International heart journal最新文献_第2页

Vasospastic Angina as a Cause of Post-Acute Sequelae of COVID-19. 血管痉挛性心绞痛是COVID-19急性后后遗症的一个原因。

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-795

Tadao Aikawa, Jiro Ogino, Naohiro Funayama, Noriko Oyama-Manabe, Tohru Minamino

引用次数: 0

Clinical Outcomes of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve. 冠状动脉ct血管造影衍生的血流储备分数的临床结果。

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-534

Kota Komiyama, Kengo Tanabe, Eiji Taguchi, Tomohiro Sakamoto, Rine Nakanishi, Ryo Okubo, Akira Saito, Taku Asano, Akihiro Ikuta, Kazushige Kadota, Yui O Nozaki, Shinichiro Fujimoto

{"title":"Clinical Outcomes of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve.","authors":"Kota Komiyama, Kengo Tanabe, Eiji Taguchi, Tomohiro Sakamoto, Rine Nakanishi, Ryo Okubo, Akira Saito, Taku Asano, Akihiro Ikuta, Kazushige Kadota, Yui O Nozaki, Shinichiro Fujimoto","doi":"10.1536/ihj.24-534","DOIUrl":"10.1536/ihj.24-534","url":null,"abstract":"Coronary computed tomography angiography-derived fractional flow reserve (FFRCT) is useful for noninvasively detecting coronary artery disease. This procedure has been covered by health insurance reimbursement in the United Kingdom, the United States of America, and Japan. This is the first study to investigate the 1-year outcomes of the FFRCT, with management covered by health insurance from the DiscoverY of Novel Assessment Myocardial IsChemia by FFRCT (DYNAMIC-FFRCT) registry.In this multicenter DYNAMIC-FFRCT registry, 410 participants who underwent FFRCT analysis under health insurance reimbursement were prospectively enrolled at six Japanese sites between October 2019 and November 2021. In accordance with recent guidelines, all participants received appropriate revascularization and/or optimal medication therapy after FFRCT. The following clinical outcomes through the 1-year defined major adverse cardiovascular event (MACE) were investigated: all-cause death, cardiovascular events including non-fatal myocardial infarction, and unplanned hospitalization for acute coronary syndrome leading to revascularization.Of the six MACE cases, four (1.6%) occurred in participants with an FFRCT value ≤ 0.80, whereas two (1.3%) occurred in a participant with an FFRCT value > 0.80.This analytical study based on the DYNAMIC-FFRCT registry for cardiovascular conditions found no significant difference in 1-year MACE between FFRCT≤ 0.80 and > 0.80 following guideline-based therapy. The registry was started shortly after reimbursement and had limited statistical power and selection bias. Further studies with sufficient statistical power are required.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"337-344"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility and Limitations of Genetic Testing in the Routine Care of Cardiovascular Disease Patients in a General Hospital. 基因检测在某综合医院心血管疾病患者常规护理中的应用与局限性

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-667

Daiki Tomidokoro, Kotaro Mori, Masaya Yamamoto, Masato Isono, Kozue Takano, Atsuko Okazaki, Reiko Arakawa, Fumihiko Takeuchi, Hisao Hara, Yukio Hiroi, Norihiro Kato

