International heart journal最新文献_第2页

A Case of Sudden Death from Takayasu Arteritis with Severe Stenosis Localized at the Origin of a Coronary Artery. 高须动脉炎并发冠状动脉起源处严重狭窄致猝死1例。

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-428

Satoshi Masutani, Seigo Korematsu, Kei Takahashi, Tomomi Shimizu, Keisuke Sawada, Morihiro Higashi, Aya Takada, Kazuyuki Saito, Keiko Mizuta, Koichi Moriwaki, Yoichi Iwamoto, Hirotaka Ishido

引用次数: 0

Remimazolam Inhibits Pyroptosis after Myocardial Ischemia-Reperfusion by Suppressing Nat10-Mediated Ac4C Acetylation of Nek7. 雷马唑仑通过抑制nat10介导的Nek7的Ac4C乙酰化抑制心肌缺血再灌注后的焦亡。

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-668

Huafeng Feng, Wei Huang, Xinyu Bi, Zhihang Tang

{"title":"Remimazolam Inhibits Pyroptosis after Myocardial Ischemia-Reperfusion by Suppressing Nat10-Mediated Ac4C Acetylation of Nek7.","authors":"Huafeng Feng, Wei Huang, Xinyu Bi, Zhihang Tang","doi":"10.1536/ihj.24-668","DOIUrl":"10.1536/ihj.24-668","url":null,"abstract":"Myocardial infarction (MI) is one of the leading causes of mortality in the world. Ischemia-reperfusion injury (IR) means that reperfusion therapy after MI aggravates its structural destruction, causes cell death, and leads to further damage to cardiac function. Remimazolam shows significant anti-myocardial I/R injury activity by inhibiting inflammation, alleviating MI, and enhancing cardiac function. However, the molecular mechanism is not clear. RNA N4-acetylcytidine (ac4C) modification, which is mediated by the ac4C writer N-acetyltransferase 10 (Nat10), is involved in MI. In this study, we explored the role of ac4C acetylation in the reduction of myocardial damage by treatment with remimazolam. The effect of remimazolam on myocardial I/R injury (MIRI) was examined using an MIRI mouse model. The H9C2 cells received hypoxia/reoxygenation (H/R) to simulate the condition of I/R in vivo. Pyroptosis in H9C2 cells was assessed by measuring the release of lactic dehydrogenase, and NLRP3-dependent release of inflammatory factors. The underlying mechanism was investigated by quantitative real-time PCR, Western blot, and RNA immunoprecipitation (RIP). The results suggested that remimazolam alleviated myocardial damage and inhibited NLRP3-dependent pyroptosis induced by H/R injury. Nat10-mediated ac4C acetylation levels were inhibited by treatment with remimazolam, which was reversed by Nat10 overexpression in the H/R cell model. We then found that Nat10 facilitated the ac4C acetylation of Nek7 and promoted the pyroptosis of cardiomyocytes through Nek7. In conclusion, we demonstrate that remimazolam ameliorates MI by suppressing cardiomyocyte pyroptosis via inhibiting the ac4C acetylation of Nek7. The results of this study suggest a therapeutic value for remimazolam and may provide a new potential therapeutic target for MI.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"475-484"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival after Right Ventricular Diverticulum Caused by Right Ventricular Rupture. 右心室破裂致右心室憩室后的生存率。

