International heart journal最新文献_第7页

Aloperine Regulates Inflammation, Apoptosis, and Autophagy in H9C2 Rat Cardiomyoblast Cells After Excessive Hypoxia. Aloperine调节H9C2大鼠心肌细胞过度缺氧后的炎症、凋亡和自噬。

IF 1.2 4区医学

International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-454

Feng Ju, Xianjie Zhang, Zhifu Zhao, Yuansheng Cao, An Xie, Leqiang Xia, Dan Zhou

{"title":"Aloperine Regulates Inflammation, Apoptosis, and Autophagy in H9C2 Rat Cardiomyoblast Cells After Excessive Hypoxia.","authors":"Feng Ju, Xianjie Zhang, Zhifu Zhao, Yuansheng Cao, An Xie, Leqiang Xia, Dan Zhou","doi":"10.1536/ihj.24-454","DOIUrl":"10.1536/ihj.24-454","url":null,"abstract":"Myocardial infarction (MI) is a cardiovascular condition that leads to increased morbidity and mortality, impacting the quality of life of individuals. Aloperine (ALO), derived from Sophora alopecuroides L, has been recognized for its beneficial effects in treating various diseases by showcasing therapeutic properties. However, the precise protective mechanisms of ALO on hypoxia/reoxygenation (H/R) -induced damage in cardiomyocytes in vitro remain unclear. In this study, it was manifested that cell proliferation was weakened after H/R treatment, but this impact was offset after ALO treatment. Furthermore, cell apoptosis was heightened after H/R treatment, but this phenomenon was neutralized after ALO treatment. ALO relieved inflammation in H/R-treated H9C2 rat cardiomyoblast cells. Moreover, ALO strengthened autophagy in H/R-triggered H9C2 rat cardiomyoblast cells through enhancing the LC3II/LC3I level and the LC3B fluorescence intensity. Lastly, it was testified that ALO can rescue the weakened autophagy, the heightened cell apoptosis, and the augmented inflammation after CC treatment in H/R-mediated H9C2 rat cardiomyoblast cells. In conclusion, ALO regulated inflammation, apoptosis, and autophagy through AMPK/Nrf2 pathway in H9C2 rat cardiomyoblast cells after excessive hypoxia. This study suggested that ALO may be an underlying drug for MI therapy.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"157-163"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myocardial Infarction Associated with a Giant Hiatal Hernia. 巨大食管裂孔疝引发心肌梗死

IF 1.2 4区医学

International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-500

Satoshi Nakawatase, Yasuhiro Ichibori, Naoki Mori, Yoshiharu Higuchi

{"title":"Myocardial Infarction Associated with a Giant Hiatal Hernia.","authors":"Satoshi Nakawatase, Yasuhiro Ichibori, Naoki Mori, Yoshiharu Higuchi","doi":"10.1536/ihj.24-500","DOIUrl":"10.1536/ihj.24-500","url":null,"abstract":"An 81-year-old woman was admitted to our hospital due to dyspnea on exertion, attributed to severe aortic stenosis, and was scheduled for transcatheter aortic valve implantation (TAVI). The day before the procedure, she experienced chest pain radiating to the left shoulder after consuming a hospital meal that was large compared to her usual meal size. An electrocardiogram (ECG) in the supine position showed ST-segment elevation in leads II, III, aVF, and reciprocal ST-segment depression in leads V1-V4. Interestingly, these changes resolved when she was in the sitting position. Chest computed tomography (CT) revealed a giant hiatal hernia slipping under the heart, with no other abnormal findings. During the TAVI procedure, the supine position again triggered chest symptoms, and subsequent coronary angiography demonstrated disruption of the left circumflex coronary artery (LCx) in the middle portion. Following drainage of the gastric contents, the coronary flow in the LCx improved to normal levels. Cardiac enzymes, including CK-MB, were elevated after TAVI. These findings suggest that the giant hiatal hernia directly compressed the coronary artery, leading to LCx flow disturbance and myocardial infarction. This case report highlights that a hiatal hernia is a common condition in the elderly and can be a potential cause of ischemic heart disease. It underscores the importance of recognizing that the cardiac effects of a hiatal hernia can vary significantly depending on the morphology of the hernia and the position of the patient.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"323-326"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of Incident Coronary Artery Disease in Patients Undergoing Atrial Fibrillation Ablation. 房颤消融患者发生冠状动脉疾病的特点

