Jorio Mascheroni , Martin Stockburger , Ashish Patwala , Hartwig Retzlaff , Christophe Garweg , Tom Verbelen , Anthony G. Gallagher
{"title":"Rigor of cardiac device implant training affects performance outcome","authors":"Jorio Mascheroni , Martin Stockburger , Ashish Patwala , Hartwig Retzlaff , Christophe Garweg , Tom Verbelen , Anthony G. Gallagher","doi":"10.1016/j.ijcard.2025.133217","DOIUrl":"10.1016/j.ijcard.2025.133217","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac Implantable Electronic Devices (CIED) training for novice implanters typically occurs in vivo, varies across institutions, and results in inconsistent skill levels. We previously demonstrated the superior effects of Proficiency-Based Progression (PBP) training on implanters' performance in a randomized controlled trial (RCT). Beforehand, we conducted a ‘pilot’ study to evaluate the robustness of PBP training, hypothesizing that a substantial majority of trainees would achieve the target proficiency after training.</div></div><div><h3>Methods</h3><div>In this international, prospective, single-arm study, novice implanters completed a metrics-based simulation training curriculum, requiring proficiency benchmark demonstration at each stage to advance. Trainees ultimately performed a cardiac resynchronization therapy implant on virtual reality simulation which was video-recorded and then scored using validated Metrics (Steps, Critical Errors, Errors non-critical) by independent assessors. The primary outcome was the number of trainees meeting the benchmark. Findings informed corrective actions for the subsequent RCT training, whose effectiveness was verified by comparing PBP-trained participants from the pilot study (PBP-PILOT) and the RCT (PBP-RCT) on Steps completed, All Errors, and benchmark achievement.</div></div><div><h3>Results</h3><div>Only 17 % achieved the proficiency benchmark. Investigations revealed insufficient faculty adherence to the PBP methodology resulting in premature trainee advancement. Corrective actions improved the subsequent RCT training: compared to the PBP-PILOT group, PBP-RCT trainees completed 15 % more Steps (<em>p</em> = .014), made 69 % fewer All Errors (<em>p</em> = .015), and 93 % met the benchmark (<em>p</em> < .001).</div></div><div><h3>Conclusions</h3><div>Pilot testing revealed deficiencies in PBP training execution, highlighting the importance of rigor and faculty compliance. Verifying novel curricula before large-scale implementation is crucial to ensuring robust training outcomes.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133217"},"PeriodicalIF":3.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of colchicine on clinical events in patients with acute coronary syndrome","authors":"Tomoyuki Kawada","doi":"10.1016/j.ijcard.2025.133214","DOIUrl":"10.1016/j.ijcard.2025.133214","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133214"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SGLT2 inhibitors: A potential therapeutic strategy for atrial fibrillation in pulmonary arterial hypertension-induced right heart failure?","authors":"Zhi-Xing Fan , Jin-Chun Wu , Jian Yang","doi":"10.1016/j.ijcard.2025.133206","DOIUrl":"10.1016/j.ijcard.2025.133206","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133206"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephan A.C. Schoonvelde , Georgios M. Alexandridis , Laura B. Price , Arend F.L. Schinkel , Alexander Hirsch , Peter-Paul Zwetsloot , Janneke A.E. Kammeraad , Marjon A. van Slegtenhorst , Judith M.A. Verhagen , Rudolf A. de Boer , Michelle Michels
{"title":"Reply to: Family screening for hypertrophic cardiomyopathy: initial cardiologic assessment, and long-term follow-up of genotype-positive phenotype-negative individuals","authors":"Stephan A.C. Schoonvelde , Georgios M. Alexandridis , Laura B. Price , Arend F.L. Schinkel , Alexander Hirsch , Peter-Paul Zwetsloot , Janneke A.E. Kammeraad , Marjon A. van Slegtenhorst , Judith M.A. Verhagen , Rudolf A. de Boer , Michelle Michels","doi":"10.1016/j.ijcard.2025.133212","DOIUrl":"10.1016/j.ijcard.2025.133212","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133212"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Colchicine for secondary prevention in patients with acute coronary syndrome","authors":"Jun Yan, Yanjiao Ren, Baihua Zhou","doi":"10.1016/j.ijcard.2025.133210","DOIUrl":"10.1016/j.ijcard.2025.133210","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133210"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Left atrial stiffness index in patients with cardiac amyloidosis","authors":"Meirong Shen , Mingming Hang , Tielong Chen","doi":"10.1016/j.ijcard.2025.133213","DOIUrl":"10.1016/j.ijcard.2025.133213","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133213"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lanqing Yang , Zhiquan Yuan , Yanxiu Chen , Yuhong Zeng , Xinghua Chen , Jun Li , Chengying Li , Ying Xiang , Long Wu , Tingting Xia , Li Zhong , Yafei Li , Na Wu
