International journal of cardiology最新文献

{"title":"Comment on “Impact of light-dark cycle on the expression of circadian clock genes, electrocardiography, and myocardial function in mice”: Bridging animal models to human chronobiology","authors":"Parth Aphale, Himanshu Shekhar, Shashank Dokania","doi":"10.1016/j.ijcard.2025.133616","DOIUrl":"10.1016/j.ijcard.2025.133616","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133616"},"PeriodicalIF":3.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “efficacy of beta-blocker therapy in Takotsubo cardiomyopathy: Insights from a systematic review and meta-analysis”","authors":"Ricardo A. Rodriguez Mejia , Arminder Singh","doi":"10.1016/j.ijcard.2025.133614","DOIUrl":"10.1016/j.ijcard.2025.133614","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133614"},"PeriodicalIF":3.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of P2Y12 inhibitors in acute coronary syndromes patients with KDIGO stage IV-V renal disfunction not on dialysis: a subanalysis of the CORALYS registry","authors":"Federico Giacobbe ,&nbsp;Francesco Bruno ,&nbsp;Giuseppe Giannino ,&nbsp;Filippo Angelini ,&nbsp;Stefano Siliano ,&nbsp;Arianna Morena ,&nbsp;Alessandra Truffa Giachet ,&nbsp;Emanuele Sagazio ,&nbsp;Fabrizio D'Ascenzo ,&nbsp;Federico Marchini ,&nbsp;Andrea Ghisletti ,&nbsp;Ilaria Pagliassotto ,&nbsp;Guglielmo Gallone ,&nbsp;Veronica Dusi ,&nbsp;Giuseppe Patti ,&nbsp;Wojciech Wanha ,&nbsp;Gianluca Campo ,&nbsp;Gaetano Maria De Ferrari ,&nbsp;Ovidio De Filippo","doi":"10.1016/j.ijcard.2025.133613","DOIUrl":"10.1016/j.ijcard.2025.133613","url":null,"abstract":"<div><h3>Background</h3><div>The impact of the most potent P2Y12i ticagrelor and prasugrel after acute coronary syndrome in patients with chronic kidney disease (CKD) remains unclear. Most evidence on dual antiplatelet therapy (DAPT) comes from real-world study but is limited to glomerular filtration rate (GFR) under 60 ml/min.</div></div><div><h3>Methods</h3><div>Consecutive patients with acute coronary syndrome (ACS) treated with percutaneous coronary intervention (PCI) and severe CKD defined as GFR under 30 ml/min not on dialysis from the CORALYS registry were included. Incidence of Net Adverse Clinical Events (NACE) defined as major adverse cardiac events (cardiovascular death, myocardial infarction and unplanned revascularizations) in addition to major bleedings was our primary endpoint. Overall MACE and their single components, all bleedings, major bleedings and hospitalizations for heart failure were the secondary ones.</div></div><div><h3>Results</h3><div>257 patients with severe CKD not on dialysis and available data on antiplatelet regimen at discharge were included, 193 (75.1 %) were given clopidogrel while 64 (24.9 %) with ticagrelor or prasugrel. Our population was predominantly male (153, 59.5 %) with an average age 75.8 ± 10.9 years old. Over a median follow-up of 459 days, Ticagrelor and Prasugrel were associated to lower rates of NACE compared to Clopidogrel (39.9 % vs 25.0 %, <em>p</em> = 0.036). This was mainly driven by an excess of both CV mortality and myocardial infarction reported in the clopidogrel group. No difference was reported regarding overall bleeding events and major bleedings. At multivariate Cox regression analysis DAPT with Ticagrelor/Prasugrel resulted independently associated with a lower risk of NACE whereas left main involvement or multivessel coronary disease led to higher risk of NACE.</div></div><div><h3>Conclusions</h3><div>In ACS patients treated with PCI with severe CKD ticagrelor and prasugrel were associated to lower risk of NACE, MACE, CV death and myocardial infarction compared to clopidogrel. No significative difference was reported in overall and major bleedings.