International Forum of Allergy & Rhinology最新文献

{"title":"Parosmia Beyond Olfactory Loss: A Propensity Score-Matched Study of Central Sensitization-Associated Comorbidities","authors":"Elay Amidor,&nbsp;Nidal Muhanna,&nbsp;Avraham Abergel,&nbsp;Narin-Nard Carmel Neiderman,&nbsp;David Rosen,&nbsp;Gurston Nyquist,&nbsp;Emma Anisman,&nbsp;Udi Shapira,&nbsp;Hen Chaushu","doi":"10.1002/alr.70222","DOIUrl":"10.1002/alr.70222","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Points</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>Parosmia is linked to migraine, chronic pain, fibromyalgia, and hypersomnia beyond anosmia.</li>\u0000 \u0000 <li>Central sensitization comorbidities distinguish parosmia from quantitative olfactory loss.</li>\u0000 \u0000 <li>Findings support parosmia as a disorder of altered central sensory processing.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"16 9","pages":"1039-1042"},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148470384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Rhinosinusitis and Nasal Polyps in Eosinophilic Granulomatosis With Polyangiitis: A Scoping Review","authors":"Alisha Sharma,&nbsp;Alyssa Y. Li,&nbsp;Teruko Kishibe,&nbsp;Dennis Wong,&nbsp;Kevin M. Sanders,&nbsp;Maggie Jiang,&nbsp;Heedo Lee,&nbsp;Christine Song,&nbsp;Kieran Mcintyre,&nbsp;Christian Pagnoux,&nbsp;Yvonne Chan,&nbsp;John M. Lee,&nbsp;Daniel J. Lee","doi":"10.1002/alr.70217","DOIUrl":"10.1002/alr.70217","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Chronic rhinosinusitis (CRS) is one of the most common manifestations of eosinophilic granulomatosis with polyangiitis (EGPA), often preceding the diagnosis of systemic vasculitis by several years. The sinonasal presentation of EGPA typically resembles CRS with nasal polyps (CRSwNP), making it clinically indistinguishable from those without EGPA. This overlap frequently contributes to significant diagnostic delays. This scoping review summarizes the prevalence, diagnosis, management, and outcomes of CRSwNP and CRS without nasal polyps (CRSsNP) in EGPA.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We searched MEDLINE, Embase, CENTRAL, CINAHL, and Web of Science from inception to June 4, 2025, for studies reporting CRS in patients with EGPA. Eligible designs included trials, cohorts, case series, and narrative reviews. Non-English studies without translation and articles without primary data were excluded. Outcomes included CRS prevalence, diagnostic modalities, management strategies, and sinonasal outcomes. This study is registered with the Open Science Framework (DOI: 10.17605/OSF.IO/DA5CK).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Eighty-three full-text and 26 abstracts were included, for a total of 109 studies, of which 88 studies (74 full-text and 14 abstracts were included in the analysis). Across the analyzed studies, 1087 patients with CRS and EGPA were included. Median age was 53 years (range: 14.5–75; &lt;i&gt;n&lt;/i&gt; = 154), and 189 (48.5%; &lt;i&gt;n&lt;/i&gt; = 390) were male. CRSwNP and CRSsNP occurred in 753 (69.3%) and 334 (30.7%) of patients, respectively. The median time from CRS onset to EGPA diagnosis was 66 months (range: 1–120; &lt;i&gt;n&lt;/i&gt; = 35). Among 857 patients, EGPA was classified using ACR 1990 criteria (51.7%), ACR/EULAR 2022 (2.7%), and combined frameworks (45.6%). Diagnostic modalities included CT sinus (97.6%), nasal endoscopy (94.7%), and sinus biopsy (91.8%). Biopsy-proven vasculitis was confirmed in three (1.3%) patients. Systemic steroids were used in 362 (91%; &lt;i&gt;n&lt;/i&gt; = 398) patients, immunosuppressants in 290 (86.6%; &lt;i&gt;n&lt;/i&gt; = 336) patients, and biologics in 154 (58.9%; &lt;i&gt;n&lt;/i&gt; = 262) patients, primarily mepolizumab (73.3%), dupilumab (23.4%), and benralizumab (11.7%). Complete CRS remission was achieved in 106 (67.9%) patients following medical therapy and in 11 (18.2%) patients after combined surgical and medical treatment. Among those receiving dupilumab (&lt;i&gt;n&lt;/i&gt; = 15), mean SNOT-22 improved by 25.2 (&lt;i&gt;n&lt;/i&gt; = 9), with complete remission in six (83.3%) patients.