International heart journal最新文献

An Interesting Cause of Cardiogenic Syncope Derived by Neck Mass. 由颈部肿块引起的心源性晕厥的有趣原因。

IF 1.3 4区医学

International heart journal Pub Date : 2025-09-30 Epub Date: 2025-09-11 DOI: 10.1536/ihj.25-286

Shitong Su, Lianjing Liang, Wei Wei

引用次数: 0

Esaxerenone Attenuates Atherogenesis and Vascular Dysfunction in Apolipoprotein E-Deficient Mice. esaxenone减轻载脂蛋白e缺乏小鼠的动脉粥样硬化和血管功能障碍。

IF 1.3 4区医学

International heart journal Pub Date : 2025-09-30 Epub Date: 2025-09-11 DOI: 10.1536/ihj.25-051

Juri Maeda, Uugantsetseg Munkhjargal, Tomoya Hara, Oyunbileg Bavuu, Daiju Fukuda, Masataka Sata

{"title":"Esaxerenone Attenuates Atherogenesis and Vascular Dysfunction in Apolipoprotein E-Deficient Mice.","authors":"Juri Maeda, Uugantsetseg Munkhjargal, Tomoya Hara, Oyunbileg Bavuu, Daiju Fukuda, Masataka Sata","doi":"10.1536/ihj.25-051","DOIUrl":"10.1536/ihj.25-051","url":null,"abstract":"The pharmacological blockade of mineralocorticoid receptors (MR) is a potential therapeutic approach to reduce cardiovascular complications. Recent studies suggest that MR blockers affect several extrarenal tissues, including vascular function. We investigated the effects of a novel non-steroidal selective MR blocker, esaxerenone, on vascular function and atherogenesis.Esaxerenone (3 mg/kg/day) was orally administered for 20 weeks or vehicle for 8 weeks to apolipoprotein E-deficient (ApoE-/-) mice fed a Western-type diet to investigate the effects on atherogenesis or vascular dysfunction. Human umbilical vein endothelial cells (HUVEC) were used to perform in vitro experiments.Administration of esaxerenone for 20 weeks suppressed the development of atherosclerotic plaques in the aortic arch compared with the vehicle group (P < 0.001) without alteration of blood pressure. In addition, esaxerenone significantly reduced the expression of intercellular cell adhesion molecule-1, macrophage infiltration, and lipid deposition as determined by immunohistochemical analysis. Moreover, phosphorylation of eNOSSer1177 and Akt were increased in the aorta of esaxerenone-treated mice. Administration of esaxerenone for 8 weeks attenuated Western-type diet-induced endothelial dysfunction, accompanied by a decrease in expression of ICAM-1 and phosphorylation of JNK in the descending aorta. In an ex vivo vascular reactivity assay using ApoE-/- aortic rings, esaxerenone diminished aldosterone-induced endothelial dysfunction. In an in vitro experiment, aldosterone decreased the phosphorylation of eNOSSer1177 and increased the phosphorylation of eNOSThr495 in a dose-dependent manner, which were attenuated by esaxerenone in HUVECs.Esaxerenone ameliorated hyperlipidemia-induced atherosclerotic plaque progression and vascular dysfunction in ApoE-/- mice, suggesting that esaxerenone is a promising therapeutic approach for cardiovascular complications.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"895-903"},"PeriodicalIF":1.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory Stability Time Transition in Acute Decompensated Heart Failure with Reduced Left Ventricular Ejection Fraction. 急性失代偿性心力衰竭伴左室射血分数降低的呼吸稳定时间过渡。

IF 1.3 4区医学

International heart journal Pub Date : 2025-09-30 Epub Date: 2025-09-11 DOI: 10.1536/ihj.25-214

Makiko Nakamura, Teruhiko Imamura, Kousuke Akao, Masaki Nakagaito, Koichiro Kinugawa

引用次数: 0

Revisiting the Relationship between Homocysteine, Vitamin B12, Folate, and Aortic Diseases. 重访同型半胱氨酸、维生素B12、叶酸与主动脉疾病之间的关系。

IF 1.3 4区医学

International heart journal Pub Date : 2025-09-30 Epub Date: 2025-09-11 DOI: 10.1536/ihj.24-603

