International journal of cardiology最新文献

{"title":"Letter to the editor: Prediction of adverse cardiovascular events in children using artificial intelligence-based electrocardiogram","authors":"Marium Kadir, Shorrem Naeem","doi":"10.1016/j.ijcard.2025.133500","DOIUrl":"10.1016/j.ijcard.2025.133500","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133500"},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Independent effect of influenza vaccination on all-cause mortality in critically ill patients with atrial fibrillation: A retrospective study from the MIMIC-IV database","authors":"Xianglin Long , Junxi Li","doi":"10.1016/j.ijcard.2025.133502","DOIUrl":"10.1016/j.ijcard.2025.133502","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133502"},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel algorithm based on left atrial strain parameters in patients with non-valvular atrial fibrillation could identify the thrombogenic milieu of left atrial appendage","authors":"Bo Su ,&nbsp;Junyu Zhao ,&nbsp;Xinjia Dai ,&nbsp;Changsheng Ma","doi":"10.1016/j.ijcard.2025.133498","DOIUrl":"10.1016/j.ijcard.2025.133498","url":null,"abstract":"<div><h3>Background</h3><div>The role of the new derived parameters of left atrial (LA) strain in cardioembolic risk stratification is unknown, besides, new algorithm is needed to provide incremental value of cardioembolic risk stratification in patients with atrial fibrillation (AF), especially in those with CHA2DS2-VASc score of 0–2.</div></div><div><h3>Methods</h3><div>We enrolled 566 consecutive subjects with non-valvular AF, who underwent transesophageal echocardiography. Left atrial appendage (LAA) thrombogenic milieu, as a surrogate for cardioembolic risk, was defined as the presence of a thrombus, severe spontaneous echo contrast, or sludge in the LAA. The impaired LAA emptying velocity was defined as LAA emptying velocity ≤ 30 cm/s. To classify LAA thrombogenic milieu, a decision tree analysis was performed to explore the way of the combination characteristic echocardiographic variables. LA strain parameters includes left atrial reservoir strain (LASr), left atrial systolic stain rate (LASRr), LA filling index, LA filling rate, LA stiffness index, and LA stiffness rate.</div></div><div><h3>Results</h3><div>Among the 566 subjects, 176 (31.1 %) identified with LAA thrombogenic milieu. Compared those without, LA filling index, LA filling rate, LA stiffness index, and LA stiffness rate was significantly increased in the patients with LAA thrombogenic milieu. The multiple logistic regression analysis suggested that left atrial strain parameters (respectively) were independently correlated with LAA thrombogenic milieu. Left atrial strain parameters (AUC: 0.846–0.916) exhibited good accuracy for identifying LAA thrombogenic milieu, and non-inferior to conventional parameters including CHA2DS2-VASc score (0.645). The decision tree analysis identified LASr, LASRr, LAEF, CHA2DS2VASc score, and LA stiffness index as the most relevant variables to correctly discriminate LAA thrombogenic milieu from patients with AF. The decision tree as a novel algorithm could accurately identify subjects with LAA thrombogenic milieu (AUC 0.930, accuracy 89.31 %) or impaired LAA emptying velocity (AUC 0.868, accuracy 87.98 %). In the subgroup analysis, among 354 the subjects with lower CHA2DS2VASc score (0–2), 85 patients with LAA thrombogenic milieu. The novel algorithm (AUC: 0.938, accuracy 90.39 %) also performed well to discriminate subjects with LAA thrombogenic milieu.</div></div><div><h3>Conclusion</h3><div>The LA strain parameters were non-inferior to conventional parameters for risk stratification of LAA thrombogenic milieu in AF patients. Furthermore, a novel algorithm, based on left atrial strain parameters and CHA2DS2-VASc score, could accurately identify patients with LAA thrombogenic milieu in non-valvular AF, even in those with lower CHA2DS2VASc score (0–2).</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133498"},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bleeding events of Cangrelor usage for the treatment of patients with acute coronary syndrome: Gender differences or study design bias?","authors":"Jian Luo","doi":"10.1016/j.ijcard.2025.133504","DOIUrl":"10.1016/j.ijcard.2025.133504","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133504"},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy and safety of dapagliflozin in pediatric heart failure: Interpreting causality in clinical outcomes","authors":"Kaiyuan Cen ,&nbsp;Fatimah Ahmedy ,&nbsp;Mexmollen Marcus ,&nbsp;Mohd Fadzli