International journal of cardiology最新文献

{"title":"Nationwide, Danish data may assist in refining ischemic stroke risk prediction in atrial fibrillation","authors":"Polychronis Dilaveris, Gerasimos Siasos","doi":"10.1016/j.ijcard.2025.133460","DOIUrl":"10.1016/j.ijcard.2025.133460","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133460"},"PeriodicalIF":3.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive evaluation of coronary microvascular dysfunction: The role of angiography-derived microcirculatory resistance","authors":"Changbin He , Lin Li","doi":"10.1016/j.ijcard.2025.133486","DOIUrl":"10.1016/j.ijcard.2025.133486","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133486"},"PeriodicalIF":3.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online rehabilitation in adult Fontan patients: Effects in functional capacity, lymphatic function and quality of life","authors":"Aida Luiza Ribeiro Turquetto ,&nbsp;Luciana Patrick Amato ,&nbsp;Lene Thorup ,&nbsp;Benjamin Kelly ,&nbsp;Vibeke Elizabeth Hjortdal ,&nbsp;Francis Ribeiro de Souza ,&nbsp;Luiz Fernando Canêo ,&nbsp;Desiree S. Machado ,&nbsp;Antonio Carlos Battaglia Filho ,&nbsp;Melissa Ganeko Ligeiro ,&nbsp;Sheyanth Mohanakumar ,&nbsp;Eduardo Rondon ,&nbsp;Maria Angélica Binotto ,&nbsp;Marcelo Biscegli Jatene ,&nbsp;Fabio Biscegli Jatene","doi":"10.1016/j.ijcard.2025.133480","DOIUrl":"10.1016/j.ijcard.2025.133480","url":null,"abstract":"<div><h3>Introduction</h3><div>Survival rates for post-Fontan patients have improved, allowing many to reach adulthood with better quality of life (QOL). However, they remain at risk for reduced functional capacity (FC), skeletal muscle loss, and lymphatic dysfunction, which negatively affect clinical outcomes. This study evaluated the feasibility of an online rehabilitation program for adult Fontan patients in the late postoperative period and its effects on FC, peripheral lymphatic function (PLF), and QOL.</div></div><div><h3>Methods</h3><div>This prospective, non-randomized, controlled clinical trial evaluated the impact of a fitness center's 36-session online aerobic and resistance training program. Participants were divided into a control group (CG), continuing usual activities, and an exercise group (EG). Outcomes included QOL (Short Form-36 questionnaire: SF-36), FC via cardiopulmonary exercise testing (CPET), and PLF assessed using near-infrared fluorescence imaging and venous occlusion plethysmography.</div></div><div><h3>Results</h3><div>A total of 26 participants (13 EG,13 CG), with a median age of 30 (25–35) years, and follow-up time after Fontan of 19 (15–21) years, were enrolled. The EG showed significant improvements in peak VO2 (ml/kg/min), predicted peak VO2 (%), peak ventilation (L/min), and oxygen pulse (mL/beat), indicating enhanced cardiovascular efficiency. Additionally, 62 % of SF-36 domains improved in the EG, while no changes were observed in the CG. However, the program did not produce significant modifications in PLF.</div></div><div><h3>Conclusions</h3><div>The proposed online rehabilitation program proved to be feasible and effectively improved FC and quality of life in adults after Fontan surgery; however, this training model did not significantly influence peripheral lymphatic function<strong>.</strong></div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133480"},"PeriodicalIF":3.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Evaluating the prognostic role of iliac artery calcification in femoropopliteal intervention","authors":"Syeda Kashaf Batool ,&nbsp;Fatima Asif ,&nbsp;Javed Iqbal","doi":"10.1016/j.ijcard.2025.133488","DOIUrl":"10.1016/j.ijcard.2025.133488","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133488"},"PeriodicalIF":3.