International heart journal最新文献

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Unrecognized Diversity in the Effects of Cardiac Rehabilitation by Age in Patients with Heart Failure.
IF 1.2 4区 医学
International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-742
Kohsaku Goto, Eisuke Amiya
{"title":"Unrecognized Diversity in the Effects of Cardiac Rehabilitation by Age in Patients with Heart Failure.","authors":"Kohsaku Goto, Eisuke Amiya","doi":"10.1536/ihj.24-742","DOIUrl":"https://doi.org/10.1536/ihj.24-742","url":null,"abstract":"","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"1-2"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of High Care Unit Management on In-Hospital Mortality in Patients with ST-Elevation Myocardial Infarction.
IF 1.2 4区 医学
International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-720
Takaaki Asano, Yorihiko Koeda, Takahito Nasu, Reisuke Yoshizawa, Yu Ishikawa, Tomonori Itoh, Yoshihiro Morino, Hidenori Saito, Hiroyuki Onodera, Tetsuji Nozaki, Yuko Maegawa, Osamu Nishiyama, Mahito Ozawa, Takuya Osaki, Akihiro Nakamura
{"title":"Impact of High Care Unit Management on In-Hospital Mortality in Patients with ST-Elevation Myocardial Infarction.","authors":"Takaaki Asano, Yorihiko Koeda, Takahito Nasu, Reisuke Yoshizawa, Yu Ishikawa, Tomonori Itoh, Yoshihiro Morino, Hidenori Saito, Hiroyuki Onodera, Tetsuji Nozaki, Yuko Maegawa, Osamu Nishiyama, Mahito Ozawa, Takuya Osaki, Akihiro Nakamura","doi":"10.1536/ihj.24-720","DOIUrl":"https://doi.org/10.1536/ihj.24-720","url":null,"abstract":"<p><p>The impact of HCU management on the short-term prognosis of STEMI patients undergoing primary percutaneous coronary intervention (PCI) remains unclear.We retrospectively assessed 694 STEMI patients who underwent primary PCI at 8 regional general hospitals in Iwate Prefecture from 2014-2018. The patients were categorized based on the hospital to which they were admitted with or without HCUs (353 versus 341 patients, from 3 versus 5 hospitals, respectively). There was no significant between-group difference for overall in-hospital mortality (7% versus 10%, P = 0.174). However, in the Killip Class II or higher, in-hospital mortality was significantly lower among patients admitted to the HCU (20% versus 44%, P < 0.001). After propensity score matching, we found that overall in-hospital mortality was significantly lower in patients admitted to HCUs (2% versus 8%, P = 0.008). Furthermore, mortality rates for patients requiring mechanical ventilation or circulatory support were significantly lower for patients admitted to HCUs, with mortality rates of 30% versus 50% (P = 0.037).Our findings suggest that in hospitals without CCUs, systemic management through HCUs may significantly improve the survival prognosis of STEMI patients with Killip classification of II or higher.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"226-233"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Cryoballoon Ablation in Paroxysmal Atrial Fibrillation Patient Post-Esophageal Cancer Surgery.
IF 1.2 4区 医学
International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-541
Yuji Miyoshi, Shota Tokuno, Yasuko Tanabe, Yuichiro Kawamura, Naoki Nakagawa
{"title":"Successful Cryoballoon Ablation in Paroxysmal Atrial Fibrillation Patient Post-Esophageal Cancer Surgery.","authors":"Yuji Miyoshi, Shota Tokuno, Yasuko Tanabe, Yuichiro Kawamura, Naoki Nakagawa","doi":"10.1536/ihj.24-541","DOIUrl":"https://doi.org/10.1536/ihj.24-541","url":null,"abstract":"<p><p>In conventional radiofrequency ablation for symptomatic paroxysmal atrial fibrillation, there are concerns regarding the risk of esophageal thermal injury (ETI), such as esophageal ulcers and left atrioesophageal fistulas. While the incidence of ETI is generally considered low with cryoballoon ablation, some cases of esophageal ulcers and gastric hypoperistalsis have been reported. In this report, we present the case of a 77-year-old male patient with atrial fibrillation after esophageal surgery who had successfully undergone cryoballoon ablation without esophageal complications, despite the close proximity of the left atrium and gastric tube. Cryoballoon ablation achieved pulmonary vein isolation without complications in the upper alimentary tract.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"183-186"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concomitant Mitral Valve Surgery in a Modified Morrow Procedure in Patients with Hypertrophic Obstructive Cardiomyopathy.
