International journal of cardiology最新文献

{"title":"Beyond the heart: Mind-body connection from birth and the holistic intervention in cardiovascular care","authors":"Daniela Polese","doi":"10.1016/j.ijcard.2025.133270","DOIUrl":"10.1016/j.ijcard.2025.133270","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"432 ","pages":"Article 133270"},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation in chronic heart failure: An unsolved puzzle","authors":"Giancarlo Trimarchi , Fausto Pizzino , Umberto Paradossi","doi":"10.1016/j.ijcard.2025.133281","DOIUrl":"10.1016/j.ijcard.2025.133281","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"432 ","pages":"Article 133281"},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular risk, meet the twins: Optimizing cardiometabolic care with SGLT2i and GLP-1RA combination therapy","authors":"Paschalis Karakasis , Dimitrios Patoulias , Panagiotis Theofilis , Nikolaos Fragakis","doi":"10.1016/j.ijcard.2025.133272","DOIUrl":"10.1016/j.ijcard.2025.133272","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"432 ","pages":"Article 133272"},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infarct-like myocarditis in adolescents: Exploring genetic insights from diagnosis through follow-up","authors":"Roger Esmel-Vilomara ,&nbsp;Lucía Riaza ,&nbsp;Paola Dolader ,&nbsp;Benjamín Rodríguez-Santiago ,&nbsp;Amaia Lasa-Aranzasti ,&nbsp;Patricia Muñoz-Cabello ,&nbsp;Paula Fernández-Álvarez ,&nbsp;Marc Figueras-Coll ,&nbsp;Lisa Bianco ,&nbsp;Andrea Bueno-Gómez ,&nbsp;Laura Vargas-Pons ,&nbsp;Elisabet Camprubí-Tubella ,&nbsp;Cristina Marimon-Blanch ,&nbsp;Anna Sabaté-Rotés ,&nbsp;Ferran Rosés-Noguer ,&nbsp;Ferran Gran","doi":"10.1016/j.ijcard.2025.133255","DOIUrl":"10.1016/j.ijcard.2025.133255","url":null,"abstract":"<div><h3>Background</h3><div>Myocarditis has traditionally been considered an acquired condition, but recent evidence suggests a genetic contribution, primarily in complicated cases. Data on pediatric uncomplicated or infarct-like myocarditis remain scarce. This study aimed to assess the prevalence of pathogenic or likely pathogenic (P/LP) variants in adolescents with infarct-like myocarditis and their association with clinical and imaging findings.</div></div><div><h3>Methods</h3><div>This prospective, multicenter study included 30 adolescents diagnosed with infarct-like myocarditis across five hospitals in Catalunya, Spain (2016–2024). Diagnosis was confirmed using the 2018 Lake Louise Criteria on cardiac magnetic resonance imaging (CMR). Follow-up CMR was performed at 12 months, and genetic testing was conducted using a next-generation sequencing panel targeting 174 genes associated with inherited cardiac diseases.</div></div><div><h3>Results</h3><div>P/LP variants in cardiomyopathy-associated genes were identified in 22.2 % of patients. Baseline CMR showed no significant differences in ventricular function or LGE extent, but a ring-like LGE pattern was significantly associated with genetic findings (<em>p</em> = 0.025), while septal involvement showed a <em>p</em>-value of 0.056. Over a median follow-up of 3 years (IQR 2–7), 9 patients (30 %) experienced recurrent myocarditis, more frequently in genetic-positive patients (66.7 % vs. 23.8 %). At 12 months, genetic-positive patients exhibited a greater LGE burden (<em>p</em> = 0.047) and persistent myocardial edema on T2-STIR (<em>p</em> = 0.009), suggesting ongoing myocardial remodeling.</div></div><div><h3>Conclusions</h3><div>The high prevalence of P/LP variants in infarct-like myocarditis highlights the need for genetic testing, particularly in patients with a ring-like LGE pattern or septal involvement. Persistent CMR abnormalities and symptomatic recurrences in genetic-positive cases support long-term monitoring, even in seemingly uncomplicated presentations.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"432 ","pages":"Article 133255"},"PeriodicalIF":3.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"U-shaped relationship between serum phosphate levels and mortality in critically ill patients with atrial fibrillation: Insights from the MIMIC-IV database","authors":"Yinying He ,&nbsp;Jiamei Huang ,&nbsp;Senlin Huang ,&nbsp;Yuewei Li ,&nbsp;Qintong Li ,&nbsp;Zhineng Lin ,&nbsp;Tucheng Huang ,&nbsp;Fuwen Huang","doi":"10.1016/j.ijcard.2025.133283","DOIUrl":"10.1016/j.ijcard.2025.133283","url":null,"abstract":"<div><h3>Introduction</h3><div>Atrial fibrillation (AF), a common arrhythmia in critically ill patients, significantly affects prognosis. While phosphate disturbances are strongly associated with cardiovascular risks, the impact of serum phosphate on critically ill AF patients' prognosis remains uncertain.