International journal of cardiology最新文献

{"title":"Reply to: Comment on \"prognostic value of angiography-derived microcirculatory resistance in patients undergoing rotational atherectomy- a multi-center study\".","authors":"Hanwen Fu, Xi Zhang, Sheng Jin, Qiang Xue, Hailong Dai","doi":"10.1016/j.ijcard.2025.133928","DOIUrl":"10.1016/j.ijcard.2025.133928","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133928"},"PeriodicalIF":3.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QTc interval dynamics in pulmonary arterial hypertension: Moving beyond static measurement in risk stratification","authors":"Ugur Canpolat","doi":"10.1016/j.ijcard.2025.133927","DOIUrl":"10.1016/j.ijcard.2025.133927","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133927"},"PeriodicalIF":3.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to clinical relevance of coronary microvascular dysfunction following rotational Atherectomy.","authors":"Xi Zhang, Tao Zhao, Kaili Chang, Qiang Xue, Hailong Dai","doi":"10.1016/j.ijcard.2025.133921","DOIUrl":"10.1016/j.ijcard.2025.133921","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133921"},"PeriodicalIF":3.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between angiography-based physiology and plaque characteristics and clinical outcomes in patients with coronary artery disease","authors":"Yoshitaka Sasahira,&nbsp;Takeshi Nishi,&nbsp;Teruyoshi Kume,&nbsp;Satoshi Koto,&nbsp;Hiroshi Okamoto,&nbsp;Ryotaro Yamada,&nbsp;Terumasa Koyama,&nbsp;Tomoko Tamada,&nbsp;Yoji Neishi,&nbsp;Shiro Uemura","doi":"10.1016/j.ijcard.2025.133909","DOIUrl":"10.1016/j.ijcard.2025.133909","url":null,"abstract":"<div><h3>Background and objective</h3><div>The fractional flow reserve (FFR) pullback curve provides insights into the physiological patterns of coronary artery disease (CAD). Quantitative flow ratio (QFR), a non-invasive alternative derived from angiography, can estimate FFR. This study investigates whether QFR-based physiological disease patterns are associated with plaque morphology evaluated by optical coherence tomography (OCT) and clinical outcomes.</div></div><div><h3>Methods</h3><div>A total of 216 patients with ≥25 % diameter stenosis in the left anterior descending artery underwent QFR and OCT evaluation. Based on QFR pullback indices—PPG index and dQFR/ds—patients were classified into four groups: Group 1 (focal disease with major gradient), Group 2 (focal without gradient), Group 3 (diffuse with major gradient), and Group 4 (diffuse without gradient).</div><div>Results: Group 3 showed the highest number of lipid-rich plaques and thin-cap fibroatheromas (2.2 ± 1.1 and 1.3 ± 1.0, respectively), followed by Groups 1, 4, and 2 (<em>p</em> = 0.002 and <em>p</em> = 0.016). Groups 1 and 3 had higher lipid arc and lipid arc index values at the peak dQFR/ds segment. Kaplan–Meier analysis revealed that patients in Group 3 had significantly worse clinical outcomes. On multivariable logistic regression, only the Group 3 physiological pattern (low PPG and high dQFR/ds) was independently associated with adverse events.</div></div><div><h3>Conclusions</h3><div>QFR-derived physiological disease patterns are closely associated with plaque vulnerability and prognosis in CAD. QFR provides a practical tool for identifying high-risk patients and may inform individualized treatment strategies.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133909"},"PeriodicalIF":3.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global survival trends in congenital heart disease: Temporal, regional, and sex disparities from global burden of disease analyses","authors":"Yucan Deng ,&nbsp;Runfang Tian ,&nbsp;Jinfeng Zhao ,&nbsp;Li Liu ,&nbsp;Panpan Sun ,&nbsp;Zhiguang Ping","doi":"10.1016/j.ijcard.2025.133925","DOIUrl":"10.1016/j.ijcard.2025.133925","url":null,"abstract":"<div><h3>Background</h3><div>Prior Global Burden of Disease (GBD) studies on congenital heart disease (CHD) emphasized incidence and mortality trends, lacking robust survival pattern assessments. Crucially, quantitative studies that leverage panel data to construct survival analyses across time periods, regions, and sexes assigned at birth (short sexes) remain scarce.