International heart journal最新文献

{"title":"Impact of Obesity on Short-Term Outcomes Following Catheter Ablation for Atrial Fibrillation in Patients with Heart Failure.","authors":"Ruobing Ning, Yongjun Zeng, Meijin Zhang, Fuling Yu","doi":"10.1536/ihj.24-141","DOIUrl":"10.1536/ihj.24-141","url":null,"abstract":"<p><p>This study aimed to evaluate the impact of obesity on in-hospital outcomes of patients with HF undergoing AF catheter ablation. This population-based, retrospective observational study extracted data from the US Nationwide Inpatient Sample (NIS) database 2005-2018. Patients ≥ 20 years with HF and undergoing catheter ablation for AF were eligible for inclusion. Propensity-score matching (PSM) was utilized to balance the baseline characteristics between obese and non-obese groups. Univariate and multivariable regression analyses were used to determine the associations between obese status and other variables with the in-hospital outcomes. These outcomes included non-home discharge, prolonged length of stay (LOS), complications, and a composite outcome that encompassed these outcomes along with in-hospital mortality. A total of 18,751 patients were included. After PSM, 8,014 patients remained in the study sample. The mean age was 64.6 ± 0.1 years. After adjustment, significant association was detected between obesity and greater odds of non-home discharge (adjusted odd ratio [aOR] = 1.18), prolonged LOS (aOR = 1.18), complications (aOR = 1.30), respiratory failure/mechanical ventilation (aOR = 1.56) and acute kidney injury (AKI) (aOR = 1.28), central nervous system and peripheral neuropathy (aOR = 1.33), and transient ischemic attack (aOR = 8.16), as well as poor composite outcome (aOR = 1.28) compared with non-obese patients. In US patients with HF undergoing AF catheter ablation, obesity is associated with a higher risk for non-home discharge, prolonged LOS, and several major complications. Clinicians should exercise heightened vigilance when administering therapy to this subgroup of patients.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"264-270"},"PeriodicalIF":1.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Different Sweep Gas Flow Rates on Respiratory Alkalosis and Cerebral Oxygenation during Cardiopulmonary Bypass.","authors":"Melis Tosun, Behic Danisan, Bulent Gucyetmez, Fevzi Toraman","doi":"10.1536/ihj.24-380","DOIUrl":"10.1536/ihj.24-380","url":null,"abstract":"<p><p>There is no consensus on the ideal sweep gas flow volume for achieving targeted blood partial gas pressures during cardiopulmonary bypass (CPB). The sweep gas flow rate is one of the oxygenator's main gas exchange variables. High sweep gas flow rates can lead to respiratory and hypocapnic cerebral alkalosis, which can cause neurological complications.This study included 84 patients aged > 18 years who were scheduled to undergo elective open-heart surgery with CPB. Before rewarming, the participants were randomly assigned to one of the three groups based on their sweep gas flow rates (Group 1, 1.35 L/m²/minute; Group 2, 1.2 L/m²/minute; and Group 3, 1 L/m²/minute). During the surgery, arterial blood gases were sampled at six different time points, and regional cerebral oxygen saturation (rSO₂) levels were monitored bilaterally on the forehead.The study found that all groups experienced a decrease in partial pressure of arterial carbon dioxide (PaCO₂) levels after the onset of hypothermia, which decreased to below the normal range at a moderate hypothermia level of 32°C. During both the baseline and hypothermic periods, the PaCO₂ were similar between the groups; however, after rewarming, Group 3 had significantly higher PaCO₂ than Groups 1 and 2 (P< 0.001). During the same period, Group 3 had significantly higher rSO₂ levels than Groups 1 and 2 (P = 0.005). For all patients, there was a significant correlation between delta-PaCO₂ and delta-rSO₂ levels after rewarming (r = 0.45, P< 0.001).This study demonstrated that low sweep gas flow prevented alkalosis and preserved cerebral autoregulation.