assessments. 口吃儿童的听觉加工：行为和电生理评估。

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International Archives of Otorhinolaryngology Pub Date : 2025-07-01 eCollection Date: 2025-04-01 DOI: 10.1055/s-0045-1804518

Letícia Gregory, Milaine Dominici Sanfins, Piotr Henryk Skarzynski, Rafael Fabiano Machado Rosa, Paulo Ricardo Gazzola Zen, Pricila Sleifer

{"title":"Auditory Processing in Stuttering Children: Behavioral and Electrophysiological Assessments.","authors":"Letícia Gregory, Milaine Dominici Sanfins, Piotr Henryk Skarzynski, Rafael Fabiano Machado Rosa, Paulo Ricardo Gazzola Zen, Pricila Sleifer","doi":"10.1055/s-0045-1804518","DOIUrl":"10.1055/s-0045-1804518","url":null,"abstract":"Introduction Stuttering is a human communication disorder characterized by involuntary interruptions to speech flow. Electrophysiological tests and behavioral evaluations allow the neuroaudiological processes involved in stuttering to be investigated. Objective To investigate group differences in the central auditory system using long-latency auditory evoked potentials, cognitive potentials, and behavioral assessments in children who stutter and compare them with fluent children. Methods We assessed 18 children with stuttering and compared them with a control group of 18 children without speech or language impairment. All children were evaluated with pure tone and speech audiometry, acoustic immittance measures, brainstem auditory evoked potentials, long latency auditory evoked potentials, cognitive potentials, and behavioral tests of auditory processing - Random Gap Detection Test (RGDT), Dichotic Digit Test (DDT); Duration Pattern Test (DPT); Pediatric Speech Intelligibility (PSI); and Masking Level Difference (MLD). The Scale of Auditory Behaviors (SAB) questionnaire was also applied. Results Children who stuttered had longer latencies of the P2 and P3 waves compared with the fluent group. There was no difference in P2 amplitudes, but there was a smaller P3 amplitude in children who stuttered, and they also showed significant alterations in the DDT and DPT. Furthermore, an association was found between increased P2 and P3 latency and SAB scores. Conclusion The present study indicates that children who stutter tend to have decreased auditory ability in terms of central auditory processing, and this shows up psychophysically and on the SAB questionnaire.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 2","pages":"1-11"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Qualitative Assessment of Quality and Readability of Patient-Directed Arabic Online Resources for Cochlear Implants in Children. 儿童人工耳蜗患者指导的阿拉伯语在线资源的质量和可读性的定性评估。

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International Archives of Otorhinolaryngology Pub Date : 2025-07-01 eCollection Date: 2025-04-01 DOI: 10.1055/s-0045-1804516

Saad A Sanad, Aseel M Mokhtar, Manar O Alharbi, Hisham B Alem, Afnan F Bukhari, Faisal Zawawi

{"title":"Qualitative Assessment of Quality and Readability of Patient-Directed Arabic Online Resources for Cochlear Implants in Children.","authors":"Saad A Sanad, Aseel M Mokhtar, Manar O Alharbi, Hisham B Alem, Afnan F Bukhari, Faisal Zawawi","doi":"10.1055/s-0045-1804516","DOIUrl":"10.1055/s-0045-1804516","url":null,"abstract":"Objective To assess the readability and quality of various websites providing information on cochlear implantation (CI) in children in Arabic. Methods The present is a cross-sectional online search. We conducted searches in the Arab language using the three most popular search engines, Yahoo, Google, and Bing, to search the topics of \"cochlear implant\" and \"cochlear implant in children.\" The information quality was evaluated through the DISCERN tool, while readability was examined using the OSMAN readability tool, which incorporated two readability metrics: the automated readability index (ARI) and the Läsbarhetsindex (LIX, reliability index). Results In a study of 50 websites, the median Discerning the Quality of Information on Treatment Choices (DISCERN) quality score was 38, with an interquartile range (IQR) of 29 to 46, suggesting poor quality. Out of the 50 websites evaluated, only 10 were deemed to be of good quality. The median readability ARI was 8th grade (IQR: 6-9), which considered above the level of general population. Certain websites were found to be at or below the suggested 6th grade reading proficiency level. The median LIX was of 69 (IQR: 64-71), indicating that the text is very difficult. There was no correlation between readability and the DISCERN score. Conclusions Our results suggest that many websites offering information on CIs for children in Arabic exhibit varying levels of quality and are composed in language surpassing the general population's reading ability. Developers should focus on improving the readability of their online content to ensure that the average reader can understand and benefit from the information.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 2","pages":"1-8"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Characteristics of Nasal Fractures: An 11-year Retrospective Study. 鼻骨折的临床特点：一项11年回顾性研究。

