International journal of cardiology最新文献

筛选
英文 中文
Beyond the numbers: Refining cardiovascular risk assessment in acute pancreatitis. 数字之外:改进急性胰腺炎的心血管风险评估。
IF 3.2 2区 医学
International journal of cardiology Pub Date : 2025-07-19 DOI: 10.1016/j.ijcard.2025.133637
Chunfeng Shi, Jingjing Zhang, Wei Wang
{"title":"Beyond the numbers: Refining cardiovascular risk assessment in acute pancreatitis.","authors":"Chunfeng Shi, Jingjing Zhang, Wei Wang","doi":"10.1016/j.ijcard.2025.133637","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133637","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133637"},"PeriodicalIF":3.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of sodium-glucose cotransporter 2 inhibitors for super-aged heart failure population. 钠-葡萄糖共转运蛋白2抑制剂对超高龄心力衰竭人群的疗效。
IF 3.2 2区 医学
International journal of cardiology Pub Date : 2025-07-19 DOI: 10.1016/j.ijcard.2025.133647
Jun-Ichi Noiri, Hidekazu Tanaka, Susumu Odajima, Wataru Fujimoto, Hiroshi Okamoto, Chihiro Fujii, Hiroshi Tsunamoto, Yu Nishihara, Shun Nagai, Koya Uemura, Terunobu Fukuda, Eriko Hisamatsu, Hiromasa Otake
{"title":"Efficacy of sodium-glucose cotransporter 2 inhibitors for super-aged heart failure population.","authors":"Jun-Ichi Noiri, Hidekazu Tanaka, Susumu Odajima, Wataru Fujimoto, Hiroshi Okamoto, Chihiro Fujii, Hiroshi Tsunamoto, Yu Nishihara, Shun Nagai, Koya Uemura, Terunobu Fukuda, Eriko Hisamatsu, Hiromasa Otake","doi":"10.1016/j.ijcard.2025.133647","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133647","url":null,"abstract":"<p><strong>Background: </strong>Sodium-glucose cotransporter 2 (SGLT2) inhibitors are indicated for patients with all phenotypes of heart failure (HF). Despite the current unprecedented super-aged society in real-world settings, the efficacy of SGLT2 inhibitors in super-aged HF patients, especially those of ≥80 years, remains unknown.</p><p><strong>Methos: </strong>This study was conducted across three hospitals in Japan, including 238 HF patients ≥80 years (mean 84.2 ± 3.3 years), who were treated with SGLT2 inhibitors (dapagliflozin or empagliflozin). SGLT2 inhibitors were used for HF, with preserved ejection fraction in 131 patients (55.0 %), mildly-reduced ejection fraction in 54 patients (22.7 %), and reduced ejection fraction in 53 patients (22.3 %). Among 238 patients, 191 (80.3 %) continued SGLT2 inhibitors, while 47 (19.7 %) discontinued SGLT2 inhibitors (for any reason) during follow-up. The primary outcome was a composite of cardiovascular death or worsening HF, with a median follow-up duration of 2.73 (2.08-3.52) years.</p><p><strong>Results: </strong>Cumulative incidence curves modified by the Simon-Makuch method with a time-varying Cox regression analysis showed that HF patients with continued SGLT2 inhibitor treatment had significantly favorable outcomes, which remained consistent after adjustment for baseline characteristics by propensity score matching, and discontinuation of SGLT2 inhibitors was the strongest contributing factor to the outcome by a multivariable analysis. Moreover, the multivariable analysis identified a higher clinical frailty scale score as an independent factor associated with discontinuation of SGLT2 inhibitors.</p><p><strong>Conclusions: </strong>This study provides real-world evidence supporting the use of SGLT2 inhibitors in super-aged patients with HF, emphasizing the importance of appropriately assessing the continuation of SGLT2 inhibitors.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133647"},"PeriodicalIF":3.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From prediction to translation: Key limitations of current machine learning models for CAD. 从预测到翻译:当前CAD机器学习模型的主要限制。
