International journal of cardiology最新文献

{"title":"Letter to the editor: Lipoproteins and lipoprotein lipid composition are associated with stages of dysglycemia and subclinical coronary atherosclerosis","authors":"Haixia Lai, Lijing Zhang","doi":"10.1016/j.ijcard.2024.132943","DOIUrl":"10.1016/j.ijcard.2024.132943","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132943"},"PeriodicalIF":3.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family screening for hypertrophic cardiomyopathy: Initial cardiologic assessment, and long-term follow-up of genotype-positive phenotype-negative individuals","authors":"Stephan A.C. Schoonvelde ,&nbsp;Georgios M. Alexandridis ,&nbsp;Laura B. Price ,&nbsp;Arend F.L. Schinkel ,&nbsp;Alexander Hirsch ,&nbsp;Peter-Paul Zwetsloot ,&nbsp;Janneke A.E. Kammeraad ,&nbsp;Marjon A. van Slegtenhorst ,&nbsp;Judith M.A. Verhagen ,&nbsp;Rudolf A. de Boer ,&nbsp;Michelle Michels","doi":"10.1016/j.ijcard.2024.132951","DOIUrl":"10.1016/j.ijcard.2024.132951","url":null,"abstract":"<div><h3>Aims</h3><div>(i) Investigate the prevalence of hypertrophic cardiomyopathy (HCM) in individuals with pathogenic/likely pathogenic (P/LP) gene variants detected through family cascade testing in relatives, and (ii) evaluate phenotypic progression in genotype-positive phenotype-negative (G+/P-) individuals during follow-up.</div></div><div><h3>Results</h3><div>From 2000 to 2023, 273 individuals underwent cardiologic evaluation following P/LP variant detection through family screening. Upon initial evaluation, HCM was diagnosed in 128 (47 %) individuals. Comparing with 145 G+/P- individuals, HCM patients were older (48 vs 38 years, <em>p</em> &lt; 0.001) and more likely male (57 % vs 34 %, <em>p</em> &lt; 0.001). During follow-up (median 11 years), 14 (11 %) of the HCM patients died (two from sudden cardiac death), four (3 %) underwent myectomy, 15 (12 %) developed atrial fibrillation and 17 (13 %) required implantable cardioverter-defibrillator implantation (15 primary prevention, 88 %). HCM-related adverse outcomes correlated with younger diagnosis age.</div><div>During follow-up (median 8 years) of 118 (out of 145) G+/P- subjects with at least one year of follow-up, seven (6 %) individuals (71 % female, diagnosed age 39–77, after median follow-up 6 years) developed HCM (mean maximal wall thickness increasing from 10.2 mm to 13.3 mm). In this G+/P- cohort, significant echocardiographic changes from baseline to last visit were negligible. Over half (56 %) had &lt;1 mm change of maximal wall thickness. No adverse cardiac outcomes occurred.</div></div><div><h3>Conclusion</h3><div>The initial evaluation was high-yield, with HCM being diagnosed in 47 % of G+ individuals, more frequently in older males. Over a median 8-year follow-up, 6 % of G+/P- individuals developed mild HCM, with no adverse cardiac outcomes. These data support initial screening in all first degree relatives, but (very) low-frequency cardiologic evaluations for G+/P- individuals thereafter.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132951"},"PeriodicalIF":3.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart failure with improved ejection fraction: A dynamic journey of recovery and possible relapse","authors":"Yu Fu Ferrari Chen ,&nbsp;Alberto Aimo ,&nbsp;Michele Emdin","doi":"10.1016/j.ijcard.2024.132944","DOIUrl":"10.1016/j.ijcard.2024.132944","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132944"},"PeriodicalIF":3.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between abnormal microvascular perfusion and quantitative flow ratio after primary PCI in patients with STEMI","authors":"Jiayu Xu ,&nbsp;Da Luo ,&nbsp;Yuhua Lei ,&nbsp;Zheng Hu ,&nbsp;Hangyu Tian ,&nbsp;Xiangzhou Chen ,&nbsp;Wenjie Zhou ,&nbsp;Mingqi Li ,&nbsp;Shuang Liu ,&nbsp;Xing Jin ,&nbsp;Yun Wang ,&nbsp;Bofang Zhang ,&nbsp;Qing Zhou ,&nbsp;Jing Chen","doi":"10.1016/j.ijcard.2024.132949","DOIUrl":"10.1016/j.ijcard.2024.132949","url":null,"abstract":"<div><h3>Aims</h3><div>Timely assessment of abnormal microvascular perfusion (MVP) may improve prognosis in patients with ST-segment elevation myocardial infarction (STEMI). This study aimed to determine the clinical implications of contrast-flow quantitative flow ratio (cQFR) in evaluating abnormal MVP and subsequent outcomes among STEMI patients after successful primary percutaneous coronary intervention (PPCI).