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International Archives of Otorhinolaryngology Pub Date : 2025-06-10 eCollection Date: 2025-04-01 DOI: 10.1055/s-0044-1788314

Ramyar Farzan, Mohammadjavad Sharifian, Mohammad Tolouei, Siamak Rimaz, Sanaz Masoumi

{"title":"Clinical Characteristics of Nasal Fractures: An 11-year Retrospective Study.","authors":"Ramyar Farzan, Mohammadjavad Sharifian, Mohammad Tolouei, Siamak Rimaz, Sanaz Masoumi","doi":"10.1055/s-0044-1788314","DOIUrl":"10.1055/s-0044-1788314","url":null,"abstract":"Introduction Nasal fractures are one of the most common diseases in the otorhinolaryngology emergency room that leads to significant complications. However, there is still no suitable method to prevent their occurrence, which may result from insufficient studies on their causes and related factors. Objectives To describe the demographic features, pattern, time of consultation, and etiological factors of patients with different types of nasal fractures. Methods We conducted a retrospective study of the records of patients with a diagnosis of nasal fracture treated between 2010 and 2021. The data included demographic characteristics, type of maxillofacial injury and associated lesions, complication rates, treatment modalities, and a description of the surgery. Results We included 599 patients, mostly male subjects (81.6%) injured in a road accident (55.3%), with a mean age of 31.64 ± 14.65 years, and mean length of hospital stay of 2.27 ± 2.21 days. Most accompanying fractures were maxillary (38.5%), multiple (24.6%), and mandibular (23.1%). The mean length of hospital stay was statistically different according to the cause of the fracture ( p = 0.036) and the types of treatment performed ( p = 0.041). Conclusion In general, trauma patients in the second to fourth decades of life and of the male gender are more prone to nasal fractures. Identifying the factors affecting the incidence of fractures enables the determination of the presentation patterns and the nature of the lesions to be evaluated. In addition, treatment evaluation and an analysis of the complication rate enable a more realistic interpretation of how patients are managed.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 2","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Blood Thinners and Increased Nosebleeds during the Coronavirus Disease 2019 Pandemic. 2019冠状病毒大流行期间血液稀释剂的使用和流鼻血增多

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International Archives of Otorhinolaryngology Pub Date : 2025-06-10 eCollection Date: 2025-04-01 DOI: 10.1055/s-0044-1791583

Lucas Diniz Costa, Ana Paula Brandão Silva, Mariane Stagi Almada, Vanessa Pinheiro Adamo, Guilherme Irie Nakazora, Gustavo Rossoni Carnelli, Antonio Carlos Cedin

