International journal of cardiology最新文献

{"title":"Right ventricular-pulmonary artery coupling assessed by two-dimensional strain predicts in-hospital complications in Takotsubo syndrome","authors":"Giulia La Vecchia ,&nbsp;Giulia Iannaccone ,&nbsp;Michele Russo ,&nbsp;Marco Giuseppe Del Buono ,&nbsp;Vincenzo Scarica ,&nbsp;Rosa Lillo ,&nbsp;Massimiliano Camilli ,&nbsp;Tommaso Sanna ,&nbsp;Antonella Lombardo ,&nbsp;Gaetano Antonio Lanza ,&nbsp;Francesco Burzotta ,&nbsp;Francesca Graziani ,&nbsp;Antonio Maria Leone ,&nbsp;Filippo Crea ,&nbsp;Rocco A. Montone","doi":"10.1016/j.ijcard.2025.133044","DOIUrl":"10.1016/j.ijcard.2025.133044","url":null,"abstract":"<div><h3>Background</h3><div>Takotsubo syndrome (TTS) is an acute condition characterized by a reversible left ventricular (LV) systolic dysfunction leading to serious in-hospital complications (IHC). The aim of our study is to investigate the prognostic impact of right ventricular-to-pulmonary artery (RV-PA) coupling in patients with TTS.</div></div><div><h3>Methods</h3><div>Consecutive TTS patients were prospectively enrolled. In all patients, standard and speckle tracking transthoracic echocardiography was performed within 48 h from hospital admission. RV function was evaluated by RV global longitudinal strain (RV-GLS) and RV free wall strain (RV-FWS) and RV-PA coupling was measured as the ratio of either tricuspid annular plane systolic excursion (TAPSE), RV-GLS or RV-FWS to pulmonary artery systolic pressure (PASP). Data about IHC (acute heart failure, life-threatening arrhythmias and death) were collected.</div></div><div><h3>Results</h3><div>A total of 80 patients were analyzed (71 ± 11 years, female 77.5 %) and IHC occurred in 33 (41 %). Patients who experienced IHC had lower LV ejection fraction (LVEF), lower left atrial (LA) reservoir strain, TAPSE/PASP, RV-FWS/PASP and RV-GLS/PASP and higher left atrial volume indexed (LAVi) values. At multivariate analysis, only LVEF (OR 0.913, 95 % CI [0.858–0.971], <em>p</em> = 0.004) was an independent predictor of IHC. Receiver operating characteristics (ROC) curve analysis showed an additional prognostic value of a combined model including RV-GLS/PASP and LVEF compared to LVEF alone in the prediction of IHC (AUC of 0.756 vs 0.736, differences between AUCs: 0.02 [<em>p</em> = 0.73]).</div></div><div><h3>Conclusion</h3><div>RV-PA coupling assessed by RV-GLS/PASP may help in identifying TTS patients at higher risk of cardiovascular complications with an additional prognostic value to LVEF alone.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"424 ","pages":"Article 133044"},"PeriodicalIF":3.2,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143394987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in mechanical circulatory support utilization, left ventricular assist device implantation and transplant during cardiogenic shock hospitalizations, after the new heart allocation policy.","authors":"Diala Steitieh, Robert Beale, Ethan Katznelson, Elizabeth Feldman, Dilan Minutello, Daniel Lu, Parag Goyal, Jim Cheung, Luke K Kim, Udhay Krishnan","doi":"10.1016/j.ijcard.2025.133054","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133054","url":null,"abstract":"<p><strong>Background: </strong>In October 2018, a new heart allocation policy was implemented to risk stratify patients listed for transplant, prioritizing patients supported with temporary mechanical circulatory support (MCS). The policy changes may have had an impact on the management of cardiogenic shock (CS). We sought to determine the changes in use of temporary MCS, durable left ventricular assist device (LVAD) and transplant in patients hospitalized before and after the new policy.</p><p><strong>Methods: </strong>A retrospective analysis was conducted using the National Inpatient Sample (NIS) between 2017 and 2020. Hospitalizations for cardiogenic shock were identified, and stratified based on whether patients were admitted before or after the policy change. Baseline characteristics were compared between cohorts, and the primary outcome of interest was the use of MCS, transplant and LVAD before and after the policy change. Subgroup analyses included patients hospitalized at transplant and non-transplant centers, LVAD recipients as well as those who underwent transplant.