{"title":"Utility and Limitations of Genetic Testing in the Routine Care of Cardiovascular Disease Patients in a General Hospital.","authors":"Daiki Tomidokoro, Kotaro Mori, Masaya Yamamoto, Masato Isono, Kozue Takano, Atsuko Okazaki, Reiko Arakawa, Fumihiko Takeuchi, Hisao Hara, Yukio Hiroi, Norihiro Kato","doi":"10.1536/ihj.24-667","DOIUrl":"10.1536/ihj.24-667","url":null,"abstract":"Genetic diagnosis is becoming more prevalent in the routine care of cardiovascular disease (CVD) but is still limited to specialized institutions. Therefore, general cardiologists are also expected to acquire fundamental knowledge for incorporating genomics into the clinical practice of inherited to multifactorial CVDs. To accomplish this, the present study evaluated the utility and limitations of genetic testing in a general hospital setting.We examined 2 clinical issues: 1) the diagnostic potential of genetic tests for known inherited CVDs across 4 disease entities, i.e., familial hypercholesterolemia (FH), hypertrophic cardiomyopathy (HCM), suspected lethal arrhythmia, and aortic aneurysm/dissection (total n = 84) and 2) the genetic components associated with 2 multifactorial pathologies, cardiac hypertrophy and atrial fibrillation (AF), through a case-control study (total n = 594). We first performed targeted gene panel tests or whole-exome sequencing to identify causative gene variants for inherited CVDs; this yielded a positive test rate of 14 to 40%. The diagnosis rate for FH increased to 70% if strict eligibility criteria were adopted. The diagnosis rate for HCM also markedly increased by modifying the interpretation criteria for genetic variant pathogenicity. Furthermore, we performed gene-based burden tests and polygenic risk score (PRS) calculations for cardiac hypertrophy and AF. For example, the PRS-based genetic risk was significantly increased in early-onset (≤ 60 years) AF compared to non-AF controls (per-SD odds ratio in standardized PRS: 1.83, P = 2.6 × 10-4).Genetic tests for CVDs may complement the diagnosis based on traditional laboratory-based diagnostics, although the currently limited capabilities of variant interpretation necessitate careful attention.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"375-384"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decrease in Caveolae-Gαq Interaction Mediates Pressure Overload-Induced Cardiac Remodeling in Rats. 小泡- g - αq相互作用减少介导压力过载诱导的大鼠心脏重构。

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-734

Lijin Wang, Lu Yang, Fang Wu, Henglin Wang

{"title":"Decrease in Caveolae-Gαq Interaction Mediates Pressure Overload-Induced Cardiac Remodeling in Rats.","authors":"Lijin Wang, Lu Yang, Fang Wu, Henglin Wang","doi":"10.1536/ihj.24-734","DOIUrl":"10.1536/ihj.24-734","url":null,"abstract":"Despite its significant clinical implications, pressure overload-induced cardiac remodeling is poorly understood. This study aimed to investigate the role of Caveolae-Gαq interaction in the pathophysiology of pressure overload-induced cardiac remodeling. We used the abdominal aortic constriction (AAC) rat model and the angiotensin II-treated cell model to simulate pressure overload-induced cardiac remodeling. Histological changes were assessed using hematoxylin-eosin staining, immunofluorescence staining, and transmission electron microscopy. The expression, colocalization, and calcium response of the Caveolae-Gαq-PLCβ3 signaling pathway were evaluated using western blotting, quantitative real-time PCR, immunofluorescence staining, and calcium green labeling. We found AAC decreased Caveolin-3 expression but increased Gαq and PLCβ3 expressions. Similar trends in mRNA expression levels were observed. The caveolae's ultrastructure was deformed at 4 and 12 weeks after AAC surgery. AAC and angiotensin II treatments reduced Caveolin-3 and Gαq colocalization while increasing Gαq and PLCβ3 colocalization, and prolonging intracellular calcium response after Gαq activation. In conclusion, pressure overload-induced cardiac remodeling involves caveolar deformation and decreased Caveolae-Gαq interactions, which result in enhanced expression and functionality of Gαq-PLCβ3 signaling. These findings highlight the mechanistic importance of Caveolae-Gαq interactions in cardiac hypertrophy under pressure overload conditions.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"485-496"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-World Data on Post-Discharge Prognosis of Elderly and Frail Hospitalized Patients with Heart Failure Reflecting the Latest Guideline-Directed Medical Therapy in Japan. 老年和体弱心力衰竭住院患者出院后预后的真实世界数据反映了日本最新的指导医学治疗

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-752

Susumu Odajima, Keisuke Fujimoto, Akihiro Kadoi, Takafumi Tsuboi, Yoshinori Nagasawa, Kiyohiro Hyogo, Kenzo Uzu, Yoko Fukuoka, Yasushi Shimokawa, Hideaki Okubo, Kazuo Mizutani, Hiroki Shimizu