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"213-219"},"PeriodicalIF":1.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism and the Co-Occurrence of Left Ventricular Hypertrophy in Patients with Hypertension.","authors":"Xian Li, Yufeng Jiang, Kuangyi Wang, Yiqing Zhang, Yiyao Zeng, Xiangyu Wang, Yafeng Zhou","doi":"10.1536/ihj.24-560","DOIUrl":"10.1536/ihj.24-560","url":null,"abstract":"<p><p>The aim of this study was to explore the association between angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism in the 16th intron and the occurrence of left ventricular hypertrophy (LVH) in hypertensive individuals.This study included 269 patients with hypertension from Dushu Lake Hospital Affiliated to Soochow University who underwent echocardiographic examinations. Among them, 55 patients had hypertension combined with LVH, while 214 patients with hypertension did not have LVH, serving as the case and control groups, respectively. Polymerase chain reaction-restriction fragment length polymorphism was used to perform genetic testing for hypertension in all 269 patients. The Hardy-Weinberg equilibrium test was used to assess genetic equilibrium. The differences in genotype frequencies between the case and control groups were analyzed using the chi-square test. All statistical analyses were performed using SPSS software (version 27.0.1), with statistical significance set at P < 0.05.Genotype distribution in the case and control groups conformed to the Hardy-Weinberg equilibrium (P > 0.05). There was a significant difference in genotype distribution between the case and control groups.Conclusion: ACE gene polymorphism is associated with an increased risk of hypertension combined with LVH.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"285-292"},"PeriodicalIF":1.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of LncRNA MYOSLID and MiR-29c-3p on the Proliferation and Migration of Angiotensin II-induced Vascular Smooth Muscle Cells.","authors":"Yumin Ye, Zhenhua Wang","doi":"10.1536/ihj.24-150","DOIUrl":"10.1536/ihj.24-150","url":null,"abstract":"<p><p>Atherosclerosis (ATH) represents a major cause of cardiovascular disease. Long noncoding RNA (LncRNA) myocardin-induced smooth muscle lncRNA, inducer of differentiation (MYOSLID) and microRNA (miR) -29c-3p show substantial roles in ATH. We investigated their regulatory mechanisms on vascular smooth muscle cell (VSMC) proliferation and migration.Angiotensin (Ang) II-induced VSMCs were used for in vitro research. The MYOSLID and miR-29c-3p expression patterns in VSMCs were assessed by reverse transcription-quantitative polymerase chain reaction. MYOSLID was overexpressed, or miR-29c-3p was silenced in VSMCs by cell transfection, followed by proliferation, migration, and apoptosis evaluation. The colocalization of MYOSLID and miR-29c-3p was observed by RNA in situ hybridization. The targeted binding relationship of miR-29c-3p and MYOSLID was verified by dual-luciferase and RNA immunoprecipitation assays. Joint experiments were performed with the overexpressed MYOSLID and miR-29c-3p via cotransfection. An ATH mouse model was established and injected with LV-MYOSLID, with the aortic root atherosclerotic lesion observed by HE staining and the α-SMA expression determined by immunohistochemistry.The MYOSLID expression was decreased, while the miR-29c-3p expression was increased in the Ang II-induced VSMCs, along with the promoted VSMC proliferation, apoptosis, and migration. Meanwhile, the MYOSLID overexpression or miR-29c-3p silencing repressed the Ang II-induced VSMC behaviors. The miR-29c-3p mimics reduced the luciferase activity of the MYOSLID 3'UTR-WT-transfected cells, but had no obvious influence on the MYOSLID 3'UTR-MUT-transfected cells. Overexpressed miR-29c-3p partially nullified the highly expressed MYOSLID-repressed Ang II-induced VSMC apoptosis, proliferation, and migration. The MYOSLID overexpression repressed the miR-29c-3p expression and reduced the atherosclerotic lesion area and the number of α-SMA-positive VSMCs in ATH mice.The MYOSLID overexpression restrained the Ang II-induced VSMC proliferation, migration, and apoptosis by repressing the miR-29c-3p expression, thus retarding the atherosclerotic plaque formation.