International journal of cardiology最新文献

{"title":"Persistent C-reactive protein elevation and heart failure: Risk marker, mediator, or therapeutic target?","authors":"Panagiotis Iliakis","doi":"10.1016/j.ijcard.2026.134989","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.134989","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"466 ","pages":"134989"},"PeriodicalIF":3.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QTc reference ranges in eastern European children aged 6 to 18 years: a large-scale population study and comparison with international normative datasets.","authors":"Gabriel Cismaru, Cecilia Lazea, Lucian Mureşan, Gabriel Gusetu, Radu Rosu, Dana Pop, Alina Negru, Simona Sorana Căinap","doi":"10.1016/j.ijcard.2026.134990","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.134990","url":null,"abstract":"<p><strong>Background: </strong>QT interval corrected for heart rate (QTc) is important. Appropriate reference ranges support ECG interpretation, but data for Eastern European children remain limited. We aimed to derive age- and sex-stratified QTc reference ranges, estimate proportions exceeding cut-offs, and compare results with normative datasets.</p><p><strong>Methods: </strong>12‑lead ECGs from 22,335 children aged 6-18 years were obtained through the CARDIOPED screening programme in northwestern Transylvania, Romania. QTc was calculated using Bazett's formula. Age- and sex-stratified percentile curves (P2.5-P97.5) were derived using spline regression. Correlations with anthropometric variables and proportions exceeding QTc cut-offs of 440, 460, and 480 ms were assessed. Results were compared with the Davignon, Rijnbeek, Saarel, Bratincsák, and Mason datasets.</p><p><strong>Results: </strong>Overall median QTc was 408.2 ms in males and 409.9 ms in females. Upper reference limits (P97.5) were 451.4 ms and 457.0 ms, respectively. The sex difference increased from 2.6 ms in the 6-12-year group to 5.7 ms in the 12-18-year group. Obesity and anthropometric variables showed weak, non-significant correlations with QTc. Values were closely aligned with Rijnbeek et al. QTc exceeded 440 ms in 6.0% of males and 460 ms in 1.2% of females; 14 children (0.06%) had a single screening QTc measurement ≥480 ms.</p><p><strong>Conclusions: </strong>QTc reference ranges in this Eastern European cohort were consistent with European paediatric normative data. Upper reference limits were approximately 450 ms in males and 460 ms in females. Proportions exceeding cut-offs describe cohort distributions, not diagnostic false-positive rates. Percentiles are statistical reference limits rather than validated clinical decision or diagnostic thresholds.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"134990"},"PeriodicalIF":3.3,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1 receptor agonist therapy and incident atrial fibrillation in non-diabetic adults with obesity and chronic kidney disease: a propensity matched cohort study.","authors":"Abdulraheem Hassan, Efeturi Okorigba, Chilaka Grace, Emmanuel Otabor, Busayo Osineye, Olalekan Olayiwola, Tutuola Oyeleye, Parthiv Amin","doi":"10.1016/j.ijcard.2026.135000","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.135000","url":null,"abstract":"<p><strong>Background: </strong>Obesity and chronic kidney disease (CKD) are potent risk factors for atrial fibrillation (AF), yet whether GLP-1 receptor agonists (GLP-1RAs) prevent incident AF in non-diabetic adults with obesity and CKD is unexamined. We assessed whether GLP-1RA therapy reduces 1-year AF incidence in this cardiorenal phenotype.</p><p><strong>Methods: </strong>Using the TriNetX US Collaborative Network (66 healthcare organizations), we conducted a retrospective target trial emulation of non-diabetic adults aged 18 or older with obesity and CKD stages 3-5 diagnosed 2021-2024. Patients receiving semaglutide, liraglutide, or tirzepatide (n = 10,985) were compared with unexposed patients (n = 94,527). After propensity score matching, 7326 patients remained per cohort. The primary outcome was incident AF at 1 year; secondary outcomes included AF subtypes, ventricular tachyarrhythmias, and all-cause hospitalization. Cox models generated hazard ratios (HRs); sensitivity analyses extended follow-up to 2-3 years with landmark analyses.</p><p><strong>Results: </strong>At 1 year, GLP-1RA use was associated with significantly lower incident AF (1.63% vs. 2.62%; HR 0.655, 95% CI 0.508-0.844; p = 0.001), a 34.5% relative risk reduction. Reductions were consistent for paroxysmal (HR 0.586), persistent (HR 0.482), and longstanding persistent AF (HR 0.527; all p < 0.05); permanent AF was non-significant at 1 year. Ventricular tachyarrhythmias (HR 0.556; p = 0.002) and hospitalization (HR 0.668; p < 0.001) were also significantly reduced. Benefits persisted across 2- and 3-year follow-up and remained consistent in landmark analyses.