International journal of cardiology最新文献

{"title":"Letter to the Editor: Points to keep in mind when integrating artificial intelligence into left atrial appendage closure","authors":"Ezgi Çamlı Babayiğit , Erdi Babayiğit , Bülent Görenek","doi":"10.1016/j.ijcard.2024.132938","DOIUrl":"10.1016/j.ijcard.2024.132938","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132938"},"PeriodicalIF":3.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143308903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of minimally invasive direct coronary artery bypass vs second generation drug eluting stent for management of isolated left anterior descending artery disease","authors":"Ryszard Stanislawski ,&nbsp;Sleiman Sebastian Aboul-Hassan ,&nbsp;Konrad Pieszko ,&nbsp;Ahmed K. Awad ,&nbsp;Tomasz Stankowski ,&nbsp;Maciej Peksa ,&nbsp;Marcin Nawotka ,&nbsp;Lukasz Moskal ,&nbsp;Jakub Marczak ,&nbsp;Gianluca Torregrossa ,&nbsp;Jaroslaw Hiczkiewicz ,&nbsp;Romuald Cichon","doi":"10.1016/j.ijcard.2024.132935","DOIUrl":"10.1016/j.ijcard.2024.132935","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to compare the long-term outcomes in a propensity matched population receiving either minimally invasive direct coronary artery bypass (MIDCAB) using left internal thoracic artery (LITA) to the left anterior descending artery (LAD) or percutaneous coronary intervention using second generation everolismus-eluting stents (DES-PCI) in patients treated for isolated proximal LAD stenosis.</div></div><div><h3>Methods</h3><div>Between January 2012 and December 2017, 421 patients with a nonemergency status undergoing primary isolated proximal LAD revascularization were retrospectively analyzed and were divided into two groups: 111 patients receiving MIDCAB LITA to LAD and 310 patients receiving DES-PCI. Propensity score matching selected 111 pairs and both groups were comparable for all baseline characteristics and well balanced.</div></div><div><h3>Results</h3><div>In the matched cohort, median follow-up time was 5.19 years (interquartile range, 3.50–6.96). MIDCAB and DES-PCI had comparable long-term outcomes in terms of mortality (Hazard ratio (HR) stratified on matched pairs: 1.60; 95 %CI; 0.58–4.37; <em>P</em> = 0.29), stroke (HR stratified on matched pairs: 0.44; 95 %CI; 0.04–5.13; <em>P</em> = 0.56) and major adverse cardiac and cerebral events (MACCE) (HR stratified on matched pairs:0.57; 95 %CI; 0.26–1.22; <em>P</em> = 0.21). However, MIDCAB was associated with reduced incidence of myocardial infarction (MI) (HR stratified on matched pairs:0.46; 95 %CI; 0.15–0.56; <em>P</em> = 0.001) as well as reduced incidence of target vessel repeat revascularization (TVR) (HR stratified on matched pairs: 0.12; 95 %CI; 0.001; <em>P</em> = 0.01).</div></div><div><h3>Conclusion</h3><div>MIDCAB LITA-LAD offers superior freedom from MI rate and TVR with similar mortality, stroke and MACCE compared with second generation DES-PCI in the treatment of isolated proximal LAD disease.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132935"},"PeriodicalIF":3.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between Hashimoto's thyroiditis and non-ischemic cardiomyopathy and the mediating role of inflammatory cytokines: Evidence from genetic association analysis","authors":"Chong Du ,&nbsp;Di Zhao ,&nbsp;Xinying Shi,&nbsp;Lingfeng Gu,&nbsp;Sibo Wang,&nbsp;Yulin Bao,&nbsp;Ze-Mu Wang,&nbsp;Liansheng Wang","doi":"10.1016/j.ijcard.2024.132934","DOIUrl":"10.1016/j.ijcard.2024.132934","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies report that Hashimoto's thyroiditis (HT) may be associated with non-ischemic cardiomyopathy (NICM); However, the causal relationship remains to be elucidated. Here, we aimed to investigate the causal relationship between HT and NICM through Mendelian randomization (MR) and explore the potential mediating role of inflammatory cytokines within this association.</div></div><div><h3>Methods</h3><div>The bidirectional two-sample MR, multivariable MR and mediation MR analyses were conducted based on genome-wide association study summary datasets, and MR results were further supported by multiple sensitivity analysis methods.</div></div><div><h3>Results</h3><div>We presented genetic evidence that HT could unidirectionally increase the risk of NICM (odds ratios [OR]: 1.09, 95 % confidence intervals [CI]: 1.03–1.15, <em>P</em> = 0.001). After adjusting for multiple potential cardiovascular risk factors such as body mass index, hypertension, blood glucose levels, several dyslipidemias, alcohol consumption, heart valve problem, thyroid function, heart rate and arrhythmia, the causal effect of HT on NICM remained statistically significant. Further mediation MR analysis results showed that monokine induced by gamma interferon (MIG) could act as a mediator (OR = 1.026, 95 % CI = 1.006–1.052), accounting for about 28.8 % of the increased risk of NICM in patients with HT.