{"title":"Real-World Data on Post-Discharge Prognosis of Elderly and Frail Hospitalized Patients with Heart Failure Reflecting the Latest Guideline-Directed Medical Therapy in Japan.","authors":"Susumu Odajima, Keisuke Fujimoto, Akihiro Kadoi, Takafumi Tsuboi, Yoshinori Nagasawa, Kiyohiro Hyogo, Kenzo Uzu, Yoko Fukuoka, Yasushi Shimokawa, Hideaki Okubo, Kazuo Mizutani, Hiroki Shimizu","doi":"10.1536/ihj.24-752","DOIUrl":"10.1536/ihj.24-752","url":null,"abstract":"The West Tokyo Heart Failure (WET-HF) registry has recently reported that the post-discharge prognosis for hospitalized patients with heart failure (HF) between 2011 and 2021 has been improving over time and that there has been an upward trend in the use of guideline-directed medical therapy (GDMT). However, there are few post-discharge prognostic data for elderly and frail hospitalized patients with HF. A total of 738 consecutive patients with HF hospitalized at the Konan Medical Center between April 2020 and March 2024 were retrospectively studied. The primary endpoint was cardiovascular death or HF hospitalization. The mean age and clinical frailty scale were 83.4 ± 11.0 years and 4.8 ± 2.3, respectively. The average prescription rates of GDMT at discharge over the 4-year period were 71.0% for beta-blockers, 23.4% for angiotensin-converting enzyme inhibitors (ACE-I) or angiotensin receptor blockers (ARB), 42.7% for angiotensin receptor neprilysin inhibitor (ARNI), 56.1% for mineralocorticoid receptor antagonists (MRA), and 23.2% for sodium-glucose cotransporter 2 (SGLT2) inhibitors. Although, there has been an upward trend in the use of GDMT, the Kaplan-Meier curve showed no improvement in prognosis over time. Multivariate analyses showed that none of the beta-blockers, ACE-I, ARB, ARNI, MRA, or SGLT2-inhibitors at discharge reduced the primary endpoint for hospitalized patients with HF. GDMT alone may not be sufficient to improve the prognosis of elderly and frail hospitalized patients with HF. In addition to GDMT, comprehensive management by a multidisciplinary team may be vital, since currently there seems to be no one-size-fits-all approach for these patients.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"404-412"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Sudden Death from Takayasu Arteritis with Severe Stenosis Localized at the Origin of a Coronary Artery. 高须动脉炎并发冠状动脉起源处严重狭窄致猝死1例。

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-428

Satoshi Masutani, Seigo Korematsu, Kei Takahashi, Tomomi Shimizu, Keisuke Sawada, Morihiro Higashi, Aya Takada, Kazuyuki Saito, Keiko Mizuta, Koichi Moriwaki, Yoichi Iwamoto, Hirotaka Ishido

引用次数: 0

Remimazolam Inhibits Pyroptosis after Myocardial Ischemia-Reperfusion by Suppressing Nat10-Mediated Ac4C Acetylation of Nek7. 雷马唑仑通过抑制nat10介导的Nek7的Ac4C乙酰化抑制心肌缺血再灌注后的焦亡。