</div></div><div><h3>Objective</h3><div>To dynamically assess CHD survival disparities across regions and sexes by applying the abbreviated life table method to multi-period data of GBD 2021, providing a critical foundation for precision prevention and control strategies.</div></div><div><h3>Methods</h3><div>Data from the GBD 2021 database for the years 2005, 2010, 2015, and 2020 were analyzed. Survival differences among CHD patients across various years, regions, and sexes were assessed using Kaplan-Meier estimates (Log-rank test) and Cox survival analysis. Additionally, the Blinder-Oaxaca decomposition method was employed to analyze survival time disparities by sex.</div></div><div><h3>Results</h3><div>Overall survival significantly improved from 23.2 % (2005) to 26.9 % (2020) (<em>P</em> &lt; 0.01), especially in high Socio-Demographic Index (SDI) regions and females. The sex survival gap narrowed with rising SDI levels and over time: declining from 11.54 years (2005) to 8.60 years (2020) in low SDI areas, while reaching 1.12 years (<em>95 %CI:</em> 0.77–1.47) in high SDI areas by 2020.</div></div><div><h3>Conclusions</h3><div>While global survival rates for CHD patients are improving, marked regional and sex disparities persist, with higher rates observed in high SDI regions and among female patients. The sex gap in survival time is narrowing as SDI levels rise.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133925"},"PeriodicalIF":3.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial to “Impact of metabolic dysfunction-associated fatty liver disease on left ventricular function and myocardial strain in patients with ASTEMI: Insights from a 3.0-T cardiac magnetic resonance study”","authors":"Weifeng Yuan,&nbsp;Yingkun Guo","doi":"10.1016/j.ijcard.2025.133913","DOIUrl":"10.1016/j.ijcard.2025.133913","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133913"},"PeriodicalIF":3.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relative survival rate over twenty years of follow-up in younger patients with STEMI treated by primary percutaneous coronary intervention","authors":"Petr Toušek ,&nbsp;Dávid Bauer ,&nbsp;Viktor Kočka ,&nbsp;Klára Benešová ,&nbsp;Andrea Kyselová ,&nbsp;Jiří Jarkovský ,&nbsp;Petr Widimský","doi":"10.1016/j.ijcard.2025.133923","DOIUrl":"10.1016/j.ijcard.2025.133923","url":null,"abstract":"<div><h3>Introduction</h3><div>Primary percutaneous coronary intervention (pPCI) has been the gold standard treatment for patients with ST-elevation myocardial infarction (STEMI) in Europe for nearly two decades. While short- and medium-term outcomes are well described, data on very long-term mortality, especially in younger patients with longer life expectancy, remain limited.</div></div><div><h3>Aim</h3><div>To analyze very long-term mortality and 20 years relative survival rate compared to the general population in younger patients (≤65 years) with a first STEMI treated by pPCI.</div></div><div><h3>Methods</h3><div>We analyzed a high-volume, single-center registry of unselected STEMI patients treated with pPCI between January 1, 2000, and December 31, 2002. Patients aged ≤65 years with no history of myocardial infarction (MI) were selected. In cooperation with the Institute of Health Information and Statistics of the Czech Republic, we obtained mortality and cause-of-death data (classified by ICD-10) with a censoring date of December 31, 2023. Observed survival was assessed using the Kaplan–Meier method, and relative survival was estimated using the Pohar–Perme method, with expected survival derived from Czech national mortality tables.