International heart journal最新文献

Sirtuin-3 Regulates the Mechanism of Doxorubicin-induced Cardiotoxicity. Sirtuin-3调控阿霉素诱导的心脏毒性机制

IF 1.2 4区医学

International heart journal Pub Date : 2025-07-09 DOI: 10.1536/ihj.24-546

Cheng Zhang, Dan Shi, Ping Yang

引用次数: 0

Nicotine Induces Fetal Cardiac Dysfunction by Promoting Cardiomyocyte Apoptosis Through Regulating the KCTD10-Notch Signaling. 尼古丁通过调节KCTD10-Notch信号通路促进心肌细胞凋亡诱导胎儿心功能障碍。

IF 1.2 4区医学

International heart journal Pub Date : 2025-07-09 DOI: 10.1536/ihj.24-427

Lilin Zhong, Xiaoqing Yang, Huifen Zhang, Meijiao Fu, Jianxing Cai, Wanting Huang, Ying Huang

{"title":"Nicotine Induces Fetal Cardiac Dysfunction by Promoting Cardiomyocyte Apoptosis Through Regulating the KCTD10-Notch Signaling.","authors":"Lilin Zhong, Xiaoqing Yang, Huifen Zhang, Meijiao Fu, Jianxing Cai, Wanting Huang, Ying Huang","doi":"10.1536/ihj.24-427","DOIUrl":"https://doi.org/10.1536/ihj.24-427","url":null,"abstract":"Congenital heart defects (CHD) are internal risk factors that cause cardiac dysfunction. Maternal smoking is a cause of inducing CHD and cardiac dysfunction. Here, we aimed to investigate the influence of nicotine on fetal cardiac dysfunction and the underlying mechanism in mice. After maternal nicotine exposure (MNE), the female mice became pregnant, and the successful pregnancy rate was calculated. Fetal weight, cardiac function, and placental weight were measured at embryonic day 18.5. For in vitro experiments, primary cardiomyocytes were isolated. Cell apoptosis and inflammation were analyzed using flow cytometry and enzyme-linked immunosorbent assay. The molecular mechanism was evaluated using molecular docking, quantitative real-time PCR, and western blotting. The results showed that MNE reduced the fetal weight, cardiac function, and maternal pregnancy rate in vivo. Nicotine promotes apoptosis and inflammation of cardiomyocytes in vitro. Moreover, nicotine decreased KCTD10 expression and activated the Notch pathway. Inactivation of the Notch pathway using DAPT reversed the effects of nicotine on cardiomyocyte injury and MNE on fetal cardiac dysfunction. In conclusion, nicotine may promote fetal cardiac dysfunction by facilitating cardiomyocyte apoptosis through the KCTD10-Notch pathway.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Causal Relationship Between Atrial Fibrillation and Work and Sleep. 心房颤动与工作和睡眠的因果关系。

IF 1.2 4区医学

International heart journal Pub Date : 2025-07-09 DOI: 10.1536/ihj.24-660

Xuejiao Wu, Fang Liu, Le Jin, Minqi Huo, Jun Chen, Ruirui Song, Xiaojing Shi, Hongmei Gao