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary hypertension induced right heart failure via upregulation of serum Dickkopf-1 expression","authors":"Ziqing Wang ,&nbsp;Qianqian Wang ,&nbsp;Hao Xu,&nbsp;Haojie Zhang,&nbsp;Shaojun Ren,&nbsp;Yimin Sun,&nbsp;Junhua Ge ,&nbsp;Jian Li","doi":"10.1016/j.ijcard.2025.133481","DOIUrl":"10.1016/j.ijcard.2025.133481","url":null,"abstract":"<div><h3>Background</h3><div>Pulmonary hypertension (PH)-induced right heart failure (RHF) is a progressive syndrome characterized by right ventricular (RV) enlargement and dysfunction. This study aimed to investigate factors associated with PH-induced RHF, with a focus on the role of Dickkopf-1 (DKK1).</div></div><div><h3>Method</h3><div>Clinical data and serum samples were collected from healthy controls (<em>n</em> = 18), patients with PH (<em>n</em> = 29), and PH-RHF (<em>n</em> = 75). DKK1 expression was quantified in serum and RV tissue.</div></div><div><h3>Results</h3><div>Serum DKK1 levels were significantly elevated in PH and PH-RHF patients compared to controls (1396.36 ± 413.40 vs. 2502.51 ± 962.81 vs. 3798.33 ± 1936.17 pg/mL, <em>P</em> &lt; 0.001). Higher DKK1 levels were associated with impaired RV function, reflected by reduced TAPSE (<em>P</em> = 0.025), lower TAPSE/sPAP ratio (<em>P</em> = 0.024), and elevated sPAP (<em>P</em> = 0.017). DKK1 also correlated with invasive hemodynamic parameters, including RVP (<em>P</em> = 0.006), mPAP (<em>P</em> &lt; 0.001), PVR (<em>P</em> = 0.014), SVR (<em>P</em> = 0.003), CO (<em>P</em> = 0.023), and CI (<em>P</em> = 0.002). Experimental models demonstrated marked DKK1 upregulation in hypoxia-stimulated cardiomyocytes and in serum and RV tissue of monocrotaline-treated and PAB rats.</div></div><div><h3>Conclusions</h3><div>Elevated DKK1 levels are associated with worsening RV dysfunction in PH, suggesting a potential pathogenic role in PH-induced RHF. DKK1 may serve as a complementary biomarker and a potential therapeutic target in PH-related RHF.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133481"},"PeriodicalIF":3.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk stratification of net adverse clinical events using CHADS-P2A2RC and CHADS2 scores in chronic coronary syndrome patients without atrial fibrillation: Insights from the CLIDAS-PCI","authors":"Takenobu Shimada ,&nbsp;Daiju Fukuda ,&nbsp;Atsushi Shibata ,&nbsp;Asahiro Ito ,&nbsp;Kenichiro Otsuka ,&nbsp;Hiroshi Okamura ,&nbsp;Tetsuya Matoba ,&nbsp;Takahide Kohro ,&nbsp;Yusuke Oba ,&nbsp;Tomoyuki Kabutoya ,&nbsp;Yasushi Imai ,&nbsp;Kazuomi Kario ,&nbsp;Arihiro Kiyosue ,&nbsp;Yoshiko Mizuno ,&nbsp;Kotaro Nochioka ,&nbsp;Masaharu Nakayama ,&nbsp;Takamasa Iwai ,&nbsp;Yoshihiro Miyamoto ,&nbsp;Masanobu Ishii ,&nbsp;Taishi Nakamura ,&nbsp;Ryozo Nagai","doi":"10.1016/j.ijcard.2025.133464","DOIUrl":"10.1016/j.ijcard.2025.133464","url":null,"abstract":"<div><h3>Background</h3><div>There are few data verifying the utility of the CHADS-P₂A₂RC score in comparison with the CHADS₂ score for estimating net adverse clinical events (NACE) in chronic coronary syndrome (CCS) patients without atrial fibrillation (AF) in real-world settings.</div></div><div><h3>Methods</h3><div>We performed analysis for a total of 3985 CCS patients without AF who underwent percutaneous coronary intervention (PCI) between April 2013 and March 2019 for whom information was obtained from the CLIDAS (Clinical Deep Data Accumulation System)-PCI database. The primary endpoint was NACE defined as the composite of 3-point major adverse cardiovascular events (3P-MACE) (cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke) and GUSTO moderate/severe bleeding events.