Qianlei Lang, Yu Liu, Hongwei Zhang, Peng Yang, Wenfan Li, Yi Xie, Wei Meng, Jia Hu

{"title":"Revisiting the Relationship between Homocysteine, Vitamin B12, Folate, and Aortic Diseases.","authors":"Qianlei Lang, Yu Liu, Hongwei Zhang, Peng Yang, Wenfan Li, Yi Xie, Wei Meng, Jia Hu","doi":"10.1536/ihj.24-603","DOIUrl":"10.1536/ihj.24-603","url":null,"abstract":"Although several observational studies have suggested an association between plasma homocysteine (Hcy), vitamin B12, and folate levels and aortic diseases, including aortic dissection (AD), thoracic aortic aneurysm (TAA), and abdominal aortic aneurysm (AAA), the causality remains unclear. The aortic diameter was also included in the analysis. Therefore, this study employed Mendelian randomization (MR) analysis to investigate the effects of plasma Hcy, vitamin B12, and folate levels on aortic diseases. Single-nucleotide polymorphisms (SNPs) associated with Hcy, vitamin B12, and folate were obtained from reliable genome-wide association studies. Data for AD, TAA, and AAA were obtained from the Finnish database. We conducted a two-sample MR analysis using the following methods: inverse variance weighted, weighted median, MR-Egger, simple mode, weighted mode, and Bayesian weighted MR. Heterogeneity and pleiotropy were assessed using the Cochran's Q test and the MR-Egger test, respectively. In addition, leave-one-out and Steiger filtering analyses were performed to test the stability of MR findings. Our MR results demonstrated no significant causal association between Hcy, vitamin B12, and folate levels and aortic diseases or aortic diameter (P > 0.05). The Cochran's Q test and MR-Egger test indicated no heterogeneity or pleiotropy (P > 0.05). The leave-one-out and Steiger filtering analyses confirmed the robustness of the MR results. The MR analysis underscored that no direct genetic predisposition promotes elevated Hcy and decreased vitamin B12 or folate levels in the development of aortic diseases. This study found that plasma Hcy, vitamin B12, and folate levels had no effect on aortic diseases or aortic diameter. Therefore, vitamin B12 or folate supplementation to lower Hcy levels may not be effective in preventing aortic diseases.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"841-851"},"PeriodicalIF":1.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequent Gas Leak Alarms Preceding Intra-Aortic Balloon Pump Rupture and Thrombosis Associated with a Calcified Aortic Wall. 主动脉内球囊泵破裂和动脉壁钙化相关血栓形成前的频繁气体泄漏警报。

IF 1.3 4区医学

International heart journal Pub Date : 2025-09-30 Epub Date: 2025-09-11 DOI: 10.1536/ihj.25-334

Ran Sumida, Riku Arai, Yasuo Okumura

引用次数: 0

Sirtuin-3 Regulates the Mechanism of Doxorubicin-induced Cardiotoxicity. Sirtuin-3调控阿霉素诱导的心脏毒性机制

IF 1.3 4区医学

International heart journal Pub Date : 2025-07-31 Epub Date: 2025-07-09 DOI: 10.1536/ihj.24-546

Cheng Zhang, Dan Shi, Ping Yang

引用次数: 0

Nicotine Induces Fetal Cardiac Dysfunction by Promoting Cardiomyocyte Apoptosis Through Regulating the KCTD10-Notch Signaling. 尼古丁通过调节KCTD10-Notch信号通路促进心肌细胞凋亡诱导胎儿心功能障碍。

IF 1.3 4区医学

International heart journal Pub Date : 2025-07-31 Epub Date: 2025-07-09 DOI: 10.1536/ihj.24-427

Lilin Zhong, Xiaoqing Yang, Huifen Zhang, Meijiao Fu, Jianxing Cai, Wanting Huang, Ying Huang

