International journal of cardiology最新文献

{"title":"Reply to “Growth differentiation factor 15 and empagliflozin in acute myocardial infarction: Correspondence”","authors":"Óscar M. Peiró , Alfredo Bardají , Anna Carrasquer , German Cediel , Isabel Serrano , Gil Bonet , María Ferrero , Víctor Del-Moral-Ronda , Mar Rocamora-Horrach , José Luis Ferreiro","doi":"10.1016/j.ijcard.2025.133531","DOIUrl":"10.1016/j.ijcard.2025.133531","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133531"},"PeriodicalIF":3.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific response to cardiac resynchronization therapy: the BIO|WOMEN trial.","authors":"Jose Luis Zamorano, Gabor Vörös, Valeria Calvi, Joaquín Osca, Aurelio Quesada, Kevin Vernooy, Juan Gabriel Martinez, Alexander H Maass, Eyal Nof, Jose Maria Tolosana, Mónica Pardo, Craig Barr, Ignacio Fernández, Jose Luis Merino, Susan Ellery, Enrique Ricoy-Martínez, Giuseppina Belotti, Lea Seidlmayer, Santiago Garcia, Tobias Tönnis, Niall G Campbell, Paul Foley, Johannes Brockmeier, Michael Nürnberg, Ricardo Ruiz-Granell, Frits W Prinzen, Álvaro Lorente-Ros, Alicia Moreno, Mariona Pinart, Mark Ver Heyen, Lieselot Van Erven","doi":"10.1016/j.ijcard.2025.133526","DOIUrl":"10.1016/j.ijcard.2025.133526","url":null,"abstract":"<p><strong>Background: </strong>Variable evidence exists about the efficacy of Cardiac resynchronization therapy (CRT) in women vs. men with reduced left ventricular ejection fraction (LVEF) and wide QRS complex. Current guidelines, hindered by underrepresentation of women in clinical trials, lack definitive recommendations. The present study was designed to achieve an equal distribution of women and men to prospectively evaluate sex-specific response to CRT.</p><p><strong>Methods: </strong>The primary endpoint was the absolute increase in core-lab-assessed LVEF 12 months after de novo implantation of a CRT device. Estimation was adjusted by several baseline confounders to correct sex-specific effect of CRT. Secondary endpoints were further echocardiographic changes including responder rate (LVEF increase ≥5 %); change in NYHA class, 6-min walk distance, quality of life, a clinical composite score (CCS) and the composite of death or HF hospitalization.</p><p><strong>Results: </strong>We enrolled 230 women and 244 men at 25 sites in eight countries. A larger improvement in LVEF (+14.7 % vs. +11.5 %, p ≤ 0.01) in women remained after adjustment for baseline variables (absolute increase attributed to female sex +2.53 %, P = 0.023). Furthermore, a better improvement was observed in reverse remodeling, responder rate (∆LVEF ≥5 %: 83.3 % vs. 70.6 %; p = 0.003), quality of life and HF symptoms in women compared to men. The CCS and the composite of death or HF hospitalization were better in women than in men after CRT.</p><p><strong>Conclusions: </strong>The effect of CRT remained superior in women regarding echocardiographic outcomes even after adjusting for baseline variables. Our results confirm the importance of recognizing sex-specific differences when screening patients for CRT.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133526"},"PeriodicalIF":3.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of CMR-derived extracellular volume in myocardial infarction with non-obstructive coronary arteries","authors":"Lei Chen ,&nbsp;Liqi Ge ,&nbsp;Fuad A. Abdu ,&nbsp;Xinjia Du ,&nbsp;Jiahua Liu ,&nbsp;Wensu Chen ,&nbsp;Yuan Lu ,&nbsp;Wenliang Che","doi":"10.1016/j.ijcard.2025.133528","DOIUrl":"10.1016/j.ijcard.2025.133528","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac magnetic resonance (CMR) is crucial for diagnosing myocardial infarction with non-obstructive coronary arteries (MINOCA) and is recommended by current guidelines for its diagnostic and prognostic capabilities. However, the prognostic value of CMR parameters, particularly extracellular volume (ECV), in predicting major adverse cardiovascular events (MACE) among MINOCA remains unclear. This study analyzes ECV distribution across different MINOCA etiologies and its predictive value for MACE in “true” MINOCA.</div></div><div><h3>Methods</h3><div>Consecutive patients with a working diagnosis of MINOCA who underwent CMR were included. We investigated the relationships between CMR parameters and MACE in “true” MINOCA. Cox regression and ROC curve analyses were used to assess ECV in predicting MACE. “True” MINOCA was defined by evidence of ischemia or infarction on CMR.</div></div><div><h3>Results</h3><div>Among 275 patients with a working diagnosis of MINOCA (median 4 days to CMR), 96 were diagnosed with “true” MINOCA, 66 with myocarditis, 31 with Takotsubo syndrome (TS), 34 with cardiomyopathies, and 48 had normal findings. “True” MINOCA had higher ECV compared to other etiologies (29.10 % vs. 26.00 %, <em>P</em> &lt; 0.001). During a median follow-up of 26.6 months, 29.2 % of “true” MINOCA patients experienced MACE. In the adjusted Cox model, ECV (HR 1.063, 95 % CI 1.019–1.108, <em>P</em> = 0.004) was an independent predictor of MACE in patients with “true” MINOCA. According to optimal cut-off values from ROC, patients with ECV &gt;28.94 % had a significantly higher MACE risk (log-rank <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>CMR-derived ECV varies by MINOCA etiology, with higher levels in “true” MINOCA. Elevated ECV independently predicts increased MACE risk in “true” MINOCA patients.