International journal of cardiology最新文献

{"title":"Reoperative mitral valve surgery in the UK: 20-year trends and early outcomes","authors":"Luke J. Rogers ,&nbsp;Tim Dong ,&nbsp;Rahul Kota ,&nbsp;Jeremy Chan ,&nbsp;Saifullalah Mohamed ,&nbsp;Franco Ciulli ,&nbsp;Gianni D. Angelini ,&nbsp;Daniel Fudulu","doi":"10.1016/j.ijcard.2025.133602","DOIUrl":"10.1016/j.ijcard.2025.133602","url":null,"abstract":"<div><h3>Introduction</h3><div>Mitral valve surgery has undergone significant expansion and improvement in early in-hospital mortality over the last 20 years. At the same time, a considerable decline seems to have occurred in reoperative mitral valve surgery, which remains a relatively high-risk procedure. We investigated the trends, early outcomes and predictors of complications in patients undergoing RMV over 20 years in the United Kingdom.</div></div><div><h3>Methods</h3><div>The UK National Adult Cardiac Surgery Audit database was used to retrospectively analyse patients who underwent reoperative mitral valve surgery (<em>n</em> = 1239). These were then compared with a cohort of patients who underwent primary mitral valve surgery (<em>n</em> = 47,213) during the same period, from November 1, 1998, to March 30, 2019. We investigated in-hospital outcomes and examined predictors of adverse outcomes in patients undergoing reoperative mitral valve surgery.</div></div><div><h3>Results</h3><div>The proportion of reoperative mitral valve surgery out of all mitral procedures decreased significantly between 1999 and 2001, from 7.31 % to 3.44 %. After this time point, the percentage remained relatively steady, ranging from 1.8 % to 3.45 %. Of the 1239 reoperative mitral valve surgery, most were replacements 1127 (91 %). When compared to primary mitral valve surgery, reoperative mitral valve surgery were associated with a significantly increased mortality (13 % vs 5.2 %), requirement for dialysis (14 % vs 5.2 %), cerebrovascular event (CVE,2.4 % vs 1.2 %), return to theatre for bleeding (8.3 % vs 5.3 %) and increased length of stay (15 vs 11 days) (all, <em>p</em> &lt; 0.001). After adjustment for baseline characteristics, reoperative mitral valve surgery was still associated with increased mortality (OR1.92; CI1.53–2.43; <em>p</em> &lt; 0.001), CVE (OR1.32, CI1.05–1.65; <em>p</em> = 0.027) and dialysis (OR1.91; CI1.5–2.42, p &lt; 0.001), compared to primary mitral valve surgery. The predictors for increased in-hospital mortality in the reoperative mitral valve surgery cohort were old age (OR 1.4, CI 1.00–1.08), creatinine &gt;200 μmol/L (OR 3.86, CI 1.93–7.70, <em>p</em> &lt; 0.001), need for emergency surgery (OR 2.18, CI 1.06–4.47, <em>p</em> = 0.034) and increased aortic cross-clamp time (OR 1.02, CI 1:00–1.03).</div></div><div><h3>Conclusion</h3><div>The incidence of reoperative mitral valve surgery has decreased in the UK over the first decade, most notably after 2001. Despite some variations, the volume remained steady in the second decade. Reoperative mitral valve surgery mortality and associated morbidity remain relatively high.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133602"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early catheter ablation versus conservative- only management in patients with electrical storm. Systematic review and meta- analysis","authors":"Ioannis Anagnostopoulos ,&nbsp;Dimitrios Vrachatis ,&nbsp;Maria Kousta ,&nbsp;Sotiria Giotaki ,&nbsp;Dimitra Katsoulotou ,&nbsp;Christos Karavasilis ,&nbsp;Gerasimos Deftereos ,&nbsp;Nikolaos Schizas ,&nbsp;Dimitrios Avramides ,&nbsp;Georgios Giannopoulos ,&nbsp;Spyridon Deftereos","doi":"10.1016/j.ijcard.2025.133597","DOIUrl":"10.1016/j.ijcard.2025.133597","url":null,"abstract":"<div><h3>Background</h3><div>Electrical storm (ES) is a life- threatening condition. Both recurrence and mortality rates remain unacceptably high. Current guidelines recommend initial conservative approach using anti-arrhythmic drugs (AADs), followed by catheter ablation (CA) for those with refractory ES.