International journal of cardiology最新文献

{"title":"Myocardial contraction fraction predicts outcomes in patients enrolled in the TOPCAT trial","authors":"Bryton J. Davis ,&nbsp;Morris Kim ,&nbsp;Yunwoo Burton ,&nbsp;Miriam Elman ,&nbsp;James Hodovan ,&nbsp;Amil M. Shah ,&nbsp;Mathew S. Maurer ,&nbsp;Scott D. Solomon ,&nbsp;Ahmad Masri","doi":"10.1016/j.ijcard.2025.133038","DOIUrl":"10.1016/j.ijcard.2025.133038","url":null,"abstract":"<div><h3>Background</h3><div>Myocardial contraction fraction (MCF)—the ratio of left ventricular stroke volume to myocardial volume—is a volumetric measure of myocardial shortening that distinguishes between pathologic and physiologic hypertrophy. In this post-hoc analysis of the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial, we investigated the prognostic value of MCF and its association with heterogeneity of treatment effect in heart failure with preserved ejection fraction (HFpEF).</div></div><div><h3>Methods</h3><div>TOPCAT randomized patients with HFpEF to spironolactone or placebo. Patients with echocardiography data allowing for the calculation of MCF were included. The primary outcome was a composite of all-cause mortality, HF hospitalization, myocardial infarction, and stroke.</div></div><div><h3>Results</h3><div>588 patients (median age 72.0 [63.0–79.3] years; 49.1 % female) were included. Median MCF was 27.0 % (21.8–32.8 %) for the overall group and was not different in the spironolactone and placebo groups. Over a median follow-up of 3.0 (1.9–4.5) years, MCF below median was associated with a worse prognosis (<em>p</em> = 0.003). On multivariable regression analysis (HR, 95 % CI), only New York Heart Association class (1.47, 1.14–1.91, p = 0.003) and MCF (0.76, 0.64–0.90, <em>p</em> = 0.001) were associated with the composite outcome. In this subset, spironolactone as compared to placebo was not associated with improved outcomes, but stratifying by MCF showed differential outcomes to spironolactone therapy (<em>p</em> = 0.010).</div></div><div><h3>Conclusions</h3><div>Among patients with HFpEF enrolled in TOPCAT, reduced MCF was independently associated with worse outcomes. Larger prospectively designed studies are needed to further assess the role of MCF in patients with HFpEF.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"424 ","pages":"Article 133038"},"PeriodicalIF":3.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter to the Editor for the “NSUN2/PARP1 signaling axis: A potential mechanism for treating aging associated atrial fibrillation”","authors":"Xinyi Gao,&nbsp;Bingxin Xie,&nbsp;Zhiqiang Zhao,&nbsp;Kang-Yin Chen,&nbsp;Tong Liu","doi":"10.1016/j.ijcard.2025.133042","DOIUrl":"10.1016/j.ijcard.2025.133042","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"424 ","pages":"Article 133042"},"PeriodicalIF":3.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Adoption of same day discharge following elective left main stem percutaneous coronary intervention” [International Journal of Cardiology. 2020; 321: 38–47]","authors":"Paraskevi Taxiarchi ,&nbsp;Evangelos Kontopantelis ,&nbsp;Tim Kinnaird ,&nbsp;Nick Curzen ,&nbsp;Adrian Banning ,&nbsp;Peter Ludman ,&nbsp;Ahmad Shoaib ,&nbsp;Muhammad Rashid ,&nbsp;Glen P. Martin ,&nbsp;Mamas A. Mamas","doi":"10.1016/j.ijcard.2025.133010","DOIUrl":"10.1016/j.ijcard.2025.133010","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"423 ","pages":"Article 133010"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Organizational and patient-level predictors for attaining key risk factor targets in cardiac rehabilitation after myocardial infarction: The Perfect-CR study☆” [International journal of Cardiology 371C (2022) 40–48].","authors":"Halldora Ögmundsdottir Michelsen ,&nbsp;Peter Henriksson ,&nbsp;John