International journal of cardiology最新文献

{"title":"Predicting takotsubo syndrome subtypes: An interpretable machine learning model for differentiating emotional versus physical aetiologies","authors":"Diego Scuppa ,&nbsp;Francesca Colaceci ,&nbsp;Marco Sciandrone ,&nbsp;Luca Arcari ,&nbsp;Enrica G. Mariano ,&nbsp;Beatrice Maria Musumeci ,&nbsp;Emanuele Barbato ,&nbsp;Leonarda Galiuto","doi":"10.1016/j.ijcard.2025.133509","DOIUrl":"10.1016/j.ijcard.2025.133509","url":null,"abstract":"<div><h3>Background</h3><div>Takotsubo syndrome (TTS) is an acute coronary syndrome characterized by a reversible, mostly apical dysfunction of the left ventricle. Based on the triggering event, TTS has been classified as primary due to emotional causes and secondary due to physical stress. Using a comprehensive machine-learning approach, we aimed to distinguish between these two types of TTS, an essential task for optimizing patient care.</div></div><div><h3>Methods</h3><div>Based on a dataset of 320 TTS patients from a research group in Rome, a logistic regression model was trained to develop an interpretable predictive model capable of accurately classifying the aetiology of TTS in individual patients using admission-based clinical markers.</div></div><div><h3>Results</h3><div>The developed model achieved 74 % accuracy, 75 % precision and recall, 72 % specificity, and an area under the curve (AUC) of 0.78. Based on the studies conducted, chest pain, dyspnoea, atrial fibrillation, sex, chronic obstructive pulmonary disease, heart rate, and cancer were identified as key clinical features for differentiating between the two TTS types. An external validation cohort of 121 TTS patients has been employed further to assess the performance of the trained classification model, obtaining 74 % accuracy, 77 % precision, 91 % recall, 27 % specificity, and an AUC of 0.62.</div></div><div><h3>Conclusions</h3><div>An interpretable machine learning model has been developed, demonstrating the ability to distinguish between emotional versus physical aetiologies in TTS, highlighting the most impactful clinical factors. As built considering clinical variables recorded at admission, the model may serve as an immediate tool that can guide clinicians in their practice.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133509"},"PeriodicalIF":3.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Reply to letter to the editor for the “Relationship between iron deficiency and expression of genes involved in iron metabolism in human myocardium and skeletal muscle” ” [International Journal of Cardiology Volume 385, 15 August 2023, Page 43]","authors":"C. Cabrera ,&nbsp;C. Frisk ,&nbsp;U. Löfström","doi":"10.1016/j.ijcard.2025.133473","DOIUrl":"10.1016/j.ijcard.2025.133473","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133473"},"PeriodicalIF":3.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing palliative care needs in worsening heart failure patients: Insights from OPPORTUNITIES registry","authors":"Emilia D’Elia ,&nbsp;Ottavio Zucchetti ,&nbsp;Francesco Pedrazzoli ,&nbsp;Alberto Cereda ,&nbsp;Cinzia Giaccherini ,&nbsp;Edoardo Sciatti ,&nbsp;Salvatore D’Isa ,&nbsp;Luca Di Odoardo ,&nbsp;Laura Tomasoni ,&nbsp;Antonello Gavazzi ,&nbsp;Mauro Gori ,&nbsp;Roberta Marchesi ,&nbsp;Simonetta Cesa ,&nbsp;Michele Senni","doi":"10.1016/j.ijcard.2025.133491","DOIUrl":"10.1016/j.ijcard.2025.133491","url":null,"abstract":"<div><h3>Background</h3><div>Worsening heart failure (WHF) patients experience frequent hospitalizations and reduced quality of life (QoL). Palliative care (PC) is recognized as essential for HF management, but its integration represent an unmet need.</div></div><div><h3>Objective</h3><div>This study aimed to assess PC needs in WHF patients using the Palliative Care Needs Assessment Tool (PCNAT), and correlate the findings with biomarkers, clinical outcomes and prognostic scores.</div></div><div><h3>Methods</h3><div>144 WHF patients were prospectively evaluated at the dedicated facility in Papa Giovanni XXIII Hospital in Bergamo, Northern Italy. Patients were stratified by the highest tertile of PCNAT, identifying two groups with PCNAT≥10 or &lt; 10. The primary outcome was the composite of all-cause mortality, HF hospitalization (HHF), emergency room (ER) visits or urgent clinical evaluation and referral to PC specialist.</div></div><div><h3>Results</h3><div>The median follow-up was 91 days. Thirty-three percent of patients (47/144) had a PCNAT score ≥ 10. These patients had lower body mass index, worse NYHA class and more comorbidities, including chronic kidney disease, diabetes, and atrial fibrillation. They also showed worse biomarkers and lower guideline directed medical therapy use, with higher diuretic doses. Prognostic scores and QoL were significantly correlated with PCNAT score. Kaplan-Meier analysis confirmed higher clinical event rates in patients with higher PCNAT scores. Univariate and multivariate Cox regression analysis showed that PCNAT score was a significant independent predictor of clinical outcomes.