International journal of cardiology最新文献

{"title":"Corrigendum to ‘Distal radial access in elderly patients aged 70 years and older for coronary procedures: Lessons from the KODRA registry’ Int J Cardiol. 2025 Nov 15:439:133645","authors":"Jun-Won Lee , Han-Young Jin , Hyun Cho , Sung Eun Kim , Joon-Hyung Doh , Yongcheol Kim , Bong-Ki Lee , Sang-Yong Yoo , Sang Yeub Lee , Chan Joon Kim , Jin Sup Park , Jung Ho Heo , Do Hoi Kim , Jin Bae Lee , Dong-Kie Kim , Jun Ho Bae , Sung-Yun Lee , Seung-Hwan Lee , Sung Woo Cho","doi":"10.1016/j.ijcard.2025.133907","DOIUrl":"10.1016/j.ijcard.2025.133907","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133907"},"PeriodicalIF":3.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145099474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and safety of ketamine for procedural sedation in pediatric patients undergoing electrophysiology procedures: A cohort study","authors":"Simone Gulletta ,&nbsp;Francesco Fioravanti ,&nbsp;Luca Barca ,&nbsp;Francesca Caparra ,&nbsp;Valentina Martello ,&nbsp;Jacopo D'Andria Ursoleo ,&nbsp;Nikita Tanese ,&nbsp;Lorenzo Rampa ,&nbsp;Alberto Barengo ,&nbsp;Gabriele Paglino ,&nbsp;Caterina Bisceglia ,&nbsp;Giovanni Battista Forleo ,&nbsp;Marco Schiavone ,&nbsp;Paolo Emilio Della Bella ,&nbsp;Fabrizio Monaco","doi":"10.1016/j.ijcard.2025.133917","DOIUrl":"10.1016/j.ijcard.2025.133917","url":null,"abstract":"<div><h3>Introduction</h3><div>Electrophysiology (EP) procedures in the pediatric population are often performed aided by anesthetic support under general anesthesia (GA), provided they require a delicate balance between appropriate sedation depth, analgesia, immobility, and hemodynamic stability. GA is still the standard of care but shows several limitations. Ketamine sedation (KS) offers an alternative to GA with preserved respiratory and cardiovascular function, yet its role in pediatric EP procedures remains understudied.</div></div><div><h3>Methods</h3><div>We retrospectively included 217 consecutive pediatric patients (&lt;18 years) who underwent their first EP procedure at our center between 2016 and 2024. Patients received either KS (<em>n</em> = 37) or GA (<em>n</em> = 180) based on anesthesiologist and cardiologist preference. Primary endpoints were the GA conversion rate, perioperative complications, “door-to-door” operating room occupation time and postprocedural recovery time. Secondary endpoints included results of the electrophysiology study (EPS), change in electrocardiography parameters before, during and after drug infusion and difference of vital signs behavior between the two groups. Propensity score matching (PSM) was performed to correct for age, body mass index (BMI), type of procedure and sex.</div></div><div><h3>Results</h3><div>Before PSM, compared with the GA group, the KS cohort was older (mean age 13.5 ± 4.5 vs. 11.3 ± 3.2 years in GA; <em>p</em> = 0.02), while sex distribution and BMI were similar. After PSM, there were no significant differences between the tested variables. No KS patient required GA conversion or experienced complications (e.g., emergence delirium). Shorter operating room door-to-door occupation time (KS 79.3 ± 47.2 min; <em>p</em> = 0.0026 vs GA 100.8 ± 37.2 min) and shorter recovery room time were reported in the KS group compared to the GA group (15 ± 19 min vs 41.5 ± 14 min; <em>p</em> = 0.001).</div><div>No significant differences in the EPS result was observed between the two groups (19.4 % vs. 22.7 %; <em>p</em> = 0.59). In KS patients, electrocardiographic parameters remained stable before, during and at the end of procedure.</div></div><div><h3>Conclusions</h3><div>Ketamine-based sedation is a safe and effective alternative to GA for pediatric EP procedures, maintaining hemodynamic and electrocardiographic stability. Moreover, KS enhances operating room efficiency by reducing both periprocedural and recovery times.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133917"},"PeriodicalIF":3.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of contractile reserve on clinical outcomes in patients with left ventricular dysfunction undergoing TAVI","authors":"Yeela Talmor-Barkan ,&nbsp;Amos Levi ,&nbsp;Marco Barbanti ,&nbsp;Roberto Valvo ,&nbsp;Giuliano Costa ,&nbsp;Valentina Frittitta ,&nbsp;Ole De Backer ,&nbsp;Yannick Willemen ,&nbsp;Mark van den Dorpel ,&nbsp;Matias Mon ,&nbsp;Atsushi Sugiura ,&nbsp;Mitsumasa Sudo ,&nbsp;Giulia Masiero ,&nbsp;Edoardo Pancaldi ,&nbsp;Dabit Arzamendi ,&nbsp;Mario Garcia-Gomez ,&nbsp;Jose A. Baz ,&nbsp;Yaron Shapira ,&nbsp;Klemen Steblovnik ,&nbsp;Victor Mauri ,&nbsp;Guy Witberg","doi":"10.1016/j.ijcard.2025.133916","DOIUrl":"10.1016/j.ijcard.2025.133916","url":null,"abstract":"<div><h3>Aims</h3><div>Patients with aortic stenosis (AS) and severe left ventricular (LV) dysfunction, have poor outcomes following transcatheter aortic valve implantation (TAVI). There is limited data regarding the role of dobutamine stress echocardiography (DSE) in patients' selection for TAVI. Our aim was to examine the prognostic value of contractile reserve (CR) and its association with ejection fraction (EF) recovery.