International heart journal最新文献_第2页

Errata: Aspirin and Celecoxib Regulate Notch1/Hes1 Pathway to Prevent Pressure Overload-Induced Myocardial Hypertrophy. 勘误：阿司匹林和塞来昔布调节Notch1/Hes1通路防止压力过载引起的心肌肥厚。

IF 1.3 4区医学

International heart journal Pub Date : 2026-01-01 DOI: 10.1536/ihj.67-2_Errata_2

引用次数: 0

MicroRNA-21 as a Potential Contributor to Cardiac Diastolic Dysfunction in Hypertensive Patients. MicroRNA-21是高血压患者心脏舒张功能障碍的潜在因素。

IF 1.3 4区医学

International heart journal Pub Date : 2026-01-01 DOI: 10.1536/ihj.25-651

Shiori Nishinosono, Tsukuru Umemura, Yoshitaka Hirooka

引用次数: 0

Exploring the Role and Mechanism of DSF in HFpEF Based on IL-1β/IL-1βR/TAK1/RIPK1 Axis-Mediated PANoptosis. 基于IL-1β/IL-1β r /TAK1/RIPK1轴介导的PANoptosis，探讨DSF在HFpEF中的作用及机制

IF 1.3 4区医学

International heart journal Pub Date : 2026-01-01 DOI: 10.1536/ihj.24-706

Weidong Li, Xuanyang Shen, Xiaolu Jiang, Yuan Shen, Hongfu Wen, Wen Zhang, Jing Wen

{"title":"Exploring the Role and Mechanism of DSF in HFpEF Based on IL-1β/IL-1βR/TAK1/RIPK1 Axis-Mediated PANoptosis.","authors":"Weidong Li, Xuanyang Shen, Xiaolu Jiang, Yuan Shen, Hongfu Wen, Wen Zhang, Jing Wen","doi":"10.1536/ihj.24-706","DOIUrl":"https://doi.org/10.1536/ihj.24-706","url":null,"abstract":"Heart failure with preserved ejection fraction (HFpEF) has a high prevalence and a low quality of life, and there are limited medications for the treatment of this disease. In recent years, disulfiram (DSF), an FDA-approved drug for the treatment of chronic alcohol addiction, has been found to have anti-inflammatory properties. The present study was designed to investigate the cardioprotective effects of DSF on patients with HFpEF and its mechanism using a model of HFpEF induced in mice fed a high-fat diet (HFD, 60% of calories from fat) and Nω-nitro-L-arginine methyl ester (L-NAME, 0.5 g/L in drinking water). The results showed that DSF effectively reversed the HFD + L-NAME-induced increases in left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), interventricular septal thickness, left ventricular mass, the ratio of peak early mitral diastolic velocity to peak late mitral diastolic velocity, the ratio of early mitral diastolic velocity to early diastolic velocity, as well as the reductions in the absolute value of global longitudinal strain (GLS), without affecting the left ventricular ejection fraction (LVEF). In addition, DSF notably attenuated the HFD + L-NAME-induced increase in blood pressure, exercise intolerance, cardiac hypertrophy, pulmonary edema, and elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. Mechanistically, we found that DSF inhibited myocardial PANoptosis-like cell death, mainly by inhibiting the release of myocardial interleukin 1β (IL-1β), which inhibited transforming growth factor-β-activated kinase 1(TAK1)-mediated PANoptosis. Given the cardioprotective effects of DSF, its clinical use would be a novel strategy for the protection and treatment of cardiac injury in patients with HFpEF.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"67 1","pages":"65-76"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomal MiR-223-3p from Adipose-Derived Stem Cells Alleviates Hypoxia/Reoxygenation-Induced Ferroptosis of H9c2 Cells by Inhibiting TFRC. 来自脂肪来源干细胞的外泌体MiR-223-3p通过抑制TFRC减轻缺氧/再氧诱导的H9c2细胞铁凋亡。

