International heart journal最新文献_第8页

Multimodality Risk Assessment of Patients with Ischemic Heart Disease Using Deep Learning Models Applied to Electrocardiograms and Chest X-rays 利用应用于心电图和胸部 X 射线的深度学习模型对缺血性心脏病患者进行多模态风险评估

IF 1.5 4区医学

International heart journal Pub Date : 2024-01-31 DOI: 10.1536/ihj.23-402

Shinnosuke Sawano, Satoshi Kodera, Masataka Sato, Hiroki Shinohara, Atsushi Kobayashi, Hiroshi Takiguchi, Kazutoshi Hirose, Tatsuya Kamon, Akihito Saito, Hiroyuki Kiriyama, Mizuki Miura, Shun Minatsuki, Hironobu Kikuchi, Norifumi Takeda, Hiroyuki Morita, Issei Komuro

{"title":"Multimodality Risk Assessment of Patients with Ischemic Heart Disease Using Deep Learning Models Applied to Electrocardiograms and Chest X-rays","authors":"Shinnosuke Sawano, Satoshi Kodera, Masataka Sato, Hiroki Shinohara, Atsushi Kobayashi, Hiroshi Takiguchi, Kazutoshi Hirose, Tatsuya Kamon, Akihito Saito, Hiroyuki Kiriyama, Mizuki Miura, Shun Minatsuki, Hironobu Kikuchi, Norifumi Takeda, Hiroyuki Morita, Issei Komuro","doi":"10.1536/ihj.23-402","DOIUrl":"https://doi.org/10.1536/ihj.23-402","url":null,"abstract":"Comprehensive management approaches for patients with ischemic heart disease (IHD) are important aids for prognostication and treatment planning. While single-modality deep neural networks (DNNs) have shown promising performance for detecting cardiac abnormalities, the potential benefits of using DNNs for multimodality risk assessment in patients with IHD have not been reported. The purpose of this study was to investigate the effectiveness of multimodality risk assessment in patients with IHD using a DNN that utilizes 12-lead electrocardiograms (ECGs) and chest X-rays (CXRs), with the prediction of major adverse cardiovascular events (MACEs) being of particular concern.DNN models were applied to detection of left ventricular systolic dysfunction (LVSD) on ECGs and identification of cardiomegaly findings on CXRs. A total of 2107 patients who underwent elective percutaneous coronary intervention were categorized into 4 groups according to the models' outputs: Dual-modality high-risk (n = 105), ECG high-risk (n = 181), CXR high-risk (n = 392), and No-risk (n = 1,429).A total of 342 MACEs were observed. The incidence of a MACE was the highest in the Dual-modality high-risk group (P < 0.001). Multivariate Cox hazards analysis for predicting MACE revealed that the Dual-modality high-risk group had a significantly higher risk of MACE than the No-risk group (hazard ratio (HR): 2.370, P < 0.001), the ECG high-risk group (HR: 1.906, P = 0.010), and the CXR high-risk group (HR: 1.624, P = 0.018), after controlling for confounding factors.The results suggest the usefulness of multimodality risk assessment using DNN models applied to 12-lead ECG and CXR data from patients with IHD.\u0000","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139665401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Message from the New Editor-in-Chief of International Heart Journal. 国际心脏杂志》新任主编的致辞。

IF 1.5 4区医学

International heart journal Pub Date : 2024-01-01 DOI: 10.1536/ihj.65.168

引用次数: 0

A Case of Ventricular Fibrillation in Masked Long-QT Syndrome Coexisting with Coronary Vasospasm. 一例被掩盖的长 QT 综合征并发冠状动脉血管痉挛的室颤病例

IF 1.5 4区医学

International heart journal Pub Date : 2024-01-01 DOI: 10.1536/ihj.23-397

Atsumasa Kurozumi, Yoshinari Enomoto, Hisao Hara, Norihiro Kato, Yukio Hiroi

引用次数: 0

Hydroxycitric Acid Tripotassium Hydrate Attenuates Monocrotaline and Hypoxia-Induced Pulmonary Hypertension in Rats. 羟基柠檬酸三钾水合物可减轻大鼠单克隆和缺氧诱发的肺动脉高压

