International journal of cardiology最新文献

{"title":"Differential determinants and prognostic value of aortic valve sclerosis over carotid atherosclerosis","authors":"Minjeong Kim ,&nbsp;Jiwon Seo ,&nbsp;In-Soo Kim ,&nbsp;Sungsoo Cho ,&nbsp;Se-Joong Rim ,&nbsp;Hyuck Moon Kown ,&nbsp;Eui-Young Choi","doi":"10.1016/j.ijcard.2025.132980","DOIUrl":"10.1016/j.ijcard.2025.132980","url":null,"abstract":"<div><h3>Background</h3><div>Aortic valve sclerosis (AVS) is a progressive atherosclerotic disease associated with future cardiovascular events (CVE). However, whether its development and prognostic value are independent of arterial atherosclerosis has not been thoroughly investigated. We evaluated the determinants and prognostic value of AVS in conjunction with carotid atherosclerosis.</div></div><div><h3>Methods</h3><div>4688 consecutive patients who underwent carotid ultrasonography and echocardiography were followed for an average of 3.6 ± 1.3 years, excluding those with bicuspid aortic valve, rheumatic heart disease, overt aortic stenosis, and prior aortic valve replacement. AVS was defined as any thickened cusps with hyper-echogenicity but a peak pressure gradient &lt;2.5 m/s.</div></div><div><h3>Results</h3><div>The mean age of the patients was 61.1 ± 11.7 years, with 1836 (39 %) being women. Among them, 523 (11 %) had AVS. AVS was independently correlated with age, diabetes, lower high-density lipoprotein levels, and presence of carotid plaques. Moreover, it was significantly related to atherosclerotic CVE (acute coronary syndromes, and all-cause death; log-rank <em>p</em> = 0.011) and future heart failure (HF) admissions (<em>p</em> &lt; 0.001). In multivariate analyses, AVS was significantly associated with atherosclerotic CVE regardless of age and sex but significantly attenuated by the presence of carotid plaques. Meanwhile, future HF admission was attenuated considerably after adjusting for E/e’ and left ventricular (LV) ejection fraction.</div></div><div><h3>Conclusions</h3><div>AVS has prognostic value for future CVE and HF. Atherosclerotic CVE was primarily mediated by vascular atherosclerosis; however, future HF admissions were mainly mediated by concomitant LV systolic and diastolic dysfunction, suggesting that AVS serves as a surrogate marker rather than an independent risk factor.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132980"},"PeriodicalIF":3.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left atrial strain and risk of atrial fibrillation after coronary artery bypass-grafting","authors":"Andrea Grasso Granchietti ,&nbsp;Niccolò Ciardetti ,&nbsp;Carlotta Mazzoni ,&nbsp;Manuel Garofalo ,&nbsp;Ruggero Mazzotta ,&nbsp;Serena Micheli ,&nbsp;Marco Chiostri ,&nbsp;Matteo Orlandi ,&nbsp;Lucrezia Biagiotti ,&nbsp;Stefano Del Pace ,&nbsp;Carlo Di Mario ,&nbsp;Sabina Caciolli","doi":"10.1016/j.ijcard.2025.132981","DOIUrl":"10.1016/j.ijcard.2025.132981","url":null,"abstract":"<div><h3>Aim</h3><div>Postoperative Atrial Fibrillation (POAF) is a common complication following Coronary Artery Bypass Grafting (CABG), associated with increased morbidity and mortality. Aim of the study is to analyze whether the measurement of preoperative Left Atrial (LA) strain can offer advantages over conventional clinical and echocardiographic parameters to identify patients at risk of developing POAF.</div></div><div><h3>Methods and results</h3><div>We conducted a prospective study involving 100 patients undergoing isolated CABG from April 2023 to April 2024. Key parameters measured included LA strain measurements, Left Atrial Emptying Fraction (LA-EF), Left Ventricular Ejection Fraction, Left Atrial Volume index (LAVi). POAF occurred in 27 patients (27 %) with a mean latency of 3.2 ± 2.1 days. Higher preoperative serum creatinine levels were significantly associated with POAF. LA strain parameters (LA Reservoir Strain, LA Contraction Strain) and LA-EF were all significantly lower in the POAF group. Multivariate logistic regression identified LA Contraction Strain (OR: 0.73, <em>p</em> = 0.04), LA Reservoir Strain (OR: 0.27, <em>p</em> = 0.02) and preoperative serum creatinine (OR: 0.55, <em>p</em> = 0.01) as significant predictors of POAF. ROC curve analysis indicated that LA Reservoir Strain ≤24.5 %, LA Contraction Strain ≤9.5 %, LA-EF ≤ 43.4 % have a good accuracy in detection of POAF. Significant correlations were found between LAVi and LA Reservoir Strain, LAVi and LA-EF, and LA Reservoir Strain and LA-EF.