</p><p><strong>Conclusions: </strong>In non-diabetic adults with obesity and CKD, GLP-1RA therapy was associated with significant, durable reductions in incident AF, ventricular arrhythmias, and hospitalization. These findings are consistent with a possible cardiorenal benefit and support prioritizing this phenotype for dedicated randomized trials.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"135000"},"PeriodicalIF":3.3,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-reactive protein-albumin-lymphocyte index and coronary microvascular dysfunction after primary percutaneous coronary intervention: The mediating role of insulin resistance.","authors":"Wei Wang, Hang Qiu, Jian Wang, Hao Jiang","doi":"10.1016/j.ijcard.2026.135001","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.135001","url":null,"abstract":"<p><strong>Background: </strong>The C-reactive protein-albumin-lymphocyte (CALLY) index integrates systemic inflammation, nutritional status, and immune function. We investigated its association with angiography-derived microvascular resistance (AMR)-defined coronary microvascular dysfunction (CMD) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI), and performed an exploratory statistical mediation analysis involving estimated glucose disposal rate (eGDR).</p><p><strong>Methods: </strong>This retrospective, single-center observational study included 456 consecutive patients with STEMI undergoing primary PCI. AMR-defined CMD was prespecified as AMR ≥250 mmHg·s/m. Multivariable logistic regression, restricted cubic spline (RCS), and prespecified subgroup analyses were performed. Sensitivity and exploratory mediation analyses were also performed.</p><p><strong>Results: </strong>AMR-defined CMD was present in 228 patients (50.0%). In Model 3, each doubling of CALLY was associated with lower odds of AMR-defined CMD (OR, 0.87; 95% CI, 0.80-0.94; P < 0.001). Compared with Q1, Q3 and Q4 were associated with 44% (OR, 0.56; 95% CI, 0.32-0.97; P = 0.037) and 52% (OR, 0.48; 95% CI, 0.28-0.84; P = 0.010) lower odds, respectively (P for trend = 0.018). RCS analysis showed an overall association (P = 0.001) without evidence of nonlinearity (P = 0.310). No significant subgroup interactions were observed. Exploratory mediation analysis estimated that eGDR statistically accounted for 15.47% of the observed association.</p><p><strong>Conclusions: </strong>Higher CALLY values were inversely associated with AMR-defined CMD after primary PCI for STEMI. eGDR may account for part of this association. CALLY may serve as an auxiliary marker for AMR-defined CMD risk stratification, pending prospective multicenter validation.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"135001"},"PeriodicalIF":3.3,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of PM_2.5 components with dynamic and accelerated progression of different kidney function states and subsequent cardiovascular events: The GOLD-Health cohort.","authors":"Manting Rao, Jiamin Chen, Peng Hu, Zhonghua Ai, Menghe Wang, Xiangyi Liu, Zhoubin Zhang, Hualiang Lin","doi":"10.1016/j.ijcard.2026.134999","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.134999","url":null,"abstract":"<p><strong>Background: </strong>Fine particulate matter (PM_2.5) has been associated with an increased risk of chronic kidney disease (CKD) and cardiovascular disease (CVD). However, the relationships between specific PM_2.5 components and the dynamic cardiorenal trajectory remain uncertain.</p><p><strong>Methods: </strong>Employing multistate and accelerated failure time (AFT) modeling in a prospective cohort of 307,639 participants, we examined the associations of 2-year exposure to PM_2.5 and its components (sulfate [SO₄^2-], nitrate [NO₃^-], ammonium [NH₄⁺], organic matter [OM], and black carbon [BC]) with dynamic and accelerated progression from different kidney function categories (1-4, according to estimated glomerular filtration rate [eGFR] and self-reported CKD) to CVD, and ultimately to cardiovascular death.</p><p><strong>Results: </strong>Over 1,058,210 person-years of follow-up, we documented 23,948 CVD cases and 7763 cardiovascular death cases. We observed that PM_2.5 and its components were significantly associated with the dynamic cardiorenal trajectory, with SO₄^2-, NO₃^-, and NH₄⁺ exhibiting larger hazard ratios (HRs). Per-interquartile range (IQR) increments in SO₄^2-, NO₃^-, and NH₄⁺ were positively correlated with the transition from kidney function category 2 to 3, and the HRs were 1.273 (95% confidence interval [CI]: 1.257-1.289), 1.304 (95% CI: 1.290-1.317), and 1.280 (95% CI: 1.267-1.294), respectively. The AFT model indicated that higher levels of PM_2.5 and its constituents significantly accelerated the dynamic cardiorenal trajectory. The predictive transition times from kidney function category 2 to 3 for 2-year NO₃^- exposure were 1727.43 days at 4.2 μg/m³ and 868.56 days at 7.0 μg/m³.