</p><p><strong>Results: </strong>A total of 643,655 hospitalizations were included, of which 260,340 (40.4 %) were before the policy change, and 383,315 (59.6 %) were after. In all patients with CS, there was a decrease in the use of LVAD (adjusted OR 0.73, p < 0.01) and an increase in cardiac transplant (adjusted OR 1.45, p < 0.01). While IABP use declined for the general CS population (adjusted OR 0.81, p < 0.01), it increased significantly in cardiac transplant recipients (adjusted OR 2.55; p < 0.01). Impella and VA-ECMO also increased in transplant recipients. No uptrend was seen in any other subgroup including LVAD recipients or CS patients managed in transplant centers.</p><p><strong>Conclusion: </strong>Our study showed that the allocation policy change had a direct impact on MCS use in the first two years after implementation, but this effect was isolated to patients who underwent transplantation. It will be important to study how policy changes influence the management of other shock populations over time.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133054"},"PeriodicalIF":3.2,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colchicine for secondary prevention in patients with acute coronary syndrome: A systematic review and meta-analysis.","authors":"Safia Shaikh, Mohammad Hamza, Sivaram Neppala, Sahib Singh, Prakash Upreti, Ahmed Muaaz Umer, K C Manish, Krutarth Pandya, Yasemin Bahar, Yasar Sattar, M Chadi Alraies","doi":"10.1016/j.ijcard.2025.133045","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133045","url":null,"abstract":"<p><strong>Background: </strong>Despite optimal therapy, coronary artery disease (CAD) remains a significant public health concern worldwide. Studies have increasingly recognized the role of inflammation in atherosclerosis. Colchicine, a potent anti-inflammatory drug commonly used to treat gout, and pericarditis is being evaluated in this study for its safety and efficacy in preventing CAD following an acute coronary syndrome (ACS).</p><p><strong>Methods: </strong>We searched PubMed and Embase for studies up to April 2024 comparing colchicine to standard medical treatment in ACS patients. Primary outcomes included major adverse cardiovascular events (MACE) and recurrent ACS, while secondary outcomes were cardiovascular death, congestive heart failure (CHF), stroke, hospitalizations, and gastrointestinal (GI) side effects. Data were pooled using a random-effects model.</p><p><strong>Results: </strong>We included nine studies with a pooled sample size of 7260 patients. The mean age was 60.1 (±11.8) years, with 19.3 % females and a mean follow-up duration of 8.5 (±6) months. Patients who received colchicine treatment demonstrated a reduced risk of re-hospitalizations (OR 0.52 [0.34-0.81]) but had increased GI effects (OR 2.10 [1.20-3.68]). There was no significant difference in cardiovascular death (OR 1.17 [0.52-2.63]), MACE (OR 0.68 [0.45-1.01]), stroke (OR 0.46 [0.18-1.18]), recurrent ACS (OR 0.55 [0.28-1.09]) and the incidence of CHF (OR 0.90 [0.38-2.12]) between patients treated with colchicine versus standard medical treatment.</p><p><strong>Conclusion: </strong>Adding colchicine to standard medical therapy in ACS patients significantly reduced hospitalizations but is associated with increased GI side effects. Further prospective trials are required to validate these findings and determine if early intervention with colchicine treatment improves clinical outcomes in ACS patients.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133045"},"PeriodicalIF":3.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apical ballooning and the rogue clot: A risky affair in Takotsubo syndrome.","authors":"Ramy Sedhom, Michael Megaly","doi":"10.1016/j.ijcard.2025.133033","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133033","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133033"},"PeriodicalIF":3.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Domain-specific association of single-nucleotide variants in the LMNA gene with the phenotypic expression of dilated cardiomyopathy","authors":"Wen Zhuo ,&nbsp;Zhenhong Jiang ,&nbsp;Mengwei Xun ,&nbsp;Mouwen Lin ,&nbsp;Qiongqiong Zhou ,&nbsp;Ali J. Marian ,&nbsp;Kui Hong","doi":"10.1016/j.ijcard.2025.133043","DOIUrl":"10.1016/j.ijcard.2025.133043","url":null,"abstract":"<div><h3>Background</h3><div><em>LMNA</em> gene variants cause a spectrum of phenotypes referred to as laminopathies. However, the topological distribution of the <em>LMNA</em> variants and their phenotypic effects have not been delineated. We investigated the associations of variants located at different LMNA domains with clinical phenotypes in dilated cardiomyopathy (DCM) patients.