International journal of cardiology最新文献

{"title":"Associations of PM_2.5 components with dynamic and accelerated progression of different kidney function states and subsequent cardiovascular events: The GOLD-Health cohort.","authors":"Manting Rao, Jiamin Chen, Peng Hu, Zhonghua Ai, Menghe Wang, Xiangyi Liu, Zhoubin Zhang, Hualiang Lin","doi":"10.1016/j.ijcard.2026.134999","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.134999","url":null,"abstract":"<p><strong>Background: </strong>Fine particulate matter (PM_2.5) has been associated with an increased risk of chronic kidney disease (CKD) and cardiovascular disease (CVD). However, the relationships between specific PM_2.5 components and the dynamic cardiorenal trajectory remain uncertain.</p><p><strong>Methods: </strong>Employing multistate and accelerated failure time (AFT) modeling in a prospective cohort of 307,639 participants, we examined the associations of 2-year exposure to PM_2.5 and its components (sulfate [SO₄^2-], nitrate [NO₃^-], ammonium [NH₄⁺], organic matter [OM], and black carbon [BC]) with dynamic and accelerated progression from different kidney function categories (1-4, according to estimated glomerular filtration rate [eGFR] and self-reported CKD) to CVD, and ultimately to cardiovascular death.</p><p><strong>Results: </strong>Over 1,058,210 person-years of follow-up, we documented 23,948 CVD cases and 7763 cardiovascular death cases. We observed that PM_2.5 and its components were significantly associated with the dynamic cardiorenal trajectory, with SO₄^2-, NO₃^-, and NH₄⁺ exhibiting larger hazard ratios (HRs). Per-interquartile range (IQR) increments in SO₄^2-, NO₃^-, and NH₄⁺ were positively correlated with the transition from kidney function category 2 to 3, and the HRs were 1.273 (95% confidence interval [CI]: 1.257-1.289), 1.304 (95% CI: 1.290-1.317), and 1.280 (95% CI: 1.267-1.294), respectively. The AFT model indicated that higher levels of PM_2.5 and its constituents significantly accelerated the dynamic cardiorenal trajectory. The predictive transition times from kidney function category 2 to 3 for 2-year NO₃^- exposure were 1727.43 days at 4.2 μg/m³ and 868.56 days at 7.0 μg/m³.</p><p><strong>Conclusions: </strong>Our findings revealed that PM_2.5 components (2-year exposure) may be important risk factors for adverse cardiorenal outcomes.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"134999"},"PeriodicalIF":3.3,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CA125 and the right ventricle in acute heart failure: A marker of dysfunction or congestion?","authors":"Takahiro Okumura, Kazuhiro Terashima, Hiroyuki Naruse, Masanobu Yanase, Hideo Izawa","doi":"10.1016/j.ijcard.2026.134992","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.134992","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"134992"},"PeriodicalIF":3.3,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Left atrial dimension and new-onset atrial fibrillation in chronic Chagas disease: a competing-risk analysis of the SEARCH-Rio cohort\" - Benchimol-Barbosa PR, Benchimol-Barbosa ACL, Kantharia BK. Int J Cardiol. 2026 Sep 15;464:134788. doi:10.1016/j.ijcard.2026.134788. Epub ahead of print. PMID: 42744019: Response to Letter to the Editor \"Beyond Left Atrial Diameter in Chagas Disease: Interatrial Block and Competing-Risk Modelling for Atrial Fibrillation Risk\" by Ullah T and Shah MT.","authors":"Paulo Roberto Benchimol-Barbosa, Ana Carolina Loayza Benchimol-Barbosa, Bharat K Kantharia","doi":"10.1016/j.ijcard.2026.134995","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.134995","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"134995"},"PeriodicalIF":3.3,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2026 update on the COVADIS diagnostic criteria of international standardization for microvascular angina.","authors":"Peter Ong, Paolo Camici, John Beltrame, Colin Berry, Filippo Crea, Javier Escaned, Tim van de Hoef, Juan Carlos Kaski, Carl Pepine, Udo Sechtem, Hiroaki Shimokawa, Christopher Zeitz, Noel Bairey