IF 3.2 2区 医学
International journal of cardiology Pub Date : 2025-07-19 DOI: 10.1016/j.ijcard.2025.133632
Sheng Huang, Jiawei Ma
{"title":"From prediction to translation: Key limitations of current machine learning models for CAD.","authors":"Sheng Huang, Jiawei Ma","doi":"10.1016/j.ijcard.2025.133632","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133632","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133632"},"PeriodicalIF":3.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distal radial access in elderly patients aged 70 years and older for coronary procedures: Lessons from the KODRA registry. 70岁 及以上老年患者冠状动脉手术的远端桡动脉通路:来自KODRA登记的经验教训。
IF 3.2 2区 医学
International journal of cardiology Pub Date : 2025-07-18 DOI: 10.1016/j.ijcard.2025.133645
Jun-Won Lee, Han-Young Jin, Hyun Cho, Sung Eun Kim, Joon-Hyung Doh, Yongcheol Kim, Bong-Ki Lee, Sang-Yong Yoo, Sang Yeub Lee, Chan Joon Kim, Jin Sup Park, Jung Ho Heo, Do Hoi Kim, Jin Bae Lee, Dong-Kie Kim, Jun Ho Bae, Sung-Yun Lee, Seung-Hwan Lee, Sung Woo Cho
{"title":"Distal radial access in elderly patients aged 70 years and older for coronary procedures: Lessons from the KODRA registry.","authors":"Jun-Won Lee, Han-Young Jin, Hyun Cho, Sung Eun Kim, Joon-Hyung Doh, Yongcheol Kim, Bong-Ki Lee, Sang-Yong Yoo, Sang Yeub Lee, Chan Joon Kim, Jin Sup Park, Jung Ho Heo, Do Hoi Kim, Jin Bae Lee, Dong-Kie Kim, Jun Ho Bae, Sung-Yun Lee, Seung-Hwan Lee, Sung Woo Cho","doi":"10.1016/j.ijcard.2025.133645","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133645","url":null,"abstract":"<p><strong>Background: </strong>While distal radial access (DRA) is increasingly adopted for coronary procedures, evidence supporting its use in elderly patients remains limited. This study evaluated the feasibility and safety of DRA in elderly patients using data from the KODRA registry.</p><p><strong>Methods: </strong>A total of 4941 patients were divided into elderly (≥70 years; n = 2091) and non-elderly (<70 years; n = 2850) groups. The efficacy endpoint was successful coronary angiography completion without access-site crossover, while the safety endpoint comprised a composite of DRA-related bleeding and access-site complications. Multivariable logistic regression analysis assessed associations between age ≥ 70 years and the efficacy and safety endpoints.</p><p><strong>Results: </strong>The mean age was 77.5 ± 5.2 years in the elderly group. The cohort was 67.4 % male, with higher obesity rates and comorbidities in the elderly group. Puncture success was higher in the elderly (95.2 % vs. 93.8 %, p = 0.033), while the elderly experienced more frequent access-site crossover after successful puncture (1.6 % vs. 0.7 %, p = 0.002). The efficacy endpoint was comparable (93.5 % vs. 93.1 %, p = 0.496), whereas the safety endpoint occurred more frequently in the elderly (8.0 % vs. 6.1 %, p = 0.010). After adjustment for confounding variables, age ≥ 70 years was not associated with efficacy (odds ratio 1.054, 95 % confidence interval 0.831-1.337, p = 0.662) or safety endpoints (odds ratio 1.105, 95 % confidence interval 0.856-1.425, p = 0.445).</p><p><strong>Conclusions: </strong>DRA in elderly patients aged ≥70 years revealed a comparable efficacy endpoint but a higher incidence of the composite outcome of DRA-related bleeding and access-site complications. Older age (≥70 years) itself was not significantly associated with either efficacy or safety endpoints.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133645"},"PeriodicalIF":3.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnoses and outcomes of patients referred for FDG PET/CT for suspected cardiac sarcoidosis. 疑似心脏结节病的FDG PET/CT诊断及预后