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-423

Hao Yu, Baolong Ding, Linlin Ji, Chunbo Zhai

{"title":"Survival after Right Ventricular Diverticulum Caused by Right Ventricular Rupture.","authors":"Hao Yu, Baolong Ding, Linlin Ji, Chunbo Zhai","doi":"10.1536/ihj.24-423","DOIUrl":"10.1536/ihj.24-423","url":null,"abstract":"Ventricular diverticula can be divided into congenital and acquired ventricular diverticulum. Cardiac rupture is a rare occurrence of cardiac injury, but the mortality rate is very high. Some cardiac ruptures may form an acquired ventricular diverticulum. We report the case of a 57-year-old man who presented with a right ventricular diverticulum caused by traumatic ventricle rupture.A 57-year-old man was admitted with chest pain and dyspnea after falling from a high place. His condition gradually stabilized after emergency surgery and rescue treatment. One week later, the patient suddenly presented with swelling of the right upper limb. Venous thrombosis in the right upper extremity was detected by vascular color ultrasound. Further pulmonary artery computed tomography angiography (CTA) revealed an upper right pulmonary artery embolism and a diverticulum in the right ventricular wall; no obvious diverticulum or pericardial effusion was found by echocardiography. After a thorough discussion with the cardiac surgeon, anticoagulant therapy was administered and his condition was closely monitored. After 10 days, pulmonary CTA showed that the pulmonary thrombus had disappeared, but the right ventricular diverticulum was more prominent than before; therefore, anticoagulant therapy was stopped, although hemostatic drugs were not administered. The right ventricular diverticulum gradually shrank and healed.Asymptomatic cardiac diverticula may resolve spontaneously with conservative treatment. We learned from this case that the diagnostic value of cardiac CTA or pulmonary artery CTA for occult heart injury might be superior to that of cardiac ultrasound.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"516-520"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined Role of Zinc and Anemia and their Association with 10-Year Atherosclerotic Cardiovascular Disease Risk in Patients with Early-Stage Chronic Kidney Disease. 锌和贫血的联合作用及其与早期慢性肾病患者10年动脉粥样硬化性心血管疾病风险的关系

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-639

Linjuan Xu, Gang Wang, Wenping Wu, Jiaheng Wang

{"title":"Combined Role of Zinc and Anemia and their Association with 10-Year Atherosclerotic Cardiovascular Disease Risk in Patients with Early-Stage Chronic Kidney Disease.","authors":"Linjuan Xu, Gang Wang, Wenping Wu, Jiaheng Wang","doi":"10.1536/ihj.24-639","DOIUrl":"10.1536/ihj.24-639","url":null,"abstract":"This study aimed to investigate the combined impact of zinc (Zn) intake and anemia on the atherosclerotic cardiovascular disease (ASCVD) risk score of patients with chronic kidney disease (CKD). A total of 2,612 individuals diagnosed with CKD from the National Health and Nutrition Examination Survey 2007-2018 were included in this study. The 10-year ASCVD risk was the outcome variable, and patients with a risk score of ≥ 20% were categorized as having a high 10-year ASCVD risk, whereas those with a risk score of < 20% were considered to be low risk. We used weighted univariate and multivariate logistic regression models to assess the independent and joint associations of Zn intake and anemia with high 10-year ASCVD risk. After adjusting all covariates, patients with CKD with adequate Zn intake had lower odds of developing high 10-year ASCVD risk [odds ratios = 0.59, 95% confidence intervals: 0.39-0.90] than those with inadequate Zn intake. We noted a significant association between anemia and developing high 10-year ASCVD risk. Considering the adequate Zn intake and non-anemia group as a reference, patients with CKD who had both inadequate Zn intake and non-anemia had higher odds of developing high 10-year ASCVD risk; those who had both adequate Zn intake and anemia had higher odds of developing high 10-year ASCVD risk. patients with CKD with both inadequate Zn intake and anemia exhibited a nearly two-fold higher 10-year ASCVD risk compared with those with both adequate Zn intake and non-anemia. A joint effect of Zn intake and anemia on the high 10-year ASCVD risk was observed.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"345-351"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Associated with Long-Term Hospitalization in Older Patients with Heart Failure in Japan. 日本老年心力衰竭患者长期住院的相关因素