</div></div><div><h3>Conclusions</h3><div>Preoperative LA analysis are significant predictors of POAF. These findings suggest that echocardiographic strain measurements offer an added value in preoperative risk assessment for POAF in CABG patients.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132981"},"PeriodicalIF":3.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fractional flow reserve (FFR) and index of microcirculatory resistance (IMR) relationship in patients with chronic or stabilized acute coronary syndromes","authors":"Domenico Galante ,&nbsp;Andrea Viceré ,&nbsp;Andrea Marrone ,&nbsp;Filippo Maria Verardi ,&nbsp;Vincenzo Viccaro ,&nbsp;Chiara Giuliana ,&nbsp;Ciro Pollio Benvenuto ,&nbsp;Simona Todisco ,&nbsp;Simone Biscaglia ,&nbsp;Cristina Aurigemma ,&nbsp;Enrico Romagnoli ,&nbsp;Gennaro Capalbo ,&nbsp;Carlo Trani ,&nbsp;Francesco Burzotta ,&nbsp;Filippo Crea ,&nbsp;Gianluca Campo ,&nbsp;Antonio Maria Leone","doi":"10.1016/j.ijcard.2025.132978","DOIUrl":"10.1016/j.ijcard.2025.132978","url":null,"abstract":"<div><h3>Aims</h3><div>To investigate the influence of index of microcirculatory resistance (IMR) on fractional flow reserve (FFR) and adenosine-induced hyperemia (ΔPd/Pa-FFR) in patients with chronic (CCS) or stabilized acute coronary syndromes (ACS), utilizing various IMR threshold values.</div></div><div><h3>Methods</h3><div>Data were extracted from two ongoing Italian registries involving patients with CCS or stabilized ACS who underwent a #FullPhysiology approach [Pd/Pa, FFR, IMR, coronary flow reserve (CFR)] by bolus thermodilution technique in the left anterior descending artery. Correlations between IMR and both FFR and ΔPd/Pa-FFR were analyzed both globally and within three IMR-defined groups: Group 1 (IMR &lt;25), Group 2 (25 ≤ IMR &lt;40), and Group 3 (IMR ≥40). A multiple linear regression was employed to adjust for confounding factors.</div></div><div><h3>Results</h3><div>Of 275 patients, 163 were in Group 1, 60 in Group 2, and 52 in Group 3. Globally, a weak but significant correlation was observed between IMR and both FFR (<em>r</em> = 0.170, <em>p</em> &lt; 0.01) and ΔPd/Pa-FFR (<em>r</em> = −0.159, p &lt; 0.01). After stratification only patients in Group 3 exhibited a significant and more pronounced, though still weak, correlation between FFR and IMR (<em>r</em> = 0.387, <em>p</em> &lt; 0.01) coupled with a reduction of ΔPd/Pa-FFR as IMR values increased (<em>r</em> = −0.411, p &lt; 0.01). After adjustment, a significant increase of 0.01 in FFR values was observed for every 14-unit rise in IMR (p &lt; 0.01) in Group 3.</div></div><div><h3>Conclusions</h3><div>FFR appears particularly influenced by elevated IMR values (≥40) highlighting the importance of the #FullPhysiology approach in understanding epicardial and microvascular contribution of myocardial ischemia.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132978"},"PeriodicalIF":3.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence for left ventricular hypertrophy detection and differentiation on echocardiography, cardiac magnetic resonance and cardiac computed tomography: A systematic review","authors":"Chiara Cirillo ,&nbsp;Margherita A.G. Matarrese ,&nbsp;Emanuele Monda ,&nbsp;Maria Elisabetta Pagnano ,&nbsp;Jacopo Vitale ,&nbsp;Federica Verrillo ,&nbsp;Giuseppe Palmiero ,&nbsp;Sabrina Bassolino ,&nbsp;Pietro Buono ,&nbsp;Martina Caiazza ,&nbsp;Francesco Loffredo ,&nbsp;Leandro Pecchia ,&nbsp;Giuseppe Limongelli","doi":"10.1016/j.ijcard.2025.132979","DOIUrl":"10.1016/j.ijcard.2025.132979","url":null,"abstract":"<div><h3>Aims</h3><div>Left ventricular hypertrophy (LVH) is a common clinical finding associated with adverse cardiovascular outcomes. Once LVH is diagnosed, defining its cause has crucial clinical implications. Artificial intelligence (AI) may allow significant progress in the automated detection of LVH and its underlying causes from cardiovascular imaging. This systematic review aims to investigate the diagnostic performance of AI models developed to diagnose LVH and its common aetiologies.