</div></div><div><h3>Methods</h3><div>We searched PubMed and Scopus for articles comparing an initial conservative approach - based on AADs/ sedation- with an early referral for CA approach. The primary endpoint was long term mortality, while secondary endpoints included ES recurrence and the incidence of ventricular arrhythmias (VAs)/ defibrillator shocks during the follow- up.</div></div><div><h3>Results</h3><div>Seven studies, primarily observational cohorts, were analyzed. The pooled population (999 patients) consisted mostly of males with ischemic cardiomyopathy, presenting with ventricular tachycardias (VTs). The mean left ventricular ejection fraction was 35.5 % (9.5 %). 493 patients were treated with CA during the index hospitalization. Early CA was associated with significantly lower long- term mortality (OR: 0.44, 95 %CI: 0.31–0.63). Additionally, it was associated with lower rates of both ES recurrence and VAs/ shocks during the follow- up (OR: 0.27, 95 %CI: 0.15–0.48 and OR: 0.33, 95 %CI: 0.21–0.52, respectively).</div></div><div><h3>Conclusions</h3><div>Meta- analysis of primarily observational studies revealed that early referral of ES patients for CA may improve their prognosis. The invasive approach was associated with lower mortality and reduced recurrence rates of major arrhythmic events. Although some inherent limitations affect the strength of these findings, they remain promising. They highlight the need for further research on the topic, as their confirmation in randomized trials could lead to a shift in the standard of care of ES patients.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133597"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectory, correlates, and outcomes of pulmonary congestion by lung ultrasound in patients hospitalized for acute pulmonary edema","authors":"Ryu Takagi ,&nbsp;Masatake Kobayashi ,&nbsp;Asuka Kuwahara ,&nbsp;Kazuya Takihara ,&nbsp;Yuki Yamashita ,&nbsp;Haruyuki Deguchi ,&nbsp;Masato Nukariya ,&nbsp;Yuki Nagamatsu ,&nbsp;Tomoaki Nakayama ,&nbsp;Miki Kitamura ,&nbsp;Taiyo Tezuka ,&nbsp;Kazumasa Ikeda ,&nbsp;Shuichiro Kazawa ,&nbsp;Ryosuke Ito ,&nbsp;Yoichi Iwasaki ,&nbsp;Satoshi Yamada ,&nbsp;Luna Gargani ,&nbsp;Kevin Duarte ,&nbsp;Takashi Kubo ,&nbsp;Kazuhiro Satomi ,&nbsp;Nobuhiro Tanaka","doi":"10.1016/j.ijcard.2025.133599","DOIUrl":"10.1016/j.ijcard.2025.133599","url":null,"abstract":"<div><h3>Aims</h3><div>Patients with acute pulmonary edema (APE) requiring an urgent heart failure (HF) hospitalization face poor prognosis largely due to pulmonary congestion. We aimed at assessing the patterns and variations of pulmonary congestion associated with different assessments of congestion and prognosis.</div></div><div><h3>Methods</h3><div>This prospective study included patients with APE who underwent lung ultrasound (8-zone B-lines method) and echocardiography immediately after emergency department visit, with follow-up assessments on days 2, 3, 7, and discharge. B-type natriuretic peptide (BNP) levels were measured at admission, day 7, and discharge. The associations between B-line changes, other congestion marker changes and outcomes were assessed.