IF 1.2 4区 医学
International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-155
Chunshui Liang, Mingwen Li, Ruiyan Ma, Zhao Jian
{"title":"Concomitant Mitral Valve Surgery in a Modified Morrow Procedure in Patients with Hypertrophic Obstructive Cardiomyopathy.","authors":"Chunshui Liang, Mingwen Li, Ruiyan Ma, Zhao Jian","doi":"10.1536/ihj.24-155","DOIUrl":"https://doi.org/10.1536/ihj.24-155","url":null,"abstract":"<p><p>Ventricular septal myectomy (modified Morrow procedure) is the gold standard surgical intervention for hypertrophic obstructive cardiomyopathy (HOCM). However, the indications for a concomitant mitral valve (MV) procedure to relieve mitral regurgitation (MR) or intrinsic MV pathological changes remain controversial. We aimed to retrospectively analyze this series of patients to evaluate the safety and efficiency of the procedure at our center.We retrospectively reviewed a total of 56 consecutive patients with HOCM who underwent concomitant MV surgery with modified Morrow procedures at our center between January 2019 and December 2021. The baseline characteristics, perioperative data, and postoperative outcomes were examined.The operative mortality rate was 0% among all 56 patients. Two patients had complete atrioventricular block, two patients experienced renal failure, and one patient required reoperation for bleeding. The peak gradient of the left ventricular outflow tract decreased from 93.6 ± 34.4 mm Hg to 20.5 ± 13.0 mm Hg. MR was significantly relieved, and the systolic anterior motion of the MV resolved completely after concomitant MV surgery. During a mean follow-up of 13.8 ± 7.1 months, no patient required cardiac reoperation.Concomitant surgery of the MV during the modified Morrow procedure was performed safely and effectively in the treatment of most types of HOCM in our practice.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"252-256"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coronary Microvascular Dysfunction and Adverse Outcomes in the Spectrum of Dilated Cardiomyopathy.
IF 1.2 4区 医学
International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-744
Hisanori Kosuge, Masatake Kobayashi, Shoko Hachiya, Yasuhiro Fujita, Satoshi Hida, Kazuhiro Satomi
{"title":"Coronary Microvascular Dysfunction and Adverse Outcomes in the Spectrum of Dilated Cardiomyopathy.","authors":"Hisanori Kosuge, Masatake Kobayashi, Shoko Hachiya, Yasuhiro Fujita, Satoshi Hida, Kazuhiro Satomi","doi":"10.1536/ihj.24-744","DOIUrl":"https://doi.org/10.1536/ihj.24-744","url":null,"abstract":"<p><p>Hypokinetic non-dilated cardiomyopathy (HNDC), a preclinical state of dilated cardiomyopathy (DCM), is characterized by left ventricular (LV) dysfunction without LV dilatation. Although myocardial fibrosis and microvascular dysfunction in DCM are associated with LV remodeling and poor outcome, these characteristics concerning HNDC remain unclear. We compared DCM and HNDC with regard to their clinical characteristics and prognosis.We retrospectively enrolled 100 patients with DCM (n = 64) or HNDC (n = 36) who underwent cardiac magnetic resonance (CMR). DCM and HNDC were classified based on an LV end-diastolic diameter index (LVEDDI). The association of LVEDDI with the composite outcome of all-cause mortality, heart failure hospitalization, or ventricular arrhythmia occurrence was assessed. Phase-contrast cine imaging was performed in a subset of 17 patients (12 with DCM and 5 with HNDC) and 7 control subjects to assess coronary flow reserve (CFR).During the follow-up period (median: 22.0 months; interquartile range: 9.0-33.8 months), patients with DCM showed higher risk of the primary outcome than those with HNDC (P = 0.026). A higher LVEDDI was significantly associated with clinical outcomes even after adjusting for covariates (i.e., brain natriuretic peptide, the presence of late gadolinium enhancement, and LV ejection fraction; adjusted hazard ratio, 1.350; 95% confidence interval, 1.008-1.808; P = 0.044). CFR in HNDC was significantly higher than that in DCM (P < 0.05) and comparable to that in the control group.LV dilatation is an independent predictor of adverse events in DCM and HNDC.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"257-263"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aloperine Regulates Inflammation, Apoptosis, and Autophagy in H9C2 Rat Cardiomyoblast Cells After Excessive Hypoxia.