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 ","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"16 9","pages":"996-1011"},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing the Scholarly Impact and Geographic Distribution of Rhinology Fellowship Graduates","authors":"Vivienne M. Li,&nbsp;Jennifer S. Lee,&nbsp;Michael C. Oca,&nbsp;Nicholas R. Rowan,&nbsp;Carol H. Yan","doi":"10.1002/alr.70209","DOIUrl":"10.1002/alr.70209","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"16 9","pages":"1024-1026"},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Learning Improves Sensitivity to Change in Sinus Computed Tomography: Evidence From Two Randomized Controlled Trials","authors":"James W. MacKay,&nbsp;Lars H. Nordenmark,&nbsp;Sofia Necander,&nbsp;David Cohen,&nbsp;Viktoria Werkström,&nbsp;Maria Jison,&nbsp;Rohit Sood,&nbsp;David Lynch,&nbsp;Stephen M. Humphries","doi":"10.1002/alr.70218","DOIUrl":"10.1002/alr.70218","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"16 9","pages":"1034-1038"},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148470434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Local Nasal Biomarkers and Olfactory Dysfunction in Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis","authors":"David Kayekjian,&nbsp;Neeti Gandra,&nbsp;Shaun A. Nguyen,&nbsp;Shaina W. Twardus,&nbsp;Rodney J. Schlosser","doi":"10.1002/alr.70223","DOIUrl":"10.1002/alr.70223","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To systematically evaluate the local biomarkers correlated with olfactory dysfunction (OD) in chronic rhinosinusitis (CRS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic review was conducted in CINAHL, Cochrane Library, PubMed, and Scopus from inception to July 2025. Studies on CRS patients who underwent olfactory testing and measurement of biomarkers within olfactory mucus were included. Collected variables included CRS phenotype, olfactory test, mucus protein levels, quantification method, and reported correlation coefficients. Meta-analysis of outcome measures in 351 participants included continuous measures (mean), proportions (%), and correlations (<i>r</i>) with 95% confidence intervals (CIs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seven prospective studies met criteria, with 4 studies comprising 201 patients with CRS with nasal polyps (CRSwNP) and 150 with CRS without nasal polyps (CRSsNP) for meta-analysis. The CRSwNP and CRSsNP cohorts were 53.08% and 58.09% male, respectively, with a mean age of 49.09 (1.36) and 46.84 (0.4), respectively. In participants with CRSwNP, IL-5, IL-6, IL-10, IL-13, IgE, CCL2, and CCL3 were inversely correlated with olfactory function scores (<i>r</i> = −0.223 to −0.333; all <i>p</i> ≤ 0.016). CXCL5 and VEGF-A were positively correlated in CRSwNP (<i>r</i> = 0.240–0.247, both <i>p</i> &lt; 0.01). Other Type 2 cytokines, including IL-4, IL-23, and IL-33, did not show any significant correlations. In CRSsNP, IL-8 was negatively correlated (<i>r</i> = −0.182, <i>p</i> = 0.028) and CXCL5 was positively correlated with olfactory function scores (<i>r</i> = 0.274, <i>p</i> = 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>OD in CRSwNP is moderately or mildly associated with specific Type 2 cytokines and other biomarkers. OD in CRSsNP is weakly correlated with IL8 and CXCL5, but not Type 2 cytokines. Further prospective studies are needed to elucidate causal relationships and prognostic utility between local biomarkers and OD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"16 9","pages":"1012-1023"},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148548887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Smell and Taste Disorders in the Post-COVID-19 Pandemic Era: A Cross-National Study of Prevalence and Quality of Life in the UK and the USA","authors":"Umar Rehman,&nbsp;Zi Jian Lau,&nbsp;Carl Philpott,&nbsp;Valerie J. Lund,&nbsp;Nicholas Eynon-Lewis,&nbsp;Jens Peter Klussmann,&nbsp;R. Peter Manes,&nbsp;Benjamin L. Judson,&nbsp;Adam J. Kimple,&nbsp;Wendell G. Yarbrough,&nbsp;Jayakar V. Nayak,&nbsp;Peter H. Hwang,&nbsp;Zara M. Patel,&nbsp;Matt Lechner","doi":"10.1002/alr.70226","DOIUrl":"10.1002/alr.70226","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Points</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>\u0000 <p>Anosmia/hyposmia affected 14.8%–19.6% of participants in the UK and the USA in the post-pandemic era. Since symptom onset, 37.1%–48.8% of affected participants reported no improvement, while 15.3%–17.6% reported worsening symptoms.