International journal of cardiology最新文献

{"title":"Limitations of pulmonary capillary wedge pressure in the validation of non-invasive filling pressure devices","authors":"Brijesh Sathian , Javed Iqbal , Hanadi Al Hamad","doi":"10.1016/j.ijcard.2025.133594","DOIUrl":"10.1016/j.ijcard.2025.133594","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133594"},"PeriodicalIF":3.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular volume in MINOCA: Yet another point scored for cardiac magnetic resonance","authors":"Damiano Fedele , Sara Amicone , Lisa Canton , Carmine Pizzi","doi":"10.1016/j.ijcard.2025.133596","DOIUrl":"10.1016/j.ijcard.2025.133596","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133596"},"PeriodicalIF":3.2,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCSK9 inhibitors and post-PCI antiplatelet therapy: Weighing bleeding vs benefit","authors":"Dina M. Awad","doi":"10.1016/j.ijcard.2025.133600","DOIUrl":"10.1016/j.ijcard.2025.133600","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133600"},"PeriodicalIF":3.2,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes in patients undergoing transcatheter edge-to-edge mitral valve repair as compared to a general and heart failure population","authors":"Daniel Erik Meulengracht ,&nbsp;Jeppe Kofoed Petersen ,&nbsp;Karsten Tange Veien ,&nbsp;Ole de Backer ,&nbsp;Lauge Østergaard ,&nbsp;Nikolaj Ihlemann ,&nbsp;Steen Hvitfeldt Poulsen ,&nbsp;Jordi S. Dahl ,&nbsp;Phillip Freeman ,&nbsp;Asger Andersen ,&nbsp;Jacob Eifer Møller ,&nbsp;Lars Køber ,&nbsp;Emil Fosbøl","doi":"10.1016/j.ijcard.2025.133605","DOIUrl":"10.1016/j.ijcard.2025.133605","url":null,"abstract":"<div><h3>Background</h3><div>Information on the use of transcatheter edge-to-edge repair (TEER) in severe mitral regurgitation in national settings is still scarce.</div></div><div><h3>Aims</h3><div>To compare patient characteristics and one-year rate of all-cause mortality and heart failure (HF) hospitalization in a nationwide cohort of patients undergoing TEER for mitral regurgitation with controls from the background population and patients with HF.</div></div><div><h3>Methods</h3><div>Using Danish nationwide registries, all patients with first-time TEER (2011−2020) were identified and matched to the background population and a population with first-time admissions with HF on sex, age, and calendar year on a 1:4 ratio. Adverse outcome was assessed using cumulative incidence plots and adjusted Cox regression analyses.</div></div><div><h3>Results</h3><div>We included 423 patients undergoing TEER and two matched control cohorts consisting of 1692 people each. Median age was 76 years (interquartile range: 70–84) with a majority being male (62.9 %). Patients treated with TEER had a considerable burden of comorbidities: chronic HF (63.1 %), atrial fibrillation (57.9 %), and diabetes mellitus (20.8 %). Use of loop diuretics in the TEER- and HF-group was 84.6 % and 39.7 %, respectively. In the TEER-group the one-year cumulative incidence rate for all-cause mortality was 21.3 % and 31.2 % for HF-hospitalization. Compared with the TEER-group: one-year all-cause mortality (background-cohort: adjusted hazard ratio [HR] 0.23 (95 % CI): 0.17–0.31], HF-cohort: HR 1.33 [95 % CI: 1.05–1.68]); one-year HF-hospitalization (background-cohort: HR 0.04 [95 % CI: 0.02–0.07], HF-cohort: HR 1.11 [95 % CI: 0.90–1.36]).</div></div><div><h3>Conclusions</h3><div>Patients undergoing TEER in Denmark are comorbid compared to the background population and have a higher index degree of symptomatic HF with a lower mortality than a matched cohort of HF patients.