{"title":"Nicotine Induces Fetal Cardiac Dysfunction by Promoting Cardiomyocyte Apoptosis Through Regulating the KCTD10-Notch Signaling.","authors":"Lilin Zhong, Xiaoqing Yang, Huifen Zhang, Meijiao Fu, Jianxing Cai, Wanting Huang, Ying Huang","doi":"10.1536/ihj.24-427","DOIUrl":"10.1536/ihj.24-427","url":null,"abstract":"Congenital heart defects (CHD) are internal risk factors that cause cardiac dysfunction. Maternal smoking is a cause of inducing CHD and cardiac dysfunction. Here, we aimed to investigate the influence of nicotine on fetal cardiac dysfunction and the underlying mechanism in mice. After maternal nicotine exposure (MNE), the female mice became pregnant, and the successful pregnancy rate was calculated. Fetal weight, cardiac function, and placental weight were measured at embryonic day 18.5. For in vitro experiments, primary cardiomyocytes were isolated. Cell apoptosis and inflammation were analyzed using flow cytometry and enzyme-linked immunosorbent assay. The molecular mechanism was evaluated using molecular docking, quantitative real-time PCR, and western blotting. The results showed that MNE reduced the fetal weight, cardiac function, and maternal pregnancy rate in vivo. Nicotine promotes apoptosis and inflammation of cardiomyocytes in vitro. Moreover, nicotine decreased KCTD10 expression and activated the Notch pathway. Inactivation of the Notch pathway using DAPT reversed the effects of nicotine on cardiomyocyte injury and MNE on fetal cardiac dysfunction. In conclusion, nicotine may promote fetal cardiac dysfunction by facilitating cardiomyocyte apoptosis through the KCTD10-Notch pathway.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"651-659"},"PeriodicalIF":1.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Causal Relationship Between Atrial Fibrillation and Work and Sleep. 心房颤动与工作和睡眠的因果关系。

IF 1.3 4区医学

International heart journal Pub Date : 2025-07-31 Epub Date: 2025-07-09 DOI: 10.1536/ihj.24-660

Xuejiao Wu, Fang Liu, Le Jin, Minqi Huo, Jun Chen, Ruirui Song, Xiaojing Shi, Hongmei Gao

{"title":"The Causal Relationship Between Atrial Fibrillation and Work and Sleep.","authors":"Xuejiao Wu, Fang Liu, Le Jin, Minqi Huo, Jun Chen, Ruirui Song, Xiaojing Shi, Hongmei Gao","doi":"10.1536/ihj.24-660","DOIUrl":"10.1536/ihj.24-660","url":null,"abstract":"Atrial fibrillation (AF) is a common arrhythmia that can reduce the quality of life of patients. Observational studies have reported that work and sleep are associated with the development of AF, but the causal relationship is unclear.Based on published genome-wide association studies (GWASs), we conducted a two-sample Mendelian Randomization (MR) analysis employing inverse variance weighted (IVW), weighted median, and MR-Egger regression analyses. We chose statistical data of 3 work factors from the MRC-IEU GWAS pipeline and 2 sleep factors from the Sleep Disorders Knowledge Portal as the exposure and the FinnGen study of AF as the outcome.The study revealed that engaging in heavy physical work was associated with an increased risk of AF (IVW OR, 1.787; 95% CI, 1.082-2.853; P = 0.023), and job satisfaction was negatively correlated with AF risk (IVW OR, 0.719; 95% CI, 0.536-0.964; P = 0.028). In addition, jobs that primarily involved walking or standing, short sleep duration (< 7 hours), and long sleep duration (≥ 9 hours) were not associated with AF. The results of the sensitivity analysis are consistent with these trends.The results support a causal relationship between heavy physical labor and increased risk of AF, and that job satisfaction has some protective effect on AF.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"555-561"},"PeriodicalIF":1.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Fatal Case of Immune Checkpoint Inhibitor-Associated Myocarditis with Severe Right Ventricular Failure. 免疫检查点抑制剂相关性心肌炎合并严重右心室衰竭1例死亡

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-701

Takuro Imaoka, Kimi Sato, Shingo Sakashita, Yuma Shibutani, Atsuko Suzuki, Daisuke Kotani, Kohei Shitara, Kazuko Tajiri

引用次数: 0

Clinical Findings after Two Years of Rheocarna^® Use. Rheocarna®使用两年后的临床结果。

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.25-063

Akinori Satake, Takahiro Tokuda, Hirofumi Ohashi, Tetsuya Amano

引用次数: 0