{"title":"Impact of High Care Unit Management on In-Hospital Mortality in Patients with ST-Elevation Myocardial Infarction.","authors":"Takaaki Asano, Yorihiko Koeda, Takahito Nasu, Reisuke Yoshizawa, Yu Ishikawa, Tomonori Itoh, Yoshihiro Morino, Hidenori Saito, Hiroyuki Onodera, Tetsuji Nozaki, Yuko Maegawa, Osamu Nishiyama, Mahito Ozawa, Takuya Osaki, Akihiro Nakamura","doi":"10.1536/ihj.24-720","DOIUrl":"10.1536/ihj.24-720","url":null,"abstract":"<p><p>The impact of HCU management on the short-term prognosis of STEMI patients undergoing primary percutaneous coronary intervention (PCI) remains unclear.We retrospectively assessed 694 STEMI patients who underwent primary PCI at 8 regional general hospitals in Iwate Prefecture from 2014-2018. The patients were categorized based on the hospital to which they were admitted with or without HCUs (353 versus 341 patients, from 3 versus 5 hospitals, respectively). There was no significant between-group difference for overall in-hospital mortality (7% versus 10%, P = 0.174). However, in the Killip Class II or higher, in-hospital mortality was significantly lower among patients admitted to the HCU (20% versus 44%, P < 0.001). After propensity score matching, we found that overall in-hospital mortality was significantly lower in patients admitted to HCUs (2% versus 8%, P = 0.008). Furthermore, mortality rates for patients requiring mechanical ventilation or circulatory support were significantly lower for patients admitted to HCUs, with mortality rates of 30% versus 50% (P = 0.037).Our findings suggest that in hospitals without CCUs, systemic management through HCUs may significantly improve the survival prognosis of STEMI patients with Killip classification of II or higher.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"226-233"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association Between Hemodynamic Monitoring Need and Prognosis of Patients with Sepsis in the Intensive Care Unit.","authors":"Ruitong Zhou, Le Fu, Yide Li, Liang Luo","doi":"10.1536/ihj.24-601","DOIUrl":"https://doi.org/10.1536/ihj.24-601","url":null,"abstract":"<p><p>Sepsis, a life-threatening disease characterized by organ dysfunction, is primarily caused by an abnormally regulated host response to infection. This study aimed to evaluate the association between hemodynamic monitoring (HM) and the prognosis of patients with sepsis in the intensive care unit (ICU). This retrospective analysis used data from the MIMIC-IV database (2008-2019) at a tertiary medical center in Boston, focusing on adult patients with sepsis. Hemodynamic monitoring was conducted using PICCO. The primary outcome was in-hospital mortality, and the secondary outcomes were ICU mortality, hospital stay, and ICU length of stay. In our study, 16,065 patients were selected for the cohort, and 109 of them underwent HM. After 1:1 matching using a genetic algorithm, the final matched cohort included 98 patients who received HM and 98 patients who did not. The HM group had significantly higher hospital (38.64% versus 14.77%, P < 0.001) and ICU mortality (32.6% versus 17.35%, P < 0.001). In conclusion, patients with sepsis who underwent HM had a worse prognosis. The association between HM and higher mortality rates necessitates further research to understand the underlying reasons and to optimize the use of HM strategies in sepsis management in the ICU.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 3","pages":"436-442"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful Cryoballoon Ablation in Paroxysmal Atrial Fibrillation Patient Post-Esophageal Cancer Surgery.","authors":"Yuji Miyoshi, Shota Tokuno, Yasuko Tanabe, Yuichiro Kawamura, Naoki Nakagawa","doi":"10.1536/ihj.24-541","DOIUrl":"10.1536/ihj.24-541","url":null,"abstract":"<p><p>In conventional radiofrequency ablation for symptomatic paroxysmal atrial fibrillation, there are concerns regarding the risk of esophageal thermal injury (ETI), such as esophageal ulcers and left atrioesophageal fistulas. While the incidence of ETI is generally considered low with cryoballoon ablation, some cases of esophageal ulcers and gastric hypoperistalsis have been reported. In this report, we present the case of a 77-year-old male patient with atrial fibrillation after esophageal surgery who had successfully undergone cryoballoon ablation without esophageal complications, despite the close proximity of the left atrium and gastric tube. Cryoballoon ablation achieved pulmonary vein isolation without complications in the upper alimentary tract.