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133605"},"PeriodicalIF":3.2,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of interpretable machine learning in Takotsubo syndrome: Toward clinical translation","authors":"Jolanda Sabatino,&nbsp;Rosalba De Sarro,&nbsp;Daniele Torella","doi":"10.1016/j.ijcard.2025.133601","DOIUrl":"10.1016/j.ijcard.2025.133601","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133601"},"PeriodicalIF":3.2,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting coronary artery disease using machine learning with optimized feature selection","authors":"Chen-Yang Su ,&nbsp;Masashi Hasebe","doi":"10.1016/j.ijcard.2025.133584","DOIUrl":"10.1016/j.ijcard.2025.133584","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133584"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretable hybrid-ensemble acute myocardial infarction diagnosis with clinical transparency","authors":"Yanmin Zhu ,&nbsp;Xian Wang ,&nbsp;Shuzhi Su ,&nbsp;Zengyong Qiao ,&nbsp;Mingquan Guo ,&nbsp;KeXue Zhang ,&nbsp;Yong Dai","doi":"10.1016/j.ijcard.2025.133598","DOIUrl":"10.1016/j.ijcard.2025.133598","url":null,"abstract":"<div><h3>Background</h3><div>Single-algorithm machine learning models for acute myocardial infarction (AMI) often struggle with heterogeneous clinical data and lack transparency, limiting their clinical adoption.</div></div><div><h3>Methods</h3><div>We propose a novel interpretable hybrid-ensemble AMI diagnosis method with clinical transparency. Our method performs nested iteration and global hyperparameter optimization via data reuse, which can improve the generalizability of single-algorithms to a certain extent. By balance criterion between ensemble robustness and performance optimization, some improved pre-ensemble algorithms and optimal ensemble strategy are determined to coordinate multiple algorithms in constructing our hybrid-ensemble model. A game-theoretic marginal contribution analysis (GMCA) framework was established to quantify the feature contribution of prediction results in global and local levels，which can improve the interpretability and clinical transparency of our hybrid-ensemble model. Based on the framework, data-driven dimensionality reduction of clinical feature is performed, while ensuring clinical effectiveness through expert guided validation. Additionally, a series of extended experiments were conducted to further validate the adaptability and generalizability of our proposed method.</div></div><div><h3>Results</h3><div>Our hybrid-ensemble model achieved 0.944 accuracy and 0.94 F1-score in binary classification, outperforming single-algorithms. The GMCA framework identified six features, achieving dual optimization of data-driven selection and domain knowledge consistency. Extended experiments confirm the model's robust accuracy and generalizability across diverse configurations.</div></div><div><h3>Conclusions</h3><div>Our study presents a replicable method for developing transparent and clinically actionable AI systems in emergency cardiology. By harmonizing algorithmic diversity with interpretability, our hybrid-ensemble method not only enhances diagnostic accuracy but also fosters clinician trust.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133598"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction models for no-reflow phenomenon after PCI in acute coronary syndrome patients: A systematic review","authors":"Fang Li ,&nbsp;Jin-jiang Zhang ,&nbsp;Gui-ji Ruan ,&nbsp;Yue-yun Zhan ,&nbsp;Ai-hua Qiu ,&nbsp;Meng-si Ye ,&nbsp;Qian-wen Xiang ,&nbsp;Hong-cheng Fang","doi":"10.1016/j.ijcard.2025.133603","DOIUrl":"10.1016/j.ijcard.2025.133603","url":null,"abstract":"<div><h3>Objective</h3><div>To comprehensively evaluate existing prediction models for the no-reflow phenomenon (NRP) after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS).</div></div><div><h3>Methods</h3><div>A systematic search was conducted across PubMed, Web of Science, Embase, Cochrane Library, Scopus, China National Knowledge Infrastructure (CNKI), Wanfang Database, Weipu (VIP), and the Chinese Biomedical Literature Service System (Sinomed) up until May 28, 2024, to identify studies on prediction models for the NRP in ACS patients after PCI. A qualitative synthesis was performed to assess study characteristics and model features.