</div></div><div><h3>Results</h3><div>Kaplan-Meier analysis showed that both the CHADS-P₂A₂RC and CHADS₂ scores stratified the risks. The incidences of NACE were stratified well by the very-high-risk category, which was uniquely defined as a CHADS-P₂A₂RC score of ≥6 (hazard ratio: 2.38, 95 % CI = 1.91–2.97, <em>p</em>-value &lt;0.001). The area under the curve (AUC) in estimating NACE within 3 years was higher when the CHADS-P₂A₂RC score was used than when the CHADS₂ score was used (0.67 vs. 0.62, <em>p</em> = 0.003). This was mainly due to the accuracy in estimating bleeding events (0.66 vs. 0.60, <em>p</em> = 0.006).</div></div><div><h3>Conclusions</h3><div>The accuracy in estimating NACE after PCI for CCS patients without AF was higher when the CHADS-P₂A₂RC score was used than when the CHADS₂ score was used, mainly due to the accuracy in predicting bleeding risk. Higher incidences of endpoints were well-stratified by a very-high-risk category defined as a CHADS-P₂A₂RC score of ≥6.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133464"},"PeriodicalIF":3.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing an alert-based strategy: A path to sustainable remote monitoring of cardiovascular electronic devices","authors":"Massimiliano Maines ,&nbsp;Francesco Peruzza ,&nbsp;Mauro Laurente ,&nbsp;Antonio Madaffari ,&nbsp;Carlo Angheben ,&nbsp;Domenico Catanzariti ,&nbsp;Sergio Valsecchi ,&nbsp;Maurizio Del Greco","doi":"10.1016/j.ijcard.2025.133478","DOIUrl":"10.1016/j.ijcard.2025.133478","url":null,"abstract":"<div><h3>Introduction</h3><div>Remote monitoring (RM) has become the standard of care for patients with cardiovascular implantable electronic devices, but its widespread use presents challenges for clinical staff.</div></div><div><h3>Methods</h3><div>We conducted a retrospective observational analysis of RM activity at a single center from 2018 to 2023. The center provides follow-up for pacemaker, implantable cardioverter defibrillator (ICD), and implantable loop recorder (ILR) patients. Interventions included reducing the frequency of scheduled transmissions, reprogramming nonactionable alerts, and transitioning to an alert-based monitoring model. Transmission and visit data were analyzed annually, and estimated staffing needs were calculated using the Heart Rhythm Society's RM Clinic Staffing Calculator.</div></div><div><h3>Results</h3><div>The number of patients enrolled in RM increased from 1887 in 2018 to 2741 in 2023. During the same period, the number of transmissions per patient-year decreased across all device types (<em>p</em> &lt; 0.05). Staffing estimates based on patient volume suggested a need for up to six full-time staff members. However, actual workload analysis showed that the service was sustained with two full-time equivalents, due to workflow optimization and alert-based RM management.</div></div><div><h3>Conclusions</h3><div>An alert-based remote monitoring strategy, tailored to patient clinical characteristics and focused on reducing nonactionable alerts, can enhance efficiency and service sustainability. While these results reflect a specific institutional model, they support broader efforts to optimize RM practices in alignment with recent expert consensus guidelines.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133478"},"PeriodicalIF":3.