</div></div><div><h3>Methods</h3><div>All reported single-nucleotide variants (SNVs) in <em>LMNA</em> were obtained from the ClinVar, HGMD and PubMed databases. The associated phenotypes were collected from PubMed. The pathogenicity of the variants was determined according to the 2015 ACMG/AMP criteria.</div></div><div><h3>Results</h3><div>236 DCM-related pathogenic/likely pathogenic (P/LP) nonsynonymous SNVs (nsSNVs) were enriched at the intermediate filament (IF) Rod region. Left ventricular ejection fraction was lower in DCM patients carrying P/LP nsSNVs at the Coil 1B and Tail regions than at those with P/LP variants at the Coil 2 region. Similarly, atrioventricular block and pacemaker implantation-related P/LP nsSNVs were enriched at the IF rod region; ventricular tachycardia/fibrillation and implantable cardiac defibrillator implantation-related P/LP nsSNVs were enriched at the Tail domain. Representative mutations in IF Rod and Tail region were selected for mechanism investigation. The ryanodine receptor (RYR2) and membrane Cav1.2 protein expression was significantly increased with variants in Tail region (C1621T and C1718T) compared with variants in IF Rod region (G497C and A575G) and WT group.</div></div><div><h3>Conclusion</h3><div><em>LMNA</em> P/LP nsSNVs were found to be enriched in the IF rod domain, and a domain-dependent association of the variants with the phenotypic features of DCM was identified. These findings are provisional and, upon replication in independent studies, might be useful in genotype–phenotype correlation studies in DCM caused by <em>LMNA</em> mutations.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"424 ","pages":"Article 133043"},"PeriodicalIF":3.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Late gadolinium enhancement on cardiac MRI: A systematic review and meta-analysis of prognosis across cardiomyopathies” [International journal of cardiology (2025)]","authors":"Joshua Helali ,&nbsp;Karthik Ramesh ,&nbsp;John Brown ,&nbsp;Carlos Preciado-Ruiz ,&nbsp;Thornton Nguyen ,&nbsp;Livia T. Silva ,&nbsp;Austin Ficara ,&nbsp;George Wesbey ,&nbsp;Jorge A. Gonzalez ,&nbsp;Kenneth C. Bilchick ,&nbsp;Michael Salerno ,&nbsp;Austin A. Robinson","doi":"10.1016/j.ijcard.2025.133009","DOIUrl":"10.1016/j.ijcard.2025.133009","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"423 ","pages":"Article 133009"},"PeriodicalIF":3.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143328502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is estimating hyperemic microvascular resistance the best available option?","authors":"Christopher Zeitz","doi":"10.1016/j.ijcard.2025.133024","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133024","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133024"},"PeriodicalIF":3.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing ischemia and bleeding in high-bleeding risk PCI: A tightrope walk","authors":"Dorian Garin,&nbsp;Stéphane Cook","doi":"10.1016/j.ijcard.2025.133031","DOIUrl":"10.1016/j.ijcard.2025.133031","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"424 ","pages":"Article 133031"},"PeriodicalIF":3.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends of characteristics and management of patients with suspected MINOCA","authors":"Giuseppe Ciliberti ,&nbsp;Federico Fortuni ,&nbsp;Andrea Santucci ,&nbsp;Alessandro Timi ,&nbsp;Emanuel Barnoffi ,&nbsp;Stefano Coiro ,&nbsp;Federico Guerra ,&nbsp;Maurizio Del Pinto ,&nbsp;Paolo Compagnucci ,&nbsp;Rocco Sclafani ,&nbsp;Michela Casella ,&nbsp;Ketty Savino ,&nbsp;Antonio Dello Russo ,&nbsp;Giuseppe Ambrosio ,&nbsp;Erberto Carluccio","doi":"10.1016/j.ijcard.2025.133039","DOIUrl":"10.1016/j.ijcard.2025.133039","url":null,"abstract":"<div><h3>Background</h3><div>Myocardial infarction without obstructive coronary artery disease (MINOCA) is a challenging condition which requires appropriate management and therapy. Although specific guidelines and recommendations for this condition have been introduced, there are few data about management implementation over time. The aim of this study is to compare two cohorts of patients affected by suspected MINOCA to assess the temporal trends change in the clinical characteristics and management.