{"title":"Effect of colchicine on clinical events in patients with acute coronary syndrome","authors":"Tomoyuki Kawada","doi":"10.1016/j.ijcard.2025.133214","DOIUrl":"10.1016/j.ijcard.2025.133214","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133214"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SGLT2 inhibitors: A potential therapeutic strategy for atrial fibrillation in pulmonary arterial hypertension-induced right heart failure?","authors":"Zhi-Xing Fan , Jin-Chun Wu , Jian Yang","doi":"10.1016/j.ijcard.2025.133206","DOIUrl":"10.1016/j.ijcard.2025.133206","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133206"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephan A.C. Schoonvelde , Georgios M. Alexandridis , Laura B. Price , Arend F.L. Schinkel , Alexander Hirsch , Peter-Paul Zwetsloot , Janneke A.E. Kammeraad , Marjon A. van Slegtenhorst , Judith M.A. Verhagen , Rudolf A. de Boer , Michelle Michels
{"title":"Reply to: Family screening for hypertrophic cardiomyopathy: initial cardiologic assessment, and long-term follow-up of genotype-positive phenotype-negative individuals","authors":"Stephan A.C. Schoonvelde , Georgios M. Alexandridis , Laura B. Price , Arend F.L. Schinkel , Alexander Hirsch , Peter-Paul Zwetsloot , Janneke A.E. Kammeraad , Marjon A. van Slegtenhorst , Judith M.A. Verhagen , Rudolf A. de Boer , Michelle Michels","doi":"10.1016/j.ijcard.2025.133212","DOIUrl":"10.1016/j.ijcard.2025.133212","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133212"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Colchicine for secondary prevention in patients with acute coronary syndrome.","authors":"Jun Yan, Yanjiao Ren, Baihua Zhou","doi":"10.1016/j.ijcard.2025.133210","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133210","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133210"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Left atrial stiffness index in patients with cardiac amyloidosis.","authors":"Meirong Shen, Mingming Hang, Tielong Chen","doi":"10.1016/j.ijcard.2025.133213","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133213","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133213"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lanqing Yang , Zhiquan Yuan , Yanxiu Chen , Yuhong Zeng , Xinghua Chen , Jun Li , Chengying Li , Ying Xiang , Long Wu , Tingting Xia , Li Zhong , Yafei Li , Na Wu
{"title":"Plasma expression level of Hsa_circ_0099734 is associated with atrial fibrillation and its poor prognosis","authors":"Lanqing Yang , Zhiquan Yuan , Yanxiu Chen , Yuhong Zeng , Xinghua Chen , Jun Li , Chengying Li , Ying Xiang , Long Wu , Tingting Xia , Li Zhong , Yafei Li , Na Wu","doi":"10.1016/j.ijcard.2025.133202","DOIUrl":"10.1016/j.ijcard.2025.133202","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation (AF) is a common arrhythmia characterized by severe complications such as stroke, resulting in high disability and mortality rates. A circular RNA (circRNA) hsa_circ_0099734 was found significantly expressed in the atrial tissue of AF patients and controls in our previous work. In this study, we aim to reveal the association between hsa_circ_0099734 and AF as well as its poor prognosis, offering novel perspectives for clinical treatment.</div></div><div><h3>Methods</h3><div>A 1:1 matched case-control study was designed to examine the association between hsa_circ_0099734 and AF. A prospective cohort study was conducted to investigate the association between hsa_circ_0099734 and AF prognosis using Cox proportional hazards regression analysis.</div></div><div><h3>Results</h3><div>An elevated plasma level of hsa_circ_0099734 was an independent risk factor for AF in a multivariable conditional logistic regression model (OR 3.23, 95 % CI: 1.11–9.44; <em>P</em> = 0.032). Regarding the prognostic role of hsa_circ_0099734, the multivariable Cox regression analysis indicated that a high level of hsa_circ_0099734 in plasma was an independent risk factor for stroke in patients with AF (HR 2.87, 95 % CI: 1.90–4.35; <em>P</em> < 0.001), and also an independent risk factor for all-cause mortality in AF patients (HR 3.16, 95 % CI: 2.25–4.45; <em>P</em> < 0.001). Adding hsa_circ_0099734 to the CHA<sub>2</sub>DS<sub>2</sub>-VA score provided better reclassification and net clinical benefit than the ABC risk score.</div></div><div><h3>Conclusions</h3><div>The plasma level of hsa_circ_0099734 was associated with AF risk and the occurrence of stroke or all-cause mortality in AF patients. Hsa_circ_0099734 has the potential to be a non-invasive biomarker for predicting AF and its poor prognosis.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133202"},"PeriodicalIF":3.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hanae F. Namba , Coen K.M. Boerhout , Peter Damman , Vijay Kunadian , Javier Escaned , Peter Ong , Divaka Perera , Colin Berry , Tim P. van de Hoef , Jan J. Piek