</p>\u0000 </li>\u0000 \u0000 <li>\u0000 <p>Anosmia/hyposmia remains strongly associated with reduced quality of life across both countries.</p>\u0000 </li>\u0000 \u0000 <li>\u0000 <p>Among respondents reporting anosmia or hyposmia, a high proportion (88.8%–93.5%) also experienced concurrent parosmia.</p>\u0000 </li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"16 9","pages":"1046-1049"},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of the Sinonasal Outcome Test (SNOT-22) in Chronic Rhinosinusitis Patients With Comorbid Depression","authors":"Shane Perelman,&nbsp;Ruifeng Cui,&nbsp;Hassan H. Ramadan,&nbsp;Chadi A. Makary","doi":"10.1002/alr.70221","DOIUrl":"10.1002/alr.70221","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"16 9","pages":"1050-1052"},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Laser Posterior Nasal Neurolysis for the Treatment of Chronic Rhinitis: A Randomized Controlled Trial","authors":"Jyun-Yi Liao,&nbsp;En-Ying Wang,&nbsp;Ying-Shuo Hsu,&nbsp;Ming-Shao Tsai,&nbsp;Cheng-Jung Wu,&nbsp;Chia-Hao Chang,&nbsp;Yi-Li Hwang,&nbsp;Han-Lo Teng,&nbsp;Jun-Wei Hsieh,&nbsp;Chien-Yu Huang","doi":"10.1002/alr.70133","DOIUrl":"10.1002/alr.70133","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To determine the safety and efficacy of laser ablation of the posterior nasal nerve (PNN) for the treatment of chronic rhinitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study was a single-center, prospective, single-blinded, randomized sham-controlled trial. Patients with a 24-h reflective Total Nasal Symptom Score (rTNSS) ≧ 5, rhinorrhea ≧ 2, and congestion ≧ 1, were randomized 2:1 to active PNN treatment with a CO₂ laser device or a sham procedure. Outcome measures included the rTNSS, Nasal Obstruction Symptom Evaluation (NOSE), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS). The primary endpoint was the change in scores at 3 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients had a mean baseline rTNSS of 8.5 (95% CI, 7.9–9.1) and 8.2 (95% CI, 7.4–8.9) (<i>p</i> = 0.589) in the active treatment (<i>n</i> = 43) and sham control (n = 22) arms, respectively. At 3 months, the active treatment arm had a significantly greater decrease in rTNSS −4.7 (95% CI, −5.5 to −3.9) versus −2.6 (95% CI, −3.4 to −1.8) (<i>p</i> = 0.002). While the responder rate (RR, defined as ≧30% improvement rTNSS) was not significantly higher in the active treatment arm (81.4% vs. 63.6%, <i>p</i> = 0.119), post-hoc analysis of RR (≧ 50% improvement) showed a significantly higher rate of 65.1% versus 31.8% (<i>p</i> = 0.011). There were greater improvements in the PSQI and ESS scores for the active arm over the sham arm at follow-ups. (<i>p = </i>0.041 and 0.005, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The CO₂ laser posterior nasal neurolysis of the PNN area is associated with minimal adverse events and is superior to a sham procedure in reducing the symptom burden of chronic rhinitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"16 9","pages":"913-923"},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional Burden of Olfactory Dysfunction: A Psychological Cluster Analysis from a Tertiary Smell and Taste Clinic","authors":"Tom Fischer,&nbsp;Keren Avirame,&nbsp;Idan Peled,&nbsp;Ella Hazan,&nbsp;Elinoy Herstain,&nbsp;Hen Chaushu,&nbsp;Nidal Muhanna,&nbsp;Avraham Abergel,&nbsp;Narin N. Carmel Neiderman","doi":"10.1002/alr.70207","DOIUrl":"10.1002/alr.70207","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Points</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>The emotional burden of olfactory dysfunction bears distinct psychological profiles.</li>\u0000 \u0000 <li>Objective olfactory dysfunction findings do not reliably reflect patients' emotional burden.</li>\u0000 \u0000 <li>Olfactory-related quality of life assessment may identify patient risk of emotional distress.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"16 9","pages":"1027-1030"},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Effect of Budesonide Nasal Irrigation in Patients With Chronic Rhinosinusitis With Nasal Polyps Without Prior Sinus Surgery: A Randomized, Double-Blind, Placebo-Controlled Study\".","authors":"Zusheng Du, Huikang Wang, Yu Zhang, Xicheng Song","doi":"10.1002/alr.70247","DOIUrl":"10.1002/alr.70247","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"1058-1059"},"PeriodicalIF":4.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}