</div></div><div><h3>Methods</h3><div>MEDLINE/PubMed, EMBASE and Cochrane databases were systematically searched to identify relevant studies on echocardiography, cardiac magnetic resonance (CMR), and cardiac computed tomography (CT).</div></div><div><h3>Results</h3><div>Thirty studies were included in this review. Of them, 14 were on echocardiography, 15 on CMR, and one on cardiac CT. Regarding the AI methods applied, 79 % of studies in echocardiography utilized deep learning (DL), 64 % employed convolutional neural networks (CNNs), and 21 % applied traditional machine learning (ML) algorithms. For CMR studies, 53 % used DL, 27 % relied on CNNs, and 47 % adopted traditional ML methods. All studies showed good diagnostic performances, but those applying AI tools to determine the underlying causes of LVH demonstrated the highest accuracy metrics compared to those focused on detecting LVH itself.</div></div><div><h3>Conclusion</h3><div>AI models designed to detect and differentiate LVH on cardiac imaging are currently under development and are demonstrating promising results. Further studies focusing on real-life validation of these models, and cost-effectiveness analyses are needed.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132979"},"PeriodicalIF":3.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiopulmonary exercise testing in children and adolescents at moderate altitude: New normative values","authors":"Julie C. Fernie ,&nbsp;Lori J. Silveira ,&nbsp;Roni Jacobsen ,&nbsp;Christopher M. Rausch","doi":"10.1016/j.ijcard.2025.132977","DOIUrl":"10.1016/j.ijcard.2025.132977","url":null,"abstract":"<div><h3>Background</h3><div>Cardiopulmonary exercise tests (CPETs) measure cardiovascular exercise response. Altitude alters exercise parameters, so standard normative datasets (Cooper, Bruce, Burstein) may not accurately predict exercise parameters for data collected at moderate altitude. This study aimed to: 1) establish modern normative exercise values for children/adolescents at moderate altitude and 2) compare these values against the Cooper, Burstein and Bruce models.</div></div><div><h3>Methods</h3><div>Maximal CPETs in children/adolescents aged 6 to 18 years were evaluated retrospectively (<em>n</em> = 1154, mean age 13.92 ± 2.70 years, 49.7 % female). Separate analysis and modeling were completed for the cycle ergometer (<em>n</em> = 907) and treadmill (<em>n</em> = 247). Polynomial regression models were developed for each exercise variable. A validation cohort of tests on the treadmill and cycle ergometer (<em>n</em> = 100, 50 cycle ergometer, 50 treadmill, mean age 14.44 ± 2.57 years, 47.0 % female) were evaluated with our polynomial models.</div></div><div><h3>Results</h3><div>On the cycle ergometer, the Burstein dataset had improved root mean square error (RMSE, 7.4) compared to the Cooper dataset (RMSE 9.6) for peak oxygen consumption (VO₂ peak), while our model demonstrated even better RMSE (5.5). Our model had improved RMSE compared to the Burstein equations for all parameters (except resting systolic blood pressure) indicating an improved model.</div></div><div><h3>Conclusions</h3><div>We present new normative data and predictive equations based on a relatively large population of healthy children/adolescents tested at moderate altitude that outperforms sea-level-based models. Among other variables (age, gender, BMI, ethnicity), altitude must be considered when reporting exercise data so that normal CPET values at moderate altitude are not misinterpreted as pathological CPET findings.