</div></div><div><h3>Methods</h3><div>The study population consisted of 2 independent cohorts. The diagnostic cohort was used to evaluate the correlation and diagnostic accuracy of cQFR in predicting abnormal MVP. In this cohort, MVP and cQFR of the culprit vessel (<em>n</em> = 186) were assessed from a prospective consecutive registry. Abnormal MVP was determined using myocardial contrast perfusion echocardiography (MCE) in the culprit vessel after PPCI. The prognostic cohort consisted of STEMI patients undergoing PPCI who were followed for a minimum of 2 years (<em>n</em> = 1931). The primary outcome was all-cause mortality.</div></div><div><h3>Results</h3><div>In the diagnostic cohort, cQFR exhibited a moderate correlation with abnormal MVP assessed by MCE. Specificity, sensitivity, and area under the curve of post-PPCI cQFR to predict abnormal MVP were 81.6 %, 50.9 % and 0.709 (95 % confidence interval: 0.635–0.783), respectively, with the best cut-off value of 0.875. In the prognostic cohort, patients with cQFR &lt;0.875 showed a significantly higher risk of long-term mortality compared to those with cQFR ≥0.875 (median follow-up: 52 months; mortality: 8.0 % vs. 3.8 %; <em>p</em> &lt; 0.001). Cox-regression analysis revealed that cQFR &lt; 0.875 was an independent predictor of long-term mortality (adjusted HR: 2.132; 95 % CI: 1.358–3.346; <em>p</em> = 0.001) after adjusting for age, gender, diabetes mellitus, hyperlipidemia, symptom to balloon time, culprit vessel.</div></div><div><h3>Conclusions</h3><div>We found that cQFR demonstrated a relatively good performance in predicting abnormal MVP in patients with STEMI after successful PPCI. A cQFR value below 0.875 is an independent predictor of both abnormal MVP and long-term mortality. (Prognostic implication of cQFR in STEMI patients; <span><span>NCT04996901</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132949"},"PeriodicalIF":3.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between cardiovascular risk and physical performance in individuals with obesity: A cross-sectional study focusing on the 5× sit-to-stand test","authors":"Jaqueline de Paula Chaves Freitas ,&nbsp;Leonardo Augusto da Costa Teixeira ,&nbsp;Joyce Noelly Vitor Santos ,&nbsp;Daniela Barreto de Moraes ,&nbsp;Vanessa Kelly da Silva Lage ,&nbsp;Gabriele Teixeira Gonçalves ,&nbsp;Maria Thereza Otoni Figueiró ,&nbsp;Tamara Cunha ,&nbsp;Ana Lúcia Danielewicz ,&nbsp;Pedro Henrique Sheidt Figueiredo ,&nbsp;Alessandro Sartorio ,&nbsp;Redha Taiar ,&nbsp;Thyago José Silva ,&nbsp;Henrique Silveira Costa ,&nbsp;Elizabethe Adriana Esteves ,&nbsp;Ana Cristina Rodrigues Lacerda ,&nbsp;Vanessa Amaral Mendonça","doi":"10.1016/j.ijcard.2024.132950","DOIUrl":"10.1016/j.ijcard.2024.132950","url":null,"abstract":"<div><h3>Introduction</h3><div>Although it is established that individuals with obesity are at increased risk of cardiovascular events, the relationship between cardiovascular risk and physical function in this population is still a topic of discussion. The objectives of the present study were: to check the association between cardiovascular risk and physical performance through physical-functional tests and to identify cutoff points for functional tests to be used for the definition of high cardiovascular risk.</div></div><div><h3>Methods</h3><div>A cross-sectional study included adults, both sexes, with obesity. Dual X-ray absorptiometry was used to assess body composition, Jamar® dynamometer to assess handgrip strength, and the sit-to-stand test to a chair with 5 repetitions and 60 s for physical performance analysis. The Framingham global risk score was used to determine cardiovascular risk.