International journal of cardiology最新文献

{"title":"Sex-specific disparities in clinical characteristics and outcomes of catheter-directed treatments for acute pulmonary embolism","authors":"Filippo Russo , Michele Morosato , Alice Sacco , Mario Iannaccone , Claudia Colombo , Giuliano Chizzola , Giacomo Giovanni Boccuzzi , Marianna Adamo , Nicolo' Capsoni , Ilaria Emanuela Bossi , Lorenzo Cianfanelli , Marco Solcia , Federica Fumarola , Daniele Savio , Barbara Bellini , Silvia Ajello , Mario Galli , Fabrizio Oliva , Alaide Chieffo , Matteo Montorfano","doi":"10.1016/j.ijcard.2025.133550","DOIUrl":"10.1016/j.ijcard.2025.133550","url":null,"abstract":"<div><h3>Background</h3><div>Acute pulmonary embolism (PE) represents a cardiovascular emergency with increasing incidence. Catheter-directed treatments (CDTs) are increasingly used for high-risk or intermediate-high-risk PE patients when surgical embolectomy or systemic thrombolysis (ST) is contraindicated or ineffective. Although prior research suggests poorer outcomes in women with PE, sex-specific differences in CDTs outcomes remain unclear.</div></div><div><h3>Aims</h3><div>To investigate the influence of sex on clinical characteristics, procedural complications, and clinical outcomes among patients undergoing CDTs for acute PE.</div></div><div><h3>Methods</h3><div>This retrospective multicenter study included consecutive high-risk and intermediate-high-risk PE patients treated with CDTs across five Italian Centers. Clinical data, procedural complications and outcomes were collected and analyzed. Bleeding events were classified according to Bleeding Academic Research Consortium (BARC) criteria.</div></div><div><h3>Results</h3><div>We included 191 patients (101 women, 53 %; 90 men, 47 %) treated primarily with ultrasound-assisted thrombolysis (USAT, 69 %), with no sex-based differences in device allocation. Compared with men, women more frequently experienced cardiac arrest (11 % vs. 3 %, <em>p</em> = 0.04), had fewer absolute contraindications to ST (23 % vs. 42 %, <em>p</em> = 0.004), and lower rates of recent major surgery (9 % vs. 22 %, <em>p</em> = 0.01). Women experienced significantly higher in-hospital mortality (20 % vs. 9 %, OR 2.53, 95 % CI 1.09–6.41, <em>p</em> = 0.037), higher bleeding rates (22 % vs. 10 %, OR 2.53, 95 % CI 1.13–6.13, <em>p</em> = 0.029), and higher 1-year all-cause mortality (29.1 % vs. 12.7 %, aHR 2.37, 95 % CI 1.12–5.04, <em>p</em> = 0.024).</div></div><div><h3>Conclusions</h3><div>Women undergoing CDTs for PE present with greater clinical severity, experienced more procedural complications, and had worse early and mid-term outcomes, underscoring the need for sex-specific management strategies in patients undergoing CDTs for PE.</div></div><div><h3>Condensed abstract</h3><div>Catheter-Directed Treatments (CDTs) are emerging therapeutic options for acute pulmonary embolism (PE) patients with contraindications or inadequate response to standard therapies. In this multicenter study, we analyzed sex-specific differences in clinical presentation and outcomes of patients with high and intermediate-high risk PE treated with CDTs. Among 191 patients enrolled, 53 % were women. Most patients presented with intermediate-high risk PE and were treated with ultrasound-assisted thrombolysis (USAT). Women presented with more severe clinical profiles, had higher procedural complication rates, and experienced significantly greater bleeding and in-hospital mortality compared with men. Female sex was an independent predictor of 1-year all-cause mortality. These findings highlight the importance of sex-specific management strategi","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133550"},"PeriodicalIF":3.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in mitral valve surgery for mitral valve regurgitation in Denmark: Changes in patient characteristics and mortality from 1996 to 2022","authors":"Liv Borum Schöps ,&nbsp;Sofie Truong ,&nbsp;Jeppe Petersen ,&nbsp;Amna Alhakak ,&nbsp;Morten Schou ,&nbsp;Christian Lildal Carranza ,&nbsp;Lars Køber ,&nbsp;Emil Fosbøl ,&nbsp;Lauge Østergaard","doi":"10.1016/j.ijcard.2025.133552","DOIUrl":"10.1016/j.ijcard.2025.133552","url":null,"abstract":"<div><h3>Background/Aims</h3><div>Mitral valve surgery (MVS) is recommended in severe mitral valve regurgitation (MR). Contemporary data on national surgical patterns and patient characteristics are lacking and are essential for the continuous epidemiologic monitoring of the disease.</div></div><div><h3>Methods</h3><div>Using Danish nationwide registries, patients undergoing MVS for MR between 1996 and 2022 were identified. Temporal trends in patient characteristics and annual incidence rates per 100,000 person years (PY) were computed. One-year cumulative mortality and mortality rates over calendar time were computed using the Kaplan-Meier estimator and multivariable adjusted Cox-analysis respectively.