</div><div>Trial registration number: <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> (ID: <span><span>NCT06502899</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133528"},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Target, track, treat: Evolving paradigms in cardiovascular molecular imaging.","authors":"Brijesh Sathian, Javed Iqbal, Syed Muhammad Ali, Khadija Said Hamood Al Shukaili","doi":"10.1016/j.ijcard.2025.133539","DOIUrl":"10.1016/j.ijcard.2025.133539","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133539"},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Outcomes of mitral valve reoperation and first-time surgery for mitral regurgitation: A nationwide study”","authors":"Aabir Imran ,&nbsp;Aaila Haider","doi":"10.1016/j.ijcard.2025.133534","DOIUrl":"10.1016/j.ijcard.2025.133534","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133534"},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"The efficacy and safety of dapagliflozin in pediatric heart failure\".","authors":"Yuting Song, Qiang Shi, Chengzhi Xu","doi":"10.1016/j.ijcard.2025.133537","DOIUrl":"10.1016/j.ijcard.2025.133537","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133537"},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating methods to detect variation in hospital level mortality and renal insufficiency within an Australian cardiac surgery registry","authors":"Jessy Hansen ,&nbsp;Susannah Ahern ,&nbsp;Ahmad Reza Pourghaderi ,&nbsp;Jenni Williams-Spence ,&nbsp;Lavinia Tran ,&nbsp;Christopher M. Reid ,&nbsp;Julian A. Smith ,&nbsp;Arul Earnest","doi":"10.1016/j.ijcard.2025.133517","DOIUrl":"10.1016/j.ijcard.2025.133517","url":null,"abstract":"<div><h3>Background</h3><div>Although clinical quality registries have been established worldwide to monitor cardiothoracic surgery outcomes through benchmarking to detect underperforming hospitals (outliers) and improve quality of care, the accuracy of such analyses remains unclear. This study aimed to compare and evaluate methods of outlier classification when applied to real-world and simulated data.</div></div><div><h3>Methods</h3><div>Data relating to isolated coronary artery bypass graft procedures were obtained from the Australian and New Zealand Society of Cardiac and Thoracic Surgeons Cardiac Surgery Database registry. Unadjusted and risk-adjusted operative mortality and new renal insufficiency were the key outcomes evaluated for two timeframes: cumulative (2018–2021) and rolling (2022); additional data were parametrically generated to simulate these datasets. Agreement in outlier flagging was compared between variations of control limit and confidence interval methods when applied to the real data, and the expected accuracy of the methods evaluated using the simulated data.</div></div><div><h3>Results</h3><div>While outlier flagging was similar between techniques, agreement between different risk-adjustment, timeframes and significance levels were moderate to poor. The expected accuracy of outlier classification also differed between these considerations, with high performance only reached for risk-adjusted outcomes using cumulative data. Of the methods, outliers flagged using exact binomial 95 % control limits had the highest accuracy.</div></div><div><h3>Conclusions</h3><div>Clinical registries should consider their data parameters before commencing benchmarking to detect underperforming sites. To optimise accuracy of outlier flagging, outcomes should be risk-adjusted, cumulative datasets should be used in the case of low patient volumes and, where possible, outcomes with higher prevalence should be evaluated.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133517"},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JAK2/STAT3 signaling: a critical axis in atherosclerosis pathogenesis and therapeutic targeting","authors":"Shuang Qiu ,&nbsp;Yiyi Zhu ,&nbsp;Fang Wu","doi":"10.1016/j.ijcard.2025.133533","DOIUrl":"10.1016/j.ijcard.2025.133533","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133533"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Letter to the editor: Risk and predictors of first-time infective endocarditis in adult patients with congenital heart disease: A nationwide, register-based study”","authors":"Noor Ul Huda ,&nbsp;Noman Ansari ,&nbsp;Rizwan Ansari","doi":"10.1016/j.ijcard.2025.133530","DOIUrl":"10.1016/j.ijcard.2025.133530","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133530"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the Gap: Addressing the Underuse of Transcatheter Edge-to-Edge Repair in Chinese Patients with Significant Mitral Regurgitation","authors":"Dina M. Awad","doi":"10.1016/j.ijcard.2025.133519","DOIUrl":"10.1016/j.ijcard.2025.133519","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133519"},"PeriodicalIF":3.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}