</div></div><div><h3>Results</h3><div>The sample consisted of 192 individuals with obesity, aged between 20 and 74 years (mean ± SD: 42.6 ± 12.7 years). The group with high cardiovascular risk presented worse values <!--> <!-->of handgrip strength and physical performance (<em>p</em> &lt; 0.05). After adjusting for age, the 5× sit-to-stand test was associated (β = 0.21; OR = 1.24 [95 %CI = 1.05-1.45]; <em>p</em> = 0.007) with high cardiovascular risk, and the cutoff point of 16 s for performing the test was found to be discriminatory of high cardiovascular risk in obesity.</div></div><div><h3>Conclusion</h3><div>The findings indicate that clinical assessment tools, specifically those that assess the functionality of individuals with obesity, are related to an increased risk of cardiovascular events. The 5× sit-to-stand test showed good diagnostic accuracy in this context.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132950"},"PeriodicalIF":3.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “ChatGPT on MKSAP cardiology board review questions: Correspondence”","authors":"Stefan Milutinovic ,&nbsp;Ricardo O. Escarcega","doi":"10.1016/j.ijcard.2024.132942","DOIUrl":"10.1016/j.ijcard.2024.132942","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132942"},"PeriodicalIF":3.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of different guidance strategies to percutaneous coronary intervention: A network meta-analysis of randomized clinical trials","authors":"Alessandro Mandurino-Mirizzi ,&nbsp;Andrea Raffaele Munafò ,&nbsp;Francesco Rizzo ,&nbsp;Luca Raone ,&nbsp;Francesco Germinal ,&nbsp;Claudio Montalto ,&nbsp;Marco Mussardo ,&nbsp;Rocco Vergallo ,&nbsp;Dionigi Fischetti ,&nbsp;Cosmo Godino ,&nbsp;Giuseppe Colonna ,&nbsp;Jacopo Oreglia ,&nbsp;Francesco Burzotta ,&nbsp;Gabriele Crimi ,&nbsp;Italo Porto","doi":"10.1016/j.ijcard.2024.132936","DOIUrl":"10.1016/j.ijcard.2024.132936","url":null,"abstract":"<div><h3>Background</h3><div>The results of randomized clinical trials comparing the outcomes of different strategies for driving PCI are mixed, and it remains unclear which technique for driving PCI offers the greatest benefit. The aim of the study was to compare the clinical efficacy of different techniques to guide percutaneous coronary intervention (PCI).</div></div><div><h3>Methods</h3><div>We search major electronic databases for randomized clinical trials evaluating clinical outcomes of PCI with stent implantation guided by coronary angiography (CA), fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The primary outcome was cardiac death.</div></div><div><h3>Results</h3><div>The results from 39 randomized trials (29,614 patients) were included in the network meta-analyses. Compared with CA, the use of OCT (RR: 0.33, 95 % CI: 0.19–0.54), IVUS (RR: 0.47, 95 % CI: 0.31–0.71) and FFR (RR: 0.61, 95 % CI: 0.38–0.97) were associated with reduced risk of cardiac death; there were no differences between OCT, IVUS and OCT was ranked as the best strategy. PCI guidance using OCT, FFR and IVUS was also associated with a reduction of myocardial infarction. The use of OCT or IVUS for PCI guidance was associated with a significant reduction in target lesion failure, target vessel revascularization, target lesion revascularization and stent thrombosis, compared with CA. OCT-guided PCI was associated with a significant reduction in all-cause death compared with CA-guided PCI and with a reduction in TLF compared with FFR- and iFR-guided PCI. Pooled estimates were mostly consistent across several sensitivity analyses.</div></div><div><h3>Conclusions</h3><div>Compared with angiography-guided PCI, both an intravascular imaging-guided strategy and a physiology-guided strategy are associated with better clinical outcomes.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132936"},"PeriodicalIF":3.