International journal of cardiology最新文献

{"title":"Distinct lipoprotein contributions to valvular heart disease: Insights from genetic analysis","authors":"Da Luo ,&nbsp;Elias Björnson ,&nbsp;Xiaoying Wang ,&nbsp;Bofang Zhang ,&nbsp;Changwu Xu ,&nbsp;Yunlong Guan ,&nbsp;Shizhen Xiang ,&nbsp;Jan Borén ,&nbsp;Xingjie Hao ,&nbsp;Jing Chen","doi":"10.1016/j.ijcard.2025.133218","DOIUrl":"10.1016/j.ijcard.2025.133218","url":null,"abstract":"<div><h3>Background</h3><div>The per-particle pathogenicity of very-low-density lipoprotein (VLDL) and lipoprotein(a) [Lp(a)] with risk of valvular heart diseases (VHD) other than aortic stenosis compared with low-density lipoprotein (LDL) remains unclear.</div></div><div><h3>Methods</h3><div>Single-nucleotide polymorphism specific clusters associated with LDL cholesterol (LDL-C), VLDL cholesterol (VLDL-C) and Lp(a) were identified. The relationships of genetically predicted variation in apolipoprotein B (apoB) in these lipoproteins with risk of VHD and its major types (aortic stenosis, aortic regurgitation, and mitral regurgitation) were evaluated to determine the comparative pathogenicity by Mendelian randomization (MR) analyses.</div></div><div><h3>Results</h3><div>The VHD odds ratio (OR) per 1 g/L higher apoB was 1.09 [95 % confidence interval (CI) 1.04–1.15] in LDL vs. 1.45 (95 % CI 1.25–1.69) in VLDL vs. 2.71 (95 % CI 1.92–3.82) in Lp(a) based on the cluster-based MR analyses. The polygenic scores for each lipoprotein weighted by apoB similarly showed a greater OR of VHD per 1 g/L apoB in VLDL [1.20 (95 % CI 1.06–1.37)] and in Lp(a) [2.54, (95 % CI 1.95–3.32)] compared with that in LDL [1.05 (95 % CI 1.01–1.08)]. Multivariable MR analyses further revealed the strong effects of VLDL-C and Lp(a) on VHD risk independent of LDL-C. In addition, significant associations between Lp(a) and all three major types of VHD were observed, while LDL and VLDL had no impact on aortic and mitral regurgitation.</div></div><div><h3>Conclusions</h3><div>VLDL and Lp(a) appear to have significantly greater per-particle pathogenicity in VHD compared to LDL. The distinct impacts of lipoproteins on different VHD subtypes suggest the inadequacy of just focusing on LDL-lowering treatment for valve disorders.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"431 ","pages":"Article 133218"},"PeriodicalIF":3.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Midterm outcomes of thoracoscopic trans-mitral myectomy for hypertrophic obstructive cardiomyopathy: A single-center, observational study","authors":"Zheng Xu ,&nbsp;Liangwan Chen ,&nbsp;Xiaofu Dai ,&nbsp;Zhiqin Lin","doi":"10.1016/j.ijcard.2025.133216","DOIUrl":"10.1016/j.ijcard.2025.133216","url":null,"abstract":"<div><h3>Background</h3><div>Hypertrophic obstructive cardiomyopathy (HOCM) is traditionally treated with septal myectomy via sternotomy. Thoracoscopic trans-mitral myectomy (TTM) is a minimally invasive alternative, but midterm outcomes remain unclear. We aimed to evaluate the midterm efficacy and safety of TTM versus open trans-aortic myectomy (OTM) in obstructive HOCM patients.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted at a single institution, including patients who underwent either TTM or OTM from January 2020 to December 2023. Primary endpoints included changes in echocardiographic parameters (left ventricular outflow tract [LVOT] gradient, septal thickness, left ventricular volume, and mitral regurgitation severity) and functional improvement (NYHA class). Secondary outcomes included complications, re-intervention, and survival at 12 months.</div></div><div><h3>Results</h3><div>A total of 102 patients were included, with 57 undergoing TTM and 45 undergoing OTM. Both techniques led to significant reductions in LVOT gradient and septal thickness (both <em>p</em> &lt; 0.001), with no significant intergroup differences. TTM showed superior improvement in mitral regurgitation severity, with moderate-to-severe mitral regurgitation decreasing from 42 % to 9 % versus 38 % to 20 % in OTM (<em>p</em> &lt; 0.05). Functional status improved, with 88 % of TTM and 87 % of OTM patients achieving NYHA class I at 12 months. No significant differences were observed with respect to re-interventions or 12-month survival.