International heart journal最新文献

{"title":"Ventricular Tachycardia Ablation Using Map Merge Capable of Integrating Multiple Sessions.","authors":"Jun Yokota, Katsuhito Fujiu, Kent Doi, Norihiko Takeda","doi":"10.1536/ihj.24-685","DOIUrl":"10.1536/ihj.24-685","url":null,"abstract":"<p><p>This case report presents a novel approach for ventricular tachycardia (VT) ablation in a patient with cardiac sarcoidosis, utilizing the Map Merge function of the CARTO 3 system to integrate mapping data from multiple ablation sessions. A 62-year-old male with recurrent VT underwent initial endocardial ablation, where voltage mapping revealed no low-voltage areas (LVA) in the endocardium, though pace mapping matched clinical VT morphology. Fragmentation potentials were noted in the coronary vein, indicating a probable epicardial substrate. Ablation successfully suppressed VT, but recurrence occurred within 4 days, prompting a second, epicardial approach. During this session, voltage mapping identified broad LVAs with late potentials in the epicardium, aligning with prior endocardial sites. The Map Merge function enabled superimposing maps from both sessions, confirming spatial consistency between endocardial and epicardial LVAs and enhancing the precision of ablation targeting. Post-ablation, no VT recurrence was observed.This case underscores the clinical value of Map Merge, which improves procedural accuracy by integrating data across temporally distinct sessions, especially in VT cases involving epicardial substrates. By enabling comprehensive mapping without repeated epicardial mapping, Map Merge facilitates efficient identification and alignment of LVAs and abnormal potentials. This approach may improve outcomes in VT ablation by ensuring precise targeting, particularly in cases requiring endo-epicardial intervention.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"327-328"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Arterial Stiffness on Cardiac Geometry.","authors":"Kazuhiro Shimizu, Ruiko Ohno, Masahiro Iwakawa, Shuji Sato, Yukihiro Morinaga, Naoaki Tanji, Tsuyoshi Tabata, Toshio Kinoshita","doi":"10.1536/ihj.24-727","DOIUrl":"https://doi.org/10.1536/ihj.24-727","url":null,"abstract":"<p><p>Left ventricular hypertrophy (LVH), with the accompanying decrease in diastolic function, can originate from an augmented cardiac load caused by arterial stiffness (AS). The Cardio-Ankle Vascular Index (CAVI) is widely used as a good evaluation index for AS in Japan. We therefore conducted a longitudinal study aiming to determine the involvement of AS in changes in cardiac geometry using ultrasonography and CAVI.Between 2015 and 2020, 131 patients for whom echocardiography and CAVI measurements were performed at intervals of 401 ± 185 days were investigated to identify factors contributing to changes in cardiac geometry.Multivariate analysis showed that the value of change in the CAVI had an independent effect on the value of change in the left ventricular mass index (B = 4.023, β = 0.180, P = 0.046), which represents cardiac geometry, and on the value of change in relative wall thickness (RWT) (B = 0.021, β = 0.211, P = 0.010).This observational study suggested that improvements in CAVI, an indicator of cardiac afterload, may contribute to better cardiac remodeling, particularly in cases of concentric remodeling and concentric hypertrophy.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 3","pages":"449-455"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difference in Strategy and Clinical Outcomes of Left Main Disease in Japan and Non-Japanese Countries.","authors":"Takayuki Warisawa, Christopher M Cook, Yousif Ahmad, James P Howard, Henry Seligman, Christopher Rajkumar, Shunichi Doi, Sonoka Yuasa, Akihiro Nakajima, Takumi Toya, Masafumi Nakayama, Yuetsu Kikuta, Yoshiaki Kawase, Hidetaka Nishina, Rasha Al-Lamee, Amir Lerman, Hitoshi Matsuo, Yoshihiro J Akashi, Javier Escaned, Justin E Davies","doi":"10.1536/ihj.24-375","DOIUrl":"10.1536/ihj.24-375","url":null,"abstract":"<p><p>Although state-of-the-art therapy for left main disease (LMD) has been demonstrated to improve overall cardiovascular outcomes, it remains unclear whether differences in strategy and outcomes for Japanese and non-Japanese patients can be observed in a contemporary treatment.In this international multicenter registry, we analyzed 314 patients who received state-of-the-art management for LMD, including physiology-guided revascularization, coronary interventions using the latest drug-eluting stents aided by intracoronary imaging, or surgical procedures employing internal thoracic artery grafts, in conjunction with guideline-directed medical therapy. The patient cohort was divided into Japanese (n = 122) and non-Japanese (n = 192) groups. The primary endpoint was major