IF 1.5 4区医学

International heart journal Pub Date : 2024-01-01 DOI: 10.1536/ihj.23-350

Shunjun Wang, Huayang Li, Quan Liu, Husai Ma, Lin Huang, Laishun Yu, Zhongkai Wu

{"title":"Hydroxycitric Acid Tripotassium Hydrate Attenuates Monocrotaline and Hypoxia-Induced Pulmonary Hypertension in Rats.","authors":"Shunjun Wang, Huayang Li, Quan Liu, Husai Ma, Lin Huang, Laishun Yu, Zhongkai Wu","doi":"10.1536/ihj.23-350","DOIUrl":"10.1536/ihj.23-350","url":null,"abstract":"This study investigated the effects of hydroxycitric acid tripotassium hydrate on right ventricular function, myocardial and pulmonary vascular remodeling in rats with pulmonary hypertension, and possible mechanisms.Methods: Pulmonary hypertension was induced in male Sprague-Dawley rats by a single subcutaneous injection of monocrotaline or hypoxic chamber. In vivo, inflammatory cytokine (including TNF-α, IL-1β, IL-6, and TGF-β, the level of SOD) expression, superoxide dismutase and hydrogen peroxide levels, and p-IκBα and p65 expressions were detected. In vitro, pulmonary artery smooth muscle cell proliferation and migration, ROS production, and hypoxia-inducible factor-1 expression were also studied.Results: Hydroxycitric acid tripotassium hydrate decreased right ventricular systolic pressure and reduced right ventricular fibrosis and pulmonary vascular remodeling in rats with two kinds of pulmonary hypertension. Moreover, the expression of both inflammatory and oxidative stress factors was effectively reduced, and the p65 signaling pathway was found to be inhibited in this study. Additionally, hydroxycitric acid tripotassium hydrate inhibited human pulmonary artery smooth cell proliferation and migration in vitro.Conclusions: This study shows that hydroxycitric acid tripotassium hydrate can alleviate pulmonary hypertension caused by hypoxia and monocycloline in rats, improve remodeling of the right ventricle and pulmonary artery, and inhibit pulmonary artery smooth muscle cell proliferation and migration. The protective effects may be achieved by regulating inflammation and oxidative stress through the p65 signaling pathway.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Errata: B-Type Natriuretic Peptide Inhibits the Expression and Function of SERCA2a in Heart Failure. 勘误：B型钠尿肽抑制心力衰竭中SERCA2a的表达和功能

IF 1.2 4区医学

International heart journal Pub Date : 2024-01-01 DOI: 10.1536/ihj.65-4_Errata

引用次数: 0

Characteristics of Shoshin Beriberi, a Fulminant Cardiovascular Type of Beriberi. Shoshin Beriberi（一种急性心血管型 Beriberi）的特征。

IF 1.5 4区医学

International heart journal Pub Date : 2024-01-01 DOI: 10.1536/ihj.24-034

Eisuke Amiya, Hiroyuki Morita

引用次数: 0

Letter by Kataoka and Imamura Regarding Article, "Impact of Preprocedural Frailty Status in Elderly Transvenous Pacemaker Recipients". Kataoka 和 Imamura 就 "经静脉起搏器受术者术前虚弱状态对老年人的影响 "一文的来信。

IF 1.2 4区医学

International heart journal Pub Date : 2024-01-01 DOI: 10.1536/ihj.24-050

Naoya Kataoka, Teruhiko Imamura

引用次数: 0

Regulatory factor X7 Represses Ox-LDL-Induced Proliferation and Migration of VSMCs via SIRT4-Mediated Inactivation of JAK2/STAT3 Pathway. 调节因子 X7 通过 SIRT4 介导的 JAK2/STAT3 通路失活抑制 Ox-LDL 诱导的血管内皮细胞增殖和迁移

IF 1.2 4区医学

International heart journal Pub Date : 2024-01-01 DOI: 10.1536/ihj.23-631

Yinheng Hao, Wei Li

{"title":"Regulatory factor X7 Represses Ox-LDL-Induced Proliferation and Migration of VSMCs via SIRT4-Mediated Inactivation of JAK2/STAT3 Pathway.","authors":"Yinheng Hao, Wei Li","doi":"10.1536/ihj.23-631","DOIUrl":"10.1536/ihj.23-631","url":null,"abstract":"The regulatory factor X7 (RFX7) is a vital mediator in atherosclerosis. This study aims to discuss the effect and underlying mechanism of RFX7 on the regulation of oxidized low-density lipoprotein (ox-LDL) -induced proliferation and migration of vascular smooth muscle cells (VSMCs).Ox-LDL was used to construct atherosclerosis in vitro model. The mRNA and protein levels of RFX7 and Sirtuin 4 (SIRT4) were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot assays. The cellular functions were measured via 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT), EdU, flow cytometry, and wound healing assay assays. The interaction between RFX7 and SIRT4 promoter was validated using chromatin immunoprecipitation and dual-luciferase reporter assays.The stimulation with ox-LDL elevated the viability of VSMCs and decreased the mRNA and protein levels of RFX7 and SIRT4 in VSMCs in a dose-dependent manner. Functionally, RFX7 overexpression restrained the VSMC viability, proliferation, and migration induced by ox-LDL, but facilitated VSMC apoptosis. RFX7 elevated SIRT4 expression via binding to its promoter. Furthermore, overexpressing either SIRT4 or RFX7 inactivated JAK2/STAT3 signaling, causing a decrease in VSMC proliferation and migration and an increase in VSMC apoptosis when exposed to ox-LDL. The impact of RFX7 overexpression on JAK2/STAT3 signaling and cellular function following ox-LDL exposure was abrogated by SIRT4 silencing.The heightened RFX7 expression restrained the proliferation and migration of ox-LDL-stimulated VSMCs via SIRT4-mediated inactivation of JAK2/STAT3 pathway.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Value of Troponin Levels to Cardiac Function and Prognosis in Patients with Fulminant Myocarditis. 肌钙蛋白水平对暴发性心肌炎患者心功能和预后的临床价值

