Roles of noncoding RNA in allergic rhinitis

IF 7.2 2区医学 Q1 OTORHINOLARYNGOLOGY

International Forum of Allergy & Rhinology Pub Date : 2024-10-05 DOI:10.1002/alr.23461

Xiangkun Zhao BS, Yuteng Yang BS, Yaqi Wang BS, Xi Chen BS, Yisong Yao BS, Ting Yuan BS, Jiaxuan Li BS, Yumei Li PhD, Xicheng Song PhD

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引用次数: 0

Abstract

Background

Allergic rhinitis (AR) is one of the most common respiratory noninfectious diseases and chronic inflammatory diseases, the incidence of which has been increasing in recent years. The main pathological characteristics of AR are repeated inflammation, airway hyperreactivity, mucus hypersecretion, and reversible airway obstruction due to inflammatory cell response. AR occurrence is associated with various factors, including those of genetic and environmental origins. Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot be converted into polypeptides. The three main categories of ncRNAs include microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs). NcRNAs play a crucial role in controlling gene expression and contribute to the development of numerous human diseases.

Methods

Articles are selected based on Pubmed's literature review and the author's personal knowledge. The largest and highest quality studies were included. The search selection is not standardized. Several recent studies have indicated the relationship of ncRNAs with the development of respiratory allergic diseases. NcRNAs, including miRNAs, lncRNAs, and circRNAs, are important gene expression regulatory factors. We review the expression and function of ncRNAs in AR, their role as disease biomarkers, and their prospective applicability in future research and clinically. We also discuss interactions between ncRNAs and their influence on AR comprehensively, these interactions are essential for determining the underlying pathological mechanisms further and discovering new drug therapeutic targets.

Results

NcRNAs can be used as biomarkers for early AR diagnosis, disease surveillance and prognosis assessment. Various categories of ncRNAs play distinct yet interconnected roles and actively contribute to intricate gene regulatory networks. They are also therapeutic targets and biomarkers in other allergic diseases.

Conclusion

This article demonstrates ncRNAs have a wide range of applications in AR treatment. The database covers three key areas: miRNAs, lncRNAs, and circRNAs. Additionally, potential avenues for future research to facilitate the practical application of ncRNAs as therapeutic targets and biomarkers will be explore. With further research and technological development, ncRNAs may provide additional innovative, effective solutions for AR treatment.

查看原文本刊更多论文

非编码 RNA 在过敏性鼻炎中的作用。

背景：过敏性鼻炎（AR）是最常见的呼吸道非感染性疾病和慢性炎症性疾病之一，近年来发病率呈上升趋势。过敏性鼻炎的主要病理特征是反复发炎、气道高反应性、粘液分泌过多以及炎症细胞反应导致的可逆性气道阻塞。AR 的发生与多种因素有关，包括遗传和环境因素。非编码 RNA（ncRNA）是一组不能转化为多肽的 RNA 分子。ncRNA 主要分为三类，包括微小 RNA（miRNA）、长 ncRNA（lncRNA）和环状 RNA（circRNA）。NcRNAs 在控制基因表达方面起着至关重要的作用，并导致多种人类疾病的发生：根据 Pubmed 的文献综述和作者的个人知识选择文章。其中包括规模最大、质量最高的研究。搜索选择没有标准化。最近的几项研究表明，ncRNA 与呼吸道过敏性疾病的发生有关。NcRNA（包括 miRNA、lncRNA 和 circRNA）是重要的基因表达调控因子。我们综述了 ncRNA 在 AR 中的表达和功能、它们作为疾病生物标志物的作用以及在未来研究和临床中的应用前景。我们还全面讨论了 ncRNA 之间的相互作用及其对 AR 的影响，这些相互作用对于进一步确定潜在的病理机制和发现新的药物治疗靶点至关重要：NcRNA可作为生物标志物用于早期AR诊断、疾病监测和预后评估。各类 ncRNA 发挥着不同但相互关联的作用，并在错综复杂的基因调控网络中发挥着积极作用。它们也是其他过敏性疾病的治疗靶点和生物标志物：本文展示了 ncRNA 在 AR 治疗中的广泛应用。该数据库涵盖三个关键领域：miRNAs、lncRNAs 和 circRNAs。此外，还将探讨未来研究的潜在途径，以促进 ncRNAs 作为治疗靶点和生物标志物的实际应用。随着进一步的研究和技术发展，ncRNA 可能会为 AR 治疗提供更多创新、有效的解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Forum of Allergy & Rhinology OTORHINOLARYNGOLOGY-

CiteScore

11.70

自引率

10.90%

发文量

185

审稿时长

6-12 weeks

期刊介绍： International Forum of Allergy & Rhinologyis a peer-reviewed scientific journal, and the Official Journal of the American Rhinologic Society and the American Academy of Otolaryngic Allergy. International Forum of Allergy Rhinology provides a forum for clinical researchers, basic scientists, clinicians, and others to publish original research and explore controversies in the medical and surgical treatment of patients with otolaryngic allergy, rhinologic, and skull base conditions. The application of current research to the management of otolaryngic allergy, rhinologic, and skull base diseases and the need for further investigation will be highlighted.