Merz","doi":"10.1016/j.ijcard.2026.134993","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.134993","url":null,"abstract":"<p><p>Microvascular angina, in the context of ischemia with non-obstructed coronary arteries (INOCA), is a highly prevalent clinical condition in cardiovascular medicine. Although it remains frequently underdiagnosed, clinical research and practice have made substantial progress in the last 10 years. This includes better characterisation of affected patient cohorts, new data on the prevalence of coronary vasomotor disorders and improved diagnostic assessments (non-invasive and invasive). The aim of this paper is to update our previous 2018 recommendations for the standardization of diagnostic criteria for microvascular angina. The updated COVADIS (Coronary Vasomotor Disorders Study Group) criteria focus on the following 4 criteria: (1) symptoms of myocardial ischemia; (2) non-obstructive coronary disease (stenosis <50%); (3) objective evidence of myocardial ischemia and (4) evidence of impaired coronary microvascular function. The updated criteria incorporate new suggestions for endotype definitions based on the invasive assessment of coronary physiology including coronary flow reserve and the index of microvascular resistance during pharmacological stress as well as acetylcholine testing for epicardial and/or microvascular spasm. The updated criteria should contribute to improved recognition and better management of this condition.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"134993"},"PeriodicalIF":3.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raising diagnoses or doubts? RAISE score for transthyretin cardiac amyloidosis identification in aortic stenosis.","authors":"Vincenzo Castiglione, Alberto Aimo, Giuseppe Vergaro, Michele Emdin","doi":"10.1016/j.ijcard.2026.134977","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.134977","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"134977"},"PeriodicalIF":3.3,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern: \"Conditional knockout of TFPI-1 in VSMCs of mice accelerates atherosclerosis by enhancing AMOT/YAP pathway\".","authors":"","doi":"10.1016/j.ijcard.2026.134958","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.134958","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"134958"},"PeriodicalIF":3.3,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endomyocardial fibrosis in adults: multimodality imaging phenotype and independent predictors of mortality.","authors":"Viviane Tiemi Hotta, Cristhian Espinoza Romero, Vagner Madrini, Luis Miguel Guerrero Cepeda, Gardenia da Silva Lobo Oishi, Diana Fernanda Lasso Rodríguez, Juliano Novaes Cardoso, Charles Mady, Ana Olga Mocumbi, Fabio Fernandes","doi":"10.1016/j.ijcard.2026.134929","DOIUrl":"https://doi.org/10.1016/j.ijcard.2026.134929","url":null,"abstract":"<p><strong>Background: </strong>Endomyocardial fibrosis (EMF) is a rare restrictive cardiomyopathy characterized by endocardial fibrosis and apical obliteration. Data on its long-term evolution and prognosis remain limited.</p><p><strong>Objectives: </strong>To describe the clinical profile, multimodality imaging findings, longitudinal evolution and independent predictors of all-cause mortality in adults with EMF.</p><p><strong>Methods: </strong>We conducted a retrospective and single-center cohort study of consecutive adults (≥18 years) diagnosed with EMF, between 1997 and 2024. Diagnosis was based on clinical features and characteristic transthoracic echocardiography, with cardiac magnetic resonance (CMR) when available. The primary outcome was all-cause mortality. Secondary outcomes included need for surgery, perioperative mortality, development of atrial fibrillation (AF), and longitudinal changes in clinical, laboratory, and echocardiographic parameters. Survival analyses used Kaplan-Meier curves and Cox regression.