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132977"},"PeriodicalIF":3.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Renin-angiotensin system inhibitors for patients with mild or moderate chronic kidney disease and heart failure with mildly reduced or preserved ejection fraction”","authors":"Shinsuke Takeuchi ,&nbsp;Takashi Kohno ,&nbsp;Ayumi Goda ,&nbsp;Shun Kohsaka ,&nbsp;Tsutomu Yoshikawa ,&nbsp;West Tokyo Heart Failure Registry Investigators","doi":"10.1016/j.ijcard.2025.132982","DOIUrl":"10.1016/j.ijcard.2025.132982","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132982"},"PeriodicalIF":3.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of obesity on cardiovascular remodeling, and aerobic capacity in adults with coarctation of aorta","authors":"Ahmed E. Ali,&nbsp;Ahmed T. Abdelhalim,&nbsp;William R. Miranda,&nbsp;Sara ElZalabany,&nbsp;Amr Moustafa,&nbsp;Ali Ali,&nbsp;Heidi M. Connolly,&nbsp;Alexander C. Egbe","doi":"10.1016/j.ijcard.2025.132970","DOIUrl":"10.1016/j.ijcard.2025.132970","url":null,"abstract":"<div><h3>Background</h3><div>We hypothesized that patients with coarctation of aorta (COA) and obesity would have more advanced cardiovascular remodeling and impaired aerobic capacity compared to COA patients without obesity. The purpose of this study was to assess the relationship between obesity, cardiovascular remodeling, and aerobic capacity in adults with repaired COA.</div></div><div><h3>Method</h3><div>The study comprised of 3 groups: (1) Obese COA group (<em>n</em>=177) (COA patients with body mass index [BMI] &gt;30 kg/m²); (2) Non-obese COA group (<em>n</em>=572) (COA patients with BMI ≤30 kg/m²); (3) Control group (<em>n</em>=59) (subjects without structural heart disease and BMI ≤30 kg/m²). Cardiovascular remodeling was assessed using the following indices: (1) Arterial stiffness - total arterial compliance index (TACI). (2) Left ventricular hypertrophy - LV mass (LVM) and relative wall thickness (RWT). (3) LV diastolic function - Doppler-derived estimated LV end-diastolic pressure (LVEDP) and Tau. (4) Right ventricular (RV)-pulmonary artery coupling - RV free wall strain and RV systolic pressure (RVFW/RVSP). Aerobic capacity was assessed using predicted peak oxygen consumption (VO₂).</div></div><div><h3>Results</h3><div>The obese COA group had higher LVM, RWT, LVEDP, and Tau, as well as lower RVFWS/RVSP, TACI and peak VO₂ compared to non-obese COA group and controls. There was a correlation between BMI and LVM (<em>r</em> = 0.39, <em>p</em> &lt; 0.001), RWT (<em>r</em> = 0.47, p &lt; 0.001), LVEDP (<em>r</em> = 0.43, <em>p</em> &lt; 0.001), tau (<em>r</em> = 0.22, <em>p</em> = 0.008), RVFWS/RVSP (<em>r</em> = − 0.24, p &lt; 0.001), and predicted peak VO₂ (<em>r</em> = −0.48, p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>These findings underscore the cardiovascular implications of obesity in the setting of COA, and provide opportunities for interventions to address obesity, and improve outcomes in this population.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132970"},"PeriodicalIF":3.2,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking hidden risks: Exercise stress echocardiography for elderly cardiac care","authors":"Sabina Istratoaie ,&nbsp;Adela Serban ,&nbsp;Erwan Donal","doi":"10.1016/j.ijcard.2025.132966","DOIUrl":"10.1016/j.ijcard.2025.132966","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132966"},"PeriodicalIF":3.2,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of low dose colchicine on long term recurrence after atrial fibrillation ablation","authors":"Mohammed Al-Sadawi ,&nbsp;Faisal Aslam ,&nbsp;Matthew D. Henriques ,&nbsp;Mahmoud Alsaiqali ,&nbsp;Chad Gier ,&nbsp;Paul Kim ,&nbsp;Ibrahim Almasry ,&nbsp;Abhijeet Singh ,&nbsp;Roger Fan ,&nbsp;Eric Rashba","doi":"10.1016/j.ijcard.2025.132972","DOIUrl":"10.1016/j.ijcard.2025.132972","url":null,"abstract":"<div><h3>Background</h3><div>Colchicine is commonly used early after atrial fibrillation (AF) ablation to reduce inflammation and reduce AF recurrence, but there is limited long-term efficacy data.