</div></div><div><h3>Conclusions</h3><div>Our study proposes a causal relationship between HT and NICM, as well as the mediating role of MIG in this process, highlighting the importance of evaluating myocardial damage in patients with HT and providing new insights into the targeted treatment for high-risk patients.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132934"},"PeriodicalIF":3.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Vericiguat in heart failure with reduced ejection fraction patients on guideline-directed medical therapy: Insights from a 6-month real-world study","authors":"Hibah Faisal Ghauri","doi":"10.1016/j.ijcard.2024.132937","DOIUrl":"10.1016/j.ijcard.2024.132937","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132937"},"PeriodicalIF":3.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steps towards closing the sex-related disparities in acute myocardial infarction–related cardiogenic shock","authors":"Ayman R. Fath ,&nbsp;Islam Y. Elgendy","doi":"10.1016/j.ijcard.2024.132928","DOIUrl":"10.1016/j.ijcard.2024.132928","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132928"},"PeriodicalIF":3.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel diagnostic model for fetal coarctation of the aorta with ventricular septal defect","authors":"Sushan Xiao ,&nbsp;Haiyan Cao ,&nbsp;Juanjuan Liu ,&nbsp;Liu Hong ,&nbsp;Jing Ma ,&nbsp;Ye Zhu ,&nbsp;Yuji Xie ,&nbsp;Zisang Zhang ,&nbsp;Jiawei Shi ,&nbsp;Li Cui ,&nbsp;Yi Zhang ,&nbsp;Mingxing Xie ,&nbsp;Li Zhang","doi":"10.1016/j.ijcard.2024.132927","DOIUrl":"10.1016/j.ijcard.2024.132927","url":null,"abstract":"<div><h3>Background</h3><div>Our study aimed to develop a novel diagnostic model for fetal coarctation of the aorta with ventricular septal defect(CoA/VSD).</div></div><div><h3>Methods and results</h3><div>We respectively included 70 fetuses with suspected CoA/VSD(January 2017–June 2023). After birth, 26 fetuses (26/47, 55.3 %) were confirmed to be true-positive CoA/VSD (TP-CoA/VSD), 21 cases had only VSDs without CoA, namely false-positive CoA/VSD (FP-CoA/VSD), and the remaining 23 fetuses were excluded due to additional major malformations, multiple pregnancies or other reasons. Large VSDs and doubly committed subarterial VSDs were more prevalent in true coarctation fetuses(all <em>p</em> &lt; 0.05). Among morphological parameters of echocardiography, the aortic isthmus (AoI)/VSD ratio had the highest area under the curve (AUC) of 0.81 (95 % CI: 0.68–0.94, <em>p</em> &lt; 0.001) and cutoff value of ≤0.67. Three new diagnostic models were constructed by adding different functional variables, namely left ventricular longitudinal strain(LVLS), LV ejection fraction, and LV fractional area of change to the morphological variable AoI/VSD ratio. The diagnostic model of AoI/VSD ratio and LVLS had the highest AUC of 0.96 (95 % CI: 0.86–1.00; <em>p</em> &lt; 0.001). In addition, risk stratification revealed a high risk of prenatal CoA/VSD when the risk probability was greater than 0.80, which required early medical counseling and intervention.</div></div><div><h3>Conclusions</h3><div>In fetuses suspected with having CoA/VSD, myocardial strains of both ventricles were lower in true CoA group. Additionally, a diagnostic model of new morphological parameter AoI/VSD ratio and functional variable LVLS, was highly valuable in diagnosing fetal CoA/VSD.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132927"},"PeriodicalIF":3.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LKB1 inhibited vascular smooth muscle cell phenotypic switching to attenuated atherosclerosis by activating AMPK","authors":"Zhiming Zou ,&nbsp;Lianjie Hou","doi":"10.1016/j.ijcard.2024.132932","DOIUrl":"10.1016/j.ijcard.2024.132932","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"421 ","pages":"Article 132932"},"PeriodicalIF":3.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining prognosis in Acute Myocarditis: The intersection of imaging and clinical markers","authors":"Gianluca Pontone ,&nbsp;Andrea Igoren Guaricci","doi":"10.1016/j.ijcard.2024.132930","DOIUrl":"10.1016/j.ijcard.2024.132930","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132930"},"PeriodicalIF":3.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different association of HDL-C, apoA-I, and HDL-C/apoA-I with multiple outcomes in HFrEF patients","authors":"Ayiguli Abudukeremu ,&nbsp;Qiaofei Chen ,&nbsp;Zhanpeng Pan ,&nbsp;Xiao Liu ,&nbsp;Tongsheng Huang ,&nbsp;Yuan Jiang ,&nbsp;Hongwei Li ,&nbsp;Runlu Sun ,&nbsp;Hong Pan ,&nbsp;Kexin Wen ,&nbsp;Yue Wang ,&nbsp;Minglong Zheng ,&nbsp;Zizhuo Su ,&nbsp;Yuling Zhang","doi":"10.1016/j.ijcard.2024.132929","DOIUrl":"10.1016/j.ijcard.2024.132929","url":null,"abstract":"<div><h3>Background</h3><div>High-density lipoprotein-cholesterol (HDL-C) has been considered a cardioprotective factor for several decades. However, its association with outcomes in patients with heart failure with reduced ejection fraction (HFrEF) remains controversial. We aimed to investigate the association of HDL-C, apolipoprotein A-I (apoA-I), and the HDL-C/apoA-I ratio with multiple outcomes of HFrEF patients and establish prognostic models using machine learning methods.