IF 1.2 4区 医学
International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-454
Feng Ju, Xianjie Zhang, Zhifu Zhao, Yuansheng Cao, An Xie, Leqiang Xia, Dan Zhou
{"title":"Aloperine Regulates Inflammation, Apoptosis, and Autophagy in H9C2 Rat Cardiomyoblast Cells After Excessive Hypoxia.","authors":"Feng Ju, Xianjie Zhang, Zhifu Zhao, Yuansheng Cao, An Xie, Leqiang Xia, Dan Zhou","doi":"10.1536/ihj.24-454","DOIUrl":"https://doi.org/10.1536/ihj.24-454","url":null,"abstract":"<p><p>Myocardial infarction (MI) is a cardiovascular condition that leads to increased morbidity and mortality, impacting the quality of life of individuals. Aloperine (ALO), derived from Sophora alopecuroides L, has been recognized for its beneficial effects in treating various diseases by showcasing therapeutic properties. However, the precise protective mechanisms of ALO on hypoxia/reoxygenation (H/R) -induced damage in cardiomyocytes in vitro remain unclear. In this study, it was manifested that cell proliferation was weakened after H/R treatment, but this impact was offset after ALO treatment. Furthermore, cell apoptosis was heightened after H/R treatment, but this phenomenon was neutralized after ALO treatment. ALO relieved inflammation in H/R-treated H9C2 rat cardiomyoblast cells. Moreover, ALO strengthened autophagy in H/R-triggered H9C2 rat cardiomyoblast cells through enhancing the LC3II/LC3I level and the LC3B fluorescence intensity. Lastly, it was testified that ALO can rescue the weakened autophagy, the heightened cell apoptosis, and the augmented inflammation after CC treatment in H/R-mediated H9C2 rat cardiomyoblast cells. In conclusion, ALO regulated inflammation, apoptosis, and autophagy through AMPK/Nrf2 pathway in H9C2 rat cardiomyoblast cells after excessive hypoxia. This study suggested that ALO may be an underlying drug for MI therapy.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"157-163"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reminiscence Therapy-Involved Care Program Alleviates Cognitive Impairment and Depression in Elderly Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention.
IF 1.2 4区 医学
International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-637
Taihua Zhou, Peilin Dong, Yaoyao Hu, Jia Wang, Mengjiao Hu, Xiaoxiao Chen, Yan Yang, Ping Zhu
{"title":"Reminiscence Therapy-Involved Care Program Alleviates Cognitive Impairment and Depression in Elderly Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention.","authors":"Taihua Zhou, Peilin Dong, Yaoyao Hu, Jia Wang, Mengjiao Hu, Xiaoxiao Chen, Yan Yang, Ping Zhu","doi":"10.1536/ihj.24-637","DOIUrl":"https://doi.org/10.1536/ihj.24-637","url":null,"abstract":"<p><p>Reminiscence therapy (RT) promotes cognitive and psychological health in elderly individuals. This study assessed the impact of the reminiscence therapy-involved care program (RTIC) on cognition, anxiety, depression, and satisfaction among patients with elderly acute coronary syndrome (ACS) who received percutaneous coronary intervention (PCI).In total, 152 elderly patients with ACS undergoing PCI were randomized into the RTIC (n = 76) and routine care (RC) (n = 76) groups to receive the corresponding 6-month interventions. The mini-mental state examination (MMSE) scores were evaluated at discharge (M0), 3rd month (M3), and 6th month (M6). The hospital anxiety and depression scale for anxiety/depression (HADS-A/HADS-D) and patient satisfaction scores were assessed at M0, 1st month (M1), M3, and M6.The MMSE score at M6 (27.6 ± 2.0 versus 26.7 ± 2.1, P = 0.011) increased, whereas the percentage of cognitive impairment at M6 (27.9% versus 44.8%, P = 0.042) declined in the RTIC group versus the RC group. Moreover, the RTIC group achieved a low HADS-D score at M3 (6.5 ± 2.0 versus 7.4 ± 2.6, P = 0.035) and M6 (6.3 ± 1.9 versus 7.2 ± 2.5, P = 0.016), but a similar HADS-A score and percentages of depression and anxiety at any assessment point versus the RC group. Patient satisfaction at M3 (82.3 ± 12.0 versus 77.7 ± 11.4, P = 0.020) and M6 (85.6 ± 11.0 versus 79.4 ± 12.0, P = 0.002) was higher in the RTIC group than in the RC group. In the subgroup analysis, patients with and without cognitive impairment at M0 and those with depression at M0 benefited from RTIC. RTIC promotes cognition, psychological health, and satisfaction among elderly patients with ACS undergoing PCI.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"293-301"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of Incident Coronary Artery Disease in Patients Undergoing Atrial Fibrillation Ablation.