IF 1.2 4区医学

International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-676

Hiroyuki Ikeda, Kanae Hasegawa, Hiroyasu Uzui, Moe Mukai, Naoto Tama, Kentaro Ishida, Hiroshi Tada

{"title":"Characteristics of Incident Coronary Artery Disease in Patients Undergoing Atrial Fibrillation Ablation.","authors":"Hiroyuki Ikeda, Kanae Hasegawa, Hiroyasu Uzui, Moe Mukai, Naoto Tama, Kentaro Ishida, Hiroshi Tada","doi":"10.1536/ihj.24-676","DOIUrl":"10.1536/ihj.24-676","url":null,"abstract":"Few reports have provided detailed characteristics of incident coronary artery disease (CAD) and its risk factors in patients undergoing ablation (ABL) for atrial fibrillation (AF).Patients undergoing ablation for AF with no documented CAD were retrospectively studied at our institution. Patients were divided into 2 groups: those in whom significant stenosis was detected incidentally on coronary angiography (CAG) performed at the same time as ablation, and those without. The detection rate and its predictors were examined.Of the 550 patients, 20 had incidental CAD (detection rate: 3.6%). We compared the clinical data between these 20 patients (ABL-CAD group) and the 530 patients who displayed no significant stenosis on CAG. In multivariate analysis, age, hemoglobin A1c (HbA1c), and high-density lipoprotein cholesterol (HDL-chol) were predictive factors (odds ratio: 1.08, 2.43, 1.58, 95% CIs: 1.01-1.14, 1.53-3.86, 0.92-0.99; P = 0.014, 0.004, 0.024, respectively) for identification of CAD. Multivariate analysis based on cut-off values from receiver operating characteristic analysis identified age, HbA1c ≥ 6.1%, and HDL-chol ≤ 49 mg/dL as predictors (odds ratios: 1.06, 4.04, 3.07; 95% CIs: 1.00-1.12, 1.58-10.3, 1.1-8.01; P = 0.04, 0.01, 0.021, respectively). The area under the curve was significantly greater for age and HbA1c ≥ 6.1% and HDL-chol ≤ 49 mg/dL than for age alone (0.810 versus 0.672; P = 0.005).Patients undergoing ablation for AF appear likely to have CAD if HbA1c is ≥ 6.1% and HDL-chol is ≤ 49 mg/dL.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"220-225"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between Uric Acid and All-Cause and Cardiovascular Mortality in Individuals with Hypertension. 高血压患者尿酸与全因死亡率和心血管死亡率的关系