{"title":"Use of Blood Thinners and Increased Nosebleeds during the Coronavirus Disease 2019 Pandemic.","authors":"Lucas Diniz Costa, Ana Paula Brandão Silva, Mariane Stagi Almada, Vanessa Pinheiro Adamo, Guilherme Irie Nakazora, Gustavo Rossoni Carnelli, Antonio Carlos Cedin","doi":"10.1055/s-0044-1791583","DOIUrl":"10.1055/s-0044-1791583","url":null,"abstract":"Introduction In May 2020, the World Health Organization declared Brazil a new epicenter of the coronavirus pandemic. Objective The present study aims to verify if the frequency of nasal bleeding and/or epistaxis in patients of a tertiary hospital was correlated with the pandemic of coronavirus disease 2019 (COVID-19) and with the use of anticoagulants. Methods The analysis performed was retrospective from the database of the otorhinolaryngology service of a Brazilian tertiary hospital, comparing 2 periods: 1 from March 2020 to July 2021 comprising the peak of pandemic setting, and another from August 2021 to May 2022. We checked data on the average number of cases/month and on the use of anticoagulants. Results In the period above mentioned, there were 61 cases of COVID-19-related epistaxis (from a total of 180 cases of nasal bleeding and/or epistaxis), with an average of 12 cases/month, demonstrating an increase in the frequency of cases at the institution, when compared to a study involving 343 cases from the same institution over a period of 42 months (October 2015-March 2019), in which the average was 8.1 cases/month. Among the patients with COVID-19 and nasal bleeding, 55 (90.17%) were using some type of anticoagulant at the time of bleeding: 41% were on subcutaneous heparin; 20% were on subcutaneous enoxaparin; 16.66% were receiving intravenous heparin on continuous infusion bomb (CIB); 6.66% were on extracorporeal membrane oxygenation (ECMO) associated with intravenous heparin on CIB; 4.99% were on oral rivaroxaban; and 1.66% are on oral apixaban. Conclusion Our study's data confirmed the increase in the number of epistaxis cases and the use of anticoagulants in COVID-19 patients.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 2","pages":"1-3"},"PeriodicalIF":1.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Symptoms and Otorhinolaryngological Sequalae in Long Covid. 长冠肺炎的症状和耳鼻咽喉后遗症。

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International Archives of Otorhinolaryngology Pub Date : 2025-06-03 eCollection Date: 2025-04-01 DOI: 10.1055/s-0045-1809026

Alessandra Loli, João Victor Costa Müller, Eric Schneider de Azevedo, Regina Helena Garcia Martins

{"title":"Symptoms and Otorhinolaryngological Sequalae in Long Covid.","authors":"Alessandra Loli, João Victor Costa Müller, Eric Schneider de Azevedo, Regina Helena Garcia Martins","doi":"10.1055/s-0045-1809026","DOIUrl":"10.1055/s-0045-1809026","url":null,"abstract":"Introduction: After the pandemic caused by the coronavirus, many patients have presented remaining otorhinolaryngological symptoms, but most of them are unknown to health professionals.Objectives: To characterize otorhinolaryngological symptoms and sequelae in hospitalized patients for Covid-19.Methods: We made a recall to patients hospitalized between April 2020 and April 2022 due to Covid-19. Demographic data, initial and remaining symptoms, days of hospitalization, intubation and/or tracheostomy, and vaccination data were collected.Results: 845 patients were hospitalized, 441 died, 404 patients were contacted by telephone, but only 109 responded to the questionnaire about initial and remaining otorhinolaryngological symptoms after 1.5 to 2 years of illness, 59 men and 50 women, with an average age of 58.61 years (20 to 94). Two study groups were composed: G 1 (n- 44; with remaining symptoms) and G 2 (n- 65; without remaining symptoms). 81% of patients in G1 and 67% of patients in G2 had been hospitalized for up to 20 days. Intubation occurred in 17 patients (G1-7; G2-10). Seven patients underwent tracheostomy. The most prevalent initial and remaining otorhinolaryngological symptoms, respectively, were dyspnea (68.8%; 14.6%), cough (65.1%; 11.92%), nasal obstruction (47.7%; 5.58%), smell dysfunction (44%; 11%), taste dysfunction (42%; 4.58%). Vaccination was reported by 54 patients (G1-21; G2-34).Conclusions: Otorhinolaryngological symptoms were common in patients hospitalized for Covid-19, especially dyspnea, cough, nasal obstruction, smell, and taste dysfunction. Although there was a favorable long-term evolution, 40% of patients maintained permanent symptoms, such as smell and taste dysfunction and dizziness, unrelated to the vaccine doses.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 2","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Two Quality Analysis Checklists Used to Appraise Studies Regarding the Assessment of Auditory Processing Disorder in Older Adults. 用于评价老年人听觉加工障碍评估研究的两种质量分析清单的比较。

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International Archives of Otorhinolaryngology Pub Date : 2025-05-29 eCollection Date: 2025-04-01 DOI: 10.1055/s-0044-1792083