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"164-174"},"PeriodicalIF":1.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonlinear Association Between Geriatric Nutritional Risk Index and Cardiovascular Disease in the Elderly Based on the NHANES Database.","authors":"Chengjun Li, Yiyan Sun, Hongyun Wu, Xiaotong Li, Wei Peng","doi":"10.1536/ihj.24-232","DOIUrl":"10.1536/ihj.24-232","url":null,"abstract":"<p><p>There is growing evidence that body nutritional status influences the development of cardiovascular disease, particularly in the elderly population. The Geriatric Nutritional Risk Index (GNRI), as a tool for assessing the nutritional status and nutritional risk of elderly individuals, is applied in clinical practice. This study aimed to elucidate the relationship between GNRI and cardiovascular disease in the elderly and to assess the impact of nutritional status on cardiovascular disease.This study is a cross-sectional study based on the National Health and Nutrition Examination Survey (NHANES) database. The data for this investigation were obtained from the NHANES database from 2007 to 2018, which included 10,277 individuals aged 60 years and older. The relationship between GNRI and cardiovascular disease in the elderly was investigated using weighted multivariable logistic regression models, and smooth fitting curves were drawn to explore their association. In addition, subgroup analyses were used to explore population differences.In this study, after adjusting for all confounding variables, the odds ratio and 95% confidence intervals (CI) of the model were 0.98 (0.96, 1.00), with no statistically significant association. Smooth fitting curves showed a nonlinear correlation between GNRI and cardiovascular disease. We found an inflection point (GNRI = 139.55). Moreover, GNRI was negatively associated with cardiovascular disease in the elderly before the inflection point and not statistically significant after the inflection point.In this large cross-sectional study, we found a nonlinear correlation between GNRI and cardiovascular disease in the general elderly population in the United States.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"13-20"},"PeriodicalIF":1.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Cardiac Tamponade Following Rotablator-Associated Coronary Perforation Treated with Additional Covered Stent Implantation.","authors":"Koichiro Hori, Shunsuke Matsuno, Mikio Kishi, Hiroto Kano, Junji Yajima, Yuji Oikawa","doi":"10.1536/ihj.24-544","DOIUrl":"10.1536/ihj.24-544","url":null,"abstract":"<p><p>Rotablator-associated coronary perforation can be fatal if bailout is delayed. Successful bailout is typically defined as the disappearance of contrast extravasation after a haemostatic intervention. We report a case of recurrent cardiac tamponade in the subacute phase, wherein haemostasis appeared to have been achieved on angiography following the implantation of a covered stent during the index procedure.A 61-year-old male underwent a percutaneous coronary intervention with a rotator placed in the middle of the left ascending artery. Coronary perforation occurred during rotablation and was treated with a covered stent. However, cardiac tamponade recurred on postoperative day 30. Emergency coronary angiography was performed, and no contrast extravasation was observed on angiography. However, intravascular ultrasonography was performed to clarify the cause of the recurrent pericardial effusion and revealed that the distal edge of the covered stent was not fully attached to the vessel wall due to protruding calcification. Another covered stent was placed distal to the previous stent for sealing the malapposed site. There was no recurrence of pericardial effusion.Malapposition of covered stents may not be detected by angiography alone, potentially resulting in recurrent bleeding. Intravascular imaging is an effective tool to confirm adequate stent apposition.