International journal of cardiology最新文献

{"title":"A safer bet for MitraClip: Choosing between single antiplatelet therapy and dual antiplatelet therapy","authors":"Yaman Jarrar ,&nbsp;Laith Alomari ,&nbsp;Emmanuel Otabor ,&nbsp;Justin Lam ,&nbsp;Layla Ellayyan ,&nbsp;Mohamad Abboud ,&nbsp;Jaspreet Singh ,&nbsp;Jana Alomari","doi":"10.1016/j.ijcard.2025.133476","DOIUrl":"10.1016/j.ijcard.2025.133476","url":null,"abstract":"<div><h3>Background</h3><div>Optimal antithrombotic therapy after mitral valve transcatheter edge-to-edge repair (TEER) remains uncertain.</div></div><div><h3>Objective</h3><div>To compare the efficacy and safety of single antiplatelet therapy (SAPT) versus dual antiplatelet therapy (DAPT) in mitral TEER recipients.</div></div><div><h3>Methods</h3><div>We retrospectively queried the TriNetX Global Network, identifying 3325 adult patients who underwent mitral TEER, excluding those with recent coronary or aortic interventions and prior major bleeding or stroke. After propensity score matching, 900 patients each received SAPT or DAPT. Primary outcomes were ischemic stroke and gastrointestinal (GI) bleeding at 30, 90, 180 days, and one year.</div></div><div><h3>Results</h3><div>Stroke incidence was similar at every interval; at one year, it was 2.7 % with SAPT versus 2.3 % with DAPT (HR 1.15, 95 % CI 0.64–2.06; <em>p</em> = 0.91). GI bleeding risk, although trending lower with SAPT, likewise showed no significant difference, occurring in 3.6 % versus 4.0 % of patients at one year (HR 0.89, 95 % CI 0.55–1.43; <em>p</em> = 0.97). Supplementary analyses comparing clopidogrel or aspirin monotherapy with DAPT yielded similar neutral findings.</div></div><div><h3>Conclusions</h3><div>In this propensity-matched cohort, SAPT offered thromboembolic protection equivalent to DAPT through one year after mitral TEER without increasing GI bleeding risk. These data support de-escalating to SAPT after the early post-procedural phase.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133476"},"PeriodicalIF":3.2,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of pulmonary valve replacement in adolescents and adults: A nationwide population-based study","authors":"Jae Hong Lim ,&nbsp;Sungkyu Cho ,&nbsp;Jae Woong Choi ,&nbsp;Mi-Sook Kim ,&nbsp;Jinhee Kim","doi":"10.1016/j.ijcard.2025.133425","DOIUrl":"10.1016/j.ijcard.2025.133425","url":null,"abstract":"<div><h3>Objective</h3><div>A study using the National Health Insurance Service database compared bioprosthetic and mechanical pulmonary valve replacement clinical results.</div></div><div><h3>Methods</h3><div>Total of 1586 patients underwent pulmonary valve replacement from 2003 to 2021 and 1295 patients were enrolled after excluding those with previous aortic valve replacement and aged less than 13 years at operation. Bioprostheses (group B) and mechanical prostheses (group M) were used in 1085 patients (83.8 %) and 210 patients (16.2 %), respectively. Propensity score matching was performed. Sub-group analysis was performed in group B based on the materials (bovine vs. porcine).</div></div><div><h3>Results</h3><div>The mean age in group B and group M was 28.4 ± 14.5 and 33.9 ± 14.6 years old. There were no differences in operative mortality (<em>p</em> = 0.485) or postoperative complications (<em>p</em> = 0.573) between the groups. After matching, the cumulative incidence of infective endocarditis was lower in group B (<em>p</em> = 0.047). In the sub-group analysis in group B, the porcine group tended to lower reoperation rate compared to the bovine group. (before matching, <em>p</em> = 0.026; after matching <em>p</em> = 0.083).</div></div><div><h3>Conclusions</h3><div>Bioprostheses are favorable compared to mechanical prostheses due to its low complications and the avoidance of anticoagulation. Further studies with longer follow-up duration might be needed to analyze long term outcomes between bovine and porcine valves.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133425"},"PeriodicalIF":3.2,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “reassessing the role of troponin in supraventricular tachycardia: Clinical utility or contextual signal?”","authors":"Sophie B. Laursen ,&nbsp;Manan Pareek ,&nbsp;Kristian H. Kragholm ,&nbsp;Christoffer Polcwiartek ,&nbsp;Anna Meta Dyrvig Kristensen ,&nbsp;Bawer J. Tofig ,&nbsp;Morten L. Hansen ,&nbsp;Sam Riahi ,&nbsp;Tor Biering-Sørensen ,&nbsp;Christian Torp-Pedersen ,&nbsp;Christina Byrne","doi":"10.1016/j.ijcard.2025.133494","DOIUrl":"10.1016/j.ijcard.2025.133494","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133494"},"PeriodicalIF":3.2,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: REVERSE trial – Key methodological considerations in rivaroxaban's