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-731

Kei Kawada, Tomoaki Ishida, Toru Kubo, Tomoyuki Hamada, Hitoshi Fukuda, Yuki Hyohdoh, Yuichi Baba, Toshinobu Hayashi, Kazuya Kawai, Yoko Nakaoka, Toshikazu Yabe, Takashi Furuno, Eisuke Yamada, Shinji Abe, Mitsuhiro Goda, Hiroaki Kitaoka, Keisuke Ishizawa

{"title":"Factors Associated with Long-Term Hospitalization in Older Patients with Heart Failure in Japan.","authors":"Kei Kawada, Tomoaki Ishida, Toru Kubo, Tomoyuki Hamada, Hitoshi Fukuda, Yuki Hyohdoh, Yuichi Baba, Toshinobu Hayashi, Kazuya Kawai, Yoko Nakaoka, Toshikazu Yabe, Takashi Furuno, Eisuke Yamada, Shinji Abe, Mitsuhiro Goda, Hiroaki Kitaoka, Keisuke Ishizawa","doi":"10.1536/ihj.24-731","DOIUrl":"10.1536/ihj.24-731","url":null,"abstract":"With the aging of the patient population with heart failure (HF), the length of hospital stay is increasing, contributing to higher healthcare costs. However, factors associated with long-term hospitalization (LTH) in older patients with HF are unknown. Therefore, the aim of the present study was to investigate these factors.Our analysis of the Kochi Registry of Subjects with Acute Decompensated Heart Failure (Kochi YOSACOI study) data of 1,061 patients with acute HF identified demographic, clinical, pre-hospital environment, and social support factors associated with LTH. A decision tree analysis was performed with the identified risk factors and using LTH as the index for risk stratification. Additionally, relationships between risk groups, length of hospital stay, and clinical outcomes were analyzed.Among 1,061 patients, 731 were included in the analysis. Among these 731 patients, 192 patients experienced LTHs (≥ 30 days). Associated factors were the Japanese version of the Cardiovascular Health Study (J-CHS) criteria score, living alone, Geriatric Nutritional Risk Index (GNRI), and systolic blood pressure at admission. Decision tree analysis categorized patients into three risk groups: low-risk (J-CHS score < 3, n = 336), medium-risk (J-CHS score ≥ 3, GNRI > 91.3, n = 395), and high-risk (J-CHS score ≥ 3, GNRI ≤ 91.3, n = 233) groups.Frailty and undernutrition were associated with LTH and worsening clinical outcomes in older patients with HF. Accordingly, the findings of this study may provide important insights into the management of older patients with HF.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"396-403"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tetrandrine Improves Ventricular Remodeling and Inflammation via Inhibition of the MAPK/NF-κB Pathway. 粉防己碱通过抑制MAPK/NF-κB通路改善心室重构和炎症。

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-697

Yu Wang, Ruoying Zhang, Jinmeng Li, Suhang Guo, Yuan Yuan, Ren Zheng, Yingying Xu, Xinjun Cai