</div></div><div><h3>Methods</h3><div>Utilizing data from the MIMIC-IV database, we retrospectively analyzed 11,744 critically ill AF patients. The primary outcome was 30-day all-cause mortality, with secondary outcomes at 90 days and 1 year. Cox regression models quantified the association between serum phosphate and mortality. Nonlinear associations were evaluated using restricted cubic splines (RCS), with inflection points further characterized through segmented Cox proportional hazards model.</div></div><div><h3>Results</h3><div>Mortality rates at 30 days, 90 days, and 1 year were 12.7 %, 14.4 %, and 15.8 %, respectively. Kaplan-Meier analysis showed higher mortality in patients with high phosphate levels. Adjusted Cox regression demonstrated that hyperphosphatemia independently predicted increased mortality at 30 days (HR: 1.55, 95 % CI: 1.36–1.78, <em>p</em> &lt; 0.001), 90 days (HR: 1.55, 95 % CI: 1.37–1.76, p &lt; 0.001), and 1 year (HR: 1.57, 95 % CI: 1.39–1.77, p &lt; 0.001). RCS and two-piece Cox regression revealed a U-shaped nonlinear relationship between serum phosphate and mortality, with risk decreasing below a threshold and increasing above it. Similar patterns were observed across all time points.</div></div><div><h3>Conclusion</h3><div>Our findings demonstrated a U-shaped relationship between serum phosphate levels and mortality in critically ill AF patients, highlighting the importance of maintaining optimal phosphate levels in managing this population.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"433 ","pages":"Article 133283"},"PeriodicalIF":3.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Considerations on Patient Age in the Study of Pulmonary Hypertension and Interstitial Lung Disease in Sjögren's Syndrome”","authors":"Francesca Coppi ,&nbsp;Gianluca Pagnoni ,&nbsp;Cecilia Campani ,&nbsp;Francesca Grossule ,&nbsp;Stefania Cerri ,&nbsp;Caterina Vacchi ,&nbsp;Dilia Giuggioli ,&nbsp;Marcello Pinti ,&nbsp;Francesco Fedele ,&nbsp;Anna Vittoria Mattioli ,&nbsp;Giuseppe Boriani","doi":"10.1016/j.ijcard.2025.133285","DOIUrl":"10.1016/j.ijcard.2025.133285","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"432 ","pages":"Article 133285"},"PeriodicalIF":3.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “ Sjögren's syndrome and pulmonary hypertension: Correspondence”","authors":"Francesca Coppi ,&nbsp;Gianluca Pagnoni ,&nbsp;Cecilia Campani ,&nbsp;Francesca Grossule ,&nbsp;Stefania Cerri ,&nbsp;Caterina Vacchi ,&nbsp;Dilia Giuggioli ,&nbsp;Marcello Pinti ,&nbsp;Francesco Fedele ,&nbsp;Anna Vittoria Mattioli ,&nbsp;Giuseppe Boriani","doi":"10.1016/j.ijcard.2025.133286","DOIUrl":"10.1016/j.ijcard.2025.133286","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"432 ","pages":"Article 133286"},"PeriodicalIF":3.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEL-1 promotes macrophage lipid accumulation and inflammation by inhibiting TGF-β","authors":"Yu-Ping Wang ,&nbsp;Xian Liu ,&nbsp;Shao-Yang Sun ,&nbsp;Lin Zhu ,&nbsp;Kun Ren","doi":"10.1016/j.ijcard.2025.133284","DOIUrl":"10.1016/j.ijcard.2025.133284","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"432 ","pages":"Article 133284"},"PeriodicalIF":3.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loganin inhibits cardiomyocyte apoptosis and myocardial ischemia/reperfusion injury via activation of the Nrf2/HO-1 signaling","authors":"Yu-Ping Wang ,&nbsp;Xian Liu ,&nbsp;Shao-Yang Sun ,&nbsp;Lin Zhu ,&nbsp;Kun Ren","doi":"10.1016/j.ijcard.2025.133287","DOIUrl":"10.1016/j.ijcard.2025.133287","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"432 ","pages":"Article 133287"},"PeriodicalIF":3.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: External evaluation of a commercial artificial intelligence-augmented digital auscultation platform in valvular heart disease detection using echocardiography as reference standard (Int J Cardiol. 2025;419:132653)","authors":"Rosalie Victoria McDonough","doi":"10.1016/j.ijcard.2025.133260","DOIUrl":"10.1016/j.ijcard.2025.133260","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"432 ","pages":"Article 133260"},"PeriodicalIF":3.2,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}