IF 1.2 4区医学

International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-220

Tian-Ming Gan, Yingjie Yang, Guan-Lian Mo, Shi-Rong Wang, Shu-Hu Li, Jin-Yi Li

{"title":"Relationship between Uric Acid and All-Cause and Cardiovascular Mortality in Individuals with Hypertension.","authors":"Tian-Ming Gan, Yingjie Yang, Guan-Lian Mo, Shi-Rong Wang, Shu-Hu Li, Jin-Yi Li","doi":"10.1536/ihj.24-220","DOIUrl":"https://doi.org/10.1536/ihj.24-220","url":null,"abstract":"Hypertension is a common disease in the general population. Serum uric acid (SUA) levels have been linked to the occurrence and worsening of hypertension. However, it is unclear whether SUA has an impact on all-cause mortality (ACM) and cardiovascular mortality (CVM) in hypertensive individuals. This research aimed to assess the relation between SUA and mortality in a hypertensive population using data from the National Health and Nutrition Examination Survey (NHANES) database.The research comprised 13,363 hypertensive patients from NHANES during 2001-2018. A weighted Cox proportional risk model and restricted cubic spline (RCS) were used for the analysis.During the follow-up period among the 13,363 participants, there were 3,066 deaths from all causes, of which 846 were from CVD. After adjusting for variables, HRs and corresponding 95% CIs were calculated for different SUA categories (Q1: SUA < 285.5 μmol/L, Q2: 285.5 μmol/L ≤ SUA < 339.0 μmol/L, Q3: 339.0 μmol/L ≤ SUA < 404.5 μmol/L, Q4: SUA ≥ 404.5 μmol/L). The ACM was 1 (reference), 1.557 (1.387, 1.747), 1.312 (1.154, 1.492), and 1.393 (1.228, 1.580) (all P < 0.01); while the CVM was 1 (reference), 1.308 (1.043, 1.641) (P = 0.041), 1.182 (0.938, 1.490) (P = 0.261), and 1.151 (0.904, 1.464) (P = 0.410). The RCS showed that both high and low levels of SUA were related to an elevated risk of ACM and CVM in a population of hypertensive individuals.In hypertensive individuals, an elevated risk of both ACM and CVM is associated with high and low levels of SUA.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 3","pages":"427-435"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reminiscence Therapy-Involved Care Program Alleviates Cognitive Impairment and Depression in Elderly Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention. 怀旧疗法介入治疗对经皮冠状动脉介入治疗的老年急性冠状动脉综合征患者认知功能障碍和抑郁的影响。

IF 1.2 4区医学

International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-637

Taihua Zhou, Peilin Dong, Yaoyao Hu, Jia Wang, Mengjiao Hu, Xiaoxiao Chen, Yan Yang, Ping Zhu

{"title":"Reminiscence Therapy-Involved Care Program Alleviates Cognitive Impairment and Depression in Elderly Patients with Acute Coronary Syndrome Treated with Percutaneous Coronary Intervention.","authors":"Taihua Zhou, Peilin Dong, Yaoyao Hu, Jia Wang, Mengjiao Hu, Xiaoxiao Chen, Yan Yang, Ping Zhu","doi":"10.1536/ihj.24-637","DOIUrl":"10.1536/ihj.24-637","url":null,"abstract":"Reminiscence therapy (RT) promotes cognitive and psychological health in elderly individuals. This study assessed the impact of the reminiscence therapy-involved care program (RTIC) on cognition, anxiety, depression, and satisfaction among patients with elderly acute coronary syndrome (ACS) who received percutaneous coronary intervention (PCI).In total, 152 elderly patients with ACS undergoing PCI were randomized into the RTIC (n = 76) and routine care (RC) (n = 76) groups to receive the corresponding 6-month interventions. The mini-mental state examination (MMSE) scores were evaluated at discharge (M0), 3rd month (M3), and 6th month (M6). The hospital anxiety and depression scale for anxiety/depression (HADS-A/HADS-D) and patient satisfaction scores were assessed at M0, 1st month (M1), M3, and M6.The MMSE score at M6 (27.6 ± 2.0 versus 26.7 ± 2.1, P = 0.011) increased, whereas the percentage of cognitive impairment at M6 (27.9% versus 44.8%, P = 0.042) declined in the RTIC group versus the RC group. Moreover, the RTIC group achieved a low HADS-D score at M3 (6.5 ± 2.0 versus 7.4 ± 2.6, P = 0.035) and M6 (6.3 ± 1.9 versus 7.2 ± 2.5, P = 0.016), but a similar HADS-A score and percentages of depression and anxiety at any assessment point versus the RC group. Patient satisfaction at M3 (82.3 ± 12.0 versus 77.7 ± 11.4, P = 0.020) and M6 (85.6 ± 11.0 versus 79.4 ± 12.0, P = 0.002) was higher in the RTIC group than in the RC group. In the subgroup analysis, patients with and without cognitive impairment at M0 and those with depression at M0 benefited from RTIC. RTIC promotes cognition, psychological health, and satisfaction among elderly patients with ACS undergoing PCI.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"293-301"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tandem Mass Tag-Labeling Proteomics Reveals TLN1 as a Potential Factor in Cardiogenic Pulmonary Edema. 串联质量标记蛋白组学揭示TLN1是心源性肺水肿的潜在因素。