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133613"},"PeriodicalIF":3.2,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between carotid atherosclerotic plaques and 90-day prognosis after acute ischemic stroke mediated by multiple inflammatory factors: A cohort and Mendelian randomization study","authors":"Tonglong Jin ,&nbsp;Yuan Zhu ,&nbsp;Hui Huang ,&nbsp;Peian Liu ,&nbsp;Yongxing Deng ,&nbsp;Peiyi Mo ,&nbsp;Ziyan Cai ,&nbsp;Hui Jiang ,&nbsp;Zhaoyao Chen ,&nbsp;Wenlei Li ,&nbsp;Zhuyuan Fang ,&nbsp;Minghua Wu","doi":"10.1016/j.ijcard.2025.133609","DOIUrl":"10.1016/j.ijcard.2025.133609","url":null,"abstract":"<div><h3>Background</h3><div>We explored the relationship between maximum carotid plaque thickness (cPTmax), carotid intima-media thickness (cIMT), and the 90-day prognosis of patients with acute ischemic stroke (AIS), as well as the mediating roles of inflammatory factors.</div></div><div><h3>Methods</h3><div>We enrolled 951 patients with AIS who underwent carotid artery ultrasonography between June 2019 and November 2023. cPTmax, monocytes (Mono) and the calculated lymphocyte-monocyte ratio (LMR) and monocyte-to-high-density lipoprotein ratio (MHR) values were obtained. Receiver operating characteristic (ROC) curve analysis was used to determine the sensitivity and specificity of Mono, LMR, and MHR as mediating variables, and their predictive value for poor prognosis was evaluated. We then performed two-sample Mendelian randomization to estimate the independent effect of cIMT on IS and explored the mediation effect of oncostatin M (OSM).</div></div><div><h3>Results</h3><div>cPTmax was positively correlated with the poor outcomes (<em>p</em> &lt; 0.001). Mediation analysis revealed that multiple inflammatory factors, including Mono, LMR, and MHR, acted as positive mediators. In the two-sample Mendelian randomization, we found that cIMT was positively associated with ischemic stroke (β = 3.115, 95 % CI: 1.519–4.710), whereas OSM played a negative mediating role, with a mediating effect value of 7.5 %.</div></div><div><h3>Conclusions</h3><div>Our cohort study showed a positive correlation between cPTmax and poor prognosis 90 days after acute stroke, with Mono, LMR, and MHR mediating this process. A Mendelian randomization (MR) study showed a causal relationship between an increase in cIMT and an increased risk of IS. The mediating role of OSM in this process can reduce the risk of IS.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133609"},"PeriodicalIF":3.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of hypertriglyceridemia and its association with extreme cardiovascular risk in patients with acute and chronic coronary syndrome enrolled in a cardiac rehabilitation program","authors":"Chiara Tognola ,&nbsp;Davide Bernasconi ,&nbsp;Rita Cristina Myriam Intravaia ,&nbsp;Giulia Brioschi ,&nbsp;Giorgio Toscani ,&nbsp;Michela Algeri ,&nbsp;Atea Shkodra ,&nbsp;Elvira Inglese ,&nbsp;Luciana Sciumè ,&nbsp;Romano Danesi ,&nbsp;Giovanna Beretta ,&nbsp;Cristina Giannattasio ,&nbsp;Alessandro Maloberti","doi":"10.1016/j.ijcard.2025.133608","DOIUrl":"10.1016/j.ijcard.2025.133608","url":null,"abstract":"<div><h3>Background</h3><div>Prevalence of hypertriglyceridemia in patients with Acute and Chronic Coronary Syndrome (ACS and CCS, respectively) in the current era of Low-Density Lipoprotein Cholesterol (LDL-C) targets remains unknown. This study aimed to evaluate the prevalence of triglyceride (TG) levels above 150 mg/dL in ACS and CCS patients enrolled in a Cardiac Rehabilitation (CR) program and to explore its association with extreme cardiovascular (CV) risk.</div></div><div><h3>Methods</h3><div>We included 905 ACS/CCS patients who participated in the CR program at Niguarda Hospital (Milan) between January 1, 2012, and March 28, 2024. Data on demographic, clinical, and laboratory variables were collected. Extreme CV risk was defined as the occurrence of a CV event within two years or the presence of peripheral artery disease or multivessel coronary involvement.