IF 1.2 4区 医学
International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-676
Hiroyuki Ikeda, Kanae Hasegawa, Hiroyasu Uzui, Moe Mukai, Naoto Tama, Kentaro Ishida, Hiroshi Tada
{"title":"Characteristics of Incident Coronary Artery Disease in Patients Undergoing Atrial Fibrillation Ablation.","authors":"Hiroyuki Ikeda, Kanae Hasegawa, Hiroyasu Uzui, Moe Mukai, Naoto Tama, Kentaro Ishida, Hiroshi Tada","doi":"10.1536/ihj.24-676","DOIUrl":"https://doi.org/10.1536/ihj.24-676","url":null,"abstract":"<p><p>Few reports have provided detailed characteristics of incident coronary artery disease (CAD) and its risk factors in patients undergoing ablation (ABL) for atrial fibrillation (AF).Patients undergoing ablation for AF with no documented CAD were retrospectively studied at our institution. Patients were divided into 2 groups: those in whom significant stenosis was detected incidentally on coronary angiography (CAG) performed at the same time as ablation, and those without. The detection rate and its predictors were examined.Of the 550 patients, 20 had incidental CAD (detection rate: 3.6%). We compared the clinical data between these 20 patients (ABL-CAD group) and the 530 patients who displayed no significant stenosis on CAG. In multivariate analysis, age, hemoglobin A1c (HbA1c), and high-density lipoprotein cholesterol (HDL-chol) were predictive factors (odds ratio: 1.08, 2.43, 1.58, 95% CIs: 1.01-1.14, 1.53-3.86, 0.92-0.99; P = 0.014, 0.004, 0.024, respectively) for identification of CAD. Multivariate analysis based on cut-off values from receiver operating characteristic analysis identified age, HbA1c ≥ 6.1%, and HDL-chol ≤ 49 mg/dL as predictors (odds ratios: 1.06, 4.04, 3.07; 95% CIs: 1.00-1.12, 1.58-10.3, 1.1-8.01; P = 0.04, 0.01, 0.021, respectively). The area under the curve was significantly greater for age and HbA1c ≥ 6.1% and HDL-chol ≤ 49 mg/dL than for age alone (0.810 versus 0.672; P = 0.005).Patients undergoing ablation for AF appear likely to have CAD if HbA1c is ≥ 6.1% and HDL-chol is ≤ 49 mg/dL.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"220-225"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myocardial Infarction Associated with a Giant Hiatal Hernia. 巨大食管裂孔疝引发心肌梗死
IF 1.2 4区 医学
International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-500
Satoshi Nakawatase, Yasuhiro Ichibori, Naoki Mori, Yoshiharu Higuchi
{"title":"Myocardial Infarction Associated with a Giant Hiatal Hernia.","authors":"Satoshi Nakawatase, Yasuhiro Ichibori, Naoki Mori, Yoshiharu Higuchi","doi":"10.1536/ihj.24-500","DOIUrl":"https://doi.org/10.1536/ihj.24-500","url":null,"abstract":"<p><p>An 81-year-old woman was admitted to our hospital due to dyspnea on exertion, attributed to severe aortic stenosis, and was scheduled for transcatheter aortic valve implantation (TAVI). The day before the procedure, she experienced chest pain radiating to the left shoulder after consuming a hospital meal that was large compared to her usual meal size. An electrocardiogram (ECG) in the supine position showed ST-segment elevation in leads II, III, aVF, and reciprocal ST-segment depression in leads V1-V4. Interestingly, these changes resolved when she was in the sitting position. Chest computed tomography (CT) revealed a giant hiatal hernia slipping under the heart, with no other abnormal findings. During the TAVI procedure, the supine position again triggered chest symptoms, and subsequent coronary angiography demonstrated disruption of