IF 3.2 2区 医学
International journal of cardiology Pub Date : 2025-07-18 DOI: 10.1016/j.ijcard.2025.133643
Stephen J Hankinson, Sylvain L Carre, Shelby S Laychak, Jon M Hainer, Akshay S Desai, Garrick C Stewart, Neal K Lakdawala, Michael M Givertz, Usha B Tedrow, William H Sauer, Ron Blankstein, Marcelo F Di Carli, Sanjay Divakaran
{"title":"Diagnoses and outcomes of patients referred for FDG PET/CT for suspected cardiac sarcoidosis.","authors":"Stephen J Hankinson, Sylvain L Carre, Shelby S Laychak, Jon M Hainer, Akshay S Desai, Garrick C Stewart, Neal K Lakdawala, Michael M Givertz, Usha B Tedrow, William H Sauer, Ron Blankstein, Marcelo F Di Carli, Sanjay Divakaran","doi":"10.1016/j.ijcard.2025.133643","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133643","url":null,"abstract":"<p><strong>Background: </strong>Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging is commonly used to facilitate diagnosis in suspected cardiac sarcoidosis (CS). However, there is a gap in evidence regarding the diagnoses and outcomes of patients who undergo FDG PET/CT.</p><p><strong>Objectives: </strong>Evaluate the diagnoses and outcomes of patients referred for FDG PET/CT imaging for suspected CS.</p><p><strong>Methods: </strong>We studied all consecutive patients referred to our center for FDG PET/CT for suspected CS from June 2006 to November 2023. Patients were characterized by their final clinical diagnosis and followed to a composite outcome of left ventricular assist device placement, heart transplant, or death.</p><p><strong>Results: </strong>A total of 1646 patients (mean age 58.4 ± 12.4 years; 66 % male) met inclusion criteria: 285 (17.3 %) with Heart Rhythm Society (HRS) criteria positive CS, 83 (5.0 %) with probable CS, 237 (14.4 %) with sarcoidosis but without HRS criteria for CS, and 1041 (63.2 %) with other diagnoses. 227 patients (13.8 %) underwent genetic testing, of whom 32 (14.1 %) were found to have a pathogenic/likely pathogenic variant. Over a median follow up of 4.4 years, 327 patients (19.9 %) met the primary outcome. There was no significant difference in outcomes by diagnosis (log-rank p = 0.4936).</p><p><strong>Conclusions: </strong>Most patients referred for FDG PET/CT for suspected CS were not found to have CS in follow up. However, they are at similar risk for the need for advanced therapies and many are found to have genetic CMP. These data highlight the importance of advanced heart disease consultation and referral for genetic testing in this population.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133643"},"PeriodicalIF":3.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to comments on “impact of PCSK9 inhibitors on bleeding and adverse outcomes in post-PCI patients undergoing antiplatelet therapy: A real-world cohort study” 回复关于“PCSK9抑制剂对pci术后接受抗血小板治疗患者出血和不良结局的影响:一项真实世界队列研究”的评论。
IF 3.2 2区 医学
International journal of cardiology Pub Date : 2025-07-17 DOI: 10.1016/j.ijcard.2025.133617
Jia-Yi Ren, Hao Zhang, Tong Liu, Kang-Yin Chen
{"title":"Reply to comments on “impact of PCSK9 inhibitors on bleeding and adverse outcomes in post-PCI patients undergoing antiplatelet therapy: A real-world cohort study”","authors":"Jia-Yi Ren,&nbsp;Hao Zhang,&nbsp;Tong Liu,&nbsp;Kang-Yin Chen","doi":"10.1016/j.ijcard.2025.133617","DOIUrl":"10.1016/j.ijcard.2025.133617","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133617"},"PeriodicalIF":3.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Comment on “Association between device-detected subclinical atrial fibrillation and diabetes in patients with implantable cardioverter defibrillators: A propensity score-matched analysis” 对“植入式心律转复除颤器患者检测到的亚临床心房颤动与糖尿病的关系:倾向评分匹配分析”评论的回复