</div></div><div><h3>Methods</h3><div>Two patient cohorts were retrospectively selected from a single centre (Cardiology Department of Perugia University Hospital) and compared to investigate the differences in characteristics and management before and after the release of 2018 MINOCA guidelines. The Group included patients enrolled from January 2006 to December 2014, and the Group 2 from July 1st, 2020, to July 31st, 2023.</div></div><div><h3>Results</h3><div>Group 1 included 150 patients and Group 2 83 patients. Compared to group 1, group 2 showed higher prevalence of hypercholesterolemia (57 % vs 27 % p &lt; 0,001), prior acute myocardial infarction (23 % vs 5 %, <em>p</em> &lt;0,001), preserved left ventricular ejection fraction (90 % vs 67 %, <em>p</em> = 0,03), use of cardiovascular magnetic resonance (27 % vs 0 %,<em>p</em> &lt; 0.001), prescription of beta-blockers (69 % vs 31 %,p &lt; 0.001), calcium channel blockers (46 % vs 16 %, <em>p</em> &lt; 0.001), statins (81 % vs 59 %, <em>p</em> = 0.03) and a less frequent occurrence of ST-elevation on admission ECG (9 % vs 24 %, <em>p</em> = 0.005), prescription of dual antiplatelet therapy (20 % vs 58 %, <em>p</em> &lt; 0.001) and nitrates (12 % vs 54 %, p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>In the present study, characteristics and management of patients with suspected MINOCA has significantly changed over time. However, discrepancies with guidelines recommendation still exist and implementation strategies are needed to fill this gap and improve clinical practice.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"424 ","pages":"Article 133039"},"PeriodicalIF":3.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143329321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic reference ranges of myocardial work in children and adolescents: A meta-analysis","authors":"Xander Jacquemyn ,&nbsp;Benjamin T. Barnes ,&nbsp;Sruti Rao ,&nbsp;Shelby Kutty","doi":"10.1016/j.ijcard.2025.133040","DOIUrl":"10.1016/j.ijcard.2025.133040","url":null,"abstract":"<div><h3>Background</h3><div>Establishing reference values for LV myocardial work (MW) is essential before its widespread implementation in pediatrics. This study aims to provide normal LV MW ranges, encompassing global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE).</div></div><div><h3>Methods</h3><div>Databases were searched through February 1st, 2024, for studies reporting MW indices in healthy children across pediatric age categories. Weighted means were obtained from random-effect models with corresponding 95 % confidence intervals (CI). Subgroup analyses were conducted to identify sex or geographic differences. Meta-regression analysis was used to identify modulating effects of demographic, clinical, and echocardiographic variables.</div></div><div><h3>Results</h3><div>The search yielded 104 articles, of which, 12 articles with 1037 patients (age 10.7 ± 0.7 years, 47.5 % female) were eligible for inclusion. The reported normal overall pooled mean values of GWI and GCW were 1525.4 (95 % CI, 1328.1–1722.6) mmHg% and 1880.3 (95 % CI, 1683.6–2077.0) mmHg%, respectively. Pooled mean GWW was 57.2 (95 % CI, 51.9–62.5) mmHg%, and pooled mean GWE was 96.8 (95 % CI, 96.6–97.0) %. Subgroup analysis found no sex differences (<em>P</em> &gt; 0.050), but significant regional variations: GCW and GWW differed in European or US cohorts versus East Asian cohorts (<em>P</em> = 0.033 and <em>P</em> = 0.039, respectively). Meta-regression identified age, blood pressure, and heart rate as significant modulators. Pooled inter-observer intraclass correlation coefficients (ICCs) ranged from 0.86 to 0.96, while pooled intra-observer ICCs ranged from 0.81 to 0.93, indicating excellent reproducibility.</div></div><div><h3>Conclusions</h3><div>We provide age-specific MW reference ranges for children, valuable for both clinical and research purposes, and confirm the reproducibility of MW.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"424 ","pages":"Article 133040"},"PeriodicalIF":3.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}