International journal of cardiology最新文献

{"title":"Long term outcomes post-ICD in Chagas cardiomyopathy and non-ischemic cardiomyopathy: A comparative analysis","authors":"Francisca Tatiana Pereira Gondim ,&nbsp;Eduardo Arrais Rocha ,&nbsp;Neiberg de Alcantara Lima ,&nbsp;Rosa Livia Freitas de Almeida ,&nbsp;David Martin ,&nbsp;Marcelo de Paula Martins Monteiro ,&nbsp;Aloisio Sales Barbosa Gondim ,&nbsp;Davi Sales Pereira Gondim ,&nbsp;Pedro Sales Pereira Gondim ,&nbsp;Roberto da Justa Pires Neto","doi":"10.1016/j.ijcard.2025.132998","DOIUrl":"10.1016/j.ijcard.2025.132998","url":null,"abstract":"<div><h3>Background</h3><div>Chagas cardiomyopathy (CCM) is a significant cause of ventricular arrhythmias and sudden cardiac death (SCD). Although, implantable cardiac defibrillators (ICD) have been used for all forms of non-ischemic cardiomyopathy (NICM), studies on ICD efficacy in CCM are scarce.</div></div><div><h3>Objective</h3><div>The present study aims to compare the long-term outcomes, mortality rates, and the occurrence of tachycardia therapies after ICD implantation in patients with CCM and NICM.</div></div><div><h3>Methods</h3><div>The study was conducted over an 18-year period beginning in 2003. The primary outcome of this study was the difference in appropriate ICD therapies and mortality among patients in a single center receiving implant for CCM or NICM management. As a secondary outcome, we compared inappropriate shocks, presence of incessant ventricular tachycardia/electrical storm, and SCD.</div></div><div><h3>Results</h3><div>The study included 207 patients (117 with CCM and 90 with NICM). The median follow-up time was 61 months [25–121] in the CCM group and 56.5 months [23–119] in the NICD group. During follow up, 39.3 % (46 patients) died in the CCM group and 5.6 % (5 patients) in the NICM group. Appropriate shocks, appropriate therapies, ATP, electrical storm and inappropriate shocks were all more frequent in patients with CCM.</div></div><div><h3>Conclusion</h3><div>CCM patients experienced higher mortality and more frequent appropriate ICD interventions compared to patients with NICM. ICDs appear effective and safe for long-term management in CCM.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"423 ","pages":"Article 132998"},"PeriodicalIF":3.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single RBM20 missense variant is a potential contributor to dilated cardiomyopathy and/or isolated left ventricular dilatation in the Emilia Romagna region of Italy","authors":"Samuela Carigi ,&nbsp;Giulia Olivucci ,&nbsp;Carlotta Pia Cristalli ,&nbsp;Francesca Marzo ,&nbsp;Federica Isidori ,&nbsp;Silvia Palmieri ,&nbsp;Maria Alessandra Schiavo ,&nbsp;Francesca Gualandi ,&nbsp;Silvia Amati ,&nbsp;Luca Maria Rocchetti ,&nbsp;Giulia Parmeggiani ,&nbsp;Luigi Monti ,&nbsp;Elisa Gardini ,&nbsp;Michela Bartolotti ,&nbsp;Milva Gobbi ,&nbsp;Anna Maria Di Cesare ,&nbsp;Giovanni Andrea Luisi ,&nbsp;Maddalena Graziosi ,&nbsp;Elena Biagini ,&nbsp;Luciano Potena ,&nbsp;Claudio Graziano","doi":"10.1016/j.ijcard.2025.132999","DOIUrl":"10.1016/j.ijcard.2025.132999","url":null,"abstract":"<div><h3>Background</h3><div>non-syndromic dilated cardiomyopathy (DCM) is found to correlate with a genetic cause in 30–40 % of cases. The identification of a causative gene variant can guide treatment options and cascade testing of at-risk family members. Cardiomyopathy multigene panels are routinely used to identify the genetic cause, but often detect variants of uncertain significance (VUS). Pathogenic variants in <em>RBM20</em> have been reported to account for 2–6 % of familial DCM, but geographic differences can be relevant.</div></div><div><h3>Methods</h3><div>we collected clinical information, cardiac imaging and family history of 101 individuals with DCM, non-dilated left ventricular cardiomyopathy (NDLVC) and isolated left ventricular dilatation from the Emilia-Romagna Region of Italy. Every subject underwent genetic testing through a next generation sequencing panel of genes related to cardiomyopathies. Analysis of single nucleotide polymorphisms (SNP) was used for haplotype analyses.