Impact of Different Sweep Gas Flow Rates on Respiratory Alkalosis and Cerebral Oxygenation during Cardiopulmonary Bypass.

IF 1.2 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
International heart journal Pub Date : 2025-03-31 Epub Date: 2025-03-15 DOI:10.1536/ihj.24-380
Melis Tosun, Behic Danisan, Bulent Gucyetmez, Fevzi Toraman
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Abstract

There is no consensus on the ideal sweep gas flow volume for achieving targeted blood partial gas pressures during cardiopulmonary bypass (CPB). The sweep gas flow rate is one of the oxygenator's main gas exchange variables. High sweep gas flow rates can lead to respiratory and hypocapnic cerebral alkalosis, which can cause neurological complications.This study included 84 patients aged > 18 years who were scheduled to undergo elective open-heart surgery with CPB. Before rewarming, the participants were randomly assigned to one of the three groups based on their sweep gas flow rates (Group 1, 1.35 L/m2/minute; Group 2, 1.2 L/m2/minute; and Group 3, 1 L/m2/minute). During the surgery, arterial blood gases were sampled at six different time points, and regional cerebral oxygen saturation (rSO2) levels were monitored bilaterally on the forehead.The study found that all groups experienced a decrease in partial pressure of arterial carbon dioxide (PaCO2) levels after the onset of hypothermia, which decreased to below the normal range at a moderate hypothermia level of 32°C. During both the baseline and hypothermic periods, the PaCO2 were similar between the groups; however, after rewarming, Group 3 had significantly higher PaCO2 than Groups 1 and 2 (P< 0.001). During the same period, Group 3 had significantly higher rSO2 levels than Groups 1 and 2 (P = 0.005). For all patients, there was a significant correlation between delta-PaCO2 and delta-rSO2 levels after rewarming (r = 0.45, P< 0.001).This study demonstrated that low sweep gas flow prevented alkalosis and preserved cerebral autoregulation.

不同扫气流量对体外循环呼吸性碱中毒和脑氧合的影响。
在体外循环(CPB)中实现目标血分气压的理想扫气流量尚无共识。扫气流量是氧合器的主要气体交换变量之一。高扫气流速可导致呼吸性和低碳酸性脑碱中毒,从而引起神经系统并发症。本研究纳入84例年龄在bb0 ~ 18岁的患者,他们计划接受选择性体外循环心脏直视手术。在重新加热之前,参与者根据他们的扫气流速随机分配到三组中的一组(第一组,1.35 L/m2/分钟;第二组,1.2 L/m2/min;第三组为1 L/m2/min)。在手术过程中,在六个不同的时间点采集动脉血气,监测双侧前额区域脑氧饱和度(rSO2)水平。研究发现,在低温开始后,所有组的动脉二氧化碳分压(PaCO2)水平均下降,在32°C的中度低温水平下,PaCO2水平降至正常范围以下。在基线期和低温期,两组间PaCO2相似;复温后,3组PaCO2显著高于1、2组(P< 0.001)。同期,第3组rSO2水平显著高于第1、2组(P = 0.005)。对于所有患者,复温后δ - paco2和δ - rso2水平之间存在显著相关性(r = 0.45, P< 0.001)。该研究表明,低扫气量可防止碱中毒并保持大脑的自动调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International heart journal
International heart journal 医学-心血管系统
CiteScore
2.50
自引率
6.70%
发文量
148
审稿时长
6-12 weeks
期刊介绍: Authors of research articles should disclose at the time of submission any financial arrangement they may have with a company whose product figures prominently in the submitted manuscript or with a company making a competing product. Such information will be held in confidence while the paper is under review and will not influence the editorial decision, but if the article is accepted for publication, the editors will usually discuss with the authors the manner in which such information is to be communicated to the reader.
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