International journal of cardiology最新文献

{"title":"Improving gender-specific management of aortic stenosis with IMPULSE registry data","authors":"Stephan Peronard Mayntz , Filip Soeskov Davidovski","doi":"10.1016/j.ijcard.2025.133293","DOIUrl":"10.1016/j.ijcard.2025.133293","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"433 ","pages":"Article 133293"},"PeriodicalIF":3.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing the clinical relevance of FFR-CT through its impact on treatment strategy","authors":"Ioannis Skalidis, Francesca Sanguineti, Antoinette Neylon","doi":"10.1016/j.ijcard.2025.133315","DOIUrl":"10.1016/j.ijcard.2025.133315","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"433 ","pages":"Article 133315"},"PeriodicalIF":3.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical suitability and clinical outcomes of transcatheter edge-to-edge repair in Chinese patients with significant mitral regurgitation: A real-world echocardiographic study","authors":"Peijian Wei ,&nbsp;Guangzhi Zhao ,&nbsp;Jing Dong ,&nbsp;Shuyi Feng ,&nbsp;Junke Chang ,&nbsp;Jianrui Ma ,&nbsp;Donglin Zhuang ,&nbsp;Fengwen Zhang ,&nbsp;Shiguo Li ,&nbsp;Fujian Duan ,&nbsp;Shouzheng Wang ,&nbsp;Fang Fang ,&nbsp;Xiangbin Pan","doi":"10.1016/j.ijcard.2025.133317","DOIUrl":"10.1016/j.ijcard.2025.133317","url":null,"abstract":"<div><h3>Background</h3><div>Data on mitral valve transcatheter edge-to-edge repair (M-TEER) in Asian patients are limited. This study evaluates the anatomical suitability and clinical efficacy of M-TEER in Chinese patients with moderate-to-severe or severe mitral regurgitation (MR).</div></div><div><h3>Methods</h3><div>This study included symptomatic patients with moderate-to-severe or severe MR who underwent M-TEER echocardiographic screening at Fuwai Hospital from January 2021 to February 2024. Patients were classified according to current anatomical criteria for M-TEER. Clinical characteristics, echocardiographic parameters, and treatments were summarized, focusing on the procedural success of M-TEER and 1-year MR recurrence rates.</div></div><div><h3>Results</h3><div>A total of 481 patients were enrolled, including 304 with degenerative MR (DMR) and 150 with functional MR (FMR). The average age was 68.81 years, 44.28 % were female, and 70.69 % had severe MR. DMR patients had smaller absolute left atrial and ventricular diameters compared to FMR patients. Ideal, suitable, challenging, and impossible M-TEER anatomy was found in 23.49 %, 36.17 %, 13.93 %, and 26.4 % of patients, respectively. Among those who underwent M-TEER, these proportions were 36 %, 46 %, 15 %, and 3 %. The 1-year cumulative incidence of MR recurrence was similar between different etiologies but significantly lower in patients with ideal/suitable anatomy compared to those with challenging/impossible anatomy (5.28 % vs 11.86 %, <em>P</em> = 0.003). Multivariable analysis showed that a leaflet-to-annulus index &lt;1.2 was associated with approximately a 5.8-fold increased risk of MR recurrence within one year.</div></div><div><h3>Conclusion</h3><div>Among patients with significant MR, 59.66 % had ideal/suitable M-TEER anatomy, but only 48 % received treatment, indicating potential undertreatment. Patients with ideal/feasible anatomy had higher procedural success rates and lower recurrence risks.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"433 ","pages":"Article 133317"},"PeriodicalIF":3.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the SPP1/TGF-β1 axis in macrophages: A potential therapeutic mechanism for atrial fibrillation?","authors":"Zhi-Xing Fan,&nbsp;Yi-Fan Huang","doi":"10.1016/j.ijcard.2025.133312","DOIUrl":"10.1016/j.ijcard.2025.133312","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"433 ","pages":"Article 133312"},"PeriodicalIF":3.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond one-size-fits-all: Revisiting the fasting blood glucose in the setting of acute coronary syndromes","authors":"Alessandro Sarai,&nbsp;Flavio Ribichini,&nbsp;Giacomo Mugnai","doi":"10.1016/j.ijcard.2025.133291","DOIUrl":"10.1016/j.ijcard.2025.133291","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"433 ","pages":"Article 133291"},"PeriodicalIF":3.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol septal ablation in hypertrophic obstructive cardiomyopathy: The more the better?","authors":"Hubert Seggewiss,&nbsp;Angelika Batzner","doi":"10.1016/j.ijcard.2025.133282","DOIUrl":"10.1016/j.ijcard.2025.133282","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"433 ","pages":"Article 133282"},"PeriodicalIF":3.