IF 1.3 4区医学

International heart journal Pub Date : 2026-01-01 DOI: 10.1536/ihj.25-398

Zhuyuan Liu, Yanru He, Chunshu Hao

{"title":"Exosomal MiR-223-3p from Adipose-Derived Stem Cells Alleviates Hypoxia/Reoxygenation-Induced Ferroptosis of H9c2 Cells by Inhibiting TFRC.","authors":"Zhuyuan Liu, Yanru He, Chunshu Hao","doi":"10.1536/ihj.25-398","DOIUrl":"https://doi.org/10.1536/ihj.25-398","url":null,"abstract":"Myocardial ischemia-reperfusion injury (MI/RI) refers to the deterioration of cardiac function after restoring ischemic myocardium perfusion. Stem cell exosomes have produced unique advantages in treating MI/RI. However, the roles of exosomal microRNA-223-3p (miR-223-3p) from adipose-derived stem cells (ADSCs) on MI/RI are still unclear. This study aimed to investigate the effects of exosomal miR-223-3p from ADSCs on hypoxia/reoxygenation (H/R)-induced H9c2 cell injuries. Our findings indicated that the separated ADSC-derived exosomes (ADSC-Exo) were spherical, with a complete cell membrane, an average diameter of 110 nm, and CD9 and CD63 expression. ADSC-Exo increased the cell viability, proliferation, glutathione (GSH) level, and glutathione peroxidase 4 (GPX4) and miR-223-3p expression and decreased the apoptosis, reactive oxygen species (ROS), malondialdehyde (MDA), and Fe2+ levels and acyl-CoA synthetase long chain family member 4 (ACSL4) and transferrin receptor (TFRC) expression of H9c2 cells. Overexpressing exosomal miR-223-3p from ADSCs further strengthened the effects of ADSC-Exo on H9c2 cells. Overexpressing TFRC in H9c2 cells effectively reversed the effects of miR-223-3p overexpressed ADSC-Exo on H9c2 cells. In addition, miR-223-3p targeted and negatively regulated TFRC. This study confirmed that exosomal miR-223-3p from ADSCs alleviated H/R-induced ferroptosis of H9c2 cells by inhibiting TFRC, providing a novel target and pathway for the clinical treatment of MI/RI.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"67 1","pages":"87-97"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paradox of Low Body Mass Index. 低体重指数悖论。

IF 1.3 4区医学

International heart journal Pub Date : 2026-01-01 DOI: 10.1536/ihj.25-347

Masamichi Yano, Yasuyuki Egami, Noriyuki Kobayashi, Ayako Sugino, Masaru Abe, Mizuki Ohsuga, Hiroaki Nohara, Shodai Kawanami, Kohei Ukita, Akito Kawamura, Koji Yasumoto, Naotaka Okamoto, Yasuharu Matsunaga-Lee, Masami Nishino

{"title":"Paradox of Low Body Mass Index.","authors":"Masamichi Yano, Yasuyuki Egami, Noriyuki Kobayashi, Ayako Sugino, Masaru Abe, Mizuki Ohsuga, Hiroaki Nohara, Shodai Kawanami, Kohei Ukita, Akito Kawamura, Koji Yasumoto, Naotaka Okamoto, Yasuharu Matsunaga-Lee, Masami Nishino","doi":"10.1536/ihj.25-347","DOIUrl":"https://doi.org/10.1536/ihj.25-347","url":null,"abstract":"Low BMI has been reported to be associated with atrial fibrillation (AF) recurrence post-ablation, as well as with cardiovascular events and mortality. However, the previous studies have not fully accounted for baseline factors including age, nutritional status, anemia, and cardiac function. Thus, the potential risks inherent in patients with AF and low BMI remain unclear. AF patients who underwent primary ablation were enrolled. To exclude the effect of baseline factors including age, nutritional status, anemia and cardiac function, propensity score-matching was performed. The incidence of composite of heart failure (HF) hospitalization and all-cause death among the patients stratified by BMI was investigated. We finally analyzed 2396 patients. Low BMI was defined as < 18.5 kg/m2 and normal/high BMI as ≥ 18.5 kg/m2. The low and normal/high BMI groups consisted of 120 patients after 1:1 propensity score-matching, respectively. In propensity score-matched population, normal/high BMI had higher risk of late arrhythmia recurrence post-ablation than low BMI in persistent AF, while no significant difference in paroxysmal AF. Kaplan-Meier analysis showed incidence of the composite endpoint was significantly higher in patients with low BMI than those with normal/high in the overall and propensity score-matched populations (Log-rank P < 0.001 and P = 0.024, respectively). Cox proportional hazard analysis revealed low BMI had significantly and independently higher risk of the composite endpoint (HR = 2.43; 95% CI = 1.098-5.374). Despite a lower recurrence rate, patients with low BMI showed a paradoxically higher incidence of HF hospitalization and all-cause mortality, highlighting the need for further investigation into potential interventions targeting low BMI patients.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"67 1","pages":"11-19"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Errata: Circ_0004771 Promotes Hypoxia/Reoxygenation Induced Cardiomyocyte Injury via Activation of Mitogen-Activated Protein Kinase Signaling Pathway. Circ_0004771通过激活丝裂原激活的蛋白激酶信号通路促进缺氧/再氧化诱导的心肌细胞损伤。