early postoperative use","authors":"Anshul Yadav ,&nbsp;Ojus Yadav ,&nbsp;Neelesh Gupta ,&nbsp;Rajeev Gupta","doi":"10.1016/j.ijcard.2025.133485","DOIUrl":"10.1016/j.ijcard.2025.133485","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133485"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic testing in inherited heart disease: Do you have the full picture?","authors":"Brittney Murray,&nbsp;Cynthia A. James","doi":"10.1016/j.ijcard.2025.133459","DOIUrl":"10.1016/j.ijcard.2025.133459","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133459"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of beta-blocker therapy in Takotsubo cardiomyopathy: A systematic review and meta-analysis","authors":"Ricardo A. Rodriguez Mejia ,&nbsp;Arminder Singh ,&nbsp;Amol Bahekar ,&nbsp;Ashish Gupta","doi":"10.1016/j.ijcard.2025.133483","DOIUrl":"10.1016/j.ijcard.2025.133483","url":null,"abstract":"<div><h3>Background</h3><div>Takotsubo cardiomyopathy (TTC) is a stress-induced condition with limited evidence-based treatment options. Beta-blockers are commonly used, yet their efficacy remains uncertain. This meta-analysis evaluates the impact of beta-blocker therapy on mortality and recurrence in TTC patients.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, EMBASE, Cochrane Library, Web of Science, Google Scholar, and Semantic Scholar, alongside trial registries and grey literature, for studies from inception to March 2025. Included studies examined adult TTC patients treated with beta-blockers versus controls, reporting all-cause mortality and recurrence. Odds ratios (ORs) with 95 % confidence intervals (CIs) were pooled using a random-effects model. Heterogeneity was assessed with I² statistics, and publication bias was evaluated via funnel plots. Subgroup analyses stratified studies by design (retrospective, prospective, mixed) to assess methodological heterogeneity. A meta-regression explored ejection fraction (EF) as a moderator of mortality outcomes.</div></div><div><h3>Results</h3><div>Nineteen studies (<em>n</em> = 11,167 patients, predominantly female, mean age 59–74 years) were included. Beta-blocker therapy significantly reduced all-cause mortality by 28 % (OR 0.72, 95 % CI: 0.62–0.84, <em>p</em> &lt; 0.001; I² = 30 %) with consistent effects across study designs (between-subgroup heterogeneity <em>p</em> = 0.86). Subgroup analyses showed a non-significant 21 % reduction in 1-year mortality (OR 0.79, 95 % CI: 0.54–1.16, <em>p</em> = 0.23; I² = 52 %) and a significant 29 % reduction in 2–5-year mortality (OR 0.71, 95 % CI: 0.61–0.82, <em>p</em> &lt; 0.001; I² = 7 %). Recurrence decreased by 29 % overall (OR 0.71, 95 % CI: 0.52–0.97, <em>p</em> = 0.03; I² = 57 %), with significant protective effects in mixed (OR 0.595) and retrospective (OR 0.485) studies but not prospective studies (OR 0.842), demonstrating significant between-subgroup heterogeneity (<em>p</em> = 0.01). Meta-regression showed no significant moderation of mortality by EF (<em>p</em> = 0.64), suggesting consistent benefits across cardiac function levels.</div></div><div><h3>Conclusions</h3><div>Beta-blockers significantly reduce long-term mortality and recurrence in TTC. While mortality benefits are consistent across study designs, recurrence outcomes show methodological sensitivity, with stronger evidence from mixed and retrospective studies. Benefits are more pronounced with sustained therapy, with no variation by EF. These findings support beta-blocker use in long-term TTC management, though randomized trials are needed to confirm causality and optimize protocols.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133483"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-based differences in patients with Loeys-Dietz syndrome: An analysis of arteriopathies and surgical interventions","authors":"Hussein Abdul Nabi ,&nbsp;George Bcharah ,&nbsp;Luke Dreher ,&nbsp;Hend Bcharah ,&nbsp;Mahmoud Abdelnabi ,&nbsp;Ramzi Ibrahim ,&nbsp;Fares Jamal ,&nbsp;Amal Youssef ,&nbsp;Linnea M. Baudhuin ,&nbsp;Yuxiang Wang ,&nbsp;Mayowa A. Osundiji ,&nbsp;Fadi E. Shamoun","doi":"10.1016/j.ijcard.2025.133477","DOIUrl":"10.1016/j.ijcard.2025.133477","url":null,"abstract":"<div><h3>Background</h3><div>Loeys-Dietz syndrome (LDS) is a rare connective tissue disorder caused by variants in genes like TGFBR1, TGFBR2, TGFB2, TGFB3, and SMAD3, leading to vascular abnormalities such as aneurysms and dissections. This study examines sex-based differences in the clinical presentation of LDS, focusing on comorbidities, physical exam findings, vascular events, and surgeries.