IF 1.2 4区医学

International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-264

Yan Tan, Zhiwei Xu, Zhihua Wang, Dongming Gu

{"title":"Tandem Mass Tag-Labeling Proteomics Reveals TLN1 as a Potential Factor in Cardiogenic Pulmonary Edema.","authors":"Yan Tan, Zhiwei Xu, Zhihua Wang, Dongming Gu","doi":"10.1536/ihj.24-264","DOIUrl":"10.1536/ihj.24-264","url":null,"abstract":"Heart failure (HF) is a complex disease. The reduced blood flow associated with HF triggers the activation of neurohormonal systems, leading to symptoms such as pulmonary congestion and peripheral edema. The precise mechanisms responsible for edema in HF are poorly understood. In this study, we aimed to analyze the differentially expressed proteins in HF-induced pulmonary edema (HF-PE) and explore the potential underlying mechanisms. Proteins in the serum of patients with HF-PE (n = 10) and patients with HF without PE or those who have not developed PE yet (n = 10) were screened using tandem mass tag-labeling proteomics. The identified proteins were screened for differentially expressed proteins, which were then analyzed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses as well as protein-protein interaction (PPI) visualization. Rats with HF were induced by myocardial infarction, whereas PE was induced by LPS. Finally, the rats were injected with lentiviruses to manipulate the expression of differentially expressed proteins. A total of 1796 proteins were identified. In the serum of patients with HF-PE, there were 143 significantly upregulated proteins and 147 significantly downregulated proteins. TLN1 interacted with multiple proteins and was upregulated in patients with HF-PE. TLN1 was significantly upregulated in the lung tissues of rats with HF-PE, and the progression of HF-PE was inhibited by TLN1 knockdown. This tandem mass tag-labeling proteomics profiling study revealed that TLN1 upregulation contributes to the progression of PE in patients with HF.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 2","pages":"313-322"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Factors After Bone Marrow-Derived Mononuclear Cell Implantation in No-Option Chronic Limb-Threatening Ischemia Patients with Atherosclerotic Lower Extremity Artery Disease. 无选择慢性肢体缺血合并动脉粥样硬化性下肢动脉疾病患者骨髓源性单核细胞植入后的预后因素

IF 1.2 4区医学

International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-440

Hirofumi Kawamata, Kenji Yanishi, Jun Yoshimura, Takaaki Ozawa, Daiki Goto, Yusuke Hori, Ayumu Fujioka, Keisuke Shoji, Arito Yukawa, Satoaki Matoba

{"title":"Prognostic Factors After Bone Marrow-Derived Mononuclear Cell Implantation in No-Option Chronic Limb-Threatening Ischemia Patients with Atherosclerotic Lower Extremity Artery Disease.","authors":"Hirofumi Kawamata, Kenji Yanishi, Jun Yoshimura, Takaaki Ozawa, Daiki Goto, Yusuke Hori, Ayumu Fujioka, Keisuke Shoji, Arito Yukawa, Satoaki Matoba","doi":"10.1536/ihj.24-440","DOIUrl":"10.1536/ihj.24-440","url":null,"abstract":"Previous studies have reported the efficacy and safety of therapeutic angiogenesis through bone marrow-derived mononuclear cell (BM-MNC) implantation in patients with no-option chronic limb-threatening ischemia (CLTI) from atherosclerotic lower extremity artery disease (LEAD). However, uncertain clinical prognostic factors impact treatment outcomes. This study aimed to elucidate the long-term outcomes of patients with atherosclerotic LEAD-derived no-option CLTI after BM-MNC implantation and to identify prognostic factors.In this retrospective, single-center, observational study, the primary endpoints included the long-term prognosis of BM-MNC implantation and factors influencing 1-year outcomes. A total of 92 limbs in 84 patients were analyzed in the final cohort (mean age: 67 years; male, 65%). The 5- and 10-year overall survival rates were 50.0% and 31.0%, respectively, while the 5- and 10-year amputation-free survival rates were 37.6% and 23.3%, respectively. Multivariate logistic analysis linked all-cause mortality to age ≥ 70 years, hemodialysis, smoking, and a controlling nutrition status score ≥ 5. Major amputation or mortality was associated with male sex, hemodialysis, and C-reactive protein levels ≥ 3.0 mg/dL. No adverse events were associated with therapeutic angiogenesis.These findings endorse the feasibility and safety of BM-MNC implantation for patients with no-option CLTI due to atherosclerotic LEAD. Moreover, the study highlights the significance of several prognostic factors, including advanced age, hemodialysis, smoking, and inflammatory markers, in influencing the long-term outcomes of this treatment.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"96-105"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Fat Diet during Mouse Pregnancy Impairs Fetal Heart Development. 小鼠妊娠期高脂肪饮食损害胎儿心脏发育。