</div></div><div><h3>Results</h3><div>Among 137 patients (mean age: 77 ± 13 years; 61 % male), 71 % had New York Heart Association IV, 65 % had left ventricular ejection fraction &lt;45 %, and median B-lines were 44 (32–58) on admission. While B-lines showed no association with other congestion markers at admission, they correlated significantly with pulmonary artery systolic pressure (PASP) from day 2 to discharge, and with E/e´ and BNP at day 7 and discharge. Throughout hospitalization, B-line changes consistently correlated with changes in other congestion markers (E/e´, PASP, and BNP) (all-<em>p</em>-values&lt;0.05). Among congestion markers, B-lines showed the most prominent reduction from admission to day 2, and this reduction was associated with a lower risk of all-cause mortality or HF rehospitalization over a median 217-day follow-up (adjusted-HR, 95 %CI = 0.96, 0.94–0.99; <em>p</em> = 0.01).</div></div><div><h3>Conclusions</h3><div>In APE, B-lines lacked association with other congestion markers immediately after hospitalization. However, B-lines decreased noticeably from admission to day 2, with changes correlating with other markers and prognosis.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133599"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of CMR-derived ECV in MINOCA patients: Progress and remaining challenges","authors":"Jianyong Wang ,&nbsp;Dezhi Li ,&nbsp;Guozhen Chen","doi":"10.1016/j.ijcard.2025.133591","DOIUrl":"10.1016/j.ijcard.2025.133591","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133591"},"PeriodicalIF":3.2,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on the prognostic value of hybrid CCTA-PET in coronary artery disease","authors":"Zhen Li,&nbsp;Gang Wang","doi":"10.1016/j.ijcard.2025.133592","DOIUrl":"10.1016/j.ijcard.2025.133592","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133592"},"PeriodicalIF":3.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world comparative effectiveness of angiotensin-neprilysin inhibition versus angiotensin receptor blockers in acute myocardial infarction","authors":"Shanshan Tang ,&nbsp;Linjie Li ,&nbsp;Hejun Chen ,&nbsp;Geru Aa ,&nbsp;Hangkuan Liu ,&nbsp;Shichen Jiang ,&nbsp;Yulong Wang ,&nbsp;Qing Yang ,&nbsp;Pengfei Sun ,&nbsp;Xin Zhou ,&nbsp;Yongle Li","doi":"10.1016/j.ijcard.2025.133543","DOIUrl":"10.1016/j.ijcard.2025.133543","url":null,"abstract":"<div><h3>Background</h3><div>Angiotensin-neprilysin inhibition (ARNI) reduces mortality and morbidity in chronic heart failure, but its efficacy in acute myocardial infarction (MI) remains uncertain. This study compares ARNI versus angiotensin receptor blockers (ARB) in acute MI patients.</div></div><div><h3>Methods and results</h3><div>This cohort study used a target trial emulation approach to include acute MI patients between 2019 and 2022 from the Tianjin Health and Medical Data Platform, China. Eligible patients newly prescribed ARB or ARNI during hospitalization were matched 1:1 using propensity scores. The primary outcome was all-cause mortality at 30 days and 1 year. Time-dependent hazard ratio (HR) was used to the explore potential benefit window of ARNI. The matched cohort included 10,480 patients (5240 per group) for intention-to-treat analysis, with 701 deaths (6.7 %) recorded. Compared with ARB, ARNI was significantly associated with a lower 30-day mortality risk (HR: 0.68, 95 % confidence interval [CI]: 0.52–0.88) but showed no association with 1-year mortality (HR: 0.99, 95 % CI: 0.85–1.14). Exploratory analysis indicates that the beneficial effect of ARNI extends to 60 days (HR: 0.68, 95 % CI: 0.52–0.88). No significant differences were observed for recurrent MI (HR: 0.98, 95 % CI: 0.87–1.10) or stroke (HR: 1.15, 95 % CI: 0.98–1.35). Subgroup analysis indicated a particular benefit of ARNI in heart failure patients at 60 days (HR: 0.75, 95 % CI: 0.58–0.96).</div></div><div><h3>Conclusions</h3><div>In patients with acute MI, ARNI was associated with improved survival compared to ARB within the first 60 days. This survival benefit diminished over time, with no significant difference observed at 1-year follow-up.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133543"},"PeriodicalIF":3.