International journal of cardiology最新文献

{"title":"The complementary effects of GLP-1 receptor agonists and SGLT2 inhibitors in transthyretin cardiac amyloidosis patients: A retrospective multicenter cohort study.","authors":"Ahmed K Mahmoud, Ibrahim Kamel, Kamal Awad, Juan Farina, Ramzi Ibrahim, Mahmoud Abdelnabi, Mohamed Allam, Hoang Nhat Pham, Julie Rosenthal, Eric Steidley, Steven J Lester, Benjamin Horn, Chadi Ayoub, Reza Arsanjani","doi":"10.1016/j.ijcard.2025.133567","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133567","url":null,"abstract":"<p><strong>Background: </strong>Transthyretin cardiac amyloidosis (ATTR-CA) is a progressive infiltrative cardiomyopathy that can lead to symptomatic heart failure (HF). Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have shown favorable cardiovascular and metabolic effects, with significant benefits in ATTR-CA. With the widespread use of GLP-1 receptor agonists (GLP-1RAs), their potential in this population is of interest. This study sought to investigate the added effects of GLP-1RA to SGLT2i in ATTR-CA patients.</p><p><strong>Methods: </strong>We identified patients with ATTR-CA and SGLT2i use from 2013 to 2024. Two cohorts were compared: patients on both GLP-1RA and SGLT2i and those on SGLT2i alone. Primary outcomes included all-cause mortality and major adverse cardiovascular events (MACE). Secondary outcomes were HF exacerbations, ischemic stroke, all-cause hospitalization, atrial fibrillation, and ventricular arrythmia.</p><p><strong>Results: </strong>After propensity score matching, the GLP-1RA cohort had a significant reduction in all-cause mortality (1.8 % vs 5.5 %; HR 0.30, 95 %CI 0.16-0.55, p < 0.0001) and MACE (14.0 % vs 19.3 %; HR 0.64, 95 %CI 0.50-0.83, p = 0.0006) at 12-month follow-up. Additionally, GLP-1RA use was associated with lower risks of ischemic stroke, HF exacerbations, and all-cause hospitalization, with no significant difference in new-onset atrial fibrillation or ventricular arrhythmias.</p><p><strong>Conclusion: </strong>The combined use of GLP-1RA and SGLT2i in ATTR-CA appears to confer incremental prognostic value.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133567"},"PeriodicalIF":3.2,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How accurate is intraprocedural transthoracic echocardiography in assessing aortic regurgitation after transcathether aortic valve implantation? A single center experience","authors":"Claire B. Ren,&nbsp;Mark M.P. van den Dorpel,&nbsp;Marcel Geleijnse,&nbsp;Nicolas M. van Mieghem","doi":"10.1016/j.ijcard.2025.133565","DOIUrl":"10.1016/j.ijcard.2025.133565","url":null,"abstract":"<div><div>Aim Transthoracic echocardiography (TTE) has been commonly used to assess the aortic regurgitation (AR), particularly paravalvular leakage, during transcatheter aortic valve implantation (TAVI). We sought to investigate the accuracy of intraprocedural TTE to grade the AR severity by comparing with discharge TTE assessments.</div><div>Methods Consecutive patients received balloon expandable (BE) or self-expanding (SE) transcatheter heart valves with both intraprocedural TTE and discharge TTE AR assessments were included. The AR was assessed following the standard approach intraprocedurally by one dedicated interventional echocardiographer and at discharge by one echo-cardiologist.</div><div>Results In total 404 patients, the AR grade was concordant in about 2/3 of the population and discordance was mainly underestimation of AR severity with intraprocedural TTE. None or trace intraprocedural AR was more seen in patients with BE valves and the concordance with discharge assessment was also higher in BE valve group than that of the SE valve group. The discordance was mainly underestimation too, regardless of valve types.</div><div>Conclusion in our single-center real-world experience, the AR assessed with intraprocedural TTE was discordant with the discharge TTE in about 1/3 of the cases with predominantly underestimation.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133565"},"PeriodicalIF":3.2,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in syndecan-1 concentration in the coronary sinus immediately after cardiac reperfusion reflect postoperative myocardial injury","authors":"Takayoshi Kato ,&nbsp;Keiko Suzuki ,&nbsp;Hiromu Kawashima ,&nbsp;Yohei Kato ,&nbsp;Daichi Watanabe ,&nbsp;Ayako Inoda ,&nbsp;Takatomo Watanabe ,&nbsp;Yuta Inoue ,&nbsp;Masayuki Sato ,&nbsp;Ryo Fujii ,&nbsp;Hiroki Ogura ,&nbsp;Etsuji Umeda ,&nbsp;Tomoaki Yoshimura ,&nbsp;Osamu Sakai ,&nbsp;Akio Suzuki ,&nbsp;Hideshi Okada ,&nbsp;Kiyoshi Doi","doi":"10.1016/j.ijcard.2025.133564","DOIUrl":"10.1016/j.ijcard.2025.133564","url":null,"abstract":"<div><h3>Objectives</h3><div>Endothelial glycocalyx (eGCX) is shed into the bloodstream during reperfusion injury and ischemia, and its core proteins, syndecan-1 and glypican-1, can be measured in the blood. However, no studies have measured cardiac serum syndecan-1 concentrations in blood from the coronary sinus. Therefore, we aimed to examine the relationship between the degree and changes in eGCX damage and postoperative clinical outcomes using blood drawn from the coronary sinus.</div></div><div><h3>Methods</h3><div>Serum eGCX concentrations in the coronary sinus of 56 patients who underwent cardiac and thoracic aortic surgery with combined ante- and retrograde cardioplegia were analyzed. The association between maximum postoperative troponin T (TnT) level, as a myocardial damage marker, and eGCX injury markers, including syndecan-1 and glypican-1, measured in coronary sinus blood drawn immediately after reperfusion, was assessed. The association between eGCX injury markers and duration of cardioplegic arrest was also investigated.