Shukor","doi":"10.1016/j.ijcard.2025.133499","DOIUrl":"10.1016/j.ijcard.2025.133499","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133499"},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of light-dark cycle on the expression of circadian clock genes, electrocardiography, and myocardial function in mice","authors":"Yung-Lung Chen ,&nbsp;Pei-Ting Lin ,&nbsp;Ming-Yu Yang ,&nbsp;Jiin-Haur Chuang","doi":"10.1016/j.ijcard.2025.133463","DOIUrl":"10.1016/j.ijcard.2025.133463","url":null,"abstract":"<div><h3>Background</h3><div>The light-dark (LD) cycle regulates circadian rhythms that influence cardiac function and autonomic regulation. However, the impact of LD cycle disturbances on cardiac electrophysiology and gene expression remains unclear. This study investigated how disrupted light exposure affects cardiac rhythm, function, and gene expression in mice.</div></div><div><h3>Methods</h3><div>Eight-week-old C57BL/6 J mice were exposed to either a normal LD cycle (12 h light/12 h dark, NLD) or a disrupted LD cycle (24 h light for 3 days/24 h dark for 4 days, DLD) for 12 and 24 weeks. Monthly electrocardiographic (ECG) and echocardiographic assessments were performed. Gene expression related to circadian regulation, mitochondrial function, and cardiac remodeling was analyzed.</div></div><div><h3>Results</h3><div>DLD mice exhibited transient weight gain and persistent cardiac hypertrophy. ECG analysis showed shortened RR intervals, prolonged QTc intervals (weeks 4 and 8), and widened QRS duration (week 16). Heart rate variability analysis indicated sustained sympathovagal imbalance (increased LF/HF ratio). Echocardiography revealed early cardiac remodeling with increased left ventricular outflow tract velocity, pressure gradient, and internal diameter. Gene analysis showed early <em>Per2</em> and <em>Nr1d1</em> dysregulation, followed by <em>Bmal1</em>, <em>Clock</em>, <em>Rora</em>, and <em>Rorc</em> downregulation and <em>Nr1d1</em> upregulation at 24 weeks. Mitochondrial dysfunction, fibrosis, and inflammation markers were also dysregulated.</div></div><div><h3>Conclusion</h3><div>Chronic LD disruption leads to circadian misalignment, autonomic imbalance, and cardiac remodeling, potentially contributing to adverse cardiovascular outcomes.</div></div><div><h3>Translational relevance</h3><div>This model simulates circadian disruption in shift workers and individuals with irregular sleep patterns, highlighting prolonged circadian misalignment may elevate cardiovascular risk and the importance of circadian health in cardiovascular prevention strategies.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133463"},"PeriodicalIF":3.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to comment on “Low chronotropic response in post-myocardial infarction exercise test predicts worse prognosis in patients with preserved or mildly reduced left ventricular ejection fraction”","authors":"Krzysztof Smarz ,&nbsp;Maciej Tysarowski","doi":"10.1016/j.ijcard.2025.133484","DOIUrl":"10.1016/j.ijcard.2025.133484","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133484"},"PeriodicalIF":3.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic utility of hybrid coronary computed tomography angiography and myocardial perfusion imaging in elderly patients with suspected coronary artery disease","authors":"Wail Nammas ,&nbsp;Iina Ajosenpää ,&nbsp;Teemu Maaniitty ,&nbsp;Iida Stenström ,&nbsp;Jeroen J. Bax ,&nbsp;Juhani Knuuti ,&nbsp;Antti Saraste","doi":"10.1016/j.ijcard.2025.133493","DOIUrl":"10.1016/j.ijcard.2025.133493","url":null,"abstract":"<div><h3>Background</h3><div>The prognostic utility of sequential hybrid imaging strategy (coronary computed tomography angiography (CCTA) followed by positron emission tomography (PET) myocardial perfusion imaging in those with obstruction) in the elderly remains unclear. We explored the predictors of adverse outcome in patients ≥65, versus those &lt;65 years, who underwent hybrid CCTA-PET for evaluation of coronary artery disease (CAD).</div></div><div><h3>Methods</h3><div>Retrospectively, we evaluated 1948 patients (43.8 % ≥65 years) referred for CCTA due to suspected CAD from 2008 through 2016. Patients with obstructive CAD by CCTA (<em>n</em> = 657) underwent ¹⁵O-water PET under adenosine stress.