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on 94 LDS patients (47 males and 47 females) at Mayo Clinic locations in Arizona, Rochester, and Florida. Data were collected from chart reviews, including comorbidities, physical exam findings, vascular events, and surgeries. Statistical analysis included Chi-square tests to compare the two groups.</div></div><div><h3>Results</h3><div>Among the cohort, females had higher rates of obesity (23.4 % vs. 8.5 %, <em>p</em> = 0.049) and migraines (44.7 % vs. 21.3 %, <em>p</em> = 0.027). Females also had more easy bruising (31.9 % vs. 8.5 %, <em>p</em> = 0.005), while dolichocephaly was more common in males (21.3 % vs. 6.4 %, <em>p</em> = 0.036). Males had more aneurysms and dissections, including ascending aortic (89.4 % vs. 72.3 %, p = 0.036) and abdominal aortic aneurysms (34 % vs. 10.6 %, <em>p</em> = 0.006), and aneurysms in other locations (63 % vs. 42.6 %, <em>p</em> = 0.048). Type A and B aortic dissections were also more common in males (21.3 % vs. 6.4 %, <em>p</em> = 0.036). Males had more aortic root replacements (74.5 % vs. 53.2 %), while females had more tricuspid valve repairs (19.1 % vs. 2.1 %, <em>p</em> = 0.007).</div></div><div><h3>Conclusion</h3><div>This study highlights significant gender differences in LDS, particularly in vascular events and surgical interventions. Males are more likely to experience aneurysms and dissections and undergo aortic root replacement. These findings stress the importance of considering sex-based factors in LDS management.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133477"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual energy CT-based Radiomics for identification of myocardial focal scar and artificial beam-hardening","authors":"Linqi Zeng ,&nbsp;Feng Hu ,&nbsp;Peixin Qin ,&nbsp;Taoyu Jia ,&nbsp;Ling Lu ,&nbsp;Zhengying Yang ,&nbsp;Xiaobing Zhou ,&nbsp;Yuqing Qiu ,&nbsp;Liyun Luo ,&nbsp;Bairong Chen ,&nbsp;Lizi Jin ,&nbsp;Wenyi Tang ,&nbsp;Yanlin Wang ,&nbsp;Fang Zhou ,&nbsp;Tianmin Liu ,&nbsp;Ani Wang ,&nbsp;Zhijuan Zhou ,&nbsp;Xiaosheng Guo ,&nbsp;Zhiwei Zheng ,&nbsp;Xiuwu Fan ,&nbsp;Cunxue Pan","doi":"10.1016/j.ijcard.2025.133482","DOIUrl":"10.1016/j.ijcard.2025.133482","url":null,"abstract":"<div><h3>Background</h3><div>Computed tomography is an inadequate method for detecting myocardial focal scar (MFS) due to its moderate density resolution, which is insufficient for distinguishing MFS from artificial beam-hardening (BH). Virtual monochromatic images (VMIs) of dual-energy coronary computed tomography angiography (DECCTA) provide a variety of diagnostic information with significant potential for detecting myocardial lesions. The aim of this study was to assess whether radiomics analysis in VMIs of DECCTA can help distinguish MFS from BH.</div></div><div><h3>Methods</h3><div>A prospective cohort of patients who were suspected with an old myocardial infarction was assembled at two different centers between Janurary 2021 and June 2024. MFS and BH segmentation and radiomics feature extraction and selection were performed on VMIs images, and four machine learning classifiers were constructed using selected strongest features. Subsequently, an independent validation was conducted, and a subjective diagnosis of the validation set was provided by an radiologist. The AUC was used to assess the performance of the radiomics models.</div></div><div><h3>Result</h3><div>The training set included 57 patients from center 1 (mean age, 54 years +/− 9, 55 men), and the external validation set included 10 patients from center 2 (mean age, 59 years +/− 10, 9 men). The radiomics models exhibited the highest AUC value of 0.937 (expressed at 130 keV VMIs), while the radiologist demonstrated the highest AUC value of 0.734 (expressed at 40 keV VMIs).</div></div><div><h3>Conclusion</h3><div>The integration of radiomic features derived from VMIs of DECCTA with machine learning algorithms has the potential to improve the efficiency of distinguishing MFS from BH.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133482"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular strain parameters in patients with alcoholic cardiomyopathy","authors":"Li-Rong Mo,&nbsp;Qiang Su,&nbsp;Yu Chen","doi":"10.1016/j.ijcard.2025.133487","DOIUrl":"10.1016/j.ijcard.2025.133487","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133487"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: “Mechanical outcomes of coronary stenting guided by intravascular ultrasound versus optical coherence tomography: A systematic review and meta-analysis with trial sequential analysis of randomized trials”","authors":"Xuan Guo,&nbsp;RongBo Yu,&nbsp;Qiang Wu","doi":"10.1016/j.ijcard.2025.133489","DOIUrl":"10.1016/j.ijcard.2025.133489","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133489"},"PeriodicalIF":3.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}