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the limitations of non-metabolic thresholds in assessing maximal effort: The role of cardiopulmonary exercise testing","authors":"Nikita Baracchini ,&nbsp;Teresa Maria Capovilla ,&nbsp;Maddalena Rossi ,&nbsp;Cosimo Carriere ,&nbsp;Antonio De Luca ,&nbsp;Irena Tavcar ,&nbsp;Giulia Barbati ,&nbsp;Marco Merlo ,&nbsp;Gianfranco Sinagra","doi":"10.1016/j.ijcard.2025.133292","DOIUrl":"10.1016/j.ijcard.2025.133292","url":null,"abstract":"<div><h3>Introduction</h3><div>Maximal effort, defined by a respiratory exchange ratio (RER) ≥ 1.10, is crucial for accurate interpretation of cardiopulmonary exercise testing (CPET). Standard tests rely on non-metabolic thresholds, such as peak predicted heart rate (ppHR) ≥ 85 %, double product (DP) ≥ 20,000 bpm*mmHg and peak metabolic equivalent of task (MET) ≥ 5.0. This study aimed to assess the effectiveness of non-metabolic thresholds in detecting maximal effort, compared with the RER ≥ 1.10 criterion.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed stable patients who underwent CPET from 2022 to 2023, regardless of test indication, history of heart failure (HF), or medication use. All patients also performed transthoracic echocardiography.</div></div><div><h3>Results</h3><div>Among 239 middle-aged patients (53 ± 14 years, 67 % male), 86 % achieved a RER ≥ 1.10, and 65 % had a diagnosis of HF. Non-metabolic thresholds correctly identified maximal efforts (RER ≥ 1.10) in 75 % of the cases (AUC &lt; 0.600). Misclassified cases were more likely to have a history of atrial fibrillation (AF), paced rhythm, HF, and beta-blockers or RAAS inhibitors use. These patients exhibited lower VO₂ peak and higher VE/VCO₂ slope. Multivariable analysis identified HF history (OR 4.8, CI 95 % 1.6–15.6, p: 0.005), low resting DP (≤ 7500 mmHg*bpm), and ramp protocol as independent predictors of discordant tests.</div></div><div><h3>Conclusion</h3><div>Non-metabolic thresholds misclassified up to 25 % of tests with RER ≥ 1.10 as non-maximal, potentially leading to inaccurate interpretation. In patients with HF, poor expected functional capacity and low DP, direct referral to CPET-equipped facilities may provide more accurate assessment than relying on non-metabolic thresholds.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"433 ","pages":"Article 133292"},"PeriodicalIF":3.2,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of TAVR in asymptomatic or minimally symptomatic patients: Insights from resting angiographic microvascular resistance","authors":"Wence Shi,&nbsp;Moyang Wang,&nbsp;Guannan Niu,&nbsp;Zhenyan Zhao,&nbsp;Zheng Zhou,&nbsp;Dejing Feng,&nbsp;Yongjian Wu,&nbsp;Hongliang Zhang","doi":"10.1016/j.ijcard.2025.133263","DOIUrl":"10.1016/j.ijcard.2025.133263","url":null,"abstract":"<div><h3>Background</h3><div>The optimal timing of transcatheter aortic valve replacement (TAVR) for asymptomatic or minimally symptomatic patients with severe aortic stenosis (AS) remains controversial. Microvascular dysfunction and increased microcirculatory resistance have been linked to adverse outcomes in AS, suggesting that resting angiographic microvascular resistance (AMRr) may aid in identifying higher-risk patients.</div></div><div><h3>Method</h3><div>We conducted a retrospective study of 180 severe AS patients who underwent TAVR at Fuwai Hospital between 2012 and 2021. Patients were grouped based on an AMRr cutoff value of 490, identified through receiver operating characteristic (ROC) analysis. The primary endpoint was the incidence of major adverse cardiovascular events (MACE), including all-cause mortality, heart failure, and myocardial infarction. Kaplan-Meier and Cox regression analyses were used to compare outcomes between groups.</div></div><div><h3>Results</h3><div>A total of 180 asymptomatic or minimally symptomatic AS patients undergoing TAVR were enrolled. After a 40-month follow-up, the AMRr &gt;490 group had a higher MACE risk, mainly driven by readmission for heart failure. Additionally, continuous analysis indicated that every 100-unit increase in AMRr was associated with an 18 %, 17 %, and 1.58-fold increased risk of MACE, all-cause mortality, and NOAF, respectively. Moreover, the addition of AMRr to a clinical model significantly improved the prediction of MACE (AUC 0.678 vs. 0.582, <em>p</em> = 0.023).</div></div><div><h3>Conclusion</h3><div>Asymptomatic or minimally symptomatic AS patients with AMRr &gt;490 had a significantly higher incidence of MACE and heart failure rehospitalization than those with AMRr ≤490 after TAVR. The inclusion of AMRr in a predictive model improved the accuracy for long-term MACE, demonstrating an incremental prognostic value.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"432 ","pages":"Article 133263"},"PeriodicalIF":3.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving our management of tricuspid regurgitation: present and future opportunities","authors":"Marta Sitges","doi":"10.1016/j.ijcard.2025.133288","DOIUrl":"10.1016/j.ijcard.2025.133288","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"433 ","pages":"Article 133288"},"PeriodicalIF":3.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking early anticoagulation in bioprosthetic valve surgery","authors":"Eihab Ghantous","doi":"10.1016/j.ijcard.2025.133289","DOIUrl":"10.1016/j.ijcard.2025.133289","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"432 ","pages":"Article 133289"},"PeriodicalIF":3.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}