</div></div><div><h3>Results</h3><div>Mean age was 61.9 ± 9.9 years, 58.9 % were females. Elderly patients had more often obstructive CAD by CCTA, and ischemia by PET. During a median follow-up of 6.7 years, the composite adverse outcome (all-cause death, myocardial infarction, or unstable angina) occurred more often in patients ≥65, versus those &lt;65 years (14.2 % vs. 5.6 %, <em>p</em> &lt; 0.001). Ischemic CAD assessed by hybrid imaging predicted events with a hazard ratio of 5.65 (95 % CI 2.35–13.57) in older patients, and 7.01 (95 % CI 3.08–15.94) in younger patients, compared with patients without CAD. The c-statistic of a multivariable model including the hybrid CCTA-PET finding (adjusted for clinical risk predictors) for predicting the composite outcome was similar between patients ≥65, versus those &lt;65 years (<em>p</em> = 0.1). There was no interaction between age category and the hybrid CCTA-PET finding for prediction of events (<em>p</em> = 0.9).</div></div><div><h3>Conclusion</h3><div>The prognostic utility of hybrid CCTA-PET for predicting adverse events at long-term follow-up was similar between patients ≥65 and those &lt;65 years.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133493"},"PeriodicalIF":3.2,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart failure and co-morbidities confer a negative prognosis in COVID-19 infection","authors":"Antonio E. Pontiroli ,&nbsp;Giuseppe Ambrosio ,&nbsp;Olivia Leoni ,&nbsp;Marco Forlani ,&nbsp;Barbara Antonelli ,&nbsp;Edoardo Gronda ,&nbsp;Alberto Palazzuoli ,&nbsp;Francesco Bandera ,&nbsp;Giuseppe Galati ,&nbsp;Elena Tagliabue","doi":"10.1016/j.ijcard.2025.133492","DOIUrl":"10.1016/j.ijcard.2025.133492","url":null,"abstract":"<div><h3>Background</h3><div>Since early reports, it has been shown that cardiovascular (CV) diseases, including heart failure (HF), represent a risk factor for infection, hospital admissions and mortality from COVID-19. The COVID-19 pandemics has been of major importance in Italy and in the Lombardy Region. Aims of this study were to compare COVID-19 infection in HF and No-HF subjects, and to quantify among HF patients the risk for COVID-19 infection and all-cause mortality.</div></div><div><h3>Methods</h3><div>All consecutive patients (98,549) with at least one hospital discharge of HF (primary diagnosis) during January 1st, 2015, to December 31st, 2019, were identified in the Lombardy Region Database (&gt;10 million inhabitants), and compared with No-HF subjects (394,104 with a lower age limit 40 years), randomly chosen in a 4:1 proportion among hospitalized patients.</div><div>The whole cohort of cases of COVID-19 infection, laboratory-confirmed by RT-PCR, aged &gt;40 years, diagnosed from the beginning of the epidemic on 21 February 2020 to 1 October 2020 was studied. The study outcomes were: occurrence, hospitalization, and death in COVID-19 cases.</div><div>Results. Incidence of COVID-19 increased with age in both HF (<em>p</em> &lt; 0.001) and No-HF patients (p &lt; 0.001); cases (and incidence rates, IR) were 8,648 (IR = 29.653 × 100.000) in HF and 14,256 (IR = 10.195) and in No-HF (p &lt; 0.001); hospital admissions were 4,974 (IR = 14.970) and 4,943 (IR = 3.484), respectively (p 〈0001); deaths were 7,650 (IR = 5.368) and 18,368 (IR = 56.921), respectively (p &lt; 0.001); the incidence rate ratio (IRR) was 2.909 (95 % C.I. 2.908–2.909) for infection (p &lt; 0.001), 4.297 (95 % C.I. 4.296–4.297) for hospital admission (p &lt; 0.001), and 10.603 (95 % C.I.10.602–10.604) for mortality (p &lt; 0.001). The excess IRR for mortality varied from 25.001 (95 % C.I. 24.971–25.032) for the age decade 40–49 to 1.925 (95 % C.I. 1.923–1.926) for the age decade 100–109. Among HF patients, age (OR = 1.087, 95 % C.I.1.05–1.088), male sex (OR = 1.27, 95 % C.I. 1.23–1.31), number of hospital admissions for HF during the period 2015–2019 (OR = 2.22, 95 % C.I. 2.11–2.33), co-morbidities (OR = 1.33, 95 % C.I. 1.32–1.35), or Charlson Index (OR = 1.21, 95 % C.I. 1.20–1.22), were risk factors for both infection and all-cause mortality at univariable and at multivariable analysis.</div></div><div><h3>Conclusion</h3><div>Infections, hospital admissions, and mortality for COVID-19 increased with age and male sex were more frequent in HF than in No-HF patients. Among HF patients, age and sex, number of hospital admissions for HF, co-morbidities, were risk factors for both infection and mortality. These data are of relevance for prioritizing interventions for prevention of infection, and for assistance to patients with COVID-19, and to inform management of future pandemics.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133492"},"PeriodicalIF":3.2,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary: Alcoholic cardiomyopathy reconsidered: The emerging role of strain imaging","authors":"Guanyu Lu ,&nbsp;Xiaohai Ma ,&nbsp;Lei Zhao","doi":"10.1016/j.ijcard.2025.133462","DOIUrl":"10.1016/j.ijcard.2025.133462","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133462"},"PeriodicalIF":3.2,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}