the left circumflex coronary artery (LCx) in the middle portion. Following drainage of the gastric contents, the coronary flow in the LCx improved to normal levels. Cardiac enzymes, including CK-MB, were elevated after TAVI. These findings suggest that the giant hiatal hernia directly compressed the coronary artery, leading to LCx flow disturbance and myocardial infarction. This case report highlights that a hiatal hernia is a common condition in the elderly and can be a potential cause of ischemic heart disease. It underscores the importance of recognizing that the cardiac effects of a hiatal hernia can vary significantly depending on the morphology of the hernia and the position of the patient.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"323-326"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Factors After Bone Marrow-Derived Mononuclear Cell Implantation in No-Option Chronic Limb-Threatening Ischemia Patients with Atherosclerotic Lower Extremity Artery Disease.
IF 1.2 4区 医学
International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-440
Hirofumi Kawamata, Kenji Yanishi, Jun Yoshimura, Takaaki Ozawa, Daiki Goto, Yusuke Hori, Ayumu Fujioka, Keisuke Shoji, Arito Yukawa, Satoaki Matoba
{"title":"Prognostic Factors After Bone Marrow-Derived Mononuclear Cell Implantation in No-Option Chronic Limb-Threatening Ischemia Patients with Atherosclerotic Lower Extremity Artery Disease.","authors":"Hirofumi Kawamata, Kenji Yanishi, Jun Yoshimura, Takaaki Ozawa, Daiki Goto, Yusuke Hori, Ayumu Fujioka, Keisuke Shoji, Arito Yukawa, Satoaki Matoba","doi":"10.1536/ihj.24-440","DOIUrl":"https://doi.org/10.1536/ihj.24-440","url":null,"abstract":"<p><p>Previous studies have reported the efficacy and safety of therapeutic angiogenesis through bone marrow-derived mononuclear cell (BM-MNC) implantation in patients with no-option chronic limb-threatening ischemia (CLTI) from atherosclerotic lower extremity artery disease (LEAD). However, uncertain clinical prognostic factors impact treatment outcomes. This study aimed to elucidate the long-term outcomes of patients with atherosclerotic LEAD-derived no-option CLTI after BM-MNC implantation and to identify prognostic factors.In this retrospective, single-center, observational study, the primary endpoints included the long-term prognosis of BM-MNC implantation and factors influencing 1-year outcomes. A total of 92 limbs in 84 patients were analyzed in the final cohort (mean age: 67 years; male, 65%). The 5- and 10-year overall survival rates were 50.0% and 31.0%, respectively, while the 5- and 10-year amputation-free survival rates were 37.6% and 23.3%, respectively. Multivariate logistic analysis linked all-cause mortality to age ≥ 70 years, hemodialysis, smoking, and a controlling nutrition status score ≥ 5. Major amputation or mortality was associated with male sex, hemodialysis, and C-reactive protein levels ≥ 3.0 mg/dL. No adverse events were associated with therapeutic angiogenesis.These findings endorse the feasibility and safety of BM-MNC implantation for patients with no-option CLTI due to atherosclerotic LEAD. Moreover, the study highlights the significance of several prognostic factors, including advanced age, hemodialysis, smoking, and inflammatory markers, in influencing the long-term outcomes of this treatment.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"96-105"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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