</div></div><div><h3>Results</h3><div>TG levels significantly decreased during the CR period (median 116.5, I-III quartiles 87–115 vs. 100, 80–133 mg/dL, <em>p</em> &lt; 0.001), as did LDL-C levels (106.8 ± 39.3 vs. 64.4 ± 24.9 mg/dL, p &lt; 0.001). At the end of CR, 17.6 % of patients had TG levels ≥150 mg/dL (15.0 % among those who reached the LDL-C target). In multivariable analysis, each 10 mg/dL increase in TG was associated with a 4.6 % increased risk of extreme CV risk (OR 1.046; 95 %CI 1.007–1.085; <em>p</em> = 0.019). Additionally, hypertriglyceridemia (TG &gt;150 mg/dL) increased the risk of extreme CV risk by 81.5 % (OR 1.815; 95 %CI 1.096–3.007; <em>p</em> = 0.021).</div></div><div><h3>Conclusions</h3><div>Despite high-intensity statin therapy and low LDL-C targets, a significant proportion of patients in CR still exhibited elevated TG levels. Both TG levels and hypertriglyceridemia were strongly associated with the presence of extreme CV risk.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133608"},"PeriodicalIF":3.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconsidering the causal role of cardiovascular risk factors in genotype-negative hypertrophic cardiomyopathy: The importance of polygenic inheritance and genetic architecture","authors":"Malik Abdullah Rasheed ,&nbsp;Qura-tul Ain ,&nbsp;Abdul Basit Rasheed ,&nbsp;Mirza Muhammad Hadeed Khawar","doi":"10.1016/j.ijcard.2025.133610","DOIUrl":"10.1016/j.ijcard.2025.133610","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133610"},"PeriodicalIF":3.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to letter: Right heart failure and mortality in patients undergoing transcatheter tricuspid valve interventions","authors":"Matteo Pagnesi,&nbsp;Marianna Adamo","doi":"10.1016/j.ijcard.2025.133611","DOIUrl":"10.1016/j.ijcard.2025.133611","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133611"},"PeriodicalIF":3.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pericardial tissue characterization with quantitative methods in cardiac magnetic resonance in acute or recurrent pericarditis","authors":"Luigi Tassetti ,&nbsp;Alice Bonomi ,&nbsp;Giulia Piccinni ,&nbsp;Alessandra Arcudi ,&nbsp;Marco Lionti ,&nbsp;Andrea Laghi ,&nbsp;Giuseppe Patti ,&nbsp;Gaetano Maria De Ferrari ,&nbsp;Andrea Annoni ,&nbsp;Andrea Baggiano ,&nbsp;Giovanni Berna ,&nbsp;Ludovica Maria Carerj ,&nbsp;Francesco Cannata ,&nbsp;Fabrizio Celeste ,&nbsp;Alberico Del Torto ,&nbsp;Fabio Fazzari ,&nbsp;Alberto Formenti ,&nbsp;Antonio Frappampina ,&nbsp;Laura Fusini ,&nbsp;Sarah Ghulam Ali ,&nbsp;Gianluca Pontone","doi":"10.1016/j.ijcard.2025.133607","DOIUrl":"10.1016/j.ijcard.2025.133607","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac Magnetic Resonance(CMR) is gaining importance for prognosis stratification of pericarditis,but data on quantitative evaluation of pericardial inflammation with CMR are currently limited. Aim of the study is to assess the utility of tissue characterization of pericardium with quantitative methods in outcome prediction of acute or recurrent pericarditis.</div></div><div><h3>Materials and methods</h3><div>Consecutive patients who performed CMR for acute or recurrent pericarditis and &gt; 6 months clinical follow up (FU) were enrolled. Quantitative evaluation of oedema and late gadolinium enhancement (LGE) amount on pericardium with different techniques and T1/T2 maximum values on inflamed pericardium with mapping were performed. The continuous variables are presented as mean ± SD or median (IQR) as appropriate. Univariate/multivariate Cox regressions were used to investigate the association between the different CMR quantitative parameters and clinical outcome.</div></div><div><h3>Results</h3><div>Sixty-one patients(mean age:48 ± 18 years; male:41 %) were enrolled, whose 46 (75 %) with acute pericarditis. Pericardial LGE median amount was 31.2(9;54.5), 42.7(17.2;72.5) and 38.8(15.2;69)cm3 when measured with FWHM, 5 and 6 SD, respectively. Median pericardial T1 and T2 values were 1356(1305;1523)ms and 77(73;81)ms, respectively. At 12 months FU, 20(32 %) patients reached the composite outcome including recurrence, constrictive evolution and right heart failure. Quantitative LGE, but neither T1 nor T2 mapping values nor T2w image, was associated to pericarditis recurrence and composite outcome in global cohort and to pericarditis recurrence in acute pericarditis cohort.