</div></div><div><h3>Results</h3><div>A total of 3738 studies were retrieved, and 21 studies involving 25 prediction models were finally included. The reported incidence of NRP ranged from 3.58 % to 33.3 %. Most models were developed using logistic regression, with area under the curve (AUC) ranged from 0.637 to 0.958. Frequently reported predictors across models included Killip classification, symptom-to-balloon time, total ischemic time, and pre-PCI TIMI thrombus grade, among others. All included studies were assessed as having a high risk of bias (ROB), mainly due to inappropriate data sources and methodological limitations in the analysis domain.</div></div><div><h3>Conclusions</h3><div>Current prediction models for NRP after PCI in ACS patients exhibit high ROB and have not been adequately validated. Currently, no suitable prediction models are recommended for clinical decision-making. Future research should adopt more rigorous methodologies and emphasize multicenter external validation to enhance model reliability and applicability.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"439 ","pages":"Article 133603"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1RA versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction: An updated meta-analysis of randomized controlled trials","authors":"Sanchit Duhan ,&nbsp;Krishna Prasad Kurpad ,&nbsp;Bijeta Keisham ,&nbsp;Jurgen Shtembari ,&nbsp;Alina Brener ,&nbsp;Uday B. Kanakadandi ,&nbsp;Anuj Garg ,&nbsp;Naveed A. Adoni ,&nbsp;Sanjay S. Mehta","doi":"10.1016/j.ijcard.2025.133604","DOIUrl":"10.1016/j.ijcard.2025.133604","url":null,"abstract":"<div><h3>Introduction</h3><div>Currently, limited guideline-directed medical therapies are available for heart failure (HF) with preserved and mildly reduced ejection fraction (EF). Both are associated with an increased risk of hospitalization and death, especially in overweight, obese, or diabetic individuals.</div></div><div><h3>Methods</h3><div>We searched Cochrane, Embase, and MEDLINE from inception to November 2024. Trials with HF patients randomized for GLP-1RA (glucagon-like peptide-1 receptor agonists) and reported adverse cardiovascular and mortality outcomes were included. Statistical analysis was performed using Cochrane Review Manager 5.4.1.</div></div><div><h3>Results</h3><div>4474 patients with HF (preserved and mildly reduced EF) were included in the study. 2278 (50.91 %) received a GLP-1RA [either semaglutide (1914, 84 %) or Tirzepatide (364, 16 %)], and 2196 (49.01 %) received a placebo. GLP-1RA reduced the composite event of cardiovascular mortality and worsening HF exacerbation [139 vs. 194, RR: 0.64 (95 % CI: 0.45–0.92)]. However, on subgroup analysis, there was no significant difference in cardiovascular (CV) deaths [67 vs. 71, RR 0.89 (95 % CI: 0.65–1.24)]. The HF exacerbations were significantly reduced in the GLP-1RA group [83 vs. 138, RR 0.59 (95 % CI: 0.45–0.76)]. Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS) was favorable for GLP-1RA [Std Mean Difference (SMD): 7.38 (95 % CI: 5.51–9.26)], reflected by an increase in 6-min walk distance in GLP-1RA groups [SMD: 17.69 (95 % CI: 11.87–23.34)] and contributed by a decrease in body weight in GLP-1RA groups [SMD -9.56 (95 % CI -12.74 to −6.39)].</div></div><div><h3>Conclusion</h3><div>GLP-1RA reduce HF exacerbations and can play a role in reducing hospitalizations, improving patient's functional status, and significantly impacting the global healthcare burden of HF. However, the current data does not indicate any overall mortality benefit.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133604"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Utilization rates and determinants of PYP and CMR among patients with unexplained left ventricular hypertrophy on echocardiography","authors":"Zhihua Cheng","doi":"10.1016/j.ijcard.2025.133595","DOIUrl":"10.1016/j.ijcard.2025.133595","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133595"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}