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid profiles in ST-elevation myocardial infarction with and without diabetes: the gap between prescription and targets","authors":"Marco Biasin ,&nbsp;Nicolò Cordioli ,&nbsp;Ilaria Armani ,&nbsp;Ludovica Guerrieri ,&nbsp;Giulia Parmegian ,&nbsp;Alessandro Sarai ,&nbsp;Lorenzo Bonadiman ,&nbsp;Sara Lomi ,&nbsp;Alessia Gambaro ,&nbsp;Flavio Luciano Ribichini","doi":"10.1016/j.ijcard.2025.133474","DOIUrl":"10.1016/j.ijcard.2025.133474","url":null,"abstract":"<div><h3>Introduction</h3><div>Lipids are critical in coronary atherosclerosis, making lipid reduction essential for prevention of cardiovascular disease. Achieving guideline-recommended LDL cholesterol (LDL-C) targets remains challenging for patients with and without diabetes. This study aims to compare clinical differences between STEMI patients with and without diabetes and evaluate lipid-lowering therapy (LLT) on admission and on discharge.</div></div><div><h3>Methods</h3><div>Retrospective study on STEMI patients admitted to our center between 2021 and 2023. Data included anthropometric details, lipid profiles, cardiovascular risk scores and drug therapy. An electronic tool that takes in account theoretical LLT potency allowed computation of LDL-C levels as if they hadn't undergone any LLT therapy (wild LDL-C).</div></div><div><h3>Results</h3><div>Of 467 screened patients, 443 were included, with 72 having diabetes. Statistically significant differences were observed in hypertension (15 % vs. 56.3 %, <em>p</em> &lt; 0.001) and peripheral arterial disease prevalence (15.2 % vs. 6.2 %, <em>p</em> = 0.01). Non-diabetic patients had higher total cholesterol, HDL<img>C, and LDL-C levels but similar wild LDL-C (110.7 mg/dL vs. 117.5 mg/dL, <em>p</em> = 0.30). At admission, 50.0 % (diabetic) and 81.1 % (non-diabetic) did not achieve LDL-C targets (<em>p</em> &lt; 0.001). At follow-up, 36.6 % (diabetic) and 42.6 % (non-diabetic) did not achieve their recommended LDL-C targets based on their cardiovascular risk classification.</div></div><div><h3>Conclusion</h3><div>A significant proportion of patients did not reach the recommended LDL-C targets upon admission for STEMI, and approximately a third were discharged without adequate LLT to meet target cholesterol levels. Aggressive lipid-lowering interventions, in particular with the support of electronic tools to assess LLT potency, are crucial for prompt LDL-C target attainment.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133474"},"PeriodicalIF":3.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotype-negative hypertrophic cardiomyopathy: Exploring the role of cardiovascular risk factors in disease expression","authors":"Stephan A.C. Schoonvelde ,&nbsp;Edgar E. Nollet ,&nbsp;Peter-Paul Zwetsloot ,&nbsp;Christian Knackstedt ,&nbsp;Tjeerd Germans ,&nbsp;Alexander Hirsch ,&nbsp;Arend F.L. Schinkel ,&nbsp;Marjon A. van Slegtenhorst ,&nbsp;Judith M.A. Verhagen ,&nbsp;Rudolf A. de Boer ,&nbsp;Jolanda van der Velden ,&nbsp;Michelle Michels","doi":"10.1016/j.ijcard.2025.133444","DOIUrl":"10.1016/j.ijcard.2025.133444","url":null,"abstract":"<div><h3>Background</h3><div>Hypertrophic cardiomyopathy (HCM) is the most common inherited myocardial disease. An inheritable cause is identified in approximately half of patients. Earlier research has identified clinical differences between genotype-positive (G+) and genotype-negative (G-) HCM patients, which this study aimed to further explore.</div></div><div><h3>Methods and results</h3><div>Differences in baseline characteristics, including cardiovascular risk factors (CVRF), and phenotypical factors between G+ and G- patients were explored. Subanalyses among distinct age groups and sexes were performed. A total of 422 HCM (46 % G-, 54 % G+) patients were included. G- patients were older (62 vs 54 years, <em>p</em> &lt; 0.001), experienced more limiting cardiac symptoms (47 % vs 28 %, <em>p</em> = 0.008), and more frequent left ventricular outflow tract obstruction (57 % vs 38 %, p &lt; 0.001). CVRF were more prevalent in G- than in G+ HCM patients (70 % vs 41 %, p &lt; 0.001), with hypertension being the most prevalent factor (51 % vs 22 %, p &lt; 0.001). Despite adjusting for patient age, CVRF presence significantly predicted G- classification (OR 2.3, 95 %CI 1.5–3.6, p &lt; 0.001). Female G- patients were less prevalent in younger age groups, and only in the older age group (&gt;60 years) were female G- patients diagnosed later than their G+ counterparts.