{"title":"Plasma expression level of Hsa_circ_0099734 is associated with atrial fibrillation and its poor prognosis","authors":"Lanqing Yang , Zhiquan Yuan , Yanxiu Chen , Yuhong Zeng , Xinghua Chen , Jun Li , Chengying Li , Ying Xiang , Long Wu , Tingting Xia , Li Zhong , Yafei Li , Na Wu","doi":"10.1016/j.ijcard.2025.133202","DOIUrl":"10.1016/j.ijcard.2025.133202","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation (AF) is a common arrhythmia characterized by severe complications such as stroke, resulting in high disability and mortality rates. A circular RNA (circRNA) hsa_circ_0099734 was found significantly expressed in the atrial tissue of AF patients and controls in our previous work. In this study, we aim to reveal the association between hsa_circ_0099734 and AF as well as its poor prognosis, offering novel perspectives for clinical treatment.</div></div><div><h3>Methods</h3><div>A 1:1 matched case-control study was designed to examine the association between hsa_circ_0099734 and AF. A prospective cohort study was conducted to investigate the association between hsa_circ_0099734 and AF prognosis using Cox proportional hazards regression analysis.</div></div><div><h3>Results</h3><div>An elevated plasma level of hsa_circ_0099734 was an independent risk factor for AF in a multivariable conditional logistic regression model (OR 3.23, 95 % CI: 1.11–9.44; <em>P</em> = 0.032). Regarding the prognostic role of hsa_circ_0099734, the multivariable Cox regression analysis indicated that a high level of hsa_circ_0099734 in plasma was an independent risk factor for stroke in patients with AF (HR 2.87, 95 % CI: 1.90–4.35; <em>P</em> < 0.001), and also an independent risk factor for all-cause mortality in AF patients (HR 3.16, 95 % CI: 2.25–4.45; <em>P</em> < 0.001). Adding hsa_circ_0099734 to the CHA<sub>2</sub>DS<sub>2</sub>-VA score provided better reclassification and net clinical benefit than the ABC risk score.</div></div><div><h3>Conclusions</h3><div>The plasma level of hsa_circ_0099734 was associated with AF risk and the occurrence of stroke or all-cause mortality in AF patients. Hsa_circ_0099734 has the potential to be a non-invasive biomarker for predicting AF and its poor prognosis.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133202"},"PeriodicalIF":3.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hanae F. Namba , Coen K.M. Boerhout , Peter Damman , Vijay Kunadian , Javier Escaned , Peter Ong , Divaka Perera , Colin Berry , Tim P. van de Hoef , Jan J. Piek
{"title":"Invasive coronary function testing in clinical practice: Implementing the 2024 ESC guidelines on chronic coronary syndromes","authors":"Hanae F. Namba , Coen K.M. Boerhout , Peter Damman , Vijay Kunadian , Javier Escaned , Peter Ong , Divaka Perera , Colin Berry , Tim P. van de Hoef , Jan J. Piek","doi":"10.1016/j.ijcard.2025.133176","DOIUrl":"10.1016/j.ijcard.2025.133176","url":null,"abstract":"<div><div>Angina with non-obstructive coronary arteries (ANOCA) is increasingly recognized as a significant aspect of chronic coronary syndromes. These patients frequently experience recurrent angina, resulting in high healthcare costs and impaired quality of life. Invasive coronary function testing (ICFT) is able to identify ANOCA endotypes, which can guide treatment and improve quality of life. Despite Class II recommendations for invasive microvascular assessments in the previous 2019 European Society of Cardiology (ESC) Guidelines, ICFT has yet to translate into widespread clinical practice. Patients with ANOCA experience poor quality of life and reduced functional capacity, highlighting the need for earlier ICFT implementation. The 2024 ESC Guidelines now strongly recommend ICFT (Class I, level of evidence B) for patients with non-obstructive coronary arteries and persistent angina despite optimal medical therapy, and for confirming or excluding ANOCA in patients with uncertain diagnoses on non-invasive testing (Class I, level of evidence B). Consequently, a standardized approach to optimize the management of ANOCA patients is warranted. Therefore, this review aims to provide interventional cardiologists with a contemporary review of the literature and a practical guideline on implementation of ICFT. It will discuss the following subjects: the definitions of the different endotypes, an example of an ICFT protocol, discontinuation of medication prior to ICFT, use of radial cocktail, target vessel for testing, acetylcholine injection techniques and rechallenge, adenosine injection techniques, the order of testing, the interpretation of ICFT, safety and feasibility, and the pharmacological treatment.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133176"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}