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-668

Huafeng Feng, Wei Huang, Xinyu Bi, Zhihang Tang

{"title":"Remimazolam Inhibits Pyroptosis after Myocardial Ischemia-Reperfusion by Suppressing Nat10-Mediated Ac4C Acetylation of Nek7.","authors":"Huafeng Feng, Wei Huang, Xinyu Bi, Zhihang Tang","doi":"10.1536/ihj.24-668","DOIUrl":"10.1536/ihj.24-668","url":null,"abstract":"Myocardial infarction (MI) is one of the leading causes of mortality in the world. Ischemia-reperfusion injury (IR) means that reperfusion therapy after MI aggravates its structural destruction, causes cell death, and leads to further damage to cardiac function. Remimazolam shows significant anti-myocardial I/R injury activity by inhibiting inflammation, alleviating MI, and enhancing cardiac function. However, the molecular mechanism is not clear. RNA N4-acetylcytidine (ac4C) modification, which is mediated by the ac4C writer N-acetyltransferase 10 (Nat10), is involved in MI. In this study, we explored the role of ac4C acetylation in the reduction of myocardial damage by treatment with remimazolam. The effect of remimazolam on myocardial I/R injury (MIRI) was examined using an MIRI mouse model. The H9C2 cells received hypoxia/reoxygenation (H/R) to simulate the condition of I/R in vivo. Pyroptosis in H9C2 cells was assessed by measuring the release of lactic dehydrogenase, and NLRP3-dependent release of inflammatory factors. The underlying mechanism was investigated by quantitative real-time PCR, Western blot, and RNA immunoprecipitation (RIP). The results suggested that remimazolam alleviated myocardial damage and inhibited NLRP3-dependent pyroptosis induced by H/R injury. Nat10-mediated ac4C acetylation levels were inhibited by treatment with remimazolam, which was reversed by Nat10 overexpression in the H/R cell model. We then found that Nat10 facilitated the ac4C acetylation of Nek7 and promoted the pyroptosis of cardiomyocytes through Nek7. In conclusion, we demonstrate that remimazolam ameliorates MI by suppressing cardiomyocyte pyroptosis via inhibiting the ac4C acetylation of Nek7. The results of this study suggest a therapeutic value for remimazolam and may provide a new potential therapeutic target for MI.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"475-484"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival after Right Ventricular Diverticulum Caused by Right Ventricular Rupture. 右心室破裂致右心室憩室后的生存率。

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-423

Hao Yu, Baolong Ding, Linlin Ji, Chunbo Zhai

{"title":"Survival after Right Ventricular Diverticulum Caused by Right Ventricular Rupture.","authors":"Hao Yu, Baolong Ding, Linlin Ji, Chunbo Zhai","doi":"10.1536/ihj.24-423","DOIUrl":"10.1536/ihj.24-423","url":null,"abstract":"Ventricular diverticula can be divided into congenital and acquired ventricular diverticulum. Cardiac rupture is a rare occurrence of cardiac injury, but the mortality rate is very high. Some cardiac ruptures may form an acquired ventricular diverticulum. We report the case of a 57-year-old man who presented with a right ventricular diverticulum caused by traumatic ventricle rupture.A 57-year-old man was admitted with chest pain and dyspnea after falling from a high place. His condition gradually stabilized after emergency surgery and rescue treatment. One week later, the patient suddenly presented with swelling of the right upper limb. Venous thrombosis in the right upper extremity was detected by vascular color ultrasound. Further pulmonary artery computed tomography angiography (CTA) revealed an upper right pulmonary artery embolism and a diverticulum in the right ventricular wall; no obvious diverticulum or pericardial effusion was found by echocardiography. After a thorough discussion with the cardiac surgeon, anticoagulant therapy was administered and his condition was closely monitored. After 10 days, pulmonary CTA showed that the pulmonary thrombus had disappeared, but the right ventricular diverticulum was more prominent than before; therefore, anticoagulant therapy was stopped, although hemostatic drugs were not administered. The right ventricular diverticulum gradually shrank and healed.Asymptomatic cardiac diverticula may resolve spontaneously with conservative treatment. We learned from this case that the diagnostic value of cardiac CTA or pulmonary artery CTA for occult heart injury might be superior to that of cardiac ultrasound.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"516-520"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined Role of Zinc and Anemia and their Association with 10-Year Atherosclerotic Cardiovascular Disease Risk in Patients with Early-Stage Chronic Kidney Disease. 锌和贫血的联合作用及其与早期慢性肾病患者10年动脉粥样硬化性心血管疾病风险的关系