</div></div><div><h3>Conclusion</h3><div>PCNAT effectively stratifies WHF patients by PC needs, correlating with poorer clinical outcomes. Early integration of PC could improve patient-centred care, highlighting the need for systematic referral pathways.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133491"},"PeriodicalIF":3.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Prognostic value of angiography-derived microcirculatory resistance in patients undergoing rotational atherectomy- a multi-center study”","authors":"Leilei Qi","doi":"10.1016/j.ijcard.2025.133506","DOIUrl":"10.1016/j.ijcard.2025.133506","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133506"},"PeriodicalIF":3.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiopulmonary exercise testing: Time to rethink the validity of non-metabolic thresholds?","authors":"Flavio Tangianu ,&nbsp;Justin M Canada ,&nbsp;Aldo Bonaventura","doi":"10.1016/j.ijcard.2025.133497","DOIUrl":"10.1016/j.ijcard.2025.133497","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133497"},"PeriodicalIF":3.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid Intraplaque neovascularization correlates with coronary atherosclerotic plaque, vulnerability detected by intracoronary optical coherence tomography","authors":"Yingying Liu ,&nbsp;Xin Fu ,&nbsp;Xin Ai,&nbsp;Guangyin Li,&nbsp;Chun Wang,&nbsp;Piao Wu,&nbsp;Haizhuo Yu,&nbsp;Shuangquan Jiang","doi":"10.1016/j.ijcard.2025.133495","DOIUrl":"10.1016/j.ijcard.2025.133495","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of the present study was to evaluate the relationships between carotid intraplaque neovascularization (IPN) measured by contrast-enhanced ultrasound (CEUS) and culprit coronary artery plaque vulnerability evaluated by optical coherence tomography (OCT) in patients with coronary artery disease (CAD).</div></div><div><h3>Methods</h3><div>A total of 131 participants were divided into the vulnerable coronary plaque (VP) and non-vulnerable coronary plaque (non-VP) group. The plaque vulnerability was determined by OCT. In CEUS, carotid IPN was assessed by semi-quantitative and quantitative evaluation, the carotid plaque with the maximum plaque height (MPH) was used for analysis. Logistic regression was used to assess risk factors of coronary plaque vulnerability.</div></div><div><h3>Results</h3><div>Patients were classified into VP group (<em>N</em> = 92) and non-VP group (<em>N</em> = 39) according to the features of plaque vulnerability in OCT. In CEUS, the IPN score between the two groups was significant different(<em>P</em> = 0.003). Quantitative analysis of CEUS showed that carotid plaque peak intensity (PI) (28.65 ± 4.21 dB vs. 22.51 ± 3.13 dB, <em>P</em> &lt; 0.001), enhancement intensity (EI) (24.91 ± 4.05 dB vs. 19.20 ± 3.17 dB, <em>P</em> &lt; 0.001), and enhanced intensity ratio of plaque/lumen (P/L ratio) (0.32 ± 0.08 vs. 0.24 ± 0.09, <em>P</em> &lt; 0.001) were higher in VP group than non-VP group. Multivariate logistic regression analyses demonstrated that EI (OR = 1.473, 95 %CI: (1.039–2.086)) and P/L ratio (OR = 1.109, 95 %CI: (1.024–1.2)) were strongly associated with coronary plaque vulnerability.</div></div><div><h3>Conclusion</h3><div>The CEUS parameters of carotid plaques is correlated with coronary plaque vulnerability. As a non-invasive examination, CEUS may provide valuable information to advance risk stratification and clinical treatment in patients with CAD.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133495"},"PeriodicalIF":3.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Comment on: Mechanical outcomes of coronary stenting guided by intravascular ultrasound versus optical coherence tomography: A systematic review and meta-analysis with trial sequential analysis of randomized trials”","authors":"Shanmukh Sai Pavan Lingamsetty ,&nbsp;Mohamed Doma ,&nbsp;Mangesh Kritya ,&nbsp;Michael S. Megaly ,&nbsp;Andrew M. Goldsweig","doi":"10.1016/j.ijcard.2025.133505","DOIUrl":"10.1016/j.ijcard.2025.133505","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133505"},"PeriodicalIF":3.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic bleeding risk assessment, inflammatory and metabolic markers: reconsidering impact of PCSK9 inhibitors on bleeding and adverse outcomes in post-PCI patients undergoing antiplatelet therapy","authors":"Qi Yang,&nbsp;Yuan Song,&nbsp;Song Li","doi":"10.1016/j.ijcard.2025.133507","DOIUrl":"10.1016/j.ijcard.2025.133507","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133507"},"PeriodicalIF":3.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of pericoronary fat in fatal plaques of coronary artery: A contributor or bystander?","authors":"Jian Luo","doi":"10.1016/j.ijcard.2025.133503","DOIUrl":"10.1016/j.ijcard.2025.133503","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133503"},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Association between device-detected subclinical atrial fibrillation and diabetes in patients with implantable cardioverter-defibrillators: A propensity score-matched analysis”","authors":"Xianglin Long","doi":"10.1016/j.ijcard.2025.133501","DOIUrl":"10.1016/j.ijcard.2025.133501","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133501"},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}