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial dysfunction assessed by the endothelial activation and stress index (EASIX) predicts risk of mortality in chronic heart failure patients","authors":"Bent Estler ,&nbsp;Hanna Fröhlich ,&nbsp;Tobias Täger ,&nbsp;Hauke Hund ,&nbsp;Norbert Frey ,&nbsp;Thomas Luft ,&nbsp;Lutz Frankenstein","doi":"10.1016/j.ijcard.2025.133566","DOIUrl":"10.1016/j.ijcard.2025.133566","url":null,"abstract":"<div><h3>Background</h3><div>Endothelial dysfunction accompanies chronic heart failure (CHF) but is hard to quantify in routine practice. The Endothelial Activation and Stress Index (EASIX), calculated from creatinine, lactate dehydrogenase, and platelets, predicts mortality and complications in conditions like allogeneic stem cell transplantation, COVID-19, and coronary artery disease.</div><div>Aim</div><div>To evaluate if EASIX is a prognostic biomarker in patients with CHF.</div></div><div><h3>Methods</h3><div>Training (<em>n</em> = 1796) and validation cohorts (n = 1796) included all patients from the outpatients' CHF registry of the University of Heidelberg, Germany, with available laboratory parameters for EASIX calculations at first clinical presentation. Five-year overall survival was assessed by multivariable Cox regression adjusting for age, sex, New York Heart Association (NYHA) score, etiology of heart failure, heart failure category, and NT- proBNP as covariates. Fractional polynomials modeled non-linear relationships, and prognostic performance was evaluated using the Brier score and concordance index.</div></div><div><h3>Results</h3><div>EASIX moderately correlated with NT- proBNP, NYHA stage and left ventricular ejection fraction (LVEF), and associated with increased hazard of death in both cohorts (hazard ratio (HR) per log2 increase: training 1.51 (1.14–2.01), <em>p</em> &lt; 0.01; validation 1.59 (1.25–2.01, <em>p</em> &lt; 0.001). The effect was consistent across all etiologies, classes and stages of heart failure as assessed by fractional polynomials. Pre-established EASIX cut-offs independently predicted increased risk of mortality (cut-off 2.32: training: HR 2.14 (1.52–3.02), <em>p</em> &lt; 0.001; validation: HR 3.34 (1.88–5.93), <em>p</em> &lt; 0.0001). Both models (continuous and discrete EASIX values) were validated in the validation cohort using integrated Brier score and C-index.</div></div><div><h3>Conclusions</h3><div>EASIX is a novel biomarker to predict risk of mortality in patients with CHF.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133566"},"PeriodicalIF":3.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Never enough; inertia across clinical practice and guidelines in lipid-lowering therapy for STEMI","authors":"Hyun-Jong Lee","doi":"10.1016/j.ijcard.2025.133580","DOIUrl":"10.1016/j.ijcard.2025.133580","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133580"},"PeriodicalIF":3.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the letter to the editor for the” left ventricular strain parameters in patients with alcoholic cardiomyopathy”","authors":"Yue Ren,&nbsp;Shuang Li,&nbsp;Lei Xu","doi":"10.1016/j.ijcard.2025.133590","DOIUrl":"10.1016/j.ijcard.2025.133590","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133590"},"PeriodicalIF":3.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to letter to the editor: “Performance evaluation of four scoring systems for mortality prediction in a contemporary cardiac intensive care unit” by B. Wang and Y. Wu","authors":"Pavlos Koutsoumpos ,&nbsp;Christina Routsi ,&nbsp;Stelios Kokkoris ,&nbsp;on behalf of all authors","doi":"10.1016/j.ijcard.2025.133579","DOIUrl":"10.1016/j.ijcard.2025.133579","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133579"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}