</div></div><div><h3>Results</h3><div>An association between degree of change in coronary sinus serum syndecan-1 concentration during reperfusion and postoperative maximum serum TnT levels was observed. No such association was found between the degree of change in coronary sinus serum glypican-1 concentration during reperfusion and postoperative serum TnT levels. Similar results were obtained for somatic circulation. Moreover, an association between maximum change in serum syndecan-1 concentration in the coronary sinus during reperfusion and cardioplegic arrest duration was observed. No such association was found for glypican-1 concentration.</div></div><div><h3>Conclusions</h3><div>The degree of endothelial damage to the coronary sinuses during reperfusion may predict myocardial injury following cardiac surgery.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133564"},"PeriodicalIF":3.2,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of high-moderate hypothermic circulatory arrest on postoperative major adverse events in acute Type A aortic dissection.","authors":"Wei Wang, Jinhua Wei, Zhan Hu, Yu Du, Chunyuan Wang, Rong Wu, Fei Xu","doi":"10.1016/j.ijcard.2025.133561","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133561","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effect of high-moderate hypothermic circulatory arrest (HMHCA) versus low-moderate and deep hypothermic circulatory arrest (LDHCA) on postoperative major adverse events (MAEs) after aortic repair procedure for patients with acute type A aortic dissection (ATAAD).</p><p><strong>Methods: </strong>Between January 2013 and December 2021, a total of 555 patients were treated with aortic repair procedure utilizing the HMHCA strategy and 262 patients utilizing the LDHCA strategy. The impact of different HCA temperatures on the postoperative MAEs was evaluated through the comparison between the HMHCA group and the LDHCA group.</p><p><strong>Results: </strong>The mean age was 48.6 ± 10.8 in the HMHCA group and 47.2 ± 10.4 in the LDHCA group (P = 0.086), with similar female gender distribution (22.3 % vs 24.4 %, P = 0.533). The frequency of preoperative cerebral malperfusion syndrome was lower in the HMHCA group than the LDHCA group (7.0 % vs 11.0 %, P = 0.058). The duration of cardiopulmonary bypass was comparable between the two groups; however, patients in the HMHCA group exhibited longer duration of aortic cross-clamp and shorter duration of HCA process. Bilateral cerebral perfusion was utilized in 11.2 % of HMHCA group and 0.8 % of LDHCA group (P < 0.001). The morbidity of postoperative MAEs was 34.2 % in the HMHCA group and 44.1 % in the LDHCA group (P = 0.008). Multivariable logistic regression analysis demonstrated that HMHCA temperature was significantly associated with lower incidence of postoperative MAEs (OR = 0.601, 95 % CI 0.393-0.919, P = 0.019).</p><p><strong>Conclusions: </strong>The utilization of high-moderate HCA presents with superior postoperative outcomes compared with low-moderate and deep HCA in patients with ATAAD.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133561"},"PeriodicalIF":3.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative Plaque Burden index for determining the diffuseness of atherosclerotic coronary artery disease","authors":"Edouard Gerbaud","doi":"10.1016/j.ijcard.2025.133551","DOIUrl":"10.1016/j.ijcard.2025.133551","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133551"},"PeriodicalIF":3.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The TAVI durability dilemma: Are we ready for what comes next?","authors":"Massimo Baudo","doi":"10.1016/j.ijcard.2025.133553","DOIUrl":"10.1016/j.ijcard.2025.133553","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133553"},"PeriodicalIF":3.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Non-invasive evaluation of coronary microvascular dysfunction: The role of angiography-derived microcirculatory resistance","authors":"Xi Zhang ,&nbsp;Qing Jin ,&nbsp;Qiang Xue","doi":"10.1016/j.ijcard.2025.133555","DOIUrl":"10.1016/j.ijcard.2025.133555","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133555"},"PeriodicalIF":3.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Prognostic utility of hybrid coronary computed tomography angiography and myocardial perfusion imaging in elderly patients with suspected coronary artery disease","authors":"Mohammed Kamel ,&nbsp;Minahil Zaheer ,&nbsp;Mantsha Ahmed ,&nbsp;Hazrat Ali","doi":"10.1016/j.ijcard.2025.133558","DOIUrl":"10.1016/j.ijcard.2025.133558","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133558"},"PeriodicalIF":3.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to editor: Right heart failure and mortality in patients undergoing transcatheter tricuspid valve interventions","authors":"Yanyan Song ,&nbsp;FuZhen Ma ,&nbsp;XiaoJing Bao ,&nbsp;YanMei Liu","doi":"10.1016/j.ijcard.2025.133560","DOIUrl":"10.1016/j.ijcard.2025.133560","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133560"},"PeriodicalIF":3.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the editorial “Beyond the heart: Mind-body connection from birth and the holistic intervention in cardiovascular care”","authors":"Alessandra Gorini ,&nbsp;Martina Vigorè ,&nbsp;Davide Sattin","doi":"10.1016/j.ijcard.2025.133556","DOIUrl":"10.1016/j.ijcard.2025.133556","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133556"},"PeriodicalIF":3.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}