</p><p><strong>Results: </strong>Eighty-nine patients were included; 79.8% were women and mean age at diagnosis was 62 ± 13 years. Most had heart failure with preserved ejection fraction, left ventricular apical obliteration, left atrial enlargement and valvular dysfunction. Late gadolinium enhancement on CMR was present in 71.6%, predominantly apical. Over a mean follow-up of 8.1 years, 51 patients (57.3%) died. Mortality was higher in surgically treated patients (p = 0.004). AF developed in 42%. In multivariate analysis, independent predictors of mortality were NYHA III/IV (HR 4.66), AF (HR 2.95), lower hemoglobin (HR 0.76 per g/dL), larger left atrial diameter (HR 1.09/mm), and greater interventricular septal thickness (HR 1.80/mm).</p><p><strong>Conclusions: </strong>Adult EMF showed a restrictive phenotype with high long-term mortality. Clinical status and structural remodeling-rather than surgery-were the main determinants of prognosis.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"134929"},"PeriodicalIF":3.3,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149060359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10-year outcome of fractional flow reserve-guided complete revascularization in patients with ST-segment elevation myocardial infarction – A DANAMI-3 PRIMULTI substudy","authors":"Utsho Islam,&nbsp;Jasmine M. Marquard,&nbsp;Ibrahim M.A. Khalek,&nbsp;Henning Kelbæk,&nbsp;Ashkan Eftekhari,&nbsp;Lars Køber,&nbsp;Dan Høfsten,&nbsp;Lene Holmvang,&nbsp;Frants Pedersen,&nbsp;Jacob T. Lønborg,&nbsp;Thomas Engstrøm","doi":"10.1016/j.ijcard.2026.134712","DOIUrl":"10.1016/j.ijcard.2026.134712","url":null,"abstract":"<div><h3>Background</h3><div>Complete revascularization is recommended in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease. However, whether the non-culprit lesions should be evaluated using angiography or fractional flow reserve (FFR) remains uncertain. The aim of this study was to evaluate the long-term outcome of patients with STEMI and multivessel disease who had non-culprit FFR-values&gt;0.80 and thus deferred PCI.</div></div><div><h3>Methods</h3><div>Of the 627 patients included in the DANAMI-3-PRIMULTI trial, 314 patients were randomized to FFR-guided complete revascularization and 280 were included in this substudy. Patients were divided into a PCI-deferral group who had no PCI of non-culprit lesions (FFR &gt; 0.80) (<em>n</em> = 106) and a PCI group encompassing patients treated with PCI of at least one non-culprit lesion (FFR ≤ 0.80 or an angiographical diameter stenosis of ≥90%) (<em>n</em> = 174). The combined endpoint included all-cause mortality, myocardial infarction, or urgent revascularization.</div></div><div><h3>Results</h3><div>During a median follow-up of 10.5 years (IQR 9.8–11.4), the composite outcome occurred in 62 (36%) patients in the PCI group and in 50 (47%) patients in the PCI-deferral group (adjusted HR 0.64, 95% CI: 0.44–0.95, <em>p</em> = 0.025). PCI-deferral was associated with a significantly higher risk of cardiovascular mortality (adjusted HR 0.48, CI 95% 0.24–0.97, <em>p</em> = 0.040) compared to the PCI group.</div></div><div><h3>Conclusion</h3><div>In patients with STEMI and multivessel disease, deferring PCI of non-culprit lesions based on FFR &gt; 0.80 was associated with an increased risk of the combination of all-cause mortality, myocardial infarction, or urgent revascularization as well as cardiovascular mortality compared to patients treated with PCI of FFR-positive non-culprit lesions.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"462 ","pages":"Article 134712"},"PeriodicalIF":3.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central venous pressure, rather than cardiac output, is associated with peripheral chemoreceptor sensitivity in heart failure patients with left ventricular assist device","authors":"Maksym Jura ,&nbsp;Roman Przybylski ,&nbsp;Piotr Niewiński ,&nbsp;Mateusz Sokolski ,&nbsp;Rafał Seredyński ,&nbsp;Michał Zakliczyński ,&nbsp;Piotr Ponikowski ,&nbsp;Jan Biegus ,&nbsp;Bartłomiej Paleczny","doi":"10.1016/j.ijcard.2026.134228","DOIUrl":"10.1016/j.ijcard.2026.134228","url":null,"abstract":"<div><h3>Background</h3><div>Heart failure (HF) patients experience elevated sympathetic tone and abnormal peripheral chemoreceptor (PChR) function (elevated sensitivity [PChS] and tonicity [PChT]), which can be attributed to a reduction in cardiac output (CO) and resultant hypoperfusion of the carotid bodies. Left ventricular assist devices (LVADs) are known to increase CO, and can be used as a unique model to examine the impact of acute hemodynamic changes on PChR.