International journal of cardiology最新文献

{"title":"Exploring the role of lipid biomarkers in linking dysglycemia to subclinical atherosclerosis.","authors":"Guo-Ming Zhang, Yanmin Song","doi":"10.1016/j.ijcard.2025.133870","DOIUrl":"10.1016/j.ijcard.2025.133870","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133870"},"PeriodicalIF":3.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CCTA-quantified pericornary inflammation and lipoprotein (a): Combined predictive value in non-obstructive CAD","authors":"Xueqiao Yang ,&nbsp;Bowen Li ,&nbsp;Huiyu Chen ,&nbsp;Ruyue Ding ,&nbsp;Na Chang ,&nbsp;Congshan Ji ,&nbsp;Hui Gu ,&nbsp;Ximing Wang","doi":"10.1016/j.ijcard.2025.133887","DOIUrl":"10.1016/j.ijcard.2025.133887","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to enhance major adverse cardiovascular events (MACEs) prediction by pericoronary adipose tissue attenuation (PCATa) in non-obstructive coronary artery disease (CAD) patients when combined with lipoprotein (a) (Lp(a)).</div></div><div><h3>Methods</h3><div>A total of 1052 patients with non-obstructive CAD were included. Detailed clinical data and CCTA features were analyzed. The MACEs in this study was defined as a composite of non-fatal myocardial infarction, new-onset heart failure requiring hospitalization, stroke, all-cause mortality, and coronary revascularization.</div></div><div><h3>Results</h3><div>During a median follow-up of 6.8 (5.6–7.9) years, 183 (17.4 %) patients suffered from MACEs. Patients experiencing MACEs demonstrated elevated Lp(a) levels and PCATa values (26.20 (17.63–45.08) vs. 12.00 (4.58–26.00), <em>P</em> &lt; 0.001; −72.6 ± 8.4 HU vs. -79.7 ± 9.5 HU, <em>P</em> &lt; 0.001). Lp(a) was associated with PCATa (<em>P</em> &lt; 0.001). Elevated PCATa was associated with quantitatively greater atherosclerotic burden (<em>P</em> &lt; 0.001). Multivariate Cox regression showed that age (HR = 1.03, <em>P</em> = 0.001), hypertension (HR = 1.39, <em>P</em> = 0.036), triglyceride (HR = 1.23, <em>P</em> = 0.003), high-risk plaque (HR = 2.30, <em>P</em> &lt; 0.001), LAPV% (HR = 2.66, <em>P</em> &lt; 0.001), Lp(a) (HR = 1.26, <em>P</em> &lt; 0.001) and PCATa (HR = 1.44, <em>P</em> &lt; 0.001) were independently associated with increased risk of MACEs. Kaplan-Meier analysis demonstrated that patients with Lp(a) ≥30 mg/dL and PCATa &gt; − 78 HU had the highest incidence of MACEs (<em>P</em> &lt; 0.001). Additionally, combination Lp(a) and PCATa showed the highest AUC (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Incorporating Lp(a) and PCATa significantly improves MACEs prediction in non-obstructive CAD patients, where higher Lp(a) levels are linked to elevated PCATa.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133887"},"PeriodicalIF":3.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision in antiplatelet therapy after ACS — Aiming for individualized care","authors":"Flavia Bittar Brito Arantes ,&nbsp;Remo H.M. Furtado","doi":"10.1016/j.ijcard.2025.133880","DOIUrl":"10.1016/j.ijcard.2025.133880","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133880"},"PeriodicalIF":3.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delineating coronary epicardial stenosis status from microvascular dysfunction using pressure-drop coefficient from multicenter ILIAS registry","authors":"Shreyash M. Manegaonkar ,&nbsp;Mohamed A. Effat ,&nbsp;Tim P. van de Hoef ,&nbsp;Joo Myung Lee ,&nbsp;Coen K.M. Boerhout ,&nbsp;Seung Hun Lee ,&nbsp;Guus A. de Waard ,&nbsp;Ji Hyun Jung ,&nbsp;Hernan Mejia Renteria ,&nbsp;Masahiro Hoshino ,&nbsp;Mauro Echavarria Pinto ,&nbsp;Martijn Meuwissen ,&nbsp;Hitoshi Matsuo ,&nbsp;Maribel Madera Cambero ,&nbsp;Ashkan Eftekhari ,&nbsp;Tadashi Murai ,&nbsp;Koen Marques ,&nbsp;Joon Hyung Doh ,&nbsp;Evald H. Christiansen ,&nbsp;Chang Wook Nam ,&nbsp;Rupak K. Banerjee","doi":"10.1016/j.ijcard.2025.133864","DOIUrl":"10.1016/j.ijcard.2025.133864","url":null,"abstract":"<div><h3>Introduction</h3><div>Pressure-based fractional flow reserve (FFR) and flow-based coronary flow reserve (CFR) assess the functional status of coronary artery disease (CAD) during cardiac catheterization. Complex hemodynamics may not be adequately explained by either pressure or flow alone. Consequently, pressure-drop coefficient (CDP, the ratio between pressure-drop across a stenosis and distal dynamic pressure) that combines both pressure and flow measurements has been developed to distinguish between epicardial stenosis (ES) and microvascular disease (MVD).</div></div><div><h3>Methods</h3><div>A global multicenter ILIAS registry was used to analyze CDP in relation to FFR/CFR among 961 subjects for 1342 intracoronary pressure and flow measurements. The correlation between FFR and CFR with CDP was analyzed. The receiver operating characteristic (ROC) curve was used to determine the CDP cut-off value, corresponding to FFR = 0.80 and 0.75 and CFR = 2.0.</div></div><div><h3>Results</h3><div>Both linear (<em>r</em> = 0.68) and logarithmic (<em>r</em> = 0.75) correlation of CDP with combined FFR and CFR improved (<em>p</em> &lt; 0.001) in relation to either FFR or CFR individually. The CDP cut-off values to predict the four possible disease combinations based on FFR(0.8) and CFR(2.0) are: 1) 0 to 15.78 (absence of both diseases); 2) 15.78 to 27.25 (absence of ES and presence of MVD); 3) 27.25 to 73.77 (presence of ES and absence of MVD); and 4) CDP ≥ 73.77 (presence of both diseases). Similar CDP cut-off ranges were obtained for FFR = 0.75 and CFR = 2.0.