</div></div><div><h3>Results and conclusions</h3><div>in our cohort, seven individuals (7 %) carried the same heterozygous variant in <em>RBM20</em> (chr10–110,821,350-G-A; c.2731G &gt; A; p.Val911Met). The referring laboratories reported four further subjects, for a total of 11 unrelated individuals with DCM or isolated left ventricular dilatation from the same geographical area carrying the same variant. These individuals showed high arrhythmic burden and a possible unfavorable evolution towards advanced heart failure. According to guidelines, this variant is classified as VUS; however, its absence in a large local control database and its clinical consistency among affected subjects supports its contributing role. SNP analysis unveiled a common haplotype in the carriers of this variant, suggesting a founder effect. We emphasize the importance of this finding in terms of diagnosis, management and cascade testing of family members.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"423 ","pages":"Article 132999"},"PeriodicalIF":3.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of cardiac output in different stages of heart failure","authors":"Kazuki Kagami,&nbsp;Masaru Obokata","doi":"10.1016/j.ijcard.2025.133001","DOIUrl":"10.1016/j.ijcard.2025.133001","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"423 ","pages":"Article 133001"},"PeriodicalIF":3.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and atrial fibrillation-associated risk estimation and management","authors":"Anke C. Fender ,&nbsp;Florian Bruns ,&nbsp;Dobromir Dobrev","doi":"10.1016/j.ijcard.2025.133000","DOIUrl":"10.1016/j.ijcard.2025.133000","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"423 ","pages":"Article 133000"},"PeriodicalIF":3.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravascular lithotripsy in calcified left main coronary artery: Procedural success and 1-year clinical outcomes","authors":"Federico Oliveri MD ,&nbsp;Martijn J.H. van Oort MsC ,&nbsp;Akshay A.S. Phagu Msc ,&nbsp;Ibtihal Al Amri MD, PhD ,&nbsp;Brian O. Bingen MD, PhD ,&nbsp;Bimmer E.P.M. Claessen MD,PhD ,&nbsp;Aukelien C. Dimitriu-Leen MD, PhD ,&nbsp;Joelle Kefer MD, PhD ,&nbsp;Hany Girgis MD, PhD ,&nbsp;Tessel Vossenberg MD, PhD ,&nbsp;Frank Van der Kley MD, PhD ,&nbsp;J. Wouter Jukema MD, PhD ,&nbsp;Josè M. Montero-Cabezas MD, PhD","doi":"10.1016/j.ijcard.2025.132996","DOIUrl":"10.1016/j.ijcard.2025.132996","url":null,"abstract":"<div><h3>Background</h3><div>Intravascular lithotripsy (IVL) has an excellent efficacy and safety profile in the treatment of calcified coronary lesions during percutaneous coronary intervention (PCI). However, data regarding its use on left main (LM) lesions are still limited.</div></div><div><h3>Objective</h3><div>We aimed to analyze the technical success and 1-year clinical outcomes in calcified LM lesions treated with IVL.</div></div><div><h3>Methods</h3><div>Patients who underwent IVL from the ongoing prospective BENELUX registry were eligible for inclusion. Patients were divided into LM and non-LM groups based on the anatomical application of the IVL pulses. The primary technical endpoint was technical success, defined as the successful delivery of the IVL catheter across the target lesion, administration of IVL pulses without angiographic complications, and achieving a residual target lesion stenosis of less than 30 %. The primary safety endpoint was in-hospital major adverse cardiac events (MACE).</div></div><div><h3>Results</h3><div>The study included 509 patients (59 LM and 450 non-LM). Patients in the LM group were significantly older (79 years [75–82] vs. 73 years [68–81], <em>p</em> &lt; 0.01). Left ventricular ejection fraction was slightly lower in the LM group (41 % [19–50] vs. 51 % [40–60], <em>p</em> = 0.053). Temporary mechanical circulatory support devices were more frequently used in the LM group, primarily as part of the “protected PCI” strategy (6.8 % in LM vs. 2.1 % in non-LM, <em>p</em> = 0.04). Technical success was comparable between the two groups (93.2 % in LM vs. 89.8 % in non-LM, <em>p</em> = 0.41). Cardiac death, MACE, and target vessel revascularization rates were also comparable at hospital discharge, 30 days, and 1-year follow-up.