Wallert ,&nbsp;Maria Bäck ,&nbsp;Ingela Sjölin ,&nbsp;Mona Schlyter ,&nbsp;Emil Hagström ,&nbsp;Anna Kiessling ,&nbsp;Claes Held ,&nbsp;Emma Hag ,&nbsp;Lennart Nilsson ,&nbsp;Alexandru Schiopu ,&nbsp;M. Justin Zaman ,&nbsp;Margret Leosdottir","doi":"10.1016/j.ijcard.2024.132876","DOIUrl":"10.1016/j.ijcard.2024.132876","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"420 ","pages":"Article 132876"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disopyramide for symptomatic obstructive hypertrophic cardiomyopathy","authors":"Mark V. Sherrid ,&nbsp;Daniele Massera","doi":"10.1016/j.ijcard.2025.133030","DOIUrl":"10.1016/j.ijcard.2025.133030","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"423 ","pages":"Article 133030"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular risk factors are associated with cerebrovascular reactivity in young adults","authors":"Jaskanwal D.S. Sara ,&nbsp;Jay J. Pillai ,&nbsp;Lilach O. Lerman ,&nbsp;Amir Lerman ,&nbsp;Kirk Welker","doi":"10.1016/j.ijcard.2025.133021","DOIUrl":"10.1016/j.ijcard.2025.133021","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Endothelial dysfunction represents the earliest detectable stage of atherosclerosis, is associated with an increased risk of cardiovascular events, and predicts cardiovascular disease (CVD) more effectively than traditional cardiovascular risk factors. Cerebrovascular reactivity (CVR) provides an index of endothelial function in the brain. Poor CVR is associated with stroke, cerebral small vessel disease, dementia, and even coronary artery disease. Traditional CVD risk factors are associated with low CVR in patients with known CVD and in older cohorts. However, the relationship between cardiovascular risk profile and reduced CVR in young adults who do not yet have CVD is uncertain. We hypothesized that in young adults undergoing routine clinical fMRI examinations for non-vascular disease low CVR measures would be associated with increased cardiovascular risk factors.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This cross-sectional study included adults with epilepsy undergoing a 3-Tesla fMRI scan of the brain for mapping of eloquent cortex with a “breath-hold task” to facilitate pre-operative planning for epilepsy-related surgery. Individuals with intracranial masses and those with baseline CVD were excluded. The task consisted of 5½, 20-s blocks of normal breathing interspersed with 20-s blocks of continuous breath holding. In breath hold fMRI scans, a voxel-wise comparison of brain T2 signal to an expected hemodynamic response curve is used to generate maps of voxel-wise t-statistics, indicating the probability that blood flow within a specific voxel had increased in response to changes in blood carbon dioxide levels. Using an axial slice 8 mm superior to the corpus callosum, a mean cerebral t-statistic was calculated for the slice as a comparative global measure of CVR in each patient. We retrospectively reviewed the charts of all individuals to characterize their clinical profile at the time of the fMRI. Based on the distribution of mean t-statistic values the sample was divided into two groups: high t-statistic (“normal reactivity”) and low t-statistic value (“abnormal reactivity”). The distribution of cardiovascular risk factors was then compared across groups.