</div></div><div><h3>Conclusion</h3><div>CVRF, particularly hypertension, are more prevalent in G- patients independent of age, suggesting that cardiovascular health may contribute to HCM disease development. Male-female differences suggest female-specific factors affecting the development of HCM in women. Recognizing G- HCM as a distinct clinical entity may have important implications for patient management, and a more comprehensive understanding of its aetiology may aid in tailoring future therapies.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133444"},"PeriodicalIF":3.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global insights of acute cardiovascular complications of COVID-19: Findings from the CARDIO COVID 19–20 and WHF COVID-19 CVD studies","authors":"Juan Esteban Gomez-Mesa ,&nbsp;Juan Pablo Arango-Ibanez ,&nbsp;David Alejandro Pantoja-Castro ,&nbsp;Jose F. Fuertes-Bucheli ,&nbsp;Paula Andrea Cárdenas-Marín ,&nbsp;Hoover O. León-Giraldo ,&nbsp;Andrea Valencia-Orozco ,&nbsp;Pablo Perel ,&nbsp;Dorairaj Prabhakaran ,&nbsp;Kavita Singh ,&nbsp;Ricardo Enrique Larrea Gómez ,&nbsp;Cesar J. Herrera ,&nbsp;Liliana Patricia Cárdenas Aldaz ,&nbsp;Victor Rossel ,&nbsp;Hugo Fernando Fernández ,&nbsp;Ricardo Ramírez Ramírez ,&nbsp;Clara Inés Saldarriaga ,&nbsp;Ivan Criollo ,&nbsp;Paula Silva ,&nbsp;Karen Sliwa","doi":"10.1016/j.ijcard.2025.133458","DOIUrl":"10.1016/j.ijcard.2025.133458","url":null,"abstract":"<div><h3>Background</h3><div>COVID-19 can cause acute and chronic cardiovascular complications. Acute complications include heart failure, coronary syndrome, arrhythmias, myocarditis, pulmonary embolism, etc. These complications are linked to pre-existing cardiovascular disease (CVD) and increase the risk of adverse outcomes. We characterized acute cardiovascular complications in COVID-19 patients from 32 countries.</div></div><div><h3>Methods</h3><div>This cohort study combined two prospective, multicenter studies of hospitalized adults with COVID-19: the CARDIO COVID 19–20 registry and the WHF COVID-19 CVD study. We performed descriptive and multivariate analyses to assess the incidence of cardiovascular complications, associated factors, and their correlation with mortality.</div></div><div><h3>Results</h3><div>We included 8045 patients from the Americas, Africa, Asia, and Europe. Median age was 59 years (IQR 47–69), and 60.9 % were male. Cardiovascular complications occurred in 1072 patients (13.3 %), most commonly arrhythmias (448, 5.5 %), acute heart failure (441, 5.4 %), and pulmonary embolism (227, 2.8 %). Patients with CVD had higher complication rates (33.1 % vs. 10.2 %), more ICU admissions (56 % vs. 36.7 %), and higher in-hospital mortality (40.4 % vs. 13.2 %). The incidence of complications was highest in the Americas (18.4 %) and Europe (14.9 %). Risk factors included age and cardiometabolic comorbidities. Regression analysis showed that having ≥1 cardiovascular complication increased the risk of in-hospital mortality (aRR 2.32, 95 % CI 2.10–2.55, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Cardiovascular complications affected over 10 % of hospitalized patients, with regional variations. These events were associated with higher mortality and were highly prevalent among those with CVD.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133458"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}