</div></div><div><h3>Methods and results</h3><div>Fourteen HF patients with LVADs underwent assessment of PChS (using the transient hypoxia test) and PChT (using low-dose dopamine infusion) under different LVAD flow parameters, previously determined using right heart catheterization to achieve significantly distinct CO levels. PChS did not differ between the low- vs high-flow conditions (0.61 [0.49;0.74] vs. 0.67 [0.33;0.9] L/min/SpO2%, <em>p</em> = 0.36) as well as PChT (0.97 [−0.36;1.96] vs. 0.81 [−1.67;2.2] L/min-1, <em>p</em> = 0.81).). In 9 patients, central venous pressure (CVP) decreased in response to higher pump speeds. In this group, PChS more frequently increased and was significantly higher than in the remaining patients. ΔCVP was also inversely related to ΔHVR (<em>R</em> = 0.75, <em>p</em> = 0.002).</div></div><div><h3>Conclusions</h3><div>Acute changes in CO, as well as pulse pressure, did not affect PChS or PChT. Surprisingly, we observed a strong correlation between a decrease in CVP in response to higher LVAD speed and an increase in PChS, which can be explained by the function of low-pressure baroreceptors. These findings provide unique data on PChR function under different hemodynamic conditions in the LVAD population.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"450 ","pages":"Article 134228"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of cardiovascular disease risk prediction using combination of TyG and ACEF in an elderly population","authors":"Shengjun Xiong ,&nbsp;Xiaotong Cui ,&nbsp;Yingmei Zhang ,&nbsp;Junbo Ge ,&nbsp;Miyesaier Abudureyimu ,&nbsp;Jun Ren","doi":"10.1016/j.ijcard.2026.134218","DOIUrl":"10.1016/j.ijcard.2026.134218","url":null,"abstract":"<div><h3>Purpose</h3><div>To explore the predictive value of TyG index and ACEF score for the risk of cardiovascular disease (CVD) in an elderly population.</div></div><div><h3>Methods</h3><div>A total of 2047 participants without history of CVD were enrolled in the follow-up. The endpoint was CVD incidence which was defined as stroke or coronary heart disease (CHD) during the follow-up period. Cox regression analyses was used to calculate hazard ratios. Kaplan-Meier curve was used to show the probability of CVD in different quartiles of TyG and ACEF. Restricted cubic spline further explored whether the relationship was linear. Finally, we assessed the discriminatory ability of TyG and ACEF for CVD using C-statistics, net reclassification index (NRI), and integrated discrimination improvement (IDI).</div></div><div><h3>Results</h3><div>During a median follow-up time of 4.66 years, 100 participants had CVD. Kaplan-Meier curve showed that TyG and ACEF were associated with CVD and participants with high TyG and ACEF were significantly more likely to have CVD. In the multivariate Cox regression analysis, the adjusted hazard ratios (HR) for TyG and ACEF were 1.21 (1.02–1.43) in TyG and 1.63 (1.25–2.17) in ACEF. In addition, multivariable adjusted HRs of TyG and ACEF still increased for CVD when stratified by various factors in subgroup analysis. Moreover, after adding TyG and ACEF to original risk prediction model, new model has higher C statistics of CVD (C-statistics = 0.733 than the original model (C-statistics = 0.656). Meanwhile, the results of NRI = 0.450 and IDI = 0.009 indicate that TyG and ACEF had enhancing effect on the prediction of CVD.</div></div><div><h3>Conclusions</h3><div>Our study showed that TyG and ACEF were associated with CVD in elderly populations in eastern China. Furthermore, it suggests that TyG could be a new tool for identifying potential patients at high risk of primary CVD in elderly population.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"450 ","pages":"Article 134218"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}