adverse cardiovascular events (MACE), defined as death, non-fatal myocardial infarction, and ischemia-driven target lesion revascularization. Propensity score matching was utilized to account for baseline clinical variables.Baseline and lesion characteristics differed among groups, demonstrating higher frequency of diabetes and chronic kidney disease, higher SYNTAX score, and more severe stenosis in the Japanese cohort, resulting in a higher rate of revascularization performed (P < 0.05 for all). Percutaneous coronary intervention was significantly more frequently selected as the revascularization option (P < 0.001). While there were no significant differences in MACE between the 2 groups before adjustment, following adjustment, the Japanese cohort demonstrated significantly lower MACE at 4 years (6.3% versus 16.7%; HR: 0.37; 95%CI: 0.14-0.97; P = 0.042). Multivariate analysis further confirmed an independent association between Japanese patients and a reduced 4-year MACE risk (HR: 0.37; 95%CI: 0.14-0.96; P = 0.040).In a contemporary study with state-of-the-art therapy for LMD, patients who underwent treatment in Japan demonstrated better cardiovascular outcomes.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"202-212"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Cholesterol Crystals Using the Filter Paper Rinse Method in Very Late Stent Thrombosis Cases.","authors":"Saki Mizobuchi, Keisuke Kojima, Yudai Tanaka, Yuta Hotsubo, Shohei Migita, Masatsugu Miyagawa, Katsunori Fukumoto, Yuki Nakajima, Yasunari Ebuchi, Riku Arai, Tomoyuki Morikawa, Takashi Mineki, Nobuhiro Murata, Daisuke Fukamachi, Yasuo Okumura","doi":"10.1536/ihj.24-450","DOIUrl":"10.1536/ihj.24-450","url":null,"abstract":"<p><p>Very late stent thrombosis (VLST) is a rare but critical complication of stent placement. In this report, we present 2 VLST cases diagnosed with neoatherosclerosis by detecting cholesterol crystals (CCs) via the filter paper rinse method. In terms of differentiating between neoatherosclerosis and stent thrombosis. There was no visible thrombus observed on thrombus aspiration. Examination of the blood sample obtained from the thrombus aspiration using the filter paper rinse method showed the presence of CCs under polarized light microscopy, thus, diagnosing VLST caused by neoatherosclerosis. Diagnosis of neoatherosclerosis would provide a rationale for intensive lipid-lowering therapy.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"175-178"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upstream Stimulatory Factor 2 Protects Cardiomyocytes by Regulating Mitochondrial Homeostasis.","authors":"Wenbin Wu, Kexin Zhao, Kejuan Li, Ziwei Zhu, Yongnan Li, Jianshu Chen, Hong Ding, Xiaowei Zhang","doi":"10.1536/ihj.23-619","DOIUrl":"10.1536/ihj.23-619","url":null,"abstract":"<p><p>Myocardial ischemia and hypoxia are the main causes of heart failure, and cardiomyocyte apoptosis induced by mitochondrial injury is the basis of adverse heart remodeling and heart failure. Upstream stimulatory factor 2 (USF2), a transcription factor involved in multiple cellular processes, was recently shown to play an active role in mitochondrial function and energy homeostasis. However, its involvement in cardiovascular disease has not been previously reported. In this study, we demonstrated that under hypoxic conditions, USF2 protein expression can be degraded via the ubiquitin-proteasome pathway in cardiomyocytes. The deletion of USF2 results in mitochondrial dysfunction and exacerbates mitochondrial damage, ultimately promoting apoptosis. Mechanistically, we demonstrated that USF2 deficiency induces apoptosis in cells by modulating the AMPK/mTOR signaling pathway. In conclusion, this study provides new insights into the protective role of USF2 in hypoxic cardiomyocyte injury and indicates that USF2 could be a potential therapeutic target for myocardial hypoxia.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"302-312"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venous Pressure Cost for Cardiac Index Increases During Exercise in Patients with Fontan Circulation Versus Those with Biventricular Circulation.","authors":"Hiroyuki Takao, Koki Sugiyama, Takuro Kojima, Yoichi Iwamoto, Hirotaka Ishido, Satoshi Masutani","doi":"10.1536/ihj.24-490","DOIUrl":"10.1536/ihj.24-490","url":null,"abstract":"<p><p>Patients with Fontan circulation (Fontan) have a higher venous pressure (VP) and lower cardiac index (CI) than those with biventricular circulation (BiV). Although the cost to increase VP per unit CI (ΔVP/ΔCI) during exercise is expected to be higher in Fontan than in BiV, to our knowledge, no previous study has specifically tested ΔVP/ΔCI as the main variable.We included 9 patients with Fontan and 10 with postoperative BiV in this pilot study and assessed