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"179-182"},"PeriodicalIF":1.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Trunk Muscle Size Decrease in Patients with Type B Acute Aortic Dissection.","authors":"Keiichi Tsuchida, Norihito Oyanagi, Komei Tanaka, Yukio Hosaka, Kazuyoshi Takahashi, Hirotaka Oda","doi":"10.1536/ihj.24-483","DOIUrl":"10.1536/ihj.24-483","url":null,"abstract":"<p><p>Trunk muscle decrease is reportedly associated with an increased risk of multiple adverse clinical outcomes. Acute aortic dissection (AAD) involves a systemic inflammatory response which is associated with exaggerated muscle protein catabolism. AAD requires prolonged hospitalization and potentially exacerbates muscle size decrease.Cross-sectional areas (CSA) of both the bilateral psoas muscle area (PMA) and L4 vertebral body were determined using CT scans on admission to calculate the psoas-lumbar vertebral index (PLVI = bilateral PMA/L4 body CSA) in 141 hospitalized type B AAD patients. Serial CT scans within 30 days were performed to investigate PLVI change (%/day) calculated as: (PLVI at follow-up - PLVI at admission) /PLVI at admission × 100/follow-up interval (days). Patients were categorized into a large decrease of PLVI (LD) group and a modest decrease and increase of PLVI (MDI) group according to the median value of decreased PLVI change (-0.48%/day).A large PLVI decrease was correlated with a higher peak C-reactive protein (CRP) value (13.8 versus 10.9 mg/dL, P = 0.010), and larger false lumen (FL) diameter (13.6 versus 11.4 mm, P = 0.015). The days until ambulation and the length of hospital stay were slightly longer in the LD group than in the MDI group (days until ambulation, P = 0.111; length of hospital stay, P = 0.053). Logistic regression model analysis demonstrated a higher peak CRP level (OR = 3.43; 95% CI, 1.50-7.84) and larger %FL diameter (OR = 3.88; 95% CI, 1.55-9.69) were predictive of a large PLVI decrease.Our results indicate that a larger FL and subsequent exaggerated inflammatory response may result in a trunk muscle decrease in type B AAD patients.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"106-113"},"PeriodicalIF":1.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Factors for a Poor Prognosis in Rutherford 4 Patients Who Undergo Endovascular Treatment.","authors":"Tetsuo Yamanaka, Michiaki Higashitani, Akihiro Matsui, Kentaro Jujo, Naotaka Murata, Takahide Kodama, Atsushi Mizuno, Yoshimaro Ichinohe, Toru Fukatsu, Daisuke Ueshima","doi":"10.1536/ihj.24-412","DOIUrl":"10.1536/ihj.24-412","url":null,"abstract":"<p><p>Current classifications of chronic limb-threatening ischemia (CLTI) are insufficient to identify Rutherford (R) 4 patients with a poor prognosis. This study aimed to investigate the prognostic factors for patients with R4 CLTI who undergo endovascular treatment (EVT) using data from the Tokyo-taMA peripheral vascular intervention research COmraDE (TOMA-CODE) registry and to propose a risk-scoring system. We analyzed the data of 2,248 prospectively enrolled patients from the registry, divided into 3 groups: intermittent claudication (IC), n = 1,185; R4, n = 401; and R5-6, n = 662. We ascertained amputation-free survival (AFS) 1, 6, 12, 18, and 24 months post-EVT. The 2-year major AFS rates for IC, R4, and R5-6 were 0.944 (95% confidence interval [CI]: 0.921-0.960), 0.830 (0.753-0.885), and 0.576 (0.508-0.638), respectively. The final logistic regression model after addressing optimism included 5 factors: Non-ambulatory status, White blood cell count ≥ 10,000/μL, Revascularization for lesions in the infrapopliteal arteries, previous history of Cerebrovascular disease, and New York Heart Association class III-IV Heart failure (NoWRiCH score). We developed 3 risk-scoring models. When non-ambulatory status was assigned 2 points and the other factors were assigned 1 point each, the prognosis of R4 patients with ≥ 2 points was equivalent to that of R5-6 patients (R4/R5-6; 2-year survival rate, 95% CI: 0.423, 0.204-0.628, P < 0.001/0.576, 0.508-0.638, P < 0.001). The NoWRiCH score facilitates the identification of R4 patients with a poor prognosis.