</div></div><div><h3>Methods and results</h3><div>This was a retrospective, single-center study. The associations between lipid levels and multiple outcomes were examined using logistic regression analysis. Prognostic models for multiple outcomes were further established using four machine learning methods. A total of 352 HFrEF patients were visited successfully. In the multivariable-adjusted logistic regression analysis, HDL-C did not show a significant association with any of the studied outcomes; apoA-I was marginally unassociated with all-cause rehospitalization (adjusted odds ratio [aOR] = 0.62, <em>p</em> = 0.063) but was significantly negatively associated with all-cause death (aOR = 0.53, <em>p</em> = 0.038), rehospitalization for cardiovascular or cerebrovascular disease (aOR = 0.43, <em>p</em> &lt; 0.001), and rehospitalization for heart failure (aOR = 0.55, <em>p</em> = 0.024); apoA-I was also significantly positively associated with left ventricular ejection fraction (LVEF) improvement (aOR = 2.00, <em>p</em> = 0.039). Although several <em>p</em>-values were not statistically significant, both the first and third HDL-C/apoA-I groups showed an increased incidence rate for all adverse outcomes compared with the middle group and a decreased incidence rate for LVEF improvement. In the machine learning analysis, the support vector machine and extreme gradient boosting models demonstrated better predictive performance. For each outcome prognosis, apoA-I and logarithmic N-terminal pro-B-type natriuretic peptide were automatically selected.</div></div><div><h3>Conclusion</h3><div>Among HFrEF patients, apoA-I may be a better marker for predicting outcomes than HDL-C. Both low and high levels of HDL-C/apoA-I may indicate a poor prognosis of HFrEF patients.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132929"},"PeriodicalIF":3.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurate prediction of bleeding risk after coronary artery bypass grafting with dual antiplatelet therapy: A machine learning model vs. the PRECISE-DAPT score","authors":"Yi Yang ,&nbsp;Yuqing Yan ,&nbsp;Zhou Zhou ,&nbsp;Jifan Zhang ,&nbsp;Haolong Han ,&nbsp;Weihui Zhang ,&nbsp;Xia Wang ,&nbsp;Chen Chen ,&nbsp;Weihong Ge ,&nbsp;Jun Pan ,&nbsp;Jianjun Zou ,&nbsp;Hang Xu","doi":"10.1016/j.ijcard.2024.132925","DOIUrl":"10.1016/j.ijcard.2024.132925","url":null,"abstract":"<div><h3>Background</h3><div>Dual antiplatelet therapy (DAPT) after coronary artery bypass grafting (CABG), although might be protective for ischemic events, can lead to varying degrees of bleeding, resulting in serious clinical events, including death. This study aims to develop accurate and scalable predictive tools for early identification of bleeding risks during the DAPT period post-CABG, comparing them with the PRECISE-DAPT score.</div></div><div><h3>Methods</h3><div>Clinical data were collected from patients who underwent isolated CABG at Nanjing Drum Tower Hospital between June 2021 and December 2023. The dataset was split into derivation and validation cohorts at a 7:3 ratio. Machine learning models were developed to predict bleeding within six months post-CABG in DAPT patients and tested in a temporal external validation cohort. The SHapley Additive exPlanations method visualized variable importance regarding outcomes. The performance of the PRECISE-DAPT score was also validated in this cohort.</div></div><div><h3>Results</h3><div>Among 561 enrolled patients, 165 (29.4 %) experienced bleeding events, with 49 (8.7 %) cases being significant. In the validation cohort, eXtreme gradient boosting (XGB) achieved the highest area under the receiver operating characteristic curve (0.915) and precision-recall curve (0.692). Compared to PRECISE-DAPT, XGB showed no difference in AUROC (<em>p</em> = 0.808) but had a higher AUPRC (<em>p</em> = 0.009). In the temporal external validation cohort, the XGB model has an AUROC of 0.926 and an AUPRC of 0.703. We developed a dynamic high-accuracy bleeding risk calculator based on the XGB model and created a mobile-friendly QR code for easy access to this tool.</div></div><div><h3>Conclusion</h3><div>Bleeding risk during DAPT in post-CABG patients can be reliably predicted using selected baseline features. The XGB model outperforms the Precise-Dapt model, showing better precision and recall.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"421 ","pages":"Article 132925"},"PeriodicalIF":3.2,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}