their hemodynamics via an ergometer-based exercise test. CI was continuously measured using impedance cardiography.The median age and quartile range values in patients with Fontan (15.0 [13.6, 16.7] years) were significantly higher than those in patients with BiV (12.9 [11.3, 14.3] years, P = 0.028). The ΔVP/ΔCI values were significantly higher in the Fontan group than in the BiV group at 25 W (4.5 [4.3, 6.0] versus 1.1 [0.9, 2.6] mmHg/ (L/minute/m²), respectively; P = 0.0008) and peak exercise (3.6 [33, 4.5] versus 1.1 [0.9, 1.5] mmHg/ (L/minute/m²), respectively; P = 0.0002) irrespective of age. The areas under the curve values of the 2 receiver operating curves (at 25 W and peak exercise time points) were 0.961 and 0.967, respectively. Patients with Fontan exhibited the 3 highest ΔVP/ΔCI values at peak exercise had an elevated New York Heart Association functional class (IIm-III) and hemodynamic concerns.Patients with Fontan displayed a higher cost to increase VP per unit CI. ΔVP/ΔCI may be a potential circulatory or prognostic marker for these patients and its value should be validated via larger prospective studies.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"271-278"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Significance of NT-proBNP in Patients with Low BNP Requiring Non-Surgical Intensive Care.","authors":"Riku Toguchi, Akihiro Shirakabe, Masato Matsushita, Shota Shighihara, Suguru Nishigoori, Tomofumi Sawatani, Kenichi Tani, Masaki Morooka, Shohei Kawakami, Yu Michiura, Nobuaki Kobayashi, Kuniya Asai","doi":"10.1536/ihj.24-702","DOIUrl":"https://doi.org/10.1536/ihj.24-702","url":null,"abstract":"<p><p>Serum N-terminal pro-brain-type natriuretic peptide (NT-proBNP) and brain-type natriuretic peptide (BNP) levels are rarely evaluated simultaneously in patients requiring intensive care.A total of 4,724 patients were screened, and 1,755 patients with BNP levels < 100 pg/mL were analyzed. Patients were divided into two groups, according to the median value of the NT-proBNP/BNP ratio (low-NT-proBNP/BNP group [Group L] versus high-NT-proBNP/BNP group [Group H]). A multivariate logistic regression model showed that the C-reactive protein levels (per 1-mg/dL increase) and serum creatinine levels (per 1-mg/dL increase) were independently associated with a high NT-proBNP/BNP ratio (odds ratio: 1.251, 95% confidence interval [95% CI]: 1.172-1.335 and odds ratio: 1.941, 95% CI: 1.468-2.567, respectively). The Kaplan-Meier curve analysis showed that the prognosis was significantly poorer in Group H than in Group L. Moreover, a multivariate Cox regression model revealed that a high NT-proBNP/BNP ratio was an independent predictor of 365-day mortality (hazard ratio: 1.468, 95% CI: 1.027-2.067). The same significant trend in prognostic impact was observed in the low-creatinine (< 0.83 mg/dL, n = 883), high-creatinine (≥ 0.83 ng/dL, n = 872), and high- C-reactive protein (≥ 0.16 mg/dL, n = 842) cohorts.A high NT-proBNP/BNP ratio was associated with a non-cardiac condition. Consequently, it was independently associated with adverse outcomes in patients requiring intensive care, even in those with a low BNP value on admission.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 3","pages":"385-395"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Prevalence of Thyroid Gland Dysfunction after Pulmonary Arterial Hypertension Treatment According to Real-World Data.","authors":"Noriaki Takama, Yohei Ishibashi, Batgerel Naidankhoo, Syunichiro Ishio, Fumitaka Murakami, Naoki Yuasa, Yukie Sano, Shiro Amanai, Hidemi Sorimachi, Toshimitsu Kato, Emi Ishida, Takashi Nagasaka, Masaru Obokata, Norimichi Koitabashi, Hideki Ishii","doi":"10.1536/ihj.24-698","DOIUrl":"https://doi.org/10.1536/ihj.24-698","url":null,"abstract":"<p><p>Continuous intravenous epoprostenol or treprostinil therapy is essential for the treatment of severe pulmonary arterial hypertension (PAH). However, it has several side effects, including thyroid gland dysfunction. This study aimed to estimate the prevalence rate of thyroid gland dysfunction.We enrolled 52 patients (9 males, 43 females) who were diagnosed with PAH at Gunma University Hospital. Treatment was selected according to disease severity. The characteristics of patients with thyroid gland dysfunction were also assessed. The mean age was 54 ± 21 years. Before PAH treatment initiation, right heart catheterization showed abnormal results (mean pulmonary arterial pressure: 43.4 ± 17.5 mmHg, cardiac index: 2.45 ± 0.97 L/minute/m², and pulmonary vascular resistance: 10.5 ± 8.0 Wood units). Regarding the initial treatment, 30 patients received oral epoprostenol, and 18 received continuous intravenous treprostinil. The overall prevalence rate of thyroid gland dysfunction was 15.4%, with a significantly higher rate in patients initiated with continuous intravenous epoprostenol therapy than in those receiving only oral agents (2.9% versus 38.9%, P = 0.0007).Patients receiving continuous intravenous epoprostenol therapy had a high prevalence rate of thyroid gland dysfunction. Thus, severe PAH should be treated with an understanding that thyroid gland dysfunction is an important side effect in patients with PAH.