{"title":"Tandem Mass Tag-Labeling Proteomics Reveals TLN1 as a Potential Factor in Cardiogenic Pulmonary Edema.","authors":"Yan Tan, Zhiwei Xu, Zhihua Wang, Dongming Gu","doi":"10.1536/ihj.24-264","DOIUrl":"https://doi.org/10.1536/ihj.24-264","url":null,"abstract":"<p><p>Heart failure (HF) is a complex disease. The reduced blood flow associated with HF triggers the activation of neurohormonal systems, leading to symptoms such as pulmonary congestion and peripheral edema. The precise mechanisms responsible for edema in HF are poorly understood. In this study, we aimed to analyze the differentially expressed proteins in HF-induced pulmonary edema (HF-PE) and explore the potential underlying mechanisms. Proteins in the serum of patients with HF-PE (n = 10) and patients with HF without PE or those who have not developed PE yet (n = 10) were screened using tandem mass tag-labeling proteomics. The identified proteins were screened for differentially expressed proteins, which were then analyzed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses as well as protein-protein interaction (PPI) visualization. Rats with HF were induced by myocardial infarction, whereas PE was induced by LPS. Finally, the rats were injected with lentiviruses to manipulate the expression of differentially expressed proteins. A total of 1796 proteins were identified. In the serum of patients with HF-PE, there were 143 significantly upregulated proteins and 147 significantly downregulated proteins. TLN1 interacted with multiple proteins and was upregulated in patients with HF-PE. TLN1 was significantly upregulated in the lung tissues of rats with HF-PE, and the progression of HF-PE was inhibited by TLN1 knockdown. This tandem mass tag-labeling proteomics profiling study revealed that TLN1 upregulation contributes to the progression of PE in patients with HF.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"313-322"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Catheter Ablation in Older Patients with Atrial Fibrillation.","authors":"Tadashi Yamamoto, Takuya Kishi, Ayako Takamori, Toshio Katagiri, Masataka Kajiwara, Takashi Fujimura, Tomohiro Imamura, Tomohito Inage, Yoshitaka Hirooka","doi":"10.1536/ihj.24-368","DOIUrl":"https://doi.org/10.1536/ihj.24-368","url":null,"abstract":"<p><p>The prevalence of atrial fibrillation (AF) increases with age and treatment with catheter ablation is performed frequently. Catheter ablation may have a lower rate of success and a higher rate of complications in older patients.We compared the characteristics, success rates, and complications of catheter ablation in patients with AF categorized into late old-aged (≥ 75 years, n = 148), early old-aged (65-74 years), n = 129), and middle-aged (< 65 years, n = 91) groups. Effects of catheter ablation on cardiac function in the left ventricle (LV) and left atrium (LA), and plasma B-type natriuretic peptide levels were evaluated at baseline and 1 year.AF ablation was successfully performed in older patients and the recurrence rate did not differ between groups (late old-aged: 29.7%, early old-aged: 15.5%, middle-aged: 23.1%). Procedural complications did not statistically differ among the groups (late old-aged: 9.5%, early old-aged: 6.2%, middle-aged: 3.3%). The LA volume index was greater in the late old-aged patients than in the other 2 groups. As comorbidities, hypertension and history of heart failure and stroke were more common in late old-aged patients. At 1 year after ablation, the LV ejection fraction, the LA volume index, and LA emptying fraction were improved, even in late old-aged patients. Plasma B-type natriuretic peptide levels were reduced in both the late old-aged and early-old-aged groups.Our findings indicate that AF ablation in late old-aged patients is effective, particularly with regard to LA structure and function, and the complication rate is similar to that in middle-aged patients.