IF 1.3 4区医学

International heart journal Pub Date : 2026-01-01 DOI: 10.1536/ihj.67-2_Errata_1

引用次数: 0

Unmasking Risk Behind the Obesity-Paradox Signal: Prognostic Value of CONUT Score Combined with BMI. 揭示肥胖悖论信号背后的风险：CONUT评分联合BMI的预后价值。

IF 1.3 4区医学

International heart journal Pub Date : 2026-01-01 DOI: 10.1536/ihj.25-603

Ran Sumida, Riku Arai, Yasunari Ebuchi, Keisuke Kojima, Michiaki Matsumoto, Naoya Matsumoto, Tomoyuki Morikawa, Wataru Atsumi, Eizo Tachibana, Hironori Haruta, Takaaki Kogo, Kazumiki Nomoto, Masaru Arai, Ken Arima, Takashi Mineki, Yutaka Koyama, Koji Oiwa, Yasuo Okumura

{"title":"Unmasking Risk Behind the Obesity-Paradox Signal: Prognostic Value of CONUT Score Combined with BMI.","authors":"Ran Sumida, Riku Arai, Yasunari Ebuchi, Keisuke Kojima, Michiaki Matsumoto, Naoya Matsumoto, Tomoyuki Morikawa, Wataru Atsumi, Eizo Tachibana, Hironori Haruta, Takaaki Kogo, Kazumiki Nomoto, Masaru Arai, Ken Arima, Takashi Mineki, Yutaka Koyama, Koji Oiwa, Yasuo Okumura","doi":"10.1536/ihj.25-603","DOIUrl":"https://doi.org/10.1536/ihj.25-603","url":null,"abstract":"The \"obesity paradox\" suggests better outcomes in overweight cardiovascular patients, yet the prognostic role of poor nutritional status-even in obese individuals-remains unclear. We evaluated whether combining body mass index (BMI) with the Controlling Nutritional Status (CONUT) score refines interpretation of the obesity-paradox signal in patients undergoing percutaneous coronary intervention (PCI).We analyzed 631 SAKURA-PCI2 Registry patients (2020-2022) and classified them into four groups: Group 1 (CONUT 0-1/BMI < 25 kg/m2), Group 2 (CONUT 0-1/BMI ≥ 25 kg/m2), Group 3 (CONUT ≥ 2/BMI < 25 kg/m2), and Group 4 (CONUT ≥ 2/BMI ≥ 25 kg/m2). The endpoint comprised all-cause death, myocardial infarction, stent thrombosis, heart-failure hospitalization, major bleeding, stroke, and venous thromboembolism. Over a median follow-up of 2.4 years, 123 events occurred (19.5%). Malnutrition (Groups 3 and 4) was associated with higher risk regardless of BMI. Among non-malnourished patients, obese individuals (Group 2) had fewer events than non-obese peers (Group 1), but this was not significant after multivariable adjustment. In adjusted models, risk was highest in Group 4 (hazard ratio [HR] 2.25, 95% confidence interval [CI] 1.01-5.00, P = 0.047) and Group 3 (HR 2.18, 95% CI 1.03-4.59, P = 0.041) versus Group 2.An obesity-paradox signal was observed primarily in nutritionally preserved patients, whereas outcomes in malnourished patients were driven by malnutrition rather than obesity. Accordingly, the obesity paradox should not be taken as evidence that obesity is protective, and nutritional assessment, including the CONUT score, may complement BMI for post-PCI risk stratification.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"67 2","pages":"132-141"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serial Intravascular Imaging of a Coronary Artery Aneurysm Treated with Biodegradable Polymer Drug-Eluting Stents. 生物可降解聚合物药物洗脱支架治疗冠状动脉瘤的一系列血管内成像。