IF 3.2 2区 医学
International journal of cardiology Pub Date : 2025-07-17 DOI: 10.1016/j.ijcard.2025.133619
Giovanni Malanchini , Eduardo Celentano
{"title":"Reply to Comment on “Association between device-detected subclinical atrial fibrillation and diabetes in patients with implantable cardioverter defibrillators: A propensity score-matched analysis”","authors":"Giovanni Malanchini ,&nbsp;Eduardo Celentano","doi":"10.1016/j.ijcard.2025.133619","DOIUrl":"10.1016/j.ijcard.2025.133619","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133619"},"PeriodicalIF":3.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing cardiac surgery registry benchmarking: A blueprint for reliable outlier detection 优化心脏手术注册基准:可靠的异常值检测蓝图。
IF 3.2 2区 医学
International journal of cardiology Pub Date : 2025-07-17 DOI: 10.1016/j.ijcard.2025.133639
Mohd Aamir , Adeeba Bilquees , Daood Saleem
{"title":"Optimizing cardiac surgery registry benchmarking: A blueprint for reliable outlier detection","authors":"Mohd Aamir ,&nbsp;Adeeba Bilquees ,&nbsp;Daood Saleem","doi":"10.1016/j.ijcard.2025.133639","DOIUrl":"10.1016/j.ijcard.2025.133639","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133639"},"PeriodicalIF":3.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prolonged dual antiplatelet therapy strategy in acute coronary syndrome patients post-standard therapy and adverse event-free: An analysis based on OPT-CAD risk score stratification 急性冠状动脉综合征患者标准治疗后和无不良事件的长期双重抗血小板治疗策略:基于OPT-CAD风险评分分层的分析
IF 3.2 2区 医学
International journal of cardiology Pub Date : 2025-07-16 DOI: 10.1016/j.ijcard.2025.133636
Xiaolin Su , Miaohan Qiu , Haiwei Liu , Kai Xu , Xiaozeng Wang , Jing Li , Yi Li , Yaling Han
{"title":"Prolonged dual antiplatelet therapy strategy in acute coronary syndrome patients post-standard therapy and adverse event-free: An analysis based on OPT-CAD risk score stratification","authors":"Xiaolin Su ,&nbsp;Miaohan Qiu ,&nbsp;Haiwei Liu ,&nbsp;Kai Xu ,&nbsp;Xiaozeng Wang ,&nbsp;Jing Li ,&nbsp;Yi Li ,&nbsp;Yaling Han","doi":"10.1016/j.ijcard.2025.133636","DOIUrl":"10.1016/j.ijcard.2025.133636","url":null,"abstract":"<div><h3>Background</h3><div>The optimal antiplatelet strategy for patients with acute coronary syndrome (ACS) after the standard 12-month dual antiplatelet therapy (DAPT) is still a matter of concern. We aimed to apply the OPT-CAD score for risk stratification and to identify those who would derive benefit from prolonged DAPT beyond 12 months.</div></div><div><h3>Methods</h3><div>In this post hoc analysis of OPT-CAD study, 7154 patients with ACS, who completed 12-month DAPT without any adverse events, were divided into low-risk (<em>n</em> = 4171) and medium-to-high-risk (<em>n</em> = 2983) groups based on the OPT-CAD risk score. The primary endpoint was ischemic events, defined as the composite of cardiac death, myocardial infarction (MI) or stroke occurring between 12 and 24 months. The secondary endpoints included all-cause death and Bleeding Academic Research Consortium (BARC) type 3 or 5 bleeding.</div></div><div><h3>Results</h3><div>After propensity score matching, in low-risk patients, ischemic events, all-cause death and BARC type 3 or 5 bleeding were comparable between prolonged DAPT and single antiplatelet therapy (SAPT) regimens. However, among the medium-to-high-risk patients, prolonged DAPT was associated with a reduction in ischemic events (hazard ratio [HR] 0.48, 95 % confidence intervals [CI] 0.29–0.81, <em>P</em> = 0.0062) and all-cause death (HR 0.44, 95 %CI 0.21–0.89, <em>P</em> = 0.0220) without apparently increasing the risk of BARC type 3 or 5 bleeding (HR 1.49, 95 %CI 0.25–8.92, <em>P</em> = 0.6622).