{"title":"Tetrandrine Improves Ventricular Remodeling and Inflammation via Inhibition of the MAPK/NF-κB Pathway.","authors":"Yu Wang, Ruoying Zhang, Jinmeng Li, Suhang Guo, Yuan Yuan, Ren Zheng, Yingying Xu, Xinjun Cai","doi":"10.1536/ihj.24-697","DOIUrl":"10.1536/ihj.24-697","url":null,"abstract":"Background: Tetrandrine (TET), a bisbenzylisoquinoline alkaloid, has been shown to possess various benefits for cardiovascular diseases and anti-inflammatory activities. However, the role of TET in hypertensive heart failure is not fully known. This study was undertaken to explore whether TET exerts anti-ventricular remodeling effects and to identify the mechanisms involved.Methods: C57BL/6 mice were subjected to 4-week infusion of angiotensin II (Ang II) or transverse aortic constriction (TAC) surgery to induce ventricular remodeling. The mice received TET (5 mg/kg/day and 10 mg/kg/day) for the last 2 weeks.Results: We found that TET dose-dependently prevented heart malfunction due to the inhibition of myocardial hypertrophy, cardiac fibrosis, and inflammation without any effect on the systolic blood pressure in Ang II-infusion mice. TET treatment also attenuated TAC-induced myocardial hypertrophy and fibrosis in the mice. The cardioprotective effects of TET were also confirmed in H9C2 cells with Ang II stimulation. TET diminished the inflammatory response in heart tissues and cardiomyocytes by suppressing the Ang II-activated mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) pathway. With a combination of JNK and ERK inhibitors and TET, the anti-inflammatory effects and the inhibition of the nuclear translocation of the NF-κB p65 subunit were enhanced in Ang II-stimulated cardiomyocytes.Conclusions: Taken together, these data strongly suggest that TET attenuated the Ang II-or TAC-induced ventricular remodeling, which was possibly associated with the inhibition of inflammation and activation of the MAPK/NF-κB pathway in mice. These findings suggest a novel pharmacological activity for TET in the treatment of heart failure.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"463-474"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Uric Acid to High-Density Lipoprotein Cholesterol Ratio Is Associated with Left Ventricular Diastolic Function in Patients with No Significant Perfusion Abnormality. 无明显灌注异常患者尿酸与高密度脂蛋白胆固醇比值与左室舒张功能的关系

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.25-016

Ryotaro Yamamoto, Yukihiro Fukuda, Takafumi Kawaguchi, Keita Kimura, Masashi Morita, Naoya Hironobe, Kiho Itakura, Shunsuke Tomomori, Yoji Urabe, Toshiharu Oka, Naoya Mitsuba, Hironori Ueda, Yukiko Nakano

{"title":"The Uric Acid to High-Density Lipoprotein Cholesterol Ratio Is Associated with Left Ventricular Diastolic Function in Patients with No Significant Perfusion Abnormality.","authors":"Ryotaro Yamamoto, Yukihiro Fukuda, Takafumi Kawaguchi, Keita Kimura, Masashi Morita, Naoya Hironobe, Kiho Itakura, Shunsuke Tomomori, Yoji Urabe, Toshiharu Oka, Naoya Mitsuba, Hironori Ueda, Yukiko Nakano","doi":"10.1536/ihj.25-016","DOIUrl":"10.1536/ihj.25-016","url":null,"abstract":"The ratio of uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) is a marker of inflammation. However, whether this ratio is associated with left ventricular (LV) diastolic function remains unknown. This study tested the hypothesis that the UA-to-HDL-C ratio is associated with LV diastolic parameters derived from gated myocardial perfusion single-photon emission computed tomography (SPECT) in patients with no significant perfusion abnormalities.The study population included 204 patients with no significant perfusion abnormalities and a preserved ejection fraction. The peak filling rate (PFR) and one-third mean filling rate (1/3 MFR) were obtained as LV diastolic parameters using gated SPECT. Serum UA and plasma HDL-C levels were also examined.Significant associations were observed between the UA-to-HDL-C ratio and the PFR (r = -0.20; P = 0.005) and 1/3 MFR (r = -0.17; P = 0.018). Multivariate linear regression analysis was performed to determine the factors associated with LV diastolic parameters. Age (β = -0.13; P = 0.046), the LV end-diastolic volume (β = -0.17; P = 0.046), and the UA-to-HDL-C ratio (β = -0.17; P = 0.023) were significantly associated with the PFR. Moreover, age (β = -0.18; P = 0.011), the LV mass index (β = -0.19; P = 0.011), and the UA-to-HDL-C ratio (β = -0.14; P = 0.047) were significantly associated with the 1/3 MFR.These results demonstrated that the UA-to-HDL-C ratio is associated with LV diastolic function derived from gated SPECT in patients with no significant perfusion abnormalities.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"413-419"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Left Ventricular Mass Index on Clinical Outcomes in Patients with Acute Myocardial Infarction. 左心室质量指数对急性心肌梗死患者临床预后的影响