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-639

Linjuan Xu, Gang Wang, Wenping Wu, Jiaheng Wang

{"title":"Combined Role of Zinc and Anemia and their Association with 10-Year Atherosclerotic Cardiovascular Disease Risk in Patients with Early-Stage Chronic Kidney Disease.","authors":"Linjuan Xu, Gang Wang, Wenping Wu, Jiaheng Wang","doi":"10.1536/ihj.24-639","DOIUrl":"10.1536/ihj.24-639","url":null,"abstract":"This study aimed to investigate the combined impact of zinc (Zn) intake and anemia on the atherosclerotic cardiovascular disease (ASCVD) risk score of patients with chronic kidney disease (CKD). A total of 2,612 individuals diagnosed with CKD from the National Health and Nutrition Examination Survey 2007-2018 were included in this study. The 10-year ASCVD risk was the outcome variable, and patients with a risk score of ≥ 20% were categorized as having a high 10-year ASCVD risk, whereas those with a risk score of < 20% were considered to be low risk. We used weighted univariate and multivariate logistic regression models to assess the independent and joint associations of Zn intake and anemia with high 10-year ASCVD risk. After adjusting all covariates, patients with CKD with adequate Zn intake had lower odds of developing high 10-year ASCVD risk [odds ratios = 0.59, 95% confidence intervals: 0.39-0.90] than those with inadequate Zn intake. We noted a significant association between anemia and developing high 10-year ASCVD risk. Considering the adequate Zn intake and non-anemia group as a reference, patients with CKD who had both inadequate Zn intake and non-anemia had higher odds of developing high 10-year ASCVD risk; those who had both adequate Zn intake and anemia had higher odds of developing high 10-year ASCVD risk. patients with CKD with both inadequate Zn intake and anemia exhibited a nearly two-fold higher 10-year ASCVD risk compared with those with both adequate Zn intake and non-anemia. A joint effect of Zn intake and anemia on the high 10-year ASCVD risk was observed.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"345-351"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Associated with Long-Term Hospitalization in Older Patients with Heart Failure in Japan. 日本老年心力衰竭患者长期住院的相关因素

IF 1.2 4区医学

International heart journal Pub Date : 2025-05-31 Epub Date: 2025-05-15 DOI: 10.1536/ihj.24-731

Kei Kawada, Tomoaki Ishida, Toru Kubo, Tomoyuki Hamada, Hitoshi Fukuda, Yuki Hyohdoh, Yuichi Baba, Toshinobu Hayashi, Kazuya Kawai, Yoko Nakaoka, Toshikazu Yabe, Takashi Furuno, Eisuke Yamada, Shinji Abe, Mitsuhiro Goda, Hiroaki Kitaoka, Keisuke Ishizawa

{"title":"Factors Associated with Long-Term Hospitalization in Older Patients with Heart Failure in Japan.","authors":"Kei Kawada, Tomoaki Ishida, Toru Kubo, Tomoyuki Hamada, Hitoshi Fukuda, Yuki Hyohdoh, Yuichi Baba, Toshinobu Hayashi, Kazuya Kawai, Yoko Nakaoka, Toshikazu Yabe, Takashi Furuno, Eisuke Yamada, Shinji Abe, Mitsuhiro Goda, Hiroaki Kitaoka, Keisuke Ishizawa","doi":"10.1536/ihj.24-731","DOIUrl":"10.1536/ihj.24-731","url":null,"abstract":"With the aging of the patient population with heart failure (HF), the length of hospital stay is increasing, contributing to higher healthcare costs. However, factors associated with long-term hospitalization (LTH) in older patients with HF are unknown. Therefore, the aim of the present study was to investigate these factors.Our analysis of the Kochi Registry of Subjects with Acute Decompensated Heart Failure (Kochi YOSACOI study) data of 1,061 patients with acute HF identified demographic, clinical, pre-hospital environment, and social support factors associated with LTH. A decision tree analysis was performed with the identified risk factors and using LTH as the index for risk stratification. Additionally, relationships between risk groups, length of hospital stay, and clinical outcomes were analyzed.Among 1,061 patients, 731 were included in the analysis. Among these 731 patients, 192 patients experienced LTHs (≥ 30 days). Associated factors were the Japanese version of the Cardiovascular Health Study (J-CHS) criteria score, living alone, Geriatric Nutritional Risk Index (GNRI), and systolic blood pressure at admission. Decision tree analysis categorized patients into three risk groups: low-risk (J-CHS score < 3, n = 336), medium-risk (J-CHS score ≥ 3, GNRI > 91.3, n = 395), and high-risk (J-CHS score ≥ 3, GNRI ≤ 91.3, n = 233) groups.Frailty and undernutrition were associated with LTH and worsening clinical outcomes in older patients with HF. Accordingly, the findings of this study may provide important insights into the management of older patients with HF.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"396-403"},"PeriodicalIF":1.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0