</div></div><div><h3>Conclusions</h3><div>The OPT-CAD risk score demonstrated moderate ability to predict long-term ischemic events and all-cause mortality in patients with ACS who completed the standard 12-month DAPT without adverse events, and might help identify those more likely to derive benefit from prolonged DAPT.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133636"},"PeriodicalIF":3.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased sympathetic outflow induced by ventromedial hypothalamic nucleus activation aggravates cardiac electrophysiology disturbance after myocardial ischemia–reperfusion injury 下丘脑腹内侧核激活引起的交感神经流出增加加重了心肌缺血再灌注损伤后的心脏电生理障碍
IF 3.2 2区 医学
International journal of cardiology Pub Date : 2025-07-16 DOI: 10.1016/j.ijcard.2025.133634
Xiao Xu , Zihan Liu , Zhihao Liu , Zeyan Li , Yuyang Zhou , Huixin Zhou , Wuping Tan , Chen Peng , Siyi Cheng , Yueyi Wang , Liping Zhou , Xiaoya Zhou , Hong Jiang
{"title":"Increased sympathetic outflow induced by ventromedial hypothalamic nucleus activation aggravates cardiac electrophysiology disturbance after myocardial ischemia–reperfusion injury","authors":"Xiao Xu ,&nbsp;Zihan Liu ,&nbsp;Zhihao Liu ,&nbsp;Zeyan Li ,&nbsp;Yuyang Zhou ,&nbsp;Huixin Zhou ,&nbsp;Wuping Tan ,&nbsp;Chen Peng ,&nbsp;Siyi Cheng ,&nbsp;Yueyi Wang ,&nbsp;Liping Zhou ,&nbsp;Xiaoya Zhou ,&nbsp;Hong Jiang","doi":"10.1016/j.ijcard.2025.133634","DOIUrl":"10.1016/j.ijcard.2025.133634","url":null,"abstract":"<div><h3>Background and aims</h3><div>The ventromedial hypothalamus (VMH) is the key brain region related to emotional stress and sympathetic activity, which can exacerbate myocardial ischemia–reperfusion (I/R) injury and induce severe ventricular arrhythmia (VA). We aim to investigate the role of increased sympathetic outflow induced by VMH activation after myocardial I/R injury, especially the changes of cardiac electrical activity.</div></div><div><h3>Methods</h3><div>Sprague-Dawley rats were divided randomly into the Sham, I/R, hM3d(Gq) and hM4d(Gi) groups, with VMH specifically activated or inhibited using Designer Receptors Exclusively Activated Designer Drugs (DREADDs) technology. I/R model was inducted by ligation of the left coronary artery for 45 min. After 24 h of reperfusion, electrocardiogram and cardiac electrophysiological studies were conducted. Then the samples were collected for histopathological and molecular analyses.</div></div><div><h3>Results</h3><div>VMH was chemogenetically manipulated using DREADDs. The activation of VMH significantly increased systemic and local cardiac sympathetic activity, aggravating I/R injury, which reduced following VMH inhibition. The ventricular electrophysiology disturbance exacerbated following VMH activation and ameliorated following VMH inhibition. The expression of myocardial potassium channel including the rapid delayed rectifier potassium channel (Kcnd3), the inward rectifier potassium channel (Kcnj2) and the slow delayed rectifier potassium channel (Kcnq1) was markedly suppressed following VMH activation, which may represent a key mechanism underlying repolarization abnormalities and increased VA susceptibility.</div></div><div><h3>Conclusions</h3><div>VMH activation exacerbated cardiac electrophysiology disturbance and increased the susceptibility of VA after I/R injury via increased sympathetic outflow, a process closely linked to repolarization impairment caused by potassium channel dysfunction.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133634"},"PeriodicalIF":3.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信