IF 1.2 4区医学

International heart journal Pub Date : 2025-03-31 Epub Date: 2025-03-15 DOI: 10.1536/ihj.24-333

Yiqian Yuan, Qianliang Ying, Jiachen Luo, Wentao Shi, Xingxu Zhang, Yuan Fang, Xiaoming Qin, Baoxin Liu, Yidong Wei

{"title":"Influence of Left Ventricular Mass Index on Clinical Outcomes in Patients with Acute Myocardial Infarction.","authors":"Yiqian Yuan, Qianliang Ying, Jiachen Luo, Wentao Shi, Xingxu Zhang, Yuan Fang, Xiaoming Qin, Baoxin Liu, Yidong Wei","doi":"10.1536/ihj.24-333","DOIUrl":"10.1536/ihj.24-333","url":null,"abstract":"The aim of this study was to analyze the correlation between left ventricular mass index (LVMI) and the prognosis of patients with acute myocardial infarction (AMI).The study retrospectively analyzed the Registry of New-onset Atrial Fibrillation Complicating Acute Myocardial Infarction-Shanghai database and included 1957 patients with AMI who were hospitalized from February 2014 to March 2018, with a median follow-up of 2.7 ± 1.3 years; it calculated the number of all-cause mortalities after AMI. Through receiver operating characteristic curve analysis of LVMI, the optimal LVMI cutoff value was obtained, and the enrolled patients were grouped accordingly. The effects of different LVMI levels on the occurrence of cardiovascular and cerebrovascular adverse events were evaluated in patients with AMI. In addition, the risk assessment and prognostic value of the combined application of LVMI and the GRACE score was explored in patients with AMI.The incidences of all-cause mortality, cardiovascular death, heart failure readmission rate, and reinfarction in patients with AMI in LVMI ≥ 98.90 group were significantly higher than those in LVMI < 98.90 group (P< 0.05). The value of LVMI combined with the GRACE score in predicting the risk of post-AMI all-cause mortality as well as cardiovascular death seemed to be better than that of using the GRACE score alone. LVMI, old age, male sex, renal insufficiency, previous heart failure, stroke history, and decreased left ventricular ejection fraction were independent risk factors for all-cause mortality after AMI.High LVMI may be closely associated with all-cause mortality and adverse cardiovascular events after AMI, especially in patients with AMI with LVMI > 98.9. The risk of all-cause mortality after AMI can also be assessed in combination with LVMI and GRACE scores.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"193-201"},"PeriodicalIF":1.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subclinical B-type Natriuretic Peptide Elevation 24 Months After Anthracycline-Containing Chemotherapy. 含蒽环类化疗 24 个月后亚临床 B 型钠尿肽升高。

IF 1.2 4区医学

International heart journal Pub Date : 2025-03-31 Epub Date: 2025-03-15 DOI: 10.1536/ihj.24-293

Tetsuya Tani, Masayoshi Oikawa, Himika Ohara, Daiki Yaegashi, Yu Sato, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Akiomi Yoshihisa, Takafumi Ishida, Yasuchika Takeishi