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-specific effects of delay in cardiology consultation following primary care physician referral in atrial fibrillation patients: Impact on one-year outcomes","authors":"Oscar Otero-Garcia ,&nbsp;Pablo de la Fuente-Lopez ,&nbsp;Sergio Cinza-Sanjurjo ,&nbsp;Alberto Cordero ,&nbsp;Pilar Mazón-Ramos ,&nbsp;Daniel Rey-Aldana ,&nbsp;Ines Gómez-Otero ,&nbsp;Manuel Portela-Romero ,&nbsp;David Garcia-Vega ,&nbsp;José Ramón González-Juanatey","doi":"10.1016/j.ijcard.2024.132947","DOIUrl":"10.1016/j.ijcard.2024.132947","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Over the last two decades, reductions in cardiovascular (CV) and cerebrovascular events for patients with atrial fibrillation (AF) have been observed, but the non-cardiovascular rates have increased. Early initiation of oral anticoagulation helps reduce AF complications; however, the impact of delayed cardiology care after referral by a Primary Care Physician (PCP) is unknown. The aim of our study is to investigate the association between the elapsed time to cardiology care following a PCP referral and one-year outcomes among patients with AF and analyses gender-specific differences in these outcomes.</div></div><div><h3>Methods</h3><div>All PCP referrals with previous AF diagnoses to cardiology consultation from 2010 to 2021 (<em>N</em> = 15,224) were analysed. The outcomes analysed were all-cause, CV, and stroke mortality and hospitalizations rates at one-year. Cox regression adjusted for age, sex, diabetes mellitus, hypertension, atrial fibrillation, peripheral arterial disease, and stroke analysed the risk associated with elapsed time. Odds ratios and 95 % confidence interval (OR [95 % CI]) were calculated.</div></div><div><h3>Results</h3><div>Delay time from PCP referral to cardiology care was associated with an increase per day of delay in all-cause (0.25 %), CV (0.13 %), HF (0.11 %) and stroke (0.14 %) mortality rates. Multivariate analyses showed that elapsed time was associated with a higher risk of all-cause (1.005 [1.003–1.007]), CV-mortalities (1.006 [1.005–1.007]), all-cause (1.005 [1.003–1.006]), and CV-hospitalizations (1.009 [1.006–1.012]). Gender-specific analyses revealed that men had higher all-cause mortality (5.3 % vs. 4.0 %, <em>p</em> &lt; 0.001), while women exhibited higher stroke mortality (2.7 % vs. 1.5 %, <em>p</em> = 0.005) and haemorrhagic mortality (4.7 % vs. 3.2 %, <em>p</em> = 0.012). AF complications also increased with the delay time: stroke (1007 [1001−1013]), and cerebral haemorrhage (1008 [1005-1011]).</div></div><div><h3>Conclusions</h3><div>Elapsed time for cardiology care was associated with an increase in AF complications (stroke and haemorrhage), all-cause, CV-related mortality and hospitalizations rates at one-year. Gender differences were evident, with women demonstrating higher stroke and haemorrhagic mortality rates despite similar delays in care. These findings underscore the need for gender-tailored risk stratification and timely cardiology care to optimise outcomes.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132947"},"PeriodicalIF":3.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticoagulation therapy for the prevention of subclinical leaflet thrombosis after transcatheter aortic valve replacement: A comprehensive literature review and future directions","authors":"Norma Nicole Gamarra-Valverde ,&nbsp;Diane Masket ,&nbsp;Mariana L. Henry ,&nbsp;Adriana C. Mares ,&nbsp;Tasha Phillips-Wilson ,&nbsp;Apurva Bhavana Challa ,&nbsp;Khristian Burke ,&nbsp;Lina Ayasrah ,&nbsp;Udochukwu Godswill Anosike ,&nbsp;Enrique Garcia-Sayan","doi":"10.1016/j.ijcard.2024.132946","DOIUrl":"10.1016/j.ijcard.2024.132946","url":null,"abstract":"<div><div>Leaflet thrombosis after transcatheter aortic valve replacement (TAVR) presents a significant challenge, leading to adverse clinical outcomes. Subclinical leaflet thrombosis (SLT) is increasingly recognized, and there is a growing concern about its role in clinical events and hemodynamic