Vipin Ghosh, Asha Yathiraj, Darshan Devananda

{"title":"Comparison of Two Quality Analysis Checklists Used to Appraise Studies Regarding the Assessment of Auditory Processing Disorder in Older Adults.","authors":"Vipin Ghosh, Asha Yathiraj, Darshan Devananda","doi":"10.1055/s-0044-1792083","DOIUrl":"10.1055/s-0044-1792083","url":null,"abstract":"Introduction A meta-analysis of published articles is usually done using standard scales and checklists. Several such scales and checklists are reported in the literature. However, there is little information regarding their utility so one can select the most appropriate one, especially in the field of audiology. Objective The current study aimed to compare a quality analysis carried out using the standard quality assessment criteria (SQAC) for evaluating primary research papers from a variety of fields', and the Modified Downs and Black Checklist (MDBC) for a set of articles in the area of auditory processing deficits (APDs) in older adults. Methods Two published checklists suitable for the field of audiology (SQAC and MDBC) were compared for a quality analysis of articles on APD in older adults. The two checklists were compared after categorizing their items into five subsections. Two audiologists rated the articles according to both checklists. Results The interrater reliability was found to be good for both checklists. Significant differences between the checklists were observed for specific subsections. However, there was no significant correlation between the two checklists. Conclusion It is inferred that the selection of an appropriate quality assessment checklist depends on the objective of the study. If the aim of a quality analysis study is to differentiate articles based on their overall caliber, or primarily based on the subsections, SQAC is recommended. However, if the aim is to distinguish research articles primarily based on the control of variables, or differentiate intervention-based studies, the MDBC is recommended.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 2","pages":"1-5"},"PeriodicalIF":1.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between the Expression of Cytochrome P450 and Glutathione S-transferase Enzyme and Antrochoanal Polyp Pathogenesis. 细胞色素P450和谷胱甘肽s -转移酶的表达与肛管息肉发病的关系

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International Archives of Otorhinolaryngology Pub Date : 2025-05-29 eCollection Date: 2025-04-01 DOI: 10.1055/s-0044-1801320

Mehmet Gökhan Demir, Sedat Aydın, Serpil Oguztuzun, Kayhan Basak

{"title":"Association Between the Expression of Cytochrome P450 and Glutathione S-transferase Enzyme and Antrochoanal Polyp Pathogenesis.","authors":"Mehmet Gökhan Demir, Sedat Aydın, Serpil Oguztuzun, Kayhan Basak","doi":"10.1055/s-0044-1801320","DOIUrl":"10.1055/s-0044-1801320","url":null,"abstract":"Introduction Antrochoanal polyp, which is a kind of smooth-surfaced single nasal polyp, is commonly present in cases of nasal obstruction. The pathogenesis of polyp formation is still unclear, but allergy is supposed to be a cause. Objectives To investigate the expression levels of antioxidant enzymes in antrochoanal polyp tissue. Methods The antrochoanal polyp group was composed of 23 patients who were diagnosed microscopically, and the control group was composed of 38 healthy patients. The sample of the control group was taken from the inferior turbinate mucosa by punch biopsy under general anesthesia, and the antrochoanal polyp sample was collected from sinus surgery. The cytochrome P450 (CYP) and glutathione S-transferase (GST) expressions of the groups were investigated under microscopy and scored by senior pathologists. Results The antrochoanal polyp group had statistically less expression of CYP family 1 subfamily A member 1 (CYP1A1) than the control group ( p < 0.05). Moreover, GST Pi 1 (GSTP1), GST Mu 1 (GSTM1), and GST Alpha 1 (GSTA1) expressions were not different between the groups ( p > 0.05). Conclusion Allergy and chronic inflammation are postulated reasons for antrochoanal polyp formation, but, according to our results, we could not detect any relation between antrochoanal polyp formation and GST expression in tissue. However, the decreased level of CYP1A1 expression in the antrochoanal polyp group may be related with the pathogenesis of the antrochoanal polyp formation.","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"29 2","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence in the Diagnosis and Treatment of Speech Disorders: Bridging Neurology and Otorhinolaryngology. 人工智能在言语障碍诊断和治疗中的应用：衔接神经病学和耳鼻喉科。

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International Archives of Otorhinolaryngology Pub Date : 2025-05-29 eCollection Date: 2025-04-01 DOI: 10.1055/s-0045-1809334

Wyllians Vendramini Borelli, Tatiana Luft, Geraldo Pereira Jotz

引用次数: 0