{"title":"Subclinical B-type Natriuretic Peptide Elevation 24 Months After Anthracycline-Containing Chemotherapy.","authors":"Tetsuya Tani, Masayoshi Oikawa, Himika Ohara, Daiki Yaegashi, Yu Sato, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Akiomi Yoshihisa, Takafumi Ishida, Yasuchika Takeishi","doi":"10.1536/ihj.24-293","DOIUrl":"10.1536/ihj.24-293","url":null,"abstract":"The incidence of anthracycline-induced cardiotoxicity typically occurs within the first year after chemotherapy, but the changes in cardiac function and biomarkers beyond this initial year have not been adequately investigated. We analyzed 105 consecutive patients followed for 24 months after anthracycline-containing chemotherapy at Fukushima Medical University Hospital from June 2018 to April 2021. Echocardiography and blood tests for cardiac troponin I and B-type natriuretic peptide (BNP) were conducted at baseline, and 3, 6, 12, and 24 months after chemotherapy initiation. In the whole patient cohort, BNP levels increased from 10.5 [6.3-18.3] pg/mL at baseline to 19.2 [12.1-34.5] pg/mL at 24 months after chemotherapy (P < 0.01). Based on BNP levels at 24 months, the patients were divided into 2 groups: a BNP-elevated group (n = 57) and a BNP-normal group (n = 48). In the BNP-elevated group, time-course changes revealed that BNP levels remained stable until 12 months, but increased at 24 months. Multivariate logistic analysis identified age, total anthracycline dose, and baseline BNP levels as predicting factors for elevated BNP levels at 24 months. Subclinical BNP elevation was observed at 24 months of follow-up after initiation of anthracycline-containing chemotherapy.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"279-284"},"PeriodicalIF":1.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Practical Scoring System for Estimating Ventricular Arrhythmia Events in Patients with Cardiac Resynchronization Therapy for Primary Prevention. 一种评估心脏再同步化治疗患者室性心律失常事件的实用评分系统。

IF 1.2 4区医学

International heart journal Pub Date : 2025-03-31 Epub Date: 2025-03-15 DOI: 10.1536/ihj.24-646

Takayuki Goto, Yasuya Inden, Satoshi Yanagisawa, Naoki Tsurumi, Kiichi Miyamae, Hiroyuki Miyazawa, Shun Kondo, Masaya Tachi, Tomoya Iwawaki, Ryota Yamauchi, Kei Hiramatsu, Masafumi Shimojo, Yukiomi Tsuji, Toyoaki Murohara

{"title":"A Practical Scoring System for Estimating Ventricular Arrhythmia Events in Patients with Cardiac Resynchronization Therapy for Primary Prevention.","authors":"Takayuki Goto, Yasuya Inden, Satoshi Yanagisawa, Naoki Tsurumi, Kiichi Miyamae, Hiroyuki Miyazawa, Shun Kondo, Masaya Tachi, Tomoya Iwawaki, Ryota Yamauchi, Kei Hiramatsu, Masafumi Shimojo, Yukiomi Tsuji, Toyoaki Murohara","doi":"10.1536/ihj.24-646","DOIUrl":"10.1536/ihj.24-646","url":null,"abstract":"The prognostic value of defibrillators in cardiac resynchronization therapy (CRT) for primary prevention remains debatable. Predicting ventricular arrhythmias (VAs) before implantation is useful for deciding whether to add a defibrillator to a CRT device. This study aimed to determine the risk factors for VA events after CRT device implantation and to construct a scoring model. A total of 153 patients who underwent CRT device implantation, with no history of sustained ventricular tachycardia or ventricular fibrillation (including 25 patients with CRT pacemakers) and with follow-up period >1 year after implantation were included. We assessed VA events requiring implantable cardioverter-defibrillator therapy and sustained VA events requiring clinical treatment. During a mean follow-up of 6.3 years, 24 patients (16%) received therapy for VA. Multivariate analysis revealed age ≤ 70 years (hazard ratio [HR] 2.936, P = 0.037), administration of tolvaptan (HR 11.259, P < 0.001), and coronary artery disease (HR 2.444, P = 0.045) were independent predictors for VA events. Risk scores were assigned based on the HR for each predictor, and the population was divided into 3 risk groups (low: 0 points; moderate: 1-3 points; high: 4-5 points). VAs occurred less frequently in the low-risk group than in the other risk groups (low: 8.1%; moderate: 18%; high: 21%) (log-rank, P < 0.001). No significant differences in mortality were observed between the groups, whereas hospitalization for heart failure occurred more frequently in the high-risk group than in the other groups. In conclusion, a scoring system using specific background information may help predict VA events in prophylactic CRT recipients.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"241-251"},"PeriodicalIF":1.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0