</div></div><div><h3>Conclusion</h3><div>Quantitative LGE evaluation with different techniques, but not parametric mapping, showed an association with clinical outcome prediction in acute and recurrent pericarditis, confirming LGE currently represents the most accurate imaging marker with prognostic value in this setting.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133607"},"PeriodicalIF":3.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144617415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial fibrillation phenotypes identified through cluster analysis in the CABANA study","authors":"Jiawei Zhang ,&nbsp;Lili Wang ,&nbsp;Yanguang Li,&nbsp;Qiaoyuan Li,&nbsp;Xu Liu,&nbsp;Sixian Weng,&nbsp;Yan Yin,&nbsp;Zhuo Liang,&nbsp;Tao Zhang,&nbsp;Yunlong Wang","doi":"10.1016/j.ijcard.2025.133606","DOIUrl":"10.1016/j.ijcard.2025.133606","url":null,"abstract":"<div><h3>Background</h3><div>We aimed to use cluster analysis to improve phenotyping of patients with AF, assess the long-term clinical outcomes of the identified clusters, and examine the impact of these clusters on the effectiveness of ablation versus drug therapy.</div></div><div><h3>Methods</h3><div>Using data from the CABANA trial, we performed cluster analysis on 2205 patients using 12 clinical variables. The primary endpoint was a composite of death, disabling stroke, serious bleeding, or cardiac arrest. We compared the differences in the primary endpoint and all-cause mortality across clusters. Additionally, we analyzed the differences in treatment outcomes within each cluster.</div></div><div><h3>Results</h3><div>Among the 2205 patients, we identified three distinct AF phenotypes using K-prototype cluster analysis. Cluster 1 predominantly included females (69.0 %) and had the highest proportion of paroxysmal AF (61.7 %). Cluster 2 consisted of the youngest male-dominated phenotype (89.4 %). Cluster 3 represented the oldest AF phenotype with multiple comorbidities. Compared to Cluster 1, Cluster 2 had a similar risk of the primary endpoint (HR 0.83, 95 %CI 0.55–1.25; <em>P</em> = 0.369) and all-cause mortality (HR 0.92, 95 % CI 0.57–1.48; <em>P</em> = 0.727). In contrast, Cluster 3 exhibited a higher risk of the primary endpoint (HR 2.38, 95 % CI 1.69–3.35; <em>P</em> &lt; 0.001) and all-cause mortality (HR 2.06, 95 % CI 1.35–3.41; <em>P</em> = 0.0001).</div></div><div><h3>Conclusions</h3><div>Through cluster analysis, we stratified CABANA trial participants into three distinct AF phenotypes with varying clinical characteristics, prognoses, and responses to treatment. These findings underscore the heterogeneity of AF and suggest the need for personalized treatment strategies tailored to individual patient characteristics.</div><div>TRIAL REGISTRATION <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> Identifier: <span><span>NCT00911508</span><svg><path></path></svg></span></div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133606"},"PeriodicalIF":3.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Percutaneous or surgical revascularization in patients with severe left main coronary artery disease in Latin America: A GRADE clinical practice guideline” [International Journal of Cardiology Volume 436, 1 October 2025, 133401]","authors":"Pablo Lamelas ,&nbsp;Michel Pompeu Sá ,&nbsp;Ariel Izcovich ,&nbsp;Federico Bottaro ,&nbsp;Matias Tisi Baña ,&nbsp;Maria Ines Sosa Liprandi ,&nbsp;Fernando Lanas ,&nbsp;Omar Asdrúbal Vilca Mejia ,&nbsp;Mauricio Zuñiga Luna ,&nbsp;Patricia Aubanel ,&nbsp;Ana Munera ,&nbsp;Juan Contreras Reyes ,&nbsp;Rodrigo Bagur ,&nbsp;Richard Whitlock ,&nbsp;Hector Garcia Garcia ,&nbsp;Mamas Mamas ,&nbsp;Mauricio G. Cohen ,&nbsp;Alejando Ricalde ,&nbsp;Alexandre Abizaid ,&nbsp;Oscar Mendiz ,&nbsp;Martín Alberto Ragusa","doi":"10.1016/j.ijcard.2025.133520","DOIUrl":"10.1016/j.ijcard.2025.133520","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133520"},"PeriodicalIF":3.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}