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"183-186"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Concomitant Mitral Valve Surgery in a Modified Morrow Procedure in Patients with Hypertrophic Obstructive Cardiomyopathy.","authors":"Chunshui Liang, Mingwen Li, Ruiyan Ma, Zhao Jian","doi":"10.1536/ihj.24-155","DOIUrl":"10.1536/ihj.24-155","url":null,"abstract":"<p><p>Ventricular septal myectomy (modified Morrow procedure) is the gold standard surgical intervention for hypertrophic obstructive cardiomyopathy (HOCM). However, the indications for a concomitant mitral valve (MV) procedure to relieve mitral regurgitation (MR) or intrinsic MV pathological changes remain controversial. We aimed to retrospectively analyze this series of patients to evaluate the safety and efficiency of the procedure at our center.We retrospectively reviewed a total of 56 consecutive patients with HOCM who underwent concomitant MV surgery with modified Morrow procedures at our center between January 2019 and December 2021. The baseline characteristics, perioperative data, and postoperative outcomes were examined.The operative mortality rate was 0% among all 56 patients. Two patients had complete atrioventricular block, two patients experienced renal failure, and one patient required reoperation for bleeding. The peak gradient of the left ventricular outflow tract decreased from 93.6 ± 34.4 mm Hg to 20.5 ± 13.0 mm Hg. MR was significantly relieved, and the systolic anterior motion of the MV resolved completely after concomitant MV surgery. During a mean follow-up of 13.8 ± 7.1 months, no patient required cardiac reoperation.Concomitant surgery of the MV during the modified Morrow procedure was performed safely and effectively in the treatment of most types of HOCM in our practice.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"252-256"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Coronary Microvascular Dysfunction and Adverse Outcomes in the Spectrum of Dilated Cardiomyopathy.","authors":"Hisanori Kosuge, Masatake Kobayashi, Shoko Hachiya, Yasuhiro Fujita, Satoshi Hida, Kazuhiro Satomi","doi":"10.1536/ihj.24-744","DOIUrl":"10.1536/ihj.24-744","url":null,"abstract":"<p><p>Hypokinetic non-dilated cardiomyopathy (HNDC), a preclinical state of dilated cardiomyopathy (DCM), is characterized by left ventricular (LV) dysfunction without LV dilatation. Although myocardial fibrosis and microvascular dysfunction in DCM are associated with LV remodeling and poor outcome, these characteristics concerning HNDC remain unclear. We compared DCM and HNDC with regard to their clinical characteristics and prognosis.We retrospectively enrolled 100 patients with DCM (n = 64) or HNDC (n = 36) who underwent cardiac magnetic resonance (CMR). DCM and HNDC were classified based on an LV end-diastolic diameter index (LVEDDI). The association of LVEDDI with the composite outcome of all-cause mortality, heart failure hospitalization, or ventricular arrhythmia occurrence was assessed. Phase-contrast cine imaging was performed in a subset of 17 patients (12 with DCM and 5 with HNDC) and 7 control subjects to assess coronary flow reserve (CFR).During the follow-up period (median: 22.0 months; interquartile range: 9.0-33.8 months), patients with DCM showed higher risk of the primary outcome than those with HNDC (P = 0.026). A higher LVEDDI was significantly associated with clinical outcomes even after adjusting for covariates (i.e., brain natriuretic peptide, the presence of late gadolinium enhancement, and LV ejection fraction; adjusted hazard ratio, 1.350; 95% confidence interval, 1.008-1.808; P = 0.044). CFR in HNDC was significantly higher than that in DCM (P < 0.05) and comparable to that in the control group.LV dilatation is an independent predictor of adverse events in DCM and HNDC.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"257-263"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Courses of Elderly Patients with Heart Failure Managed by Local Partnership Clinical Pathway and Multidisciplinary Care.","authors":"Yuki Yamamoto, Noboru Watanabe, Satoru Hasegawa, Chieko Tanaka, Chie Takano, Takahiro Shimizu, Hirohiko Motoki, Mitsuaki Isobe, Koichiro Kuwahara","doi":"10.1536/ihj.24-467","DOIUrl":"https://doi.org/10.1536/ihj.24-467","url":null,"abstract":"<p><p>Heart failure (HF) is the most critical issue in the medical and long-term care for the elderly because HF is an economic and social burden due to its high prevalence and poor prognosis. General practitioners (GPs) have recently managed patients with chronic HF (CHF) in collaboration with hospital cardiologists. However, little is known about how to