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"44-50"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High Plasma Levels of Sestrin2 Are Associated with Cardiovascular Events in Patients Undergoing Coronary Angiography.","authors":"Yoshimi Kishimoto, Emi Saita, Reiko Ohmori, Kazuo Kondo, Yukihiko Momiyama","doi":"10.1536/ihj.24-407","DOIUrl":"https://doi.org/10.1536/ihj.24-407","url":null,"abstract":"<p><p>Atherosclerotic diseases, like coronary artery disease (CAD), are recognized to be associated with oxidative stress and inflammation. Sestrin2 is a stress-inducible protein that has anti-oxidant and anti-inflammatory properties. We previously reported that plasma sestrin2 levels were high in patients with CAD. However, no study has shown their prognostic value in patients with CAD. We investigated the association between plasma sestrin2 levels and major adverse cardiovascular events (MACE) (cardiovascular death, myocardial infarction, unstable angina, coronary revascularization, heart failure, or stroke) in 320 patients undergoing coronary angiography, of whom 191 had CAD. During a mean follow-up of 7.0 ± 4.2 years, 58 patients had MACE. Plasma sestrin2 levels were higher in patients with CAD than without CAD (median 16.4 versus 14.2 ng/mL, P < 0.05). Notably, patients with MACE had higher sestrin2 levels (19.5 versus 14.9 ng/mL) and more often had sestrin2 > 15.0 ng/mL (79% versus 49%) than those without MACE (P < 0.001). Kaplan-Meier analysis showed lower event-free survival in patients with sestrin2 > 15.0 ng/mL than in those with ≤ 15.0 ng/mL (P < 0.001). In multivariate Cox hazards analysis, sestrin2 level (> 15.0 ng/mL) was a significant predictor of MACE (hazard ratio: 2.44; 95%CI: 1.28-4.67), independent of CAD and atherosclerotic risk factors. Moreover, among 191 patients with CAD, sestrin2 level was also a significant predictor of MACE (hazard ratio: 2.51; 95%CI: 1.28-4.82), independent of the severity of CAD and coronary revascularization. Thus, high plasma levels of sestrin2 at baseline angiography were found to be associated with an increased risk of cardiovascular events in patients with CAD and patients undergoing coronary angiography.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"28-35"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaixin Ge, Diyaerjiang Aierken, Defang Deng, Zhen Jiang, Teng Feng, Jufeng Meng, Hui Zhang, Jinjun Cao, Chen Liu
{"title":"High-Fat Diet during Mouse Pregnancy Impairs Fetal Heart Development.","authors":"Kaixin Ge, Diyaerjiang Aierken, Defang Deng, Zhen Jiang, Teng Feng, Jufeng Meng, Hui Zhang, Jinjun Cao, Chen Liu","doi":"10.1536/ihj.24-245","DOIUrl":"https://doi.org/10.1536/ihj.24-245","url":null,"abstract":"<p><p>Maternal overnutrition correlates with detrimental outcomes in offspring. However, the specific effects of gestational exposure to a high-fat diet (HFD) on fetal development remain unclear. This study aimed to elucidate the developmental phenotypes of neonatal organs and cardiomyocytes of mice exposed to gestational HFD, revealing growth retardation and a notable reduction in cardiomyocyte cell cycle activity. In this study, an HFD model was used to investigate the effects of maternal HFD on offspring development. Defective development was observed in the offspring, and severe restriction of cell proliferation was noted in the neonatal organs as a result of maternal HFD. Based on this evidence, we detected a reduction in cardiomyocyte proliferation in offspring exposed to maternal HFD. Moreover, RNA sequencing analysis revealed that HFD diminished fatty acid metabolism, enhanced the inflammatory response, and upregulated the transcription of genes involved in Tp53-regulated cell cycle arrest in postnatal day 0 (P0) cardiomyocytes. Furthermore, our results showed that the effects of the maternal diet during gestation are profound and normal lactation and feeding after delivery cannot help adult offspring recover from defective heart development. These findings highlight the diverse pathways affected by maternal HFD, particularly implicating a potential TP53-dependent mechanism contributing to cardiac defects in offspring.