IF 1.5 4区医学

International heart journal Pub Date : 2024-01-01 DOI: 10.1536/ihj.23-589

Naoki Shibata, Toru Kondo, Takahiro Okumura, Takahiro Imaizumi, Kaoru Dohi, Hideo Izawa, Nobuyuki Ohte, Tetsuya Amano, Toyoaki Murohara

{"title":"Clinical Value of Troponin Levels to Cardiac Function and Prognosis in Patients with Fulminant Myocarditis.","authors":"Naoki Shibata, Toru Kondo, Takahiro Okumura, Takahiro Imaizumi, Kaoru Dohi, Hideo Izawa, Nobuyuki Ohte, Tetsuya Amano, Toyoaki Murohara","doi":"10.1536/ihj.23-589","DOIUrl":"10.1536/ihj.23-589","url":null,"abstract":"Troponin (Tn) is a biomarker related to myocardial necrosis and is elevated in patients with myocarditis. This study aimed to investigate the association between cardiac Tn levels and the course of cardiac function, and prognosis in patients with fulminant myocarditis (FM) receiving percutaneous mechanical circulatory support (MCS).We used data from a multicenter retrospective registry, CHANGE PUMP 2, which included 216 patients with FM who required MCS. Among them, 141 patients whose Tn levels were available were analyzed. The patients were divided into low and high Tn groups according to the median values of TnT and TnI.The median age was 54 years, and 59.6% were male. The TnT and TnI on day 1 (at MCS initiation) were 3.8 (1.4-10.0) and 21.4 (8.4-68.8) ng/mL. While the left ventricular ejection fraction (LVEF) was similar on day 1 (25.0% versus 24.5%), the low Tn group showed better LVEF improvement on day 7 than the high Tn group (45.0% versus 25.3%, P < 0.001). LVEF at 1 year after admission was higher in the low Tn group (65.0% versus 59.7%, P = 0.039). The low Tn group had a better 90-day composite endpoint in death, durable left ventricular assist device implantation, and heart transplantation compared to the high Tn group (hazard ratio 0.47, 95% CI 0.23-0.95).Tn levels were associated with short- and long-term cardiac recovery and adverse outcomes in patients with FM receiving MCS due to cardiogenic shock.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Late Gadolinium Enhancement with or Without Reverse Remodeling and Prognosis. 伴有或不伴有逆重塑的晚期钆增强与预后之间的关系

IF 1.2 4区医学

International heart journal Pub Date : 2024-01-01 DOI: 10.1536/ihj.24-087

Toshinaru Kawakami, Kazuyuki Yahagi, Asahi Oshima, Yuki Gonda, Daiki Yoshiura, Yu Horiuchi, Masahiko Asami, Hitomi Yuzawa, Kota Komiyama, Jun Tanaka, Jiro Aoki, Kengo Tanabe

{"title":"Association Between Late Gadolinium Enhancement with or Without Reverse Remodeling and Prognosis.","authors":"Toshinaru Kawakami, Kazuyuki Yahagi, Asahi Oshima, Yuki Gonda, Daiki Yoshiura, Yu Horiuchi, Masahiko Asami, Hitomi Yuzawa, Kota Komiyama, Jun Tanaka, Jiro Aoki, Kengo Tanabe","doi":"10.1536/ihj.24-087","DOIUrl":"https://doi.org/10.1536/ihj.24-087","url":null,"abstract":"Late gadolinium enhancement (LGE) in cardiovascular magnetic resonance imaging (CMR) prevents left ventricular reverse remodeling (LVRR), resulting in a poor prognosis. However, the prognosis of patients who have LGE and achieve LVRR and patients who do not have LGE and do not achieve LVRR remains unknown. This study aimed to answer this question by sorting patients with heart failure based on the presence of LGE and LVRR and comparing their prognoses. Another aim was to identify useful factors for predicting LVRR.All patients were followed-up for 24 months. LVRR was defined as a ≥ 10% increase at the last follow-up at 12 ± 6 months from baseline, on echocardiography. The primary endpoint was a composite of cardiovascular death and hospitalization due to worsening heart failure within 18 ± 6 months. Baseline data and data from each outpatient visit were collected and analyzed. We enrolled 80 consecutive patients with heart failure and reduced left ventricular ejection fraction (< 50%) who underwent CMR.LGE was positive in 40 patients (50.0%) and LVRR was observed in 50 patients (63%). The incidence of the primary endpoint was significantly lower in the group that achieved LVRR, regardless of LGE status (LGE-positive group, P = 0.01; LGE-negative group, P = 0.02). In the multivariate analysis, the percentage change in NT-pro BNP levels at 3 months, NT-pro BNP levels at 6 months, and age were independent predictors of LVRR.LGE-positive patients may have a better prognosis if they achieve LVRR. Serial NT-pro BNP testing may be a valuable predictor of LVRR.","PeriodicalId":13711,"journal":{"name":"International heart journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0