International journal of cardiology最新文献

{"title":"Investigating the MINOCA: Are the times actually A-Changin’?","authors":"Luca Siega Vignut , Federico Angriman , Luca Franchin , Massimo Imazio","doi":"10.1016/j.ijcard.2025.133244","DOIUrl":"10.1016/j.ijcard.2025.133244","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"431 ","pages":"Article 133244"},"PeriodicalIF":3.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the letter by Babayiğit et al. “ABO blood groups and early stent thrombosis: A closer look at the Evidence”","authors":"Walter S. Speidl, Caglayan Demirel","doi":"10.1016/j.ijcard.2025.133188","DOIUrl":"10.1016/j.ijcard.2025.133188","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"431 ","pages":"Article 133188"},"PeriodicalIF":3.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eligibility for and practical implications of semaglutide in overweight and obese patients with acute coronary syndrome, A letter to editor","authors":"Ayesha Parvaiz Malik MBBS , Urooj Fatima Malik MBBS","doi":"10.1016/j.ijcard.2025.133237","DOIUrl":"10.1016/j.ijcard.2025.133237","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"431 ","pages":"Article 133237"},"PeriodicalIF":3.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arrhythmic risk prediction in non-dilated left ventricular cardiomyopathy: The role of overlap with arrhythmogenic cardiomyopathy.","authors":"Ignazio Alessio Gueli, Alberto Aimo, Bianca Alderotti, Giancarlo Trimarchi, Irina Bellisario, Giancarlo Todiere, Chrysanthos Grigoratos, Carmelo De Gori, Alberto Clemente, Iacopo Fabiani, Nicoletta Botto, Simona Vittorini, Giorgia Panichella, Giuseppe Vergaro, Alberto Giannoni, Giovanni Donato Aquaro, Claudio Passino, Michele Emdin, Andrea Barison","doi":"10.1016/j.ijcard.2025.133224","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133224","url":null,"abstract":"<p><strong>Background: </strong>Non-dilated left ventricular cardiomyopathy (NDLVC) has been defined as non-ischemic LV scarring or fatty replacement regardless of global or regional wall motion abnormalities, or isolated global LV hypokinesia without scarring. We evaluated the arrhythmic risk in NDLVC and assessed the prognostic value of overlapping features with arrhythmogenic cardiomyopathy (ACM).</p><p><strong>Methods: </strong>All patients who underwent cardiovascular magnetic resonance (CMR) scan and genetic testing between 2012 and 2022 and met the diagnostic criteria for NDLVC were selected. All patients were evaluated for the presence of the 2024 diagnostic criteria for ACM. The primary endpoint was a composite of sudden cardiac death (SCD), ventricular fibrillation (VF) or sustained ventricular tachycardia (VT),.</p><p><strong>Results: </strong>The cohort included 225 patients (35 % women, median age 55 years [interquartile range 44-64]). The etiology was genetic in 44 % of cases, with 51 pathogenetic/likely pathogenetic (P/LP) variant and 49 variant of uncertain significance (VUS). Over 3.3 years (1.5-6.0), 12 patients (5 %) developed an endpoint event. The risk increased in patients meeting the criteria for definite or borderline arrhythmogenic left ventricular (ALVC) and biventricular (ABVC) cardiomyopathy. In the whole cohort, LGE >9 % of LV mass was the most significant predictor of outcome. In patients with LGE >9 %, fatty replacement significantly increased the risk of arrhythmic events.</p><p><strong>Conclusions: </strong>LGE >9 % of LV mass and fatty replacement are associated with an increased arrhythmic risk in NDLVC. The risk is also higher if patients meet the 2024 criteria for definite or borderline ALVC/ABVC.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133224"},"PeriodicalIF":3.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PERK's novel agonist protects against myocardial ischemia-reperfusion injury by modulating ER-mitochondria contacts and phosphatidic acid transport.","authors":"Zeyu Li, Suiqing Huang, Huayang Li, Quan Liu, Jing Lu, Peiqing Liu, Zhongkai Wu","doi":"10.1016/j.ijcard.2025.133222","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133222","url":null,"abstract":"<p><p>The role of PERK in maintaining the homeostasis of MAM is believed to exert a significant impact on mitochondrial energy metabolism and structural morphology. However, there exists controversy regarding the therapeutic effect of PERK activation on ischemia-reperfusion injury. We have discovered a novel agonist for PERK named ZY341. ZY341 interacts with the active pocket of PERK through π-π stacking interactions, and surface plasmon resonance experiments have confirmed its exceptional potency as an agonist with a Kd value of 17.5 μM. This study provides initial evidence that ZY341 exhibits potent activity as a PERK agonist, effectively activating the PERK/eIF2α pathway in a mouse model of ischemia-reperfusion and demonstrating significant anti-apoptotic effects on cardiomyocytes. Ischemia-reperfusion not only induces cardiomyocyte apoptosis but also leads to substantial increases in MAM-mediated mitochondrial calcium overload, resulting in severe damage to mitochondrial structure and function. ZY341 significantly protects cardiac myocytes' respiratory capacity and improves heart function. Mechanistically, through PERK activation, ZY341 inhibits abnormal binding between VAPB-PTPIP51 complex in OGD/R models, regulates MAM-mediated calcium ion and phosphatidic acid transport homeostasis, suppresses mitochondrial fragmentation thereby significantly enhancing cardiac function. In conclusion, this study unveils new avenues for targeting PERK as a therapeutic strategy for myocardial ischemia-reperfusion treatment.