</div></div><div><h3>Conclusion</h3><div>The established diagnostic cut-off values of CDP can differentiate between the concomitant ES and MVD, improving the functional assessment of CAD.</div></div><div><h3>Condensed abstract</h3><div>Fractional flow reserve and coronary flow reserve assess the functional status of coronary artery disease (CAD) during cardiac catheterization, but the complex hemodynamics may not be adequately explained by either parameter alone. Pressure-drop coefficient (CDP) is a novel composite parameter that combines both pressure and flow measurements to delineate between epicardial stenosis (ES) and microvascular disease (MVD). ILIAS registry was used to analyze the diagnostic performance of CDP relative to FFR/CFR. The receiver operating characteristic curve was used to determine the CDP cut-off values, that delineate the various combinations of ES and MVD; hence, improving the functional assessment of CAD.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133864"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stable Cytokine Network during Hypoxia and Exercise in Patients with Fontan Circulation","authors":"Julian Alexander von Hasselbach ,&nbsp;Boris Dragutinovic ,&nbsp;Nicole Müller ,&nbsp;Johannes Breuer ,&nbsp;Jens Tank ,&nbsp;Jens Jordan ,&nbsp;Wilhelm Bloch ,&nbsp;Marijke Grau","doi":"10.1016/j.ijcard.2025.133861","DOIUrl":"10.1016/j.ijcard.2025.133861","url":null,"abstract":"<div><h3>Background</h3><div>Patients with Fontan circulation are often advised to avoid hypoxic exposure due to presumed cardiopulmonary vulnerability. Low-grade inflammation has also been reported in this population and may be influenced by hypoxia and/or exercise. Based on the potential interaction between hypoxia and submaximal exercise in modulating inflammatory signaling, we hypothesized that this combination could exacerbate subclinical inflammation.</div></div><div><h3>Methods</h3><div>Eighteen clinically stable patients with Fontan circulation (age 25 ± 6 years, 9 female, NYHA I) underwent a submaximal cycling step test under normoxia, followed by 24 hours of normobaric hypoxia (FiO₂ ≈ 15 %, ∼2500 m), and a second test under hypoxia at the :envihab research facility of the German Aerospace Centre. Venous blood was sampled at rest and peak exercise to analyse cytokines (IL-2, IL-6, TNF-α, TNF-β), adipo-myokines (irisin, asprosin), and immune cell indices (WBC, lymphocytes, neutrophils, NLR, PLR, SII).</div></div><div><h3>Results</h3><div>Baseline cytokine levels and cell counts were within reference ranges. Exercise induced a mild increase in WBC under both conditions without affecting derived indices (<em>p</em> ≤ 0.05). Cytokine concentrations remained stable. Irisin increased after normoxic (<em>p</em> ≤ 0.05) but not hypoxic exercise; asprosin showed no significant changes.</div></div><div><h3>Conclusion</h3><div>Moderate normobaric hypoxia combined with submaximal exercise did not elicit systemic immune activation in stable patients with Fontan circulation. These data challenge assumptions of latent immune vulnerability and support the safety of controlled hypoxic exposure in the tested cohort.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133861"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical appraisal of early diagnosis and progression to heart failure with preserved ejection fraction among hypertensive patients with left ventricular hypertrophy.","authors":"Abdul Moeez Rana, Muhammad Abdul Rafay, Muhammad Waqar Amjad, Muhammad Hassan Aslam","doi":"10.1016/j.ijcard.2025.133877","DOIUrl":"10.1016/j.ijcard.2025.133877","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133877"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiogenic shock after acute myocardial infarction: The importance of adherence to management recommendations","authors":"Fernando Alfonso,&nbsp;Jorge Salamanca,&nbsp;Fernando Rivero","doi":"10.1016/j.ijcard.2025.133860","DOIUrl":"10.1016/j.ijcard.2025.133860","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133860"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Glucagon-like peptide-1 receptor agonists improve outcomes in individuals with type 2 diabetes with and without heart failure.","authors":"Muneeba Umar, Minahil Zaheer, Zeeshan Gillani","doi":"10.1016/j.ijcard.2025.133871","DOIUrl":"10.1016/j.ijcard.2025.133871","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133871"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tertiary-centric data and AMI-CS care: Does it reflect real-world adherence?","authors":"Yuqing You, Jinyan Guo, Xue Han, Weifeng Yao","doi":"10.1016/j.ijcard.2025.133873","DOIUrl":"10.1016/j.ijcard.2025.133873","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133873"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Tertiary-centric data and AMI-CS care: Does it reflect real-world adherence?\"","authors":"Hong Wang, Yuwei Liu, Xiaotong Hou","doi":"10.1016/j.ijcard.2025.133868","DOIUrl":"10.1016/j.ijcard.2025.133868","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133868"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}