{"title":"The Causal Relationship Between Atrial Fibrillation and Work and Sleep.","authors":"Xuejiao Wu, Fang Liu, Le Jin, Minqi Huo, Jun Chen, Ruirui Song, Xiaojing Shi, Hongmei Gao","doi":"10.1536/ihj.24-660","DOIUrl":"https://doi.org/10.1536/ihj.24-660","url":null,"abstract":"Atrial fibrillation (AF) is a common arrhythmia that can reduce the quality of life of patients. Observational studies have reported that work and sleep are associated with the development of AF, but the causal relationship is unclear.Based on published genome-wide association studies (GWASs), we conducted a two-sample Mendelian Randomization (MR) analysis employing inverse variance weighted (IVW), weighted median, and MR-Egger regression analyses. We chose statistical data of 3 work factors from the MRC-IEU GWAS pipeline and 2 sleep factors from the Sleep Disorders Knowledge Portal as the exposure and the FinnGen study of AF as the outcome.The study revealed that engaging in heavy physical work was associated with an increased risk of AF (IVW OR, 1.787; 95% CI, 1.082-2.853; P = 0.023), and job satisfaction was negatively correlated with AF risk (IVW OR, 0.719; 95% CI, 0.536-0.964; P = 0.028). In addition, jobs that primarily involved walking or standing, short sleep duration (< 7 hours), and long sleep duration (≥ 9 hours) were not associated with AF. The results of the sensitivity analysis are consistent with these trends.The results support a causal relationship between heavy physical labor and increased risk of AF, and that job satisfaction has some protective effect on AF.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Fatal Case of Immune Checkpoint Inhibitor-Associated Myocarditis with Severe Right Ventricular Failure. 免疫检查点抑制剂相关性心肌炎合并严重右心室衰竭1例死亡

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-701

Takuro Imaoka, Kimi Sato, Shingo Sakashita, Yuma Shibutani, Atsuko Suzuki, Daisuke Kotani, Kohei Shitara, Kazuko Tajiri

引用次数: 0

Clinical Findings after Two Years of Rheocarna^® Use. Rheocarna®使用两年后的临床结果。

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.25-063

Akinori Satake, Takahiro Tokuda, Hirofumi Ohashi, Tetsuya Amano

引用次数: 0

Vasospastic Angina as a Cause of Post-Acute Sequelae of COVID-19. 血管痉挛性心绞痛是COVID-19急性后后遗症的一个原因。

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-795

Tadao Aikawa, Jiro Ogino, Naohiro Funayama, Noriko Oyama-Manabe, Tohru Minamino

引用次数: 0

Clinical Outcomes of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve. 冠状动脉ct血管造影衍生的血流储备分数的临床结果。

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-534

Kota Komiyama, Kengo Tanabe, Eiji Taguchi, Tomohiro Sakamoto, Rine Nakanishi, Ryo Okubo, Akira Saito, Taku Asano, Akihiro Ikuta, Kazushige Kadota, Yui O Nozaki, Shinichiro Fujimoto

{"title":"Clinical Outcomes of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve.","authors":"Kota Komiyama, Kengo Tanabe, Eiji Taguchi, Tomohiro Sakamoto, Rine Nakanishi, Ryo Okubo, Akira Saito, Taku Asano, Akihiro Ikuta, Kazushige Kadota, Yui O Nozaki, Shinichiro Fujimoto","doi":"10.1536/ihj.24-534","DOIUrl":"10.1536/ihj.24-534","url":null,"abstract":"Coronary computed tomography angiography-derived fractional flow reserve (FFRCT) is useful for noninvasively detecting coronary artery disease. This procedure has been covered by health insurance reimbursement in the United Kingdom, the United States of America, and Japan. This is the first study to investigate the 1-year outcomes of the FFRCT, with management covered by health insurance from the DiscoverY of Novel Assessment Myocardial IsChemia by FFRCT (DYNAMIC-FFRCT) registry.In this multicenter DYNAMIC-FFRCT registry, 410 participants who underwent FFRCT analysis under health insurance reimbursement were prospectively enrolled at six Japanese sites between October 2019 and November 2021. In accordance with recent guidelines, all participants received appropriate revascularization and/or optimal medication therapy after FFRCT. The following clinical outcomes through the 1-year defined major adverse cardiovascular event (MACE) were investigated: all-cause death, cardiovascular events including non-fatal myocardial infarction, and unplanned hospitalization for acute coronary syndrome leading to revascularization.Of the six MACE cases, four (1.6%) occurred in participants with an FFRCT value ≤ 0.80, whereas two (1.3%) occurred in a participant with an FFRCT value > 0.80.This analytical study based on the DYNAMIC-FFRCT registry for cardiovascular conditions found no significant difference in 1-year MACE between FFRCT≤ 0.80 and > 0.80 following guideline-based therapy. The registry was started shortly after reimbursement and had limited statistical power and selection bias. Further studies with sufficient statistical power are required.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"337-344"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility and Limitations of Genetic Testing in the Routine Care of Cardiovascular Disease Patients in a General Hospital. 基因检测在某综合医院心血管疾病患者常规护理中的应用与局限性