</div></div><div><h3>Results</h3><div>A total of 960 patients (71.4 % male, <em>n</em> = 686) with STEMI were treated with pPCI during the three-year study period. Among them, 385 patients (40.1 %) were ≤ 65 years with no previous MI. The mean age at STEMI was 55.03 ± 6.97 years for women (<em>n</em> = 71) and 54.16 ± 6.85 years for men (<em>n</em> = 314; <em>p</em> = 0.168). Over the entire very-long term follow-up period, 211 patients (54.8 %) died; cardiovascular causes were responsible in 111 cases (28.8 %). The 20-year overall survival was 50.6 %, while the 20-year relative survival was 79.5 %.</div></div><div><h3>Conclusion</h3><div>Despite high overall very-long term mortality in patients treated with primary PCI, the relative 20-year survival compared to the general population remained nearly 80 %. Furthermore, cardiovascular causes accounted for only half of all deaths.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133923"},"PeriodicalIF":3.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac manifestations in children with osteogenesis imperfecta: A single-center observational study","authors":"Stefanie Stasek ,&nbsp;Julia Kronenberger ,&nbsp;Ingo Germund-Maiwald ,&nbsp;Shino Junghänel-Welzing ,&nbsp;Susanna Reincke ,&nbsp;Oliver Semler ,&nbsp;Heike Hoyer-Kuhn ,&nbsp;Mirko Rehberg","doi":"10.1016/j.ijcard.2025.133922","DOIUrl":"10.1016/j.ijcard.2025.133922","url":null,"abstract":"<div><h3>Background</h3><div>Osteogenesis imperfecta (OI) is a rare hereditary connective tissue disorder characterized by defective type I collagen synthesis. In the cardiovascular system, type I collagen provides tensile strength and structural integrity to the myocardium, cardiac valves, chordae tendineae and great vessels. OI may therefore predispose affected individuals to various cardiovascular diseases. Limited existing literature suggests an increased risk of developing heart failure and valvular diseases in adults with OI, but data on cardiac involvement in pediatric OI remains limited.</div></div><div><h3>Objectives</h3><div>This study aimed to investigate the prevalence and characteristics of structural and functional cardiac abnormalities in children with OI.</div></div><div><h3>Methods</h3><div>In 78 children (aged 1–18 years) with OI, pediatric cardiologists performed standardized ECG and echocardiographic evaluations. <em>Z</em>-scores were calculated using pediatric reference values and compared between OI subtypes.</div></div><div><h3>Results</h3><div>None of our patients had clinically significant arrhythmias or required cardiovascular medication. Congenital heart defects were identified in 13 % of patients, most commonly ASD and PDA. Mild aortic or mitral valve regurgitation were observed in 7.3 % and 8.7 % of patients and aortic root dilation in 8.7 %, predominantly in moderate to severe OI. Aortic root and annulus diameters correlated with disease severity. Left ventricular systolic function and diastolic function were normal in all patients.</div></div><div><h3>Conclusions</h3><div>Clinically relevant cardiovascular disease is rare in children with OI, but mitral and aortic valve regurgitations and aortic root dilation are more prevalent in severe phenotypes. Echocardiographic screening should be considered before transition to adult care in patients with moderate to severe OI.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133922"},"PeriodicalIF":3.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of hospitalisation burden on mortality in adult congenital heart disease: A nationwide population study","authors":"Chee Woon Lim,&nbsp;Annette Schophuus Jensen,&nbsp;Christian Jøns,&nbsp;Jani Thuraiaiyah,&nbsp;Dar Nerst,&nbsp;Troels Højsgaard Jørgensen,&nbsp;Michael Rahbek Schmidt","doi":"10.1016/j.ijcard.2025.133924","DOIUrl":"10.1016/j.ijcard.2025.133924","url":null,"abstract":"<div><h3>Background</h3><div>As the hospitalisation rate for adults with congenital heart disease (ACHD) increases, information regarding the outcome of these hospitalisations is needed.</div></div><div><h3>Method</h3><div>This retrospective cohort study utilized the Danish National Patient Registry to identify ACHD patients who reached 18 years old ≥1st Jan 1995 and followed them to either death or 31st Dec 2018. Each patient was matched 1:10 to controls. Mortality was estimated as the mortality rate per 100 patient-years (/100PY) and the association of hospitalisation burden and mortality was examined.