collaborate and its outcomes.We have operated a local partnership program using clinical pathway (LPCP) for CHF to facilitate medical and nursing care teamwork in the local community since June 2009. The hospital's multidisciplinary teams evaluate and share patient information periodically. Among 500 patients with available follow-up data as of December 2020, we defined patients who withdrew from the LPCP for reasons other than death as path-dropout (n = 164) and the remaining as path-continue patients (n = 336). The Kaplan-Meier method considering time co-variability of path-dropout, showed a significantly higher hazard ratio of all-cause death in the path-dropout group than in the path-continue group (HR: 5.09; 95% CI: 3.54-7.30, P < 0.001).LPCP provides integrated disease management for CHF by cardiologists and multidisciplinary professionals in the hospital collaborating with local GPs and home care teams. A multivariate analysis identified LPCP as the most important independent predictor of clinical outcome. LPCP may work as an observational tool to distinguish HF patient clinical outcomes.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 3","pages":"352-362"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk Factors and Construction of a Predictive Model for Postoperative Early Cognitive Dysfunction in Aortic Dissecting Aneurysms.","authors":"Lu Ding, Yinhuan Xu, Guangpu Fan","doi":"10.1536/ihj.24-686","DOIUrl":"https://doi.org/10.1536/ihj.24-686","url":null,"abstract":"<p><p>This study aimed to investigate the factors influencing cognitive dysfunction in patients with aortic dissection after surgery and to construct a risk prediction model for it.This retrospective study analyzed 122 patients with aortic dissection who were admitted to our hospital between January 1, 2015, and February 29, 2024. First, we grouped the patients based on the early occurrence of postoperative cognitive dysfunction (POCD) after surgery into the POCD and non-POCD groups. We subsequently compared the general clinical data and relevant surgical information between the two groups. Multivariate binary logistic regression analysis was performed to identify the factors influencing early POCD in patients with aortic dissection. Then, the risk prediction model was constructed. Receiver operating characteristic (ROC) curves were used to analyze each factor's predictive effectiveness.Multivariate binary logistic regression analysis revealed that age at surgery (P = 0.042), intensive care unit (ICU) stay duration (P = 0.003), mechanical ventilation time (P = 0.020), and aortic cross-clamping time (P = 0.010) were independent risk factors for early POCD in patients with aortic dissection, while postoperative oxygen saturation (P < 0.001) acted as an independent protective factor. A predictive model was established, achieving a ROC curve, area under the curve of 0.955, 95% confidence interval (0.917, 0.993), sensitivity of 0.878, and specificity of 0.926.Age at surgery, ICU stay duration, mechanical ventilation time, aortic cross-clamping time, and postoperative oxygen saturation were independent influencing factors for predicting early POCD.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 3","pages":"456-462"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Feng Ju, Xianjie Zhang, Zhifu Zhao, Yuansheng Cao, An Xie, Leqiang Xia, Dan Zhou
{"title":"Aloperine Regulates Inflammation, Apoptosis, and Autophagy in H9C2 Rat Cardiomyoblast Cells After Excessive Hypoxia.","authors":"Feng Ju, Xianjie Zhang, Zhifu Zhao, Yuansheng Cao, An Xie, Leqiang Xia, Dan Zhou","doi":"10.1536/ihj.24-454","DOIUrl":"10.1536/ihj.24-454","url":null,"abstract":"<p><p>Myocardial infarction (MI) is a cardiovascular condition that leads to increased morbidity and mortality, impacting the quality of life of individuals. Aloperine (ALO), derived from Sophora alopecuroides L, has been recognized for its beneficial effects in treating various diseases by showcasing therapeutic properties. However, the precise protective mechanisms of ALO on hypoxia/reoxygenation (H/R) -induced damage in cardiomyocytes in vitro remain unclear. In this study, it was manifested that cell proliferation was weakened after H/R treatment, but this impact was offset after ALO treatment. Furthermore, cell apoptosis was heightened after H/R treatment, but this phenomenon was neutralized after ALO treatment. ALO relieved inflammation in H/R-treated H9C2 rat cardiomyoblast cells. Moreover, ALO strengthened autophagy in H/R-triggered H9C2 rat cardiomyoblast cells through enhancing the LC3II/LC3I level and the LC3B fluorescence intensity. Lastly, it was testified that ALO can rescue the weakened autophagy, the heightened cell apoptosis, and the augmented inflammation after CC treatment in H/R-mediated H9C2 rat cardiomyoblast cells. In conclusion, ALO regulated inflammation, apoptosis, and autophagy through AMPK/Nrf2 pathway in H9C2 rat cardiomyoblast cells after excessive hypoxia. This study suggested that ALO may be an underlying drug for MI therapy.