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-667

Daiki Tomidokoro, Kotaro Mori, Masaya Yamamoto, Masato Isono, Kozue Takano, Atsuko Okazaki, Reiko Arakawa, Fumihiko Takeuchi, Hisao Hara, Yukio Hiroi, Norihiro Kato

{"title":"Utility and Limitations of Genetic Testing in the Routine Care of Cardiovascular Disease Patients in a General Hospital.","authors":"Daiki Tomidokoro, Kotaro Mori, Masaya Yamamoto, Masato Isono, Kozue Takano, Atsuko Okazaki, Reiko Arakawa, Fumihiko Takeuchi, Hisao Hara, Yukio Hiroi, Norihiro Kato","doi":"10.1536/ihj.24-667","DOIUrl":"10.1536/ihj.24-667","url":null,"abstract":"Genetic diagnosis is becoming more prevalent in the routine care of cardiovascular disease (CVD) but is still limited to specialized institutions. Therefore, general cardiologists are also expected to acquire fundamental knowledge for incorporating genomics into the clinical practice of inherited to multifactorial CVDs. To accomplish this, the present study evaluated the utility and limitations of genetic testing in a general hospital setting.We examined 2 clinical issues: 1) the diagnostic potential of genetic tests for known inherited CVDs across 4 disease entities, i.e., familial hypercholesterolemia (FH), hypertrophic cardiomyopathy (HCM), suspected lethal arrhythmia, and aortic aneurysm/dissection (total n = 84) and 2) the genetic components associated with 2 multifactorial pathologies, cardiac hypertrophy and atrial fibrillation (AF), through a case-control study (total n = 594). We first performed targeted gene panel tests or whole-exome sequencing to identify causative gene variants for inherited CVDs; this yielded a positive test rate of 14 to 40%. The diagnosis rate for FH increased to 70% if strict eligibility criteria were adopted. The diagnosis rate for HCM also markedly increased by modifying the interpretation criteria for genetic variant pathogenicity. Furthermore, we performed gene-based burden tests and polygenic risk score (PRS) calculations for cardiac hypertrophy and AF. For example, the PRS-based genetic risk was significantly increased in early-onset (≤ 60 years) AF compared to non-AF controls (per-SD odds ratio in standardized PRS: 1.83, P = 2.6 × 10-4).Genetic tests for CVDs may complement the diagnosis based on traditional laboratory-based diagnostics, although the currently limited capabilities of variant interpretation necessitate careful attention.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"375-384"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decrease in Caveolae-Gαq Interaction Mediates Pressure Overload-Induced Cardiac Remodeling in Rats. 小泡- g - αq相互作用减少介导压力过载诱导的大鼠心脏重构。