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"144-156"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anterior Upper Lateral Versus Anterior-Lateral Electrode Positions for External Cardioversion in Atrial Fibrillation.","authors":"Dengke Ou, Wei Cai, Yongchun Zeng, Mingyang Tang","doi":"10.1536/ihj.23-274","DOIUrl":"https://doi.org/10.1536/ihj.23-274","url":null,"abstract":"<p><p>Electrical cardioversion is the first-line rhythm control therapy for symptomatic persistent atrial fibrillation (AF). Although the anterior-posterior and anterior-lateral electrode positions are widely used as the standard for external cardioversion in the current guidelines, they are ineffective in > 10% of patients. Therefore, we assessed the efficacy of the anterior upper lateral electrode positioning on defibrillation electrodes during cardioversion in AF.In this randomized, investigator-initiated, open-label trial, we randomly assigned patients with AF scheduled for elective cardioversion to either the anterior-lateral or anterior-posterior electrode positioning groups. The primary outcome was the proportion of patients with sinus rhythm after the first shock. The secondary outcome was the proportion of patients in sinus rhythm after up to 3 shocks escalating to maximum energy. Safety outcomes included arrhythmia during or after cardioversion, skin redness, and patient-reported periprocedural pain.We randomly selected 333 patients. The primary outcome occurred in 125 (75%) patients in the anterior upper lateral electrode position group and 88 (53%) patients in the anterior-lateral electrode position group (risk difference, 22 percentage points, 95% CI: 14-35; P < 0.001). After the final cardioversion shock, 155 (93%) patients were in the anterior upper lateral electrode positioning group and 141 (85%) patients were in the anterior-posterior electrode positioning group (risk difference, 8 percentage points, 95% CI: 2-15). There were no significant differences in any safety outcomes between the groups.The anterior upper lateral electrode positioning was more effective than the anterior-lateral electrode positioning for biphasic cardioversion in AF. There were no significant differences in the safety outcomes.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"234-240"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Modulate the NLRP3 Inflammasome/Caspase-1 Pathway to Repress Pyroptosis Induced by Hypoxia/Reoxygenation in Cardiac Microvascular Endothelial Cells.","authors":"Liwei Diao, Yi Wu, Xiuzheng Jiang, Bojiao Chen, Wen Zhang, Li Chen, Weijin Zhou, Lihong Jiang, Xinyuan Liu, Jingang Deng, Zhongqun Zhan, Benqing Wu, Xiaoshen Zhang","doi":"10.1536/ihj.23-500","DOIUrl":"10.1536/ihj.23-500","url":null,"abstract":"<p><p>Human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) have the ability to treat cardiovascular diseases (CVDs). We explored their mechanism on pyroptosis modulation in cardiac microvascular endothelial cells (CMECs).Exosomes were extracted from hUCMSCs using a differential high-speed centrifugation method, and then identified by transmission electron microscopy, nanoparticle tracking analysis, and Western blot analysis. Later, the CMECs were induced by hypoxia/reoxygenation (H/R) in vitro and processed with hUCMSC-Exos or the NLRP3 inflammasome inhibitor CY-09 and the NLRP3 inflammasome activator Nigerian sodium sulfate (NSS). A rat model of ischemia/reperfusion (I/R) injury was established in vivo, followed by hUCMSC-Exo injection. Cell viability and death, and myocardial injury were assessed by CCK-8 and LDH assays and H&E staining. Levels of GSDMD-N, NLRP3, cleaved Caspase-1, IL-1β and IL-18 proteins, and inflammatory factors (IL-1β, IL-18) were determined by Western blot analysis and ELISA.H/R-induced CMECs represented attenuated cell viability and increased cell death, as well as up-regulated levels of pyroptosis proteins (cleaved Caspase-1, GSDMD-N, IL-18, IL-1β), inflammasome key protein (NLRP3) and cell supernatant inflammatory factors (IL-18, IL-1β), while hUCMSC-Exos amplified H/R-induced CMEC viability and lowered cell death, and diminished levels of NLRP3, cleaved Caspase-1, GSDMD-N, IL-18 and IL-1β proteins, and cell supernatant inflammatory factors IL-1β and IL-18. Activating the NLRP3 inflammasome/Caspase-1 pathway partially reversed the inhibitory effect of hUCMSC-Exos on CMEC pyroptosis. hUCMSC-Exos alleviated myocardial injury in I/R rats by modulating the NLRP3 inflammasome/Caspase-1 pathway.hUCMSC-Exos weakened CMEC pyroptosis by inactivating the NLRP3 inflammasome/Caspase-1 pathway.