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"157-163"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Myocardial Infarction Associated with a Giant Hiatal Hernia.","authors":"Satoshi Nakawatase, Yasuhiro Ichibori, Naoki Mori, Yoshiharu Higuchi","doi":"10.1536/ihj.24-500","DOIUrl":"10.1536/ihj.24-500","url":null,"abstract":"<p><p>An 81-year-old woman was admitted to our hospital due to dyspnea on exertion, attributed to severe aortic stenosis, and was scheduled for transcatheter aortic valve implantation (TAVI). The day before the procedure, she experienced chest pain radiating to the left shoulder after consuming a hospital meal that was large compared to her usual meal size. An electrocardiogram (ECG) in the supine position showed ST-segment elevation in leads II, III, aVF, and reciprocal ST-segment depression in leads V1-V4. Interestingly, these changes resolved when she was in the sitting position. Chest computed tomography (CT) revealed a giant hiatal hernia slipping under the heart, with no other abnormal findings. During the TAVI procedure, the supine position again triggered chest symptoms, and subsequent coronary angiography demonstrated disruption of the left circumflex coronary artery (LCx) in the middle portion. Following drainage of the gastric contents, the coronary flow in the LCx improved to normal levels. Cardiac enzymes, including CK-MB, were elevated after TAVI. These findings suggest that the giant hiatal hernia directly compressed the coronary artery, leading to LCx flow disturbance and myocardial infarction. This case report highlights that a hiatal hernia is a common condition in the elderly and can be a potential cause of ischemic heart disease. It underscores the importance of recognizing that the cardiac effects of a hiatal hernia can vary significantly depending on the morphology of the hernia and the position of the patient.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"323-326"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reminiscence Therapy-Involved Care Program Alleviates Cognitive Impairment and Depression in Elderly Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention.","authors":"Taihua Zhou, Peilin Dong, Yaoyao Hu, Jia Wang, Mengjiao Hu, Xiaoxiao Chen, Yan Yang, Ping Zhu","doi":"10.1536/ihj.24-637","DOIUrl":"10.1536/ihj.24-637","url":null,"abstract":"<p><p>Reminiscence therapy (RT) promotes cognitive and psychological health in elderly individuals. This study assessed the impact of the reminiscence therapy-involved care program (RTIC) on cognition, anxiety, depression, and satisfaction among patients with elderly acute coronary syndrome (ACS) who received percutaneous coronary intervention (PCI).In total, 152 elderly patients with ACS undergoing PCI were randomized into the RTIC (n = 76) and routine care (RC) (n = 76) groups to receive the corresponding 6-month interventions. The mini-mental state examination (MMSE) scores were evaluated at discharge (M0), 3rd month (M3), and 6th month (M6). The hospital anxiety and depression scale for anxiety/depression (HADS-A/HADS-D) and patient satisfaction scores were assessed at M0, 1st month (M1), M3, and M6.The MMSE score at M6 (27.6 ± 2.0 versus 26.7 ± 2.1, P = 0.011) increased, whereas the percentage of cognitive impairment at M6 (27.9% versus 44.8%, P = 0.042) declined in the RTIC group versus the RC group. Moreover, the RTIC group achieved a low HADS-D score at M3 (6.5 ± 2.0 versus 7.4 ± 2.6, P = 0.035) and M6 (6.3 ± 1.9 versus 7.2 ± 2.5, P = 0.016), but a similar HADS-A score and percentages of depression and anxiety at any assessment point versus the RC group. Patient satisfaction at M3 (82.3 ± 12.0 versus 77.7 ± 11.4, P = 0.020) and M6 (85.6 ± 11.0 versus 79.4 ± 12.0, P = 0.002) was higher in the RTIC group than in the RC group. In the subgroup analysis, patients with and without cognitive impairment at M0 and those with depression at M0 benefited from RTIC. RTIC promotes cognition, psychological health, and satisfaction among elderly patients with ACS undergoing PCI.</p>","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"293-301"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}