{"title":"Invasive coronary function testing in clinical practice: Implementing the 2024 ESC guidelines on chronic coronary syndromes","authors":"Hanae F. Namba , Coen K.M. Boerhout , Peter Damman , Vijay Kunadian , Javier Escaned , Peter Ong , Divaka Perera , Colin Berry , Tim P. van de Hoef , Jan J. Piek","doi":"10.1016/j.ijcard.2025.133176","DOIUrl":"10.1016/j.ijcard.2025.133176","url":null,"abstract":"<div><div>Angina with non-obstructive coronary arteries (ANOCA) is increasingly recognized as a significant aspect of chronic coronary syndromes. These patients frequently experience recurrent angina, resulting in high healthcare costs and impaired quality of life. Invasive coronary function testing (ICFT) is able to identify ANOCA endotypes, which can guide treatment and improve quality of life. Despite Class II recommendations for invasive microvascular assessments in the previous 2019 European Society of Cardiology (ESC) Guidelines, ICFT has yet to translate into widespread clinical practice. Patients with ANOCA experience poor quality of life and reduced functional capacity, highlighting the need for earlier ICFT implementation. The 2024 ESC Guidelines now strongly recommend ICFT (Class I, level of evidence B) for patients with non-obstructive coronary arteries and persistent angina despite optimal medical therapy, and for confirming or excluding ANOCA in patients with uncertain diagnoses on non-invasive testing (Class I, level of evidence B). Consequently, a standardized approach to optimize the management of ANOCA patients is warranted. Therefore, this review aims to provide interventional cardiologists with a contemporary review of the literature and a practical guideline on implementation of ICFT. It will discuss the following subjects: the definitions of the different endotypes, an example of an ICFT protocol, discontinuation of medication prior to ICFT, use of radial cocktail, target vessel for testing, acetylcholine injection techniques and rechallenge, adenosine injection techniques, the order of testing, the interpretation of ICFT, safety and feasibility, and the pharmacological treatment.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133176"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Coppi , G. Pagnoni , C. Campani , F. Grossule , C. Vacchi , D. Giuggioli , A.V. Mattioli , G. Boriani
{"title":"Sjögren's syndrome and pulmonary hypertension: Exploring the intricate link with interstitial lung disease","authors":"F. Coppi , G. Pagnoni , C. Campani , F. Grossule , C. Vacchi , D. Giuggioli , A.V. Mattioli , G. Boriani","doi":"10.1016/j.ijcard.2025.133185","DOIUrl":"10.1016/j.ijcard.2025.133185","url":null,"abstract":"<div><h3>Background</h3><div>Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease commonly presenting with sicca symptoms and, in approximately one-third of cases, extra-glandular manifestations, including pulmonary involvement. Pulmonary hypertension (pH) is a recognized, though less frequently studied, complication in pSS, particularly in patients with interstitial lung disease (ILD). This study evaluates the prevalence of PH in pSS and the relationship between ILD and cardiovascular risk in this population.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 63 patients with pSS, diagnosed according to ACR/EULAR criteria. Among them, 24 patients (38.1 %) had ILD, with 9 presenting pulmonary fibrosis. Comprehensive evaluations were conducted, including 2D/3D echocardiography, HRCT, and pulmonary function tests. Right heart catheterization confirmed PH when indicated. Patients were categorized into pSS-ILD and pSS-noILD groups for comparative analysis.</div></div><div><h3>Results</h3><div>The cohort comprised 7 males (11.1 %) and 56 females (88.9 %), with a mean age of 69.1 ± 12.5 years. The prevalence of PH was low (1.6 %), with only one confirmed case via right heart catheterization, significantly below previous reports. Notably, pSS-ILD patients were older (77.1 ± 10.7 years) and diagnosed with pSS later (68.5 ± 12.6 years; <em>p</em> = 0.001) than pSS-noILD patients. Cardiovascular comorbidities, including arterial hypertension (32.8 %) and dyslipidemia (24.2 %), were more prevalent in pSS-ILD patients (<em>p</em> = 0.003 and <em>p</em> = 0.001, respectively). Pulmonary function tests revealed lower FVC (2.23 ± 0.70 vs. 2.98 ± 0.56; <em>p</em> = 0.004) and DLCO-Sb (3.87 ± 1.52 vs. 5.31 ± 1.26; <em>p</em> = 0.017) in pSS-ILD patients, indicating reduced lung function. Echocardiographic findings showed higher sPA<em>P</em> values (>35 mmHg) and reduced TAPSE/sPAP ratios in the pSS-ILD group (<em>p</em> = 0.028 and <em>p</em> = 0.026, respectively), suggesting early signs of right ventricular impairment.</div></div><div><h3>Conclusions</h3><div>PH prevalence in pSS is lower than previously reported, likely due to rigorous diagnostic criteria. Patients with pSS-ILD exhibit a higher risk of cardiovascular comorbidities and lung function decline. Echocardiographic monitoring of parameters like TAPSE/sPAP may aid in early PH detection, emphasizing the need for tailored management in pSS-ILD patients. Further studies are warranted to explore PH subtypes in diverse populations and to optimize follow-up protocols for at-risk patients.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133185"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}