</div></div><div><h3>Conclusions</h3><div>TTM is a safe and effective alternative to OTM for HOCM, offering similar relief of LVOT obstruction and functional improvement, with superior reduction in mitral regurgitation severity. Larger, multicenter studies are needed to confirm these findings and define TTM's role in HOCM management.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133216"},"PeriodicalIF":3.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rigor of cardiac device implant training affects performance outcome","authors":"Jorio Mascheroni ,&nbsp;Martin Stockburger ,&nbsp;Ashish Patwala ,&nbsp;Hartwig Retzlaff ,&nbsp;Christophe Garweg ,&nbsp;Tom Verbelen ,&nbsp;Anthony G. Gallagher","doi":"10.1016/j.ijcard.2025.133217","DOIUrl":"10.1016/j.ijcard.2025.133217","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac Implantable Electronic Devices (CIED) training for novice implanters typically occurs in vivo, varies across institutions, and results in inconsistent skill levels. We previously demonstrated the superior effects of Proficiency-Based Progression (PBP) training on implanters' performance in a randomized controlled trial (RCT). Beforehand, we conducted a ‘pilot’ study to evaluate the robustness of PBP training, hypothesizing that a substantial majority of trainees would achieve the target proficiency after training.</div></div><div><h3>Methods</h3><div>In this international, prospective, single-arm study, novice implanters completed a metrics-based simulation training curriculum, requiring proficiency benchmark demonstration at each stage to advance. Trainees ultimately performed a cardiac resynchronization therapy implant on virtual reality simulation which was video-recorded and then scored using validated Metrics (Steps, Critical Errors, Errors non-critical) by independent assessors. The primary outcome was the number of trainees meeting the benchmark. Findings informed corrective actions for the subsequent RCT training, whose effectiveness was verified by comparing PBP-trained participants from the pilot study (PBP-PILOT) and the RCT (PBP-RCT) on Steps completed, All Errors, and benchmark achievement.</div></div><div><h3>Results</h3><div>Only 17 % achieved the proficiency benchmark. Investigations revealed insufficient faculty adherence to the PBP methodology resulting in premature trainee advancement. Corrective actions improved the subsequent RCT training: compared to the PBP-PILOT group, PBP-RCT trainees completed 15 % more Steps (<em>p</em> = .014), made 69 % fewer All Errors (<em>p</em> = .015), and 93 % met the benchmark (<em>p</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>Pilot testing revealed deficiencies in PBP training execution, highlighting the importance of rigor and faculty compliance. Verifying novel curricula before large-scale implementation is crucial to ensuring robust training outcomes.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133217"},"PeriodicalIF":3.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomics for abdominal aortic aneurysm prognosis prediction: Additional feature suggestions","authors":"Chia-Ter Chao MD, PhD","doi":"10.1016/j.ijcard.2025.133208","DOIUrl":"10.1016/j.ijcard.2025.133208","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133208"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of colchicine on clinical events in patients with acute coronary syndrome","authors":"Tomoyuki Kawada","doi":"10.1016/j.ijcard.2025.133214","DOIUrl":"10.1016/j.ijcard.2025.133214","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133214"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGLT2 inhibitors: A potential therapeutic strategy for atrial fibrillation in pulmonary arterial