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-734

Lijin Wang, Lu Yang, Fang Wu, Henglin Wang

{"title":"Decrease in Caveolae-Gαq Interaction Mediates Pressure Overload-Induced Cardiac Remodeling in Rats.","authors":"Lijin Wang, Lu Yang, Fang Wu, Henglin Wang","doi":"10.1536/ihj.24-734","DOIUrl":"10.1536/ihj.24-734","url":null,"abstract":"Despite its significant clinical implications, pressure overload-induced cardiac remodeling is poorly understood. This study aimed to investigate the role of Caveolae-Gαq interaction in the pathophysiology of pressure overload-induced cardiac remodeling. We used the abdominal aortic constriction (AAC) rat model and the angiotensin II-treated cell model to simulate pressure overload-induced cardiac remodeling. Histological changes were assessed using hematoxylin-eosin staining, immunofluorescence staining, and transmission electron microscopy. The expression, colocalization, and calcium response of the Caveolae-Gαq-PLCβ3 signaling pathway were evaluated using western blotting, quantitative real-time PCR, immunofluorescence staining, and calcium green labeling. We found AAC decreased Caveolin-3 expression but increased Gαq and PLCβ3 expressions. Similar trends in mRNA expression levels were observed. The caveolae's ultrastructure was deformed at 4 and 12 weeks after AAC surgery. AAC and angiotensin II treatments reduced Caveolin-3 and Gαq colocalization while increasing Gαq and PLCβ3 colocalization, and prolonging intracellular calcium response after Gαq activation. In conclusion, pressure overload-induced cardiac remodeling involves caveolar deformation and decreased Caveolae-Gαq interactions, which result in enhanced expression and functionality of Gαq-PLCβ3 signaling. These findings highlight the mechanistic importance of Caveolae-Gαq interactions in cardiac hypertrophy under pressure overload conditions.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"485-496"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-World Data on Post-Discharge Prognosis of Elderly and Frail Hospitalized Patients with Heart Failure Reflecting the Latest Guideline-Directed Medical Therapy in Japan. 老年和体弱心力衰竭住院患者出院后预后的真实世界数据反映了日本最新的指导医学治疗

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-752

Susumu Odajima, Keisuke Fujimoto, Akihiro Kadoi, Takafumi Tsuboi, Yoshinori Nagasawa, Kiyohiro Hyogo, Kenzo Uzu, Yoko Fukuoka, Yasushi Shimokawa, Hideaki Okubo, Kazuo Mizutani, Hiroki Shimizu

{"title":"Real-World Data on Post-Discharge Prognosis of Elderly and Frail Hospitalized Patients with Heart Failure Reflecting the Latest Guideline-Directed Medical Therapy in Japan.","authors":"Susumu Odajima, Keisuke Fujimoto, Akihiro Kadoi, Takafumi Tsuboi, Yoshinori Nagasawa, Kiyohiro Hyogo, Kenzo Uzu, Yoko Fukuoka, Yasushi Shimokawa, Hideaki Okubo, Kazuo Mizutani, Hiroki Shimizu","doi":"10.1536/ihj.24-752","DOIUrl":"10.1536/ihj.24-752","url":null,"abstract":"The West Tokyo Heart Failure (WET-HF) registry has recently reported that the post-discharge prognosis for hospitalized patients with heart failure (HF) between 2011 and 2021 has been improving over time and that there has been an upward trend in the use of guideline-directed medical therapy (GDMT). However, there are few post-discharge prognostic data for elderly and frail hospitalized patients with HF. A total of 738 consecutive patients with HF hospitalized at the Konan Medical Center between April 2020 and March 2024 were retrospectively studied. The primary endpoint was cardiovascular death or HF hospitalization. The mean age and clinical frailty scale were 83.4 ± 11.0 years and 4.8 ± 2.3, respectively. The average prescription rates of GDMT at discharge over the 4-year period were 71.0% for beta-blockers, 23.4% for angiotensin-converting enzyme inhibitors (ACE-I) or angiotensin receptor blockers (ARB), 42.7% for angiotensin receptor neprilysin inhibitor (ARNI), 56.1% for mineralocorticoid receptor antagonists (MRA), and 23.2% for sodium-glucose cotransporter 2 (SGLT2) inhibitors. Although, there has been an upward trend in the use of GDMT, the Kaplan-Meier curve showed no improvement in prognosis over time. Multivariate analyses showed that none of the beta-blockers, ACE-I, ARB, ARNI, MRA, or SGLT2-inhibitors at discharge reduced the primary endpoint for hospitalized patients with HF. GDMT alone may not be sufficient to improve the prognosis of elderly and frail hospitalized patients with HF. In addition to GDMT, comprehensive management by a multidisciplinary team may be vital, since currently there seems to be no one-size-fits-all approach for these patients.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"404-412"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0