</div></div><div><h3>Results</h3><div>7830 ACHD patients were included (50.5 % female, 64.7 % mild ACHD, 28.1 % moderate ACHD and 7.2 % severe ACHD) and followed for a median of 8.6 years. When not having any hospitalisation in the past one year, the mortality rate for all ACHD patients was 0.04/100PY[95 % confidence interval: 0.02;0.05]. Having any hospitalisation in the past year increased the mortality rate by 5.2-fold to 0.55/100PY[0.42;0.72]. In mild ACHD, the mortality rate increased by 10.7-fold. In moderate ACHD, it increased by 4.8-fold, while in severe ACHD, no significant increase in mortality was observed. Compared to the matched controls, mild ACHD patients also had an increase in excess mortality from 0.8-fold when having no hospitalisation to 1.6-fold when having any hospitalisation in the past year. This increase in excess mortality was however not observed in moderate and severe ACHD.</div></div><div><h3>Conclusion</h3><div>Hospitalisation in the past year has a greater impact on mortality in mild ACHD patients than in other ACHD severities. This indicates a greater gap in the follow-up care needed by patients with mild ACHD.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133924"},"PeriodicalIF":3.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower interventricular septal thickness from computed tomography predicts the need for pacemaker implantation after TAVR","authors":"Manuel Garofalo ,&nbsp;Valentina Scheggi ,&nbsp;Yohann Bohbot ,&nbsp;Jasim Hasan ,&nbsp;Pierre Vanhaecke ,&nbsp;Emilion Hucleux ,&nbsp;Giorgia Panichella ,&nbsp;Francesco Meucci ,&nbsp;Ruggero Mazzotta ,&nbsp;Samuele Salvi ,&nbsp;Lucrezia Biagiotti ,&nbsp;Matteo Orlandi ,&nbsp;Angela Ilaria Fanizzi ,&nbsp;Nicola Zoppetti ,&nbsp;Renato Valenti ,&nbsp;Matilde Papi ,&nbsp;Antonio Fidanzati ,&nbsp;Francesca Ciatti ,&nbsp;Alessio Mattesini ,&nbsp;Miroslava Stolcova ,&nbsp;Carlo Di Mario","doi":"10.1016/j.ijcard.2025.133915","DOIUrl":"10.1016/j.ijcard.2025.133915","url":null,"abstract":"<div><h3>Background</h3><div>Transcatheter aortic valve replacement (TAVR) is the standard treatment for severe aortic stenosis (AS) in select patients. While membranous septum length and pre-TAVR conduction disturbances are known predictors of permanent pacemaker implantation (PPI), the impact of muscular interventricular septal (IVS) thickness, assessed via pre-procedural computed tomography (CT), remains unclear.</div></div><div><h3>Objectives</h3><div>The aim of the study was to evaluate the role of septal thickness with cardiac CT in predicting the need for PPI after TAVR.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed patients undergoing TAVR between January 2019 and December 2022. IVS thickness was measured in end-systole at various levels below the membranous septum on pre-procedural CT scans. Multivariable logistic regression models assessed predictors of PPI, including IVS thickness.</div></div><div><h3>Results</h3><div>Among the 338 patients (median age: 81 years; 42.6 % women), 20.1 % required PPI post-TAVR. Patients needing PPI had significantly lower IVS thickness 2 mm (3.9 ± 0.8 mm vs. 4.5 ± 1.3 mm, <em>p</em> &lt; 0.001), 5 mm (5.9 ± 1.1 mm vs. 6.8 ± 1.8 mm, p &lt; 0.001), and 10 mm (9.3 ± 1.1 mm vs. 10.6 ± 2.3 mm, <em>p</em> &lt; 0.001) below the membranous septum. Multivariable analysis identified IVS thickness at 10 mm (HR: 0.73, 95 % CI: 0.56–0.96, <em>p</em> = 0.023), membranous septum length (HR: 0.79, 95 % CI: 0.67–0.94, <em>p</em> = 0.007), and right bundle branch block (HR: 7.70, 95 % CI: 3.70–15.90, p &lt; 0.001) as independent predictors of PPI.</div></div><div><h3>Conclusions</h3><div>IVS thickness on pre-procedural CT independently predicts PPI post-TAVR and improves risk stratification.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133915"},"PeriodicalIF":3.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}