hypertension-induced right heart failure?","authors":"Zhi-Xing Fan ,&nbsp;Jin-Chun Wu ,&nbsp;Jian Yang","doi":"10.1016/j.ijcard.2025.133206","DOIUrl":"10.1016/j.ijcard.2025.133206","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133206"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Family screening for hypertrophic cardiomyopathy: initial cardiologic assessment, and long-term follow-up of genotype-positive phenotype-negative individuals","authors":"Stephan A.C. Schoonvelde ,&nbsp;Georgios M. Alexandridis ,&nbsp;Laura B. Price ,&nbsp;Arend F.L. Schinkel ,&nbsp;Alexander Hirsch ,&nbsp;Peter-Paul Zwetsloot ,&nbsp;Janneke A.E. Kammeraad ,&nbsp;Marjon A. van Slegtenhorst ,&nbsp;Judith M.A. Verhagen ,&nbsp;Rudolf A. de Boer ,&nbsp;Michelle Michels","doi":"10.1016/j.ijcard.2025.133212","DOIUrl":"10.1016/j.ijcard.2025.133212","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133212"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colchicine for secondary prevention in patients with acute coronary syndrome","authors":"Jun Yan,&nbsp;Yanjiao Ren,&nbsp;Baihua Zhou","doi":"10.1016/j.ijcard.2025.133210","DOIUrl":"10.1016/j.ijcard.2025.133210","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133210"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left atrial stiffness index in patients with cardiac amyloidosis","authors":"Meirong Shen ,&nbsp;Mingming Hang ,&nbsp;Tielong Chen","doi":"10.1016/j.ijcard.2025.133213","DOIUrl":"10.1016/j.ijcard.2025.133213","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133213"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma expression level of Hsa_circ_0099734 is associated with atrial fibrillation and its poor prognosis","authors":"Lanqing Yang ,&nbsp;Zhiquan Yuan ,&nbsp;Yanxiu Chen ,&nbsp;Yuhong Zeng ,&nbsp;Xinghua Chen ,&nbsp;Jun Li ,&nbsp;Chengying Li ,&nbsp;Ying Xiang ,&nbsp;Long Wu ,&nbsp;Tingting Xia ,&nbsp;Li Zhong ,&nbsp;Yafei Li ,&nbsp;Na Wu","doi":"10.1016/j.ijcard.2025.133202","DOIUrl":"10.1016/j.ijcard.2025.133202","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation (AF) is a common arrhythmia characterized by severe complications such as stroke, resulting in high disability and mortality rates. A circular RNA (circRNA) hsa_circ_0099734 was found significantly expressed in the atrial tissue of AF patients and controls in our previous work. In this study, we aim to reveal the association between hsa_circ_0099734 and AF as well as its poor prognosis, offering novel perspectives for clinical treatment.</div></div><div><h3>Methods</h3><div>A 1:1 matched case-control study was designed to examine the association between hsa_circ_0099734 and AF. A prospective cohort study was conducted to investigate the association between hsa_circ_0099734 and AF prognosis using Cox proportional hazards regression analysis.</div></div><div><h3>Results</h3><div>An elevated plasma level of hsa_circ_0099734 was an independent risk factor for AF in a multivariable conditional logistic regression model (OR 3.23, 95 % CI: 1.11–9.44; <em>P</em> = 0.032). Regarding the prognostic role of hsa_circ_0099734, the multivariable Cox regression analysis indicated that a high level of hsa_circ_0099734 in plasma was an independent risk factor for stroke in patients with AF (HR 2.87, 95 % CI: 1.90–4.35; <em>P</em> &lt; 0.001), and also an independent risk factor for all-cause mortality in AF patients (HR 3.16, 95 % CI: 2.25–4.45; <em>P</em> &lt; 0.001). Adding hsa_circ_0099734 to the CHA₂DS₂-VA score provided better reclassification and net clinical benefit than the ABC risk score.</div></div><div><h3>Conclusions</h3><div>The plasma level of hsa_circ_0099734 was associated with AF risk and the occurrence of stroke or all-cause mortality in AF patients. Hsa_circ_0099734 has the potential to be a non-invasive biomarker for predicting AF and its poor prognosis.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133202"},"PeriodicalIF":3.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}