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"1107-1117"},"PeriodicalIF":1.2,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Features and Postoperative Mobilization following Total Aortic Arch Replacement.","authors":"Yuya Shirai, Yoshiyuki Tokuda, Yohei Tsuchikawa, Kiyonori Kobayashi, Shinya Tanaka, Natsumi Yoshito, Yuto Hori, Daichi Takagi, Yoshihiro Nishida, Masato Mutsuga","doi":"10.1536/ihj.24-261","DOIUrl":"10.1536/ihj.24-261","url":null,"abstract":"<p><p>Open thoracic aortic surgery is believed to necessitate more intensive rehabilitation. This study aimed to compare the progress of postoperative rehabilitation between standard and delayed mobilization. A retrospective review was conducted on 199 patients who underwent isolated total aortic arch replacement via median sternotomy. Cases of in-hospital mortality and postoperative stroke were excluded. Based on the current guidelines for cardiovascular rehabilitation of the Japanese Circulation Society, patients were categorized into standard mobilization (could sit on the edge of bed within 2 days) and delayed mobilization (could not do so) groups. Rehabilitation progress was compared among both groups. Initial mobilization was delayed in 100 patients (delayed mobilization group), primarily because of respiratory failure (46.0%). Preoperative risk characteristics, including EuroSCORE II (median, 2.9 versus 3.5), were similar between the standard and delayed mobilization groups. The delayed mobilization group had longer operation (median, 6.1 versus 8.0 hours, P < 0.001) and cardiopulmonary bypass (median, 3.2 versus 4.1 hours, P < 0.001) times. Independent ambulation occurred earlier in the standard mobilization group (median, 6.0 versus 8.0 days, P < 0.001).In conclusion, early initiation of sitting on the edge of the bed within 2 days was associated with earlier independent ambulation during postoperative rehabilitation, which supports the current guidelines. Longer operation and cardiopulmonary bypass times were associated with delayed mobilization initiation, suggesting the need for more tailored approaches in such cases.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"1075-1078"},"PeriodicalIF":1.2,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Early Rhythm Control Strategy in Early Atrial Fibrillation Patients.","authors":"Yiwei Liu, Xiaowei Chen, Hongbo Lin, Peng Shen, Feng Sun, Yang Xu","doi":"10.1536/ihj.24-137","DOIUrl":"10.1536/ihj.24-137","url":null,"abstract":"<p><p>Atrial fibrillation (AF) pharmaceutical treatment strategy on when to start rhythm control has been debated for decades. In early studies, these 2 strategies exhibited equivalent efficacy; however, more recent studies based on CHA<sub>2</sub>DS<sub>2</sub>-VASc score indicated that early rhythm control (ERC) is more beneficial than UC. We hypothesized that ERC might benefit persons with AF in other cardiovascular outcomes, regardless of the CHA<sub>2</sub>DS<sub>2</sub>-VASc score. To elucidate this, we conducted the present study.A retrospective cohort study was conducted using the Yinzhou Regional Health Care Database. We included all patients diagnosed with AF within 1 year and excluded those without age/sex information, without ERC/UC treatment prescription, or with ongoing cancer. The primary outcome was major cardiovascular events (MACE). We used inverse probability of treatment weighting (IPTW) for covariate weighting.A total of 7,161 patients diagnosed with early-stage AF were included in this study. Of them, 2,248 and 4,913 were included in the ERC and UC groups, respectively. During the mean follow-up period of 3.2 years (27,945 person-year), and after IPTW, ERC showed significantly lower risk for MACE (HR: 0.75 [0.61, 0.96], P = 0.02) and heart failure (HF; HR: 0.71 [0.54, 0.95], P = 0.01). No significant results were obtained for stroke, cardiovascular death, or all-cause mortality.ERC is more beneficial to early-stage Persons with AF than UC for MACEs, particularly HF.