IF 1.2 4区医学

International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-245

Kaixin Ge, Diyaerjiang Aierken, Defang Deng, Zhen Jiang, Teng Feng, Jufeng Meng, Hui Zhang, Jinjun Cao, Chen Liu

{"title":"High-Fat Diet during Mouse Pregnancy Impairs Fetal Heart Development.","authors":"Kaixin Ge, Diyaerjiang Aierken, Defang Deng, Zhen Jiang, Teng Feng, Jufeng Meng, Hui Zhang, Jinjun Cao, Chen Liu","doi":"10.1536/ihj.24-245","DOIUrl":"10.1536/ihj.24-245","url":null,"abstract":"Maternal overnutrition correlates with detrimental outcomes in offspring. However, the specific effects of gestational exposure to a high-fat diet (HFD) on fetal development remain unclear. This study aimed to elucidate the developmental phenotypes of neonatal organs and cardiomyocytes of mice exposed to gestational HFD, revealing growth retardation and a notable reduction in cardiomyocyte cell cycle activity. In this study, an HFD model was used to investigate the effects of maternal HFD on offspring development. Defective development was observed in the offspring, and severe restriction of cell proliferation was noted in the neonatal organs as a result of maternal HFD. Based on this evidence, we detected a reduction in cardiomyocyte proliferation in offspring exposed to maternal HFD. Moreover, RNA sequencing analysis revealed that HFD diminished fatty acid metabolism, enhanced the inflammatory response, and upregulated the transcription of genes involved in Tp53-regulated cell cycle arrest in postnatal day 0 (P0) cardiomyocytes. Furthermore, our results showed that the effects of the maternal diet during gestation are profound and normal lactation and feeding after delivery cannot help adult offspring recover from defective heart development. These findings highlight the diverse pathways affected by maternal HFD, particularly implicating a potential TP53-dependent mechanism contributing to cardiac defects in offspring.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"144-156"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Plasma Levels of Sestrin2 Are Associated with Cardiovascular Events in Patients Undergoing Coronary Angiography. 高血浆Sestrin2水平与冠状动脉造影患者心血管事件相关