</div></div><div><h3>Results</h3><div>8098 patients were included. Median age increased from 65.5 (1996–2001) to 69.4 years (2018–2022). Patients became less comorbid regarding ischemic heart disease and heart failure. The overall incidence rate of MVS increased from 4.09 to 8.66/100,000 PY (1996–2022), with significantly increasing incidences of mitral repair, biological replacement, and transcatheter-edge-to-edge repair (TEER), and significantly decreased incidence of mechanical replacement. The overall cumulative one-year mortalities were: TEER 18.9 %, biological replacement 15.5 %, mechanical replacement 10.2 %, mitral repair 4.8 %. Adjusted analysis showed a significant decrease in one-year mortality across time for mitral repair (HR 0.27 [95 % CI 0.15–0.49], <em>p</em> &lt; 0.001) and TEER (HR 0.55 [95 % CI 0.31–0.97], <em>p</em> = 0.04). No significant mortality differences were observed for other interventions.</div></div><div><h3>Conclusions</h3><div>From 1996 to 2022, more patients underwent mitral valve surgery driven by increasing incidence rates of mitral repair, biological replacement, and TEER. Patients got older but less comorbid regarding major cardiovascular comorbidities. Mortality significantly improved over time for patients undergoing mitral repair and TEER. Results could reflect earlier diagnosis and increased echocardiographic surveillance.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133552"},"PeriodicalIF":3.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cangrelor: A new P2Y12 inhibitor with gender differences","authors":"Chunsong Hu","doi":"10.1016/j.ijcard.2025.133511","DOIUrl":"10.1016/j.ijcard.2025.133511","url":null,"abstract":"<div><div>This commentary article discusses a recent study article published in <em>Journal of International Cardiology,</em> entitled “Abusnina, W., Chaturvedi, A., Chitturi, K.R., Lupu, L., Haberman, D., Cellamare, M., Sawant, V., Zhang, C., Ben-Dor, I., Satler, L.F., Hashim, H.D., Case, B.C., Waksman, R. Gender disparities in<!--> <!-->cangrelor<!--> <!-->usage for the treatment of patients with acute coronary syndrome undergoing percutaneous coronary intervention. Int J Cardiol., 432 (2025), pp. 133280. doi: 10.1016/j.ijcard.2025.133280.”. <u>PMID:</u> 40228585<u>.</u> Online ahead of print.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133511"},"PeriodicalIF":3.2,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular disease and climatic strain in the Philippines: A call to action","authors":"Danilo V. Rogayan Jr.","doi":"10.1016/j.ijcard.2025.133548","DOIUrl":"10.1016/j.ijcard.2025.133548","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133548"},"PeriodicalIF":3.2,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGLT2 inhibitors for paediatric heart failure: time for innovative trials","authors":"Sebastiano A.G. Lava","doi":"10.1016/j.ijcard.2025.133521","DOIUrl":"10.1016/j.ijcard.2025.133521","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133521"},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to comment on “The efficacy and safety of dapagliflozin in pediatric heart failure”","authors":"Swasthi S. Kumar,&nbsp;Arun Gopalakrishnan,&nbsp;K.M. Krishnamoorthy,&nbsp;Harikrishnan Sivadasanpillai","doi":"10.1016/j.ijcard.2025.133547","DOIUrl":"10.1016/j.ijcard.2025.133547","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133547"},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: « The role of pericoronary fat in in fatal plaques of coronary artery: a contributor or bystander?”","authors":"G. Ocana ,&nbsp;K. Michaud ,&nbsp;V. Magnin ,&nbsp;A.C. Van der Wal ,&nbsp;S. Grabherr ,&nbsp;C. Pozzessere ,&nbsp;G. Tzimas ,&nbsp;G. Fahrni ,&nbsp;S.D. Qanadli ,&nbsp;D.C. Rotzinger","doi":"10.1016/j.ijcard.2025.133541","DOIUrl":"10.1016/j.ijcard.2025.133541","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133541"},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply by Schreurs et al. to letter regarding article: Physical activity characteristics in adults with bicuspid aortic valve versus age and sex matched controls","authors":"Bibi A. Schreurs ,&nbsp;Roland R.J. van Kimmenade ,&nbsp;Thijs M.H. Eijsvogels","doi":"10.1016/j.ijcard.2025.133545","DOIUrl":"10.1016/j.ijcard.2025.133545","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133545"},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Cardiopulmonary remodeling following repetitive acute pulmonary emboli and inhibition of endogenous fibrinolysis in a porcine model","authors":"Yan Yuehua ,&nbsp;Miao Jia ,&nbsp;Yang Yang","doi":"10.1016/j.ijcard.2025.133546","DOIUrl":"10.1016/j.ijcard.2025.133546","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133546"},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential role of Loganin in modulating JAK2/STAT3 signaling pathway in atherosclerosis","authors":"Sisi Li ,&nbsp;Xiaogang Li ,&nbsp;Yanmin Song","doi":"10.1016/j.ijcard.2025.133549","DOIUrl":"10.1016/j.ijcard.2025.133549","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133549"},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}