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"1012-1019"},"PeriodicalIF":1.2,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deep Learning to Detect Pulmonary Hypertension from the Chest X-Ray Images of Patients with Systemic Sclerosis.","authors":"Mai Shimbo, Masaru Hatano, Susumu Katsushika, Satoshi Kodera, Yoshitaka Isotani, Shinnosuke Sawano, Ryo Matsuoka, Shun Minatsuki, Toshiro Inaba, Hisataka Maki, Hayakazu Sumida, Norifumi Takeda, Hiroshi Akazawa, Issei Komuro","doi":"10.1536/ihj.24-111","DOIUrl":"10.1536/ihj.24-111","url":null,"abstract":"<p><p>Pulmonary hypertension (PH) is a serious prognostic complication in patients with systemic sclerosis (SSc). Deep learning models can be applied to detect PH in the chest X-ray images of these patients. The aim of the study was to investigate the performance and prognostic implications of a deep learning algorithm for the diagnosis of PH in SSc patients using chest X-ray images.Chest X-ray images were acquired from 230 SSc patients with suspected PH who underwent chest X-ray and right heart catheterization (RHC). A convolutional neural network was trained to identify the data of patients with PH (mean pulmonary arterial pressure > 20 mmHg). Kaplan-Meier analysis was used to evaluate survival. The area under the receiver operating characteristic curve (AUC) obtained with the deep learning algorithm was 0.826 while the AUC obtained with cardiologist assessments of the same images was 0.804. The 5-year prognosis was 83.4% in patients with PH detected by RHC, and 85% in those with PH detected by the model.The deep learning model developed in this study can detect PH from the chest X-ray data of SSc patients. The prognostic accuracy of the model was demonstrated as well.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"1066-1074"},"PeriodicalIF":1.2,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rie Aoyama, Yuta Fujimoto, Shinichi Okino, Shigeru Fukuzawa, Kenji Mogi
{"title":"Late-Onset Left Ventricular Pseudoaneurysm After Dor Operation in an Elderly Male Patient.","authors":"Rie Aoyama, Yuta Fujimoto, Shinichi Okino, Shigeru Fukuzawa, Kenji Mogi","doi":"10.1536/ihj.24-281","DOIUrl":"10.1536/ihj.24-281","url":null,"abstract":"<p><p>Left ventricular (LV) pseudoaneurysm is a rare complication that occurs shortly after myocardial infarction or previous cardiac surgery. We present here a case of an elderly patient with an LV pseudoaneurysm that developed over a long period of time after Dor operation. An 83-year-old man with rapid LV enlargement 18 years after Dor operation presented with dyspnea. We diagnosed his mass as an LV pseudoaneurysm using multiple non-invasive imaging modalities. The suture between the patch and the LV myocardium became fragile and detached over time. However, due to adhesion in the thorax and slow blood flow, the enlargement stopped. Surgery was considered, but due to his age and renal dysfunction, he did not undergo surgery. Conservative treatment with antihypertensive and heart failure therapy was continued. Clinical manifestations of LV pseudoaneurysm vary from asymptomatic to signs of heart failure and even sudden death. Surgery is recommended for LV pseudoaneurysm because of the high risk of rupture, but conservative treatment may be an option that has been developed long after surgery in the era of an increasing number of elderly OMI or post-cardiac surgery patients. Proper diagnosis using multiple imaging modalities may lead to the avoidance of this devastating complication.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":" ","pages":"1161-1166"},"PeriodicalIF":1.2,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}