</p><p><strong>Conclusions: </strong>Our findings revealed that PM_2.5 components (2-year exposure) may be important risk factors for adverse cardiorenal outcomes.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"134999"},"PeriodicalIF":3.3,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CA125 and the right ventricle in acute heart failure: A marker of dysfunction or congestion?","authors":"Takahiro Okumura, Kazuhiro Terashima, Hiroyuki Naruse, Masanobu Yanase, Hideo Izawa","doi":"10.1016/j.ijcard.2026.134992","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.134992","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"134992"},"PeriodicalIF":3.3,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Left atrial dimension and new-onset atrial fibrillation in chronic Chagas disease: a competing-risk analysis of the SEARCH-Rio cohort\" - Benchimol-Barbosa PR, Benchimol-Barbosa ACL, Kantharia BK. Int J Cardiol. 2026 Sep 15;464:134788. doi:10.1016/j.ijcard.2026.134788. Epub ahead of print. PMID: 42744019: Response to Letter to the Editor \"Beyond Left Atrial Diameter in Chagas Disease: Interatrial Block and Competing-Risk Modelling for Atrial Fibrillation Risk\" by Ullah T and Shah MT.","authors":"Paulo Roberto Benchimol-Barbosa, Ana Carolina Loayza Benchimol-Barbosa, Bharat K Kantharia","doi":"10.1016/j.ijcard.2026.134995","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.134995","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"134995"},"PeriodicalIF":3.3,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2026 update on the COVADIS diagnostic criteria of international standardization for microvascular angina.","authors":"Peter Ong, Paolo Camici, John Beltrame, Colin Berry, Filippo Crea, Javier Escaned, Tim van de Hoef, Juan Carlos Kaski, Carl Pepine, Udo Sechtem, Hiroaki Shimokawa, Christopher Zeitz, Noel Bairey Merz","doi":"10.1016/j.ijcard.2026.134993","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.134993","url":null,"abstract":"<p><p>Microvascular angina, in the context of ischemia with non-obstructed coronary arteries (INOCA), is a highly prevalent clinical condition in cardiovascular medicine. Although it remains frequently underdiagnosed, clinical research and practice have made substantial progress in the last 10 years. This includes better characterisation of affected patient cohorts, new data on the prevalence of coronary vasomotor disorders and improved diagnostic assessments (non-invasive and invasive). The aim of this paper is to update our previous 2018 recommendations for the standardization of diagnostic criteria for microvascular angina. The updated COVADIS (Coronary Vasomotor Disorders Study Group) criteria focus on the following 4 criteria: (1) symptoms of myocardial ischemia; (2) non-obstructive coronary disease (stenosis <50%); (3) objective evidence of myocardial ischemia and (4) evidence of impaired coronary microvascular function. The updated criteria incorporate new suggestions for endotype definitions based on the invasive assessment of coronary physiology including coronary flow reserve and the index of microvascular resistance during pharmacological stress as well as acetylcholine testing for epicardial and/or microvascular spasm. The updated criteria should contribute to improved recognition and better management of this condition.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"134993"},"PeriodicalIF":3.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raising diagnoses or doubts? RAISE score for transthyretin cardiac amyloidosis identification in aortic stenosis.","authors":"Vincenzo Castiglione, Alberto Aimo, Giuseppe Vergaro, Michele Emdin","doi":"10.1016/j.ijcard.2026.134977","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.134977","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"134977"},"PeriodicalIF":3.3,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern: \"Conditional knockout of TFPI-1 in VSMCs of mice accelerates atherosclerosis by enhancing AMOT/YAP pathway\".","authors":"","doi":"10.1016/j.ijcard.2026.134958","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.134958","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"134958"},"PeriodicalIF":3.3,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}