</div></div><div><h3>Methods and results</h3><div>A multicenter registry of consecutive patients with EF ≤ 30 % undergoing TAVI at 17 European centers. Patients were grouped according to those with/without CR, and further stratified by EF recovery post TAVI. The primary endpoint was 3-year mortality. Our cohort included 296 patients who performed DSE, of whom 158 were CR+.</div><div>After a median follow-up of 2.4 (IQR 2–3) years, 3-year mortality was 43.7 %-vs.34.0 % in the CR- and CR+ groups, respectively (Adjusted HR 1.98,95 % CI[1.21–3.29],<em>p</em> = 0.009). There was no interaction between CR+ and low-flow low-gradient AS. In the entire cohort, EF recovery occurred in 141 (47.6 %) patients, who experienced lower 3-year mortality (29.6 % vs.45.1 % for those without EF recovery; HR 1.68,95 % CI[1.24–2.97],<em>p</em> &lt; 0.01). Following multivariate adjustment, CR+ was an independent predictor of EF recovery (OR 6.06 95 % CI[3.48–10.53],<em>p</em> &lt; 0.001). Stratified by CR status and EF recovery, 3-year mortality was similar in the different EF recovery groups.</div></div><div><h3>Conclusion</h3><div>CR on DSE is associated with reduced mortality, mediated through its impact on EF recovery. Our results highlight the potential of DSE and CR status in the triage of patients with severe AS and LV dysfunction, and support its routine use in the pre-TAVI assessment.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133916"},"PeriodicalIF":3.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and inactivity cluster the strongest risk factor for the development of heart failure in a population-based study","authors":"Bart J. van Essen ,&nbsp;Nathalie Ang En Dan ,&nbsp;Ganash N. Tharsana ,&nbsp;Palvinder Kaur ,&nbsp;J.E. Emmens ,&nbsp;Wouter Ouwerkerk ,&nbsp;Ron T. Gansevoort ,&nbsp;Stephan J.L. Bakker ,&nbsp;Rudolf A. de Boer ,&nbsp;Kevin Damman ,&nbsp;Dirk J. van Veldhuisen ,&nbsp;Adriaan A. Voors ,&nbsp;Jasper Tromp","doi":"10.1016/j.ijcard.2025.133914","DOIUrl":"10.1016/j.ijcard.2025.133914","url":null,"abstract":"<div><h3>Background</h3><div>Comorbidities are associated with an increased risk of incident heart failure (HF). However, comorbidities usually cluster together and data on the association between multimorbidity clusters and incident HF with preserved (HFpEF) and reduced ejection fraction (HFrEF) are lacking.</div></div><div><h3>Methods</h3><div>We identified multimorbidity patterns in 6839 participants from the prospective observational Prevention of Renal and Vascular End-stage Disease (PREVEND) cohort study using latent class analysis and investigated their association with new-onset HF.</div></div><div><h3>Results</h3><div>The participants' mean age at baseline was 53.8 years, and 50 % were women. We identified six multimorbidity clusters: 1) young [<em>N</em> = 2118, youngest age and lowest number of chronic conditions], 2) elderly [<em>N</em> = 1198, oldest age, high prevalence of chronic kidney disease and hypercholesterolemia], 3) pulmonary disease [<em>N</em> = 578, high prevalence of respiratory problems], 4) psychosomatic [<em>N</em> = 527, high prevalence of myalgic encephalomyelitis, anxiety and stress], 5) psychological [<em>N</em> = 1815, high prevalence of depression] and 6) obese/physical inactivity [<em>N</em> = 603, high prevalence of obesity, hypertension, myocardial infarction and stroke]. During 110,621 person-years of follow-up 622 participants developed heart failure of which 390 with HFrEF and 220 with HFpEF. After adjusting for potential confounders, the elderly (adjusted hazard ratio (aHR) 2.46, 95 % confidence interval (CI) 1.89–3.20), pulmonary disease (aHR 2.10, 95 % CI 1.51–2.92), and obese/physical inactivity (aHR 3.80, 95 % CI 2.86–5.06) clusters had a higher risk of HF compared with the young cluster, which had the lowest risk. Among all clusters, patients were more likely to develop HFrEF compared to HFpEF. However, the obese/physical inactivity cluster was relatively more likely to develop HFpEF than HFrEF.