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 3","pages":"443-448"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute and Mid-Term Assessment of Microvascular Dysfunction with Index of Microcirculatory Resistance in ST-Segment Elevation Myocardial Infarction Patients.","authors":"Shojiro Hirano, Takayuki Yabe, Yosuke Oka, Hiroto Aikawa, Hideo Amano, Takanori Ikeda","doi":"10.1536/ihj.24-447","DOIUrl":"10.1536/ihj.24-447","url":null,"abstract":"<p><p>In patients diagnosed with ST-segment elevation myocardial infarction (STEMI), despite exhibiting normal patency in the culprit arteries following percutaneous coronary intervention (PCI), coronary microvessels do not recover adequately, leading to microvascular dysfunction (MVD). Limited data are available regarding microcirculation assessed through invasive measures during the midterm period. This study aimed to investigate the assessment of MVD in STEMI patients using the index of microvascular resistance (IMR) during the midterm period.We prospectively evaluated 41 patients with STEMI who underwent PCI. IMR was measured by placing a coronary pressure wire with intravenous adenosine at 1 week as the acute phase and at 6 months after primary PCI as the midterm period. An improvement in IMR was observed from baseline to follow-up, with values changing from 30.00 (15.00-45.50) to 19.00 (10.50-30.50) (P = 0.020). The degree of MVD significantly decreased during follow-up (from 61.0% to 34.1%, McNemar's test: P = 0.016). Compared to patients with normal microcirculation, those with MVD (IMR > 25) at midterm follow-up exhibited significantly elevated levels of brain natriuretic peptide (180.25 [68.25-370.65] pg/mL versus 75.90 [18.70-169.70] pg/mL, P = 0.043) and prolonged symptom-onset-to-balloon time (727.00 [213.50-1170.00] minutes versus 186.00 [125.00-316.00] minutes, P = 0.002).These findings indicate that the extent of MVD 6 months post-PCI has significantly diminished compared to discharge levels and is associated with symptom-onset-to-balloon time. Therefore, MVD in patients with STEMI can potentially improve in the midterm under specific circumstances.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"36-43"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Assessment of Skeletal Muscle Area Using Computed Tomography in Elderly Patients with Aortic Valve Stenosis Undergoing Transcatheter Aortic Valve Replacement.","authors":"Ryota Ando, Manabu Uematsu, Takamitsu Nakamura, Tsuyoshi Kobayashi, Toru Yoshizaki, Takeo Horikoshi, Miu Eguchi, Ryota Yamada, Yosuke Watanabe, Kenji Kuroki, Kazuto Nakamura, Akira Sato","doi":"10.1536/ihj.24-320","DOIUrl":"10.1536/ihj.24-320","url":null,"abstract":"<p><p>The psoas muscle area (PMA) and rectus femoris muscle area (RFMA) have been used to estimate whole-body muscle mass in elderly patients. However, it is unclear whether combining these measurements can improve the predictive ability of traditional risk factors for adverse clinical events in elderly patients with aortic valve stenosis (AVS). We analyzed data from 153 patients with AVS who underwent transcatheter aortic valve replacement (TAVR), and measured PMA and RFMA using computed tomography (CT) before the procedure. This study assessed a composite of adverse clinical events including all-cause death and heart failure (HF) requiring hospitalization for up to 3 years after TAVR. During the follow-up period, 31 patients experienced adverse clinical events (19 died, and 12 had HF). The multivariate Cox hazards analysis demonstrated that patients exhibiting lower PMA (males with < 3.36 cm²/m² and females with < 2.52 cm²) and lower RFMA (males with < 3.26 cm²/m² and females with < 3.15 cm²/m²) had a higher probability of experiencing adverse clinical events compared to those with higher PMA and RFMA values, whether in combination or alone (P < 0.05). Additionally, net reclassification improvement (NRI) and integrated discrimination improvement (IDI) analyses showed that the combination of lower PMA and RFMA had a greater incremental effect on the predictive value of clinical risk factors for adverse clinical events. Therefore, the combined measurement of skeletal muscles using CT scans may be a valuable tool for assessing the risk of AVS in elderly patients undergoing TAVR.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"51-59"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}