</div></div><div><h3>Objective</h3><div>To evaluate the effect of low dose colchicine use on long-term AF recurrence after AF ablation.</div></div><div><h3>Methods</h3><div>From 2013 to 2021, all AF ablations performed at a single tertiary care medical center were analyzed for colchicine use, clinical and procedural characteristics, and AF recurrence. The colchicine dose was 0.3–0.6 mg once daily for 30 days. The primary outcome was AF recurrence, defined as AF detection for more than 30 s after a three-month blanking period. Propensity score matching (PSM, 1:1 match) was performed using covariates that were significant predictors of AF recurrence in prior studies. The minimum duration of follow-up was 6 months. Kaplan-Meier analysis was conducted to assess time to AF recurrence in the entire cohort and the PSM cohort.</div></div><div><h3>Results</h3><div>The study population consisted of 1568 AF ablations in 1412 patients (67 % male, age 65 ± 7 years and mean follow up 34 ± 14 months); 78 % of the patients received colchicine. Colchicine use was associated with decreased AF recurrence (HR 0.78, CI 0.63–0.96, <em>p</em> = 0.022). After PSM there were 275 patients in each group. AF recurrence was lower with colchicine (HR 0.71, CI 0.53–0.96, <em>p</em> = 0.026).</div></div><div><h3>Conclusions</h3><div>Low dose colchicine use was associated with lower long-term AF recurrence after AF ablation. A randomized, placebo-controlled trial is warranted to confirm if low dose colchicine should be used routinely after AF ablation.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"423 ","pages":"Article 132972"},"PeriodicalIF":3.2,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating trans fatty acids are related to serum levels of NT-proBNP in general population","authors":"Xiaoqian Wang ,&nbsp;Xiaotian Chen ,&nbsp;Fengjuan Jiang ,&nbsp;Yongqing Cheng ,&nbsp;Yuan Li","doi":"10.1016/j.ijcard.2025.132974","DOIUrl":"10.1016/j.ijcard.2025.132974","url":null,"abstract":"<div><h3>Background</h3><div>The consumption of trans fatty acids (TFAs) increases the risk of heart disease morbidity and mortality. However, the relationship between measurable indicators of TFAs and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in general population remains unclear.</div></div><div><h3>Methods</h3><div>1478 adult participants with complete information on circulating TFA and NT-proBNP levels from National Health and Nutrition Examination Survey (NHANES) 1999–2000 were included in our cross-sectional survey. Smooth curve fitting, multivariable linear regression and binary logistic regression were performed to analyze the relationship between TFAs and NT-proBNP. We also conducted stratified analyses and interaction terms to explore the potential modifiers of the association.</div></div><div><h3>Results</h3><div>Participants were grouped by quartiles of NT-proBNP levels. One-way ANOVA indicated significant differences in the plasma TFA concentrations across the groups. The smooth curve fitting diagram confirmed a significant linear relationship between TFAs and NT-proBNP. Multivariable linear regression analysis revealed that palmitelaidic acid, elaidic acid, vaccenic acid, linolelaidic acid and total TFAs was linearly and positively related to NT-proBNP. Stratified analyses and the interaction test showed that age, sex, and BMI did not affect the relation between them (<em>P</em> value for interaction &gt;0.05). The results of binary logistic regression indicated that participants who were in higher quartiles of elaidic acid, vaccenic acid, linolelaidic acid and total TFAs showed a higher prevalence of elevated NT-proBNP.</div></div><div><h3>Conclusion</h3><div>In a national sample of adults, circulating TFAs, regardless of their industrial or ruminant origin, were positively associated with NT-proBNP.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132974"},"PeriodicalIF":3.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}