International journal of cardiology最新文献

{"title":"Clinical parameters of death and heart failure hospitalization in biventricular systolic dysfunction assessed via cardiac magnetic resonance","authors":"Subhi J. Al’Aref ,&nbsp;Nitesh Gautam ,&nbsp;Munthir Mansour ,&nbsp;Omar Alqaisi ,&nbsp;Tushar Tarun ,&nbsp;Subodh Devabhaktuni ,&nbsp;Auras Atreya ,&nbsp;Raffaele Abete ,&nbsp;Giovanni Donato Aquaro ,&nbsp;Andrea Baggiano ,&nbsp;Andrea Barison ,&nbsp;Jan Bogaert ,&nbsp;Giovanni Camastra ,&nbsp;Samuela Carigi ,&nbsp;Nazario Carrabba ,&nbsp;Grazia Casavecchia ,&nbsp;Stefano Censi ,&nbsp;Gloria Cicala ,&nbsp;Carlo N. De Cecco ,&nbsp;Manuel De Lazzari ,&nbsp;Gianluca Pontone","doi":"10.1016/j.ijcard.2024.132709","DOIUrl":"10.1016/j.ijcard.2024.132709","url":null,"abstract":"<div><h3>Aims</h3><div>While factors associated with adverse events are well elucidated in setting of isolated left ventricular dysfunction, clinical and imaging-based prognosticators of adverse outcomes are lacking in context of biventricular dysfunction. The purpose of this study was to establish role of clinical variables in prognosis of biventricular heart failure (HF), as assessed by cardiac magnetic resonance imaging.</div></div><div><h3>Methods</h3><div>Study cohort consisted of 840 patients enrolled in DERIVATE registry with coexisting CMR-derived right ventricular (RV) and left ventricular (LV) dysfunction, as defined by RV and LV ejection fractions ≤45 % and ≤ 50 %, respectively. The primary objective was to identify factors associated with adverse long-term outcomes, defined as composite of all-cause death and HF hospitalizations (DHFH). Kaplan-Meir curves were plotted for survival analysis. Cox proportional hazard models were constructed to estimate adjusted hazard ratios (aHRs) and associated 95 % confidence intervals for clinical variables and their correlation with adverse events.</div></div><div><h3>Results</h3><div>Mean age was 61.0 years; 83.1 % were male, 26.6 % had diabetes mellitus (DM), and 45.9 % had non-ischemic cardiomyopathy. At median follow-up of 2 years, DHFH occurred in 32.5 % of the cohort. Kaplan-Meir analysis showed higher rate of DHFH in patients with DM (35.2 % vs. 22.6 %, <em>p</em> &lt; 0.001). Multivariate Cox regression analysis showed that DM was independently associated with DHFH (aHR 1.61 [95 % CI: 1.15–2.25]; <em>p</em> = 0.003). Importantly, ACE-inhibitor/ARB usage in patients with DM was associated with significant reduction in DHFH (aHR 0.53 [95 % CI: 0.31–0.90]; <em>p</em> = 0.02).</div></div><div><h3>Conclusion</h3><div>In patients with biventricular HF, DM was a strong predictor of DHFH, with ACE-inhibitor/ARB usage having cardioprotective effect.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Letter to the editor: Incidence of de novo malignancy and all-cause mortality among heart transplant recipients”","authors":"Francisco J. Barrera Flores ,&nbsp;Elizabeth Mostofsky ,&nbsp;Soziema Salia ,&nbsp;Laura Lehman ,&nbsp;Lathan Liou ,&nbsp;Lorelei Mucci ,&nbsp;Murray A. Mittleman","doi":"10.1016/j.ijcard.2024.132691","DOIUrl":"10.1016/j.ijcard.2024.132691","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A phenotypic comparison of the Romanian and French ATTRv cohorts: Glu54Gln founder pathogenic variant vs the most common variants in Western Europe","authors":"Gabriela Neculae ,&nbsp;Amira Zaroui ,&nbsp;Mounira Kharoubi ,&nbsp;Mélanie Bézard ,&nbsp;Benoit Funalot ,&nbsp;Robert Adam ,&nbsp;Andreea Jercan ,&nbsp;Sorina Badelita ,&nbsp;Mirela Draghici ,&nbsp;Claudiu Stan ,&nbsp;Daniel Coriu ,&nbsp;Ruxandra Jurcut ,&nbsp;Thibaud Damy","doi":"10.1016/j.ijcard.2024.132714","DOIUrl":"10.1016/j.ijcard.2024.132714","url":null,"abstract":"<div><h3>Aim and methods</h3><div>We conducted a retrospective observational study of the ATTRv heterozygous mutation frequency, phenotype, and all-cause mortality at two cardiac amyloidosis centers in Romania and France.</div></div><div><h3>Results</h3><div>291 patients were included: 26 Glu54Gln (all Romanian), 200 Val122Ile, 47 Val30Met and 18 Ser77Tyr. On diagnosis, Gu54Gln patients were younger than Val122Ile or late-onset Val30Met (median age: 46 [42–