IF 1.2 4区医学

International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-407

Yoshimi Kishimoto, Emi Saita, Reiko Ohmori, Kazuo Kondo, Yukihiko Momiyama

{"title":"High Plasma Levels of Sestrin2 Are Associated with Cardiovascular Events in Patients Undergoing Coronary Angiography.","authors":"Yoshimi Kishimoto, Emi Saita, Reiko Ohmori, Kazuo Kondo, Yukihiko Momiyama","doi":"10.1536/ihj.24-407","DOIUrl":"10.1536/ihj.24-407","url":null,"abstract":"Atherosclerotic diseases, like coronary artery disease (CAD), are recognized to be associated with oxidative stress and inflammation. Sestrin2 is a stress-inducible protein that has anti-oxidant and anti-inflammatory properties. We previously reported that plasma sestrin2 levels were high in patients with CAD. However, no study has shown their prognostic value in patients with CAD. We investigated the association between plasma sestrin2 levels and major adverse cardiovascular events (MACE) (cardiovascular death, myocardial infarction, unstable angina, coronary revascularization, heart failure, or stroke) in 320 patients undergoing coronary angiography, of whom 191 had CAD. During a mean follow-up of 7.0 ± 4.2 years, 58 patients had MACE. Plasma sestrin2 levels were higher in patients with CAD than without CAD (median 16.4 versus 14.2 ng/mL, P < 0.05). Notably, patients with MACE had higher sestrin2 levels (19.5 versus 14.9 ng/mL) and more often had sestrin2 > 15.0 ng/mL (79% versus 49%) than those without MACE (P < 0.001). Kaplan-Meier analysis showed lower event-free survival in patients with sestrin2 > 15.0 ng/mL than in those with ≤ 15.0 ng/mL (P < 0.001). In multivariate Cox hazards analysis, sestrin2 level (> 15.0 ng/mL) was a significant predictor of MACE (hazard ratio: 2.44; 95%CI: 1.28-4.67), independent of CAD and atherosclerotic risk factors. Moreover, among 191 patients with CAD, sestrin2 level was also a significant predictor of MACE (hazard ratio: 2.51; 95%CI: 1.28-4.82), independent of the severity of CAD and coronary revascularization. Thus, high plasma levels of sestrin2 at baseline angiography were found to be associated with an increased risk of cardiovascular events in patients with CAD and patients undergoing coronary angiography.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"28-35"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catheter Ablation in Older Patients with Atrial Fibrillation. 老年房颤患者的导管消融。

IF 1.2 4区医学

International heart journal Pub Date : 2025-01-01 DOI: 10.1536/ihj.24-368

Tadashi Yamamoto, Takuya Kishi, Ayako Takamori, Toshio Katagiri, Masataka Kajiwara, Takashi Fujimura, Tomohiro Imamura, Tomohito Inage, Yoshitaka Hirooka

{"title":"Catheter Ablation in Older Patients with Atrial Fibrillation.","authors":"Tadashi Yamamoto, Takuya Kishi, Ayako Takamori, Toshio Katagiri, Masataka Kajiwara, Takashi Fujimura, Tomohiro Imamura, Tomohito Inage, Yoshitaka Hirooka","doi":"10.1536/ihj.24-368","DOIUrl":"10.1536/ihj.24-368","url":null,"abstract":"The prevalence of atrial fibrillation (AF) increases with age and treatment with catheter ablation is performed frequently. Catheter ablation may have a lower rate of success and a higher rate of complications in older patients.We compared the characteristics, success rates, and complications of catheter ablation in patients with AF categorized into late old-aged (≥ 75 years, n = 148), early old-aged (65-74 years), n = 129), and middle-aged (< 65 years, n = 91) groups. Effects of catheter ablation on cardiac function in the left ventricle (LV) and left atrium (LA), and plasma B-type natriuretic peptide levels were evaluated at baseline and 1 year.AF ablation was successfully performed in older patients and the recurrence rate did not differ between groups (late old-aged: 29.7%, early old-aged: 15.5%, middle-aged: 23.1%). Procedural complications did not statistically differ among the groups (late old-aged: 9.5%, early old-aged: 6.2%, middle-aged: 3.3%). The LA volume index was greater in the late old-aged patients than in the other 2 groups. As comorbidities, hypertension and history of heart failure and stroke were more common in late old-aged patients. At 1 year after ablation, the LV ejection fraction, the LA volume index, and LA emptying fraction were improved, even in late old-aged patients. Plasma B-type natriuretic peptide levels were reduced in both the late old-aged and early-old-aged groups.Our findings indicate that AF ablation in late old-aged patients is effective, particularly with regard to LA structure and function, and the complication rate is similar to that in middle-aged patients.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":"66 1","pages":"44-50"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0