</div></div><div><h3>Conclusions</h3><div>Comorbidities naturally clustered in six distinct multimorbidity clusters, each impacting participants' HF risk differently. These data emphasize the importance of addressing multimorbidity as a risk factor for HF.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133914"},"PeriodicalIF":3.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head-up tilt testing in patients with suspected vasovagal syncope: A meta-regression modelling","authors":"Pietro Guida ,&nbsp;Federica Troisi ,&nbsp;Antonio Di Monaco ,&nbsp;Giusi Romanazzi ,&nbsp;Massimo Iacoviello ,&nbsp;Massimo Grimaldi","doi":"10.1016/j.ijcard.2025.133908","DOIUrl":"10.1016/j.ijcard.2025.133908","url":null,"abstract":"<div><h3>Background</h3><div>Head-up tilt testing (HUT) is a useful diagnostic tool for patients with suspected reflex syncope. We conducted a meta-regression analysis to evaluate the influence of age and instrumental parameters on HUT outcome.</div></div><div><h3>Methods</h3><div>Searching in multiple databases, 97 articles were identified until July 2024 among studies enrolling at least 100 patients with history of syncope or 50 subjects without (controls) who underwent to passive HUT (60 or 70 degree) eventually potentiated with isoproterenol or nitroglycerin.</div></div><div><h3>Results</h3><div>The pooled positivity rate of patients was 34 % (95 % confidence interval: 29–39 %) in 8362 drug-free HUT, 53 % (45–60 %) in 2121 with isoproterenol and 62 % (59–66 %) in 14,054 with nitroglycerin. The pooled negativity rate of controls was 86 % (81–91 %) in 876 drug-free HUT, 83 % (76–91 %) in 276 with isoproterenol and 88 % (83–94 %) in 806 with nitroglycerin. In patients, a greater HUT positivity rate was associate to younger age for the passive stage and overall, and to pharmacological provocation that showed, during the active phase, a significant higher diagnostic yield of nitroglycerin than isoproterenol. A longer duration of passive stage increased the rate of syncope during the unmedicated phase but reduced probability during the active one. In controls, older age was associated to a greater proportion of negative response.</div></div><div><h3>Conclusions</h3><div>In HUT used in clinical practice, tilt angle is less important than patient's age and methodology with shorter protocols requiring pharmacological provocation to improve positivity rate. The diagnostic role of HUT modifies with age, being more relevant in older patients whether potentiated with nitroglycerin.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133908"},"PeriodicalIF":3.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"On the puzzling speckle tracking echocardiography/clinical severity dissociation between patients with takotsubo syndrome and anterior ST-elevation myocardial infarction\".","authors":"Angela Poller, Odd Bech-Hanssen, Björn Redfors","doi":"10.1016/j.ijcard.2025.133910","DOIUrl":"10.1016/j.ijcard.2025.133910","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133910"},"PeriodicalIF":3.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial of “effect of continuous positive airway pressure on ventricular remodelling of patients with combined diabetes mellitus and obstructive sleep apnea: A cross-sectional study follow on randomised clinical trial” to international journal of cardiology","authors":"Reinaldo B. Bestetti","doi":"10.1016/j.ijcard.2025.133903","DOIUrl":"10.1016/j.ijcard.2025.133903","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133903"},"PeriodicalIF":3.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac arrest and aortic dissection: A bad combination","authors":"Josephine Warren ,&nbsp;James A. Shaw","doi":"10.1016/j.ijcard.2025.133904","DOIUrl":"10.1016/j.ijcard.2025.133904","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133904"},"PeriodicalIF":3.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seeing beyond normal: Perivascular fat radiomics for predicting coronary plaque development","authors":"Christoforos K. Travlos","doi":"10.1016/j.ijcard.2025.133906","DOIUrl":"10.1016/j.ijcard.2025.133906","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133906"},"PeriodicalIF":3.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy in women with highest cardiovascular risk: Progress achieved, challenges ahead","authors":"María Josefa Azpiroz-Franch ,&nbsp;Maria Antonia Pijuan-Doménech ,&nbsp;Laura Dos-Subirà","doi":"10.1016/j.ijcard.2025.133905","DOIUrl":"10.1016/j.ijcard.2025.133905","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133905"},"PeriodicalIF":3.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}