IF 1.3 4区医学

International heart journal Pub Date : 2026-01-01 DOI: 10.1536/ihj.25-630

Minoru Ichikawa

引用次数: 0

Association between Tubular Injury Biomarkers and Early Renal Injury in Hypertensive Patients. 高血压患者肾小管损伤生物标志物与早期肾损伤的关系

IF 1.3 4区医学

International heart journal Pub Date : 2026-01-01 DOI: 10.1536/ihj.25-515

Jianhui Zhang, Xiaoyi Zhang, Zheng Kuai, Yunzeng Zou, Jie Yuan

{"title":"Association between Tubular Injury Biomarkers and Early Renal Injury in Hypertensive Patients.","authors":"Jianhui Zhang, Xiaoyi Zhang, Zheng Kuai, Yunzeng Zou, Jie Yuan","doi":"10.1536/ihj.25-515","DOIUrl":"https://doi.org/10.1536/ihj.25-515","url":null,"abstract":"The lack of uniform diagnostic criteria and effective biomarkers for hypertensive nephrosclerosis makes early detection challenging. This study aimed to explore renal dysfunction biomarkers in hypertensive patients to identify early renal injury.The current study enrolled 106 hypertensive patients divided into 3 groups according to their urine microalbumin/creatinine ratio (ACR) to investigate the association between tubular injury biomarkers and early renal impairment. The serum levels of human and animal models were measured by ELISA, and the statistical analysis was conducted by SPSS. The degree of renal injury was assessed by histological staining.Serum levels of kidney injury molecule-1 (KIM-1) and insulin-like growth factor-binding protein 7 (IGFBP-7) correlated with renal function in hypertensive patients. Moreover, the area under the curve (AUC) for Kim-1 and IGFBP-7 remained greater than 0.6 in detecting nephron injury. In spontaneously hypertensive rats (SHR), serum KIM-1 and IGFBP-7 increased markedly in 12-week-old SHR compared with 8-week-old SHR and Wistar-Kyoto (WKY) rats, while serum creatinine (SCr) and blood urea nitrogen (BUN) were upregulated with no significance at the same time point.Our findings suggest that serum levels of KIM-1 and IGFBP-7 may serve as more sensitive biomarkers for early renal injury in hypertensive nephropathy than conventional biomarkers. Identification of the relationship between tubular injury biomarkers and hypertensive nephropathy offers novel insights into the potential use of biomarkers for cardiorenal syndrome as well as the management of hypertensive patients.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"67 2","pages":"156-163"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Trends in Hypertrophic Cardiomyopathy Research. 肥厚性心肌病研究的新趋势。

IF 1.3 4区医学

International heart journal Pub Date : 2026-01-01 DOI: 10.1536/ihj.25-257

Yuanguo Chen, Shixi Luo, Jing Li, Haibo Zhang

{"title":"Emerging Trends in Hypertrophic Cardiomyopathy Research.","authors":"Yuanguo Chen, Shixi Luo, Jing Li, Haibo Zhang","doi":"10.1536/ihj.25-257","DOIUrl":"https://doi.org/10.1536/ihj.25-257","url":null,"abstract":"Hypertrophic cardiomyopathy (HCM), recognized as the most prevalent inherited heart condition, is found in about 0.2% to 0.5% of the population globally. Recent years have witnessed a notable surge in HCM-related scholarly investigations. The aim of this study was to delineate the trajectory of HCM research over the preceding decade through a comprehensive bibliometric analysis. Utilizing the Web of Science Core Collection (WoSCC) database, we retrieved data on HCM-related studies conducted between 2013 and 2023. The acquired bibliographic data were methodically processed and examined using VOSviewer and CiteSpace software. A remarkable escalation in HCM-related publications was observed throughout the last decade. The United States emerged as the foremost contributor, amassing a total of 2,479 publications and exhibiting the most extensive international collaborative efforts. Mayo Clinic was recognized for its significant contributions and leadership in research collaborations within the HCM domain. Dr. Iacopo Olivotto stood out as a leading figure in the field, authoring 152 articles over this period. The decade was marked by robust transnational collaborations among countries, institutions, and authors. Notably, the publications 'Circulation,' 'JACC,' and 'European Heart Journal' recorded the most citations, receiving 30,736, 26,769, and 13,192 citations, respectively. Our study presents the first in-depth bibliometric and visual exploration of the global HCM research landscape, providing an invaluable reference for clinical researchers engaged in this field.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"67 1","pages":"43-52"},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0