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133222"},"PeriodicalIF":3.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiography-derived index of microcirculatory resistance as a novel tool to assess coronary microvascular dysfunction in patients with diabetic cardiomyopathy","authors":"Zhan Gao ,&nbsp;Xue Hua Qian ,&nbsp;Jia Yu Ke ,&nbsp;Ken Lin ,&nbsp;Jian Han Zhu ,&nbsp;Xi Zhou ,&nbsp;Hao Zhou ,&nbsp;Liang Guo Wang","doi":"10.1016/j.ijcard.2025.133220","DOIUrl":"10.1016/j.ijcard.2025.133220","url":null,"abstract":"<div><h3>Backgrounds</h3><div>Coronary microvascular dysfunction (CMD) has been proposed as a major mechanism and a potential therapeutic target for diabetic cardiomyopathy (DbCM); however, it has not been fully investigated in a clinical setting. The angiography-derived index of microcirculatory resistance (AMR) is a novel non-invasive measurement of CMD that exhibits promising clinical applications.</div></div><div><h3>Methods</h3><div>AMR was measured in hospitalized patients with DbCM and in control patients. The incidence, clinical characteristics, risk factors, and effects of pharmacological interventions on CMD were investigated.</div></div><div><h3>Results</h3><div>AMR was significantly higher in patients who met the DbCM-2B diagnostic criteria. The independent risk factors for abnormal AMR included diabetes, body mass index (BMI), and N-terminal pro-brain natriuretic peptide (NT-pro-BNP). Patients with elevated NT-pro-BNP had high AMR, and those grouped by medication indicated that ACEI/ARB, sacubitril/valsartan, and trimetazidine might lower AMR in patients with elevated NT-pro-BNP.</div></div><div><h3>Conclusions</h3><div>The DbCM-2B diagnostic criteria demonstrated a strong correlation with CMD. ACEI/ARB, sacubitril/valsartan, and trimetazidine might improve CMD in patients with DbCM.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"431 ","pages":"Article 133220"},"PeriodicalIF":3.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary artery denervation: From hope to clinical reality","authors":"Masafumi Fukumitsu,&nbsp;Keita Saku","doi":"10.1016/j.ijcard.2025.133225","DOIUrl":"10.1016/j.ijcard.2025.133225","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"431 ","pages":"Article 133225"},"PeriodicalIF":3.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced myocardial CARF and the underlying implications in left ventricular noncompaction cardiomyopathy.","authors":"Liu Hui, Li Xinrun, Xiao Yana, Chen Liyuan, Yin Shangqi, Liu Wuzheng, Zhang Yao, Yubin Wang, Li Chunyan","doi":"10.1016/j.ijcard.2025.133221","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133221","url":null,"abstract":"<p><strong>Background: </strong>Left ventricular noncompaction cardiomyopathy (LVNC) has been used to describe a ventricular phenotype characterized by thick LV trabeculae and the formation of crypts by depression. Some studies have shown that apoptosis of cardiomyocytes leads to impaired development and densification, resulting in LVNC formation. The applicant's previous results showed that CARF protein was specifically down-regulated in myocardial tissue of LVNC disease, and the pathway specifically enriched in LVNC was the p53 apoptosis pathway, and CARF was enriched in the p53 apoptosis pathway.</p><p><strong>Methods: </strong>Comparative proteomic analysis by iTRAQ-2DLC-MS/MS was used to screen differentially expressed proteins in heart samples obtained from heart transplantation patients diagnosed with LVNC, ARVC, and HCM in comparison to normal heart samples. Decresing expressed CARF in heart samples from LVNC was further confirmed by Western blot. Immunofluorescence, western blots were used to study the effects of knock out CARF on the structure and function of HL1 cardiomyocytes. Functional and morphological changes were observed by TUNEL staining in cardiomyocytes whose left ventricle knock out CARF.</p><p><strong>Results: </strong>In our study, CARF protein is specifically down-regulated in myocardial tissue of LVNC disease. The pathway specifically enriched in LVNC is the p53 apoptosis pathway, and CARF is enriched in the p53 apoptosis pathway. We hypothesized that CARF interacts with p53 to influence apoptotic pathway activity resulting in LVNC. In view of the localization and function of CARF in the heart, we hypothesized that knock out the CARF might be involved in the apoptosis pathway and participated in the molecular mechanism of LVNC.</p><p><strong>Conclusion: </strong>Myocardial CARF phosphorylation participate in the apoptosis pathway which result in cardiomyocytes apoptosis. Our findings suggest that decreased myocardial CARF might be involved in the molecular mechanism of LVNC. CARF participates in the occurrence and development of LVNC by mediating the p53 pathway, so as to develop new therapeutic targets for LVNC.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133221"},"PeriodicalIF":3.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Sex and clinical outcomes in new-onset heart failure.","authors":"Yaru Zhang, Xiaorong Yin, Haoran Zhu, Cheng Shen","doi":"10.1016/j.ijcard.2025.133241","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133241","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133241"},"PeriodicalIF":3.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Machine learning risk-prediction model for in-hospital mortality in Takotsubo cardiomyopathy”","authors":"Muhammad Hasan,&nbsp;Muhammad Hammad Chola","doi":"10.1016/j.ijcard.2025.133240","DOIUrl":"10.1016/j.ijcard.2025.133240","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"431 ","pages":"Article 133240"},"PeriodicalIF":3.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}