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"88-95"},"PeriodicalIF":1.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous Transvenous Mitral Commissurotomy for Patients with Rheumatic Heart Disease.","authors":"Xin Li, Yinfan Zhu, Jiajun Liang, Wenjian Jiang, Yuyong Liu, Hongjia Zhang","doi":"10.1536/ihj.24-330","DOIUrl":"10.1536/ihj.24-330","url":null,"abstract":"<p><p>Rheumatic heart disease remains common in developing countries. Current guidelines recommend percutaneous mitral commissurotomy (PTMC) as the preferred treatment for patients with rheumatic mitral stenosis (MS). This study reports the clinical outcomes of PTMC for rheumatic MS in contemporary Chinese patients and analyzes prognostic factors.Data from patients who underwent PTMC at our center between January 2007 and July 2023 were retrospectively analyzed. The primary outcome was the composite of all-cause death, repeated PTMC, and mitral valve surgery. Survival curve was constructed using the Kaplan-Meier method. Multivariate Cox regression analysis was used to identify prognostic predictors, and hazards ratio (HRs) with 95% confidence intervals (CIs) were reported.A total of 262 patients with a mean age of 50.1 ± 14.1 years were included. The median follow-up time was 69.5 months. Kaplan-Meier analysis showed that primary outcome-free survival rate was 85.6% ± 2.5%, 67.2% ± 4.2%, and 55.2% ± 6.5% at 5, 10, and 15 years, respectively. In multivariate Cox regression analysis, preprocedural transmitral E peak velocity (Emax) (HR = 1.009, 95% CI: 1.002-1.016, P = 0.015), postprocedural mitral valve orifice area (MVOA) (HR = 0.284, 95% CI: 0.108-0.746, P = 0.011), and postprocedural mitral regurgitation (MR) ≥ 2+ (HR = 2.710, 95% CI: 1.382-5.314, P = 0.004) were identified as the independent predictors of the primary outcome.The clinical outcomes of PTMC are favorable for suitable patients with rheumatic MS. Meanwhile, preprocedural Emax, postprocedural MVOA, and postprocedural MR ≥ 2+ are the prognostic factors.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"60-65"},"PeriodicalIF":1.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ticagrelor and the Risk of In-Hospital Gout.","authors":"Hong Liu, Guo Jiangxue, Yu Dong, Ying Yang, Xitong Yang, Biao Sun, Lilan Ma, Tao Li, Xin-Hua Wu","doi":"10.1536/ihj.24-306","DOIUrl":"10.1536/ihj.24-306","url":null,"abstract":"<p><p>Ticagrelor, an effective antiplatelet for acute coronary syndrome (ACS), may elevate serum uric acid (SUA), potentially causing gout. This study aims to identify risk factors for ticagrelor-induced in-hospital gout in patients with ACS and create a predictive model for clinical use.A total of 1164 patients with ACS treated with ticagrelor (n = 640) or clopidogrel (n = 524) were retrospectively analyzed. The incidence of in-hospital gout and changes in SUA levels were compared between the groups. Patients with ticagrelor were further divided into gout and non-gout groups to identify risk factors using logistic regression. A nomogram model was constructed based on significant risk factors.The incidence of in-hospital gout was significantly higher in patients with ticagrelor than in patients with clopidogrel (9.8% versus 1.9%, P < 0.001). There were significant differences in SUA levels between the groups. Logistic regression revealed alcohol consumption, total cholesterol, and baseline SUA as independent risk factors for gout. A nomogram model was developed and demonstrated good predictive accuracy.Ticagrelor was associated with a higher risk of in-hospital gout than clopidogrel in patients with ACS. Alcohol use, total cholesterol, and baseline uric acid are key risk factors. The nomogram model developed in this study can assist in predicting the risk of in-hospital gout in patients with ACS treated with ticagrelor.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"21-27"},"PeriodicalIF":1.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}