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Between January 2014 and December 2023, 76 individuals underwent brain fMRI employing a “breath hold task” with suitable image quality for the current analysis (mean ± SD age, 35.46 ± 12.09 yrs.; 31.6 % female). Mean ± SD global CVR T-statistic was 3.97 ± 1.62. Low CVR was defined as a mean T-statistic ≤4.2 (&lt;em&gt;n&lt;/em&gt; = 44, 57.9 %). Individuals with abnormal CVR were older (age: 45.1 ± 10.3 vs. 27.0 ± 3.4 yrs., &lt;em&gt;p&lt;/em&gt; &lt; 0.001), had a higher frequency of hypertension (31.8 % vs. 14.3 %, &lt;em&gt;p&lt;/em&gt; = 0.0069) and hyperlipidemia (18.2 % vs. 3.1 %, &lt;em&gt;p&lt;/em&gt; = 0.0449), and had higher systolic (123.5 ± 13.2 vs. 116.9 ± 12.2 mmHg, &lt;em&gt;p&lt;/em&gt; = 0.0282) and diastolic blood pressures (77.9 ± 11.8 vs. 72.2 ± 8.9, &lt;em&gt;p&lt;/em&gt; =","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"424 ","pages":"Article 133021"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and rationale of the multicenter randomized clinical trial (REVERSE): Efficacy and safety of rivaroxaban in the early postoperative period for patients with bioprosthetic valve replacement or valve repair.","authors":"Xin Wang, Chi Zhang, Mang-Mang Pan, Hou-Wen Lin, Song Xue, Bo Xie, Zhi-Chun Gu","doi":"10.1016/j.ijcard.2025.133023","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133023","url":null,"abstract":"<p><strong>Background: </strong>Rivaroxaban, a Non-vitamin K oral anticoagulant (NOAC), is extensively employed for patients at heightened risk of thrombosis, including those with non-valvular atrial fibrillation (NVAF) and venous thromboembolism (VTE). However, to date, there is a lack of robust clinical data to explore the efficacy and safety of rivaroxaban in thromboprophylaxis during the early postoperative period (<6 months) in patients following surgical bioprosthetic valve (BPV).</p><p><strong>Methods: </strong>The REVERSE trial is a prospective, multicenter, non-inferior, randomized controlled trial enrolling a planned 250 patients in China. Patients are randomly assigned 1:1 to receive rivaroxaban (20 mg once daily) or dose-adjusted warfarin (target international normalized ratio 2.0-3.0) for 6 months. The primary outcome is defined as the composite of all-cause death, major cardiovascular events, or major bleeding. The safety outcome is all bleeding events defined by the International Society on Thrombosis and Haemostasis (ISTH).</p><p><strong>Conclusions: </strong>The REVERSE trial stands as the inaugural multicenter study dedicated to evaluating the efficacy and safety of rivaroxaban for early postoperative anticoagulation in BPV surgery patients. Its findings are anticipated to contribute pivotal evidence regarding the clinical advantages of NOACs.</p><p><strong>Registration: </strong>URL: https:// www.</p><p><strong>Clinicaltrials: </strong>gov; Unique identifier: NCT06476301.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133023"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variants in childhood-onset dilatation of thoracic aorta in a consanguineous population","authors":"Abeer Essa Almostafa ,&nbsp;Maarab Mohammed Al-Korashy ,&nbsp;Nadiah Salem Al-Ruwaili ,&nbsp;Saud Takroni ,&nbsp;Mohammed Alhabdan ,&nbsp;Abdullah AlQwaee ,&nbsp;Ziad Issa ,&nbsp;Fareed Khouqeer ,&nbsp;Dimpna C. Albert Brotons ,&nbsp;Abdulrahman Almesned ,&nbsp;Zohair Alhalees ,&nbsp;Zuhair Nasser Al-Hassnan","doi":"10.1016/j.ijcard.2024.132695","DOIUrl":"10.1016/j.ijcard.2024.132695","url":null,"abstract":"<div><h3>Introduction</h3><div>Childhood-onset thoracic aortic dilatation (TAD) is a heterogenous group of genetic conditions the inheritance of which is largely dominant. To our knowledge, the influence of consanguinity on childhood-onset TAD has not been addressed systematically. We aim to study a cohort of children with TAD in our highly consanguineous population.</div></div><div><h3>Methods</h3><div>Children with TAD were consecutively recruited. Based on the likelihood of a founder mutation, genetic test was categorized to either targeted gene testing or multi-gene sequencing, followed by genetic screening of first-degree relatives. Clinical data and outcome were reviewed.