valve deterioration. Current recommendations for prophylactic anticoagulation or antiplatelet therapy following TAVR are primarily based on expert consensus rather than definitive evidence from randomized trials, resulting in a variety of antithrombotic strategies in clinical practice. While observational data suggest that prophylactic anticoagulation may be beneficial, clinical trial results are inconsistent, particularly for patients without an existing indication for OAC. Given the conflicting findings and potential safety concerns associated with prophylactic anticoagulation, further research is imperative. This review aims to summarize the existing literature on risk factors for SLT, preventive strategies, current recommendations, and future research directions to better understand the benefits and risks of prophylactic anticoagulation in this context.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132946"},"PeriodicalIF":3.2,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous coronary intervention of the left main coronary artery bifurcation: Insights from the PROGRESS-BIFURCATION registry","authors":"Pedro E.P. Carvalho ,&nbsp;Dimitrios Strepkos ,&nbsp;Michaella Alexandrou ,&nbsp;Deniz Mutlu ,&nbsp;Athanasios Rempakos ,&nbsp;Sandeep Jalli ,&nbsp;Barkin Kultursay ,&nbsp;Ali Karagoz ,&nbsp;Oleg Krestyaninov ,&nbsp;Dmitrii Khelimskii ,&nbsp;Mahmut Uluganyan ,&nbsp;Korhan Soylu ,&nbsp;Ufuk Yildirim ,&nbsp;Olga Mastrodemos ,&nbsp;Bavana V. Rangan ,&nbsp;Konstantinos Voudris ,&nbsp;M. Nicholas Burke ,&nbsp;Yader Sandoval ,&nbsp;Emmanouil S. Brilakis","doi":"10.1016/j.ijcard.2024.132933","DOIUrl":"10.1016/j.ijcard.2024.132933","url":null,"abstract":"<div><h3>Background</h3><div>There is limited data on the long-term outcomes of percutaneous coronary intervention (PCI) in patients with left main coronary artery (LM) bifurcation lesions.</div></div><div><h3>Methods</h3><div>This observational, cohort study was performed across 6 centers in the United States, Russia, and Turkey between 2013 and 2024, as part of the Prospective Global Registry of Percutaneous Coronary Intervention in Bifurcation Lesions (PROGRESS-BIFURCATION, <span><span>NCT05100992</span><svg><path></path></svg></span>). We examined procedural characteristics and follow-up outcomes of patients with versus without LM bifurcation lesions undergoing PCI. Multivariable adjusted hazard ratios (aHR) with 95 % confidence intervals [CI] were calculated using mixed effects Cox regression.</div></div><div><h3>Results</h3><div>Of 1171 patients who underwent bifurcation PCI, 308 (26.3 %) underwent LM PCI. Patients in the LM group were older (76.3 ± 11.0 vs 65.5 ± 11.5 years; <em>p</em> &lt; 0.001) and had more comorbidities, such as diabetes, heart failure, prior PCI, and prior coronary artery bypass graft surgery. Two-stent techniques were more commonly used in LM vs. non-LM patients (38.7 % vs 26.2 %, <em>p</em> &lt; 0.001), with similar technical (95.6 % vs 94.8 %, <em>p</em> = 0.56) and procedural (90.6 % vs 91.1 %; <em>p</em> = 0.796) success. Side-branch occlusion was less common in LM patients (4.0 % vs 16.9 %, <em>p</em> &lt; 0.001). During a median follow-up period of 1095 days, LM bifurcation PCI patients had higher incidence of major adverse cardiac events (MACE) (aHR 1.91; 95 % CI 1.42–2.56;p &lt; 0.001) and all-cause mortality (aHR 2.29; 95 % CI 1.55–3.41; p &lt; 0.001) compared with non-LM bifurcation PCI patients. There was no difference between groups in the incidence of other individual components of MACE<strong>.</strong></div></div><div><h3>Conclusion</h3><div>Compared with patients undergoing non-LM bifurcation those who underwent LM bifurcation PCI were older, had more comorbidities, similar procedural success but higher follow-up MACE and mortality.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132933"},"PeriodicalIF":3.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143308754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}