</div></div><div><h3>Conclusion</h3><div>IVL in calcified LM lesions achieved comparable technical success and long-term clinical outcomes to non-LM lesions.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"423 ","pages":"Article 132996"},"PeriodicalIF":3.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular risk emerges earlier by birth weight and preterm birth status in the United States Add Health sample","authors":"Michelle M. Kelly ,&nbsp;Margaret Brace","doi":"10.1016/j.ijcard.2025.132994","DOIUrl":"10.1016/j.ijcard.2025.132994","url":null,"abstract":"<div><h3>Background</h3><div>Preterm birth and low birth weight are associated with an increased risk of chronic conditions such as hypertension, diabetes and cardiovascular disease, which significantly contribute to increased mortality. Much of the literature supporting these assertions are from countries outside of the United States. The current study aims to explore the relationship between preterm birth and birth weight status, and cardiovascular risk emergence among young adults in the United States.</div></div><div><h3>Methods</h3><div>The National Longitudinal Study of Adolescent Health (Add Health) is a nationally representative sample from the United States. Survival analyses were conducted that compare the onset of high blood pressure, high cholesterol and diabetes across the sample members categorized by preterm birth and birth weight status. Body mass index was investigated for potential mediation for timing of diagnosis.</div></div><div><h3>Results</h3><div>Across health outcomes, there was no evidence that BMI acted as a mediator between preterm low birth weight status and the timing of diagnoses. Preterm low birth weight participants were diagnosed with diabetes approximately 12 % earlier compared to normal birth weight groups. Effect sizes for full term low birth weight were small across high cholesterol and hypertension, but not significant in this sample.</div></div><div><h3>Conclusions &amp; relevance</h3><div>This analysis highlights the importance of both preterm birth and birth weight in influencing adolescent and adult health. The two components are inextricably linked and contribute significantly to comorbidity. Risk mitigation through proactive lifestyle counseling and early treatment are critical to health risk mitigation for those born early or small.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"423 ","pages":"Article 132994"},"PeriodicalIF":3.2,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Canary in the Coal Mine: Left atrial function in heart failure","authors":"Tadafumi Sugimoto","doi":"10.1016/j.ijcard.2025.132989","DOIUrl":"10.1016/j.ijcard.2025.132989","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"423 ","pages":"Article 132989"},"PeriodicalIF":3.2,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining the bleeding risk assessment in patients on DAPT","authors":"Remo Holanda de Mendonca Furtado","doi":"10.1016/j.ijcard.2025.132995","DOIUrl":"10.1016/j.ijcard.2025.132995","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"423 ","pages":"Article 132995"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regarding clinical profiles of chronic kidney disease in heart failure with reduced and preserved ejection fraction","authors":"Yan Chen ,&nbsp;Xin-Hua Yang ,&nbsp;Yuan-Lin Cheng ,&nbsp;Qing Zhou","doi":"10.1016/j.ijcard.2025.132992","DOIUrl":"10.1016/j.ijcard.2025.132992","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"423 ","pages":"Article 132992"},"PeriodicalIF":3.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NSUN2/PARP1 signaling axis: A potential mechanism for treating aging-associated atrial fibrillation","authors":"Zhi-Xing Fan,&nbsp;Jian Yang","doi":"10.1016/j.ijcard.2025.132993","DOIUrl":"10.1016/j.ijcard.2025.132993","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"422 ","pages":"Article 132993"},"PeriodicalIF":3.2,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}