</div></div><div><h3>Results</h3><div>Thirty-three children, from 20 families, had childhood-onset TAD. Genetic test was positive in 20 children, from 13 families, providing a yield of 65 % (13/20). The median age of onset of TAD was 4.5 years. Eight variants were detected in 4 genes (<em>FBN1, EFEMP2, ACTA2, KANSL1</em>) with a homozygous <em>EFEMP2</em> variant found in 6 families (46.2 %). Surgical intervention was required in 14 (70 %) cases (13 with <em>EFEMP2</em>, 1 with <em>FBN1</em> variants) at a median age of 3.5 years. All patients are alive (ages range:3–31 years).</div></div><div><h3>Conclusions</h3><div>Our work illustrates the impact of consanguinity on the genetics of childhood-onset TAD elucidating severe presentation of recessively inherited form. Our data underscores the importance of genetic screening and early recognition of TAD to achieve excellent outcome.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"420 ","pages":"Article 132695"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of hypertension and diabetes in patients with cardiac amyloidosis","authors":"Alessia Argirò ,&nbsp;Giulia Biagioni ,&nbsp;Carlotta Mazzoni ,&nbsp;Mattia Zampieri ,&nbsp;Marco Allinovi ,&nbsp;Beatrice Musumeci ,&nbsp;Giacomo Tini ,&nbsp;Alessandro Cianca ,&nbsp;Marco Merlo ,&nbsp;Gianfranco Sinagra ,&nbsp;Aldostefano Porcari ,&nbsp;Marco Pozzan ,&nbsp;Marco Canepa ,&nbsp;Margherita Zanoletti ,&nbsp;Marianna Eleonora Labate ,&nbsp;Alberto Ponziani ,&nbsp;Giulia Saturi ,&nbsp;Irene Ruotolo ,&nbsp;Simone Longhi ,&nbsp;Elena Biagini ,&nbsp;Francesco Cappelli","doi":"10.1016/j.ijcard.2025.133027","DOIUrl":"10.1016/j.ijcard.2025.133027","url":null,"abstract":"<div><h3>Background</h3><div>Hypertension and diabetes may increase the risk of adverse events in the general population and patients with cardiomyopathies, however, their role in patients with cardiac amyloidosis (CA) is still unclarified.</div></div><div><h3>Aims</h3><div>to evaluate the effect on phenotype and clinical outcomes of hypertension and diabetes in patients with CA.</div></div><div><h3>Methods</h3><div>Data from 5 Italian Amyloidosis Referral Centres were used to describe clinical characteristics and outcomes of patients with CA based on the presence of a history of hypertension and diabetes.</div></div><div><h3>Results</h3><div>The study includes 887 patients with CA (311 light chain CA, 87 hereditary transthyretin CA, 489 wild-type transthyretin CA). Median age was 75 years (67–81), and 692 (78 %) were men. Five hundred-seven (57 %) patients had hypertension, 127 (14 %) had diabetes. In multivariable linear regression analysis, hypertension was associated with an increased interventricular septal thickness (coefficient 0.63,95 % CI 0.2–1.06), and augmented E/e’ ratio (1.92,95 % CI 0.55–3.29). On Cox regression, diabetes was independently associated with death and heart failure hospitalizations (HR 1.45,95 % CI 1.05–1.99, <em>p</em> = 0.02).</div></div><div><h3>Conclusions</h3><div>Patients with hypertension present a more severe phenotype with increased LV wall thickness and more severe diastolic dysfunction compared to non-hypertensive. The presence of diabetes in this cohort is associated with an increased risk of adverse outcomes.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"424 ","pages":"Article 133027"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravascular lithotripsy in calcified left main coronary artery: Time to dare?","authors":"Monica Verdoia,&nbsp;Andrea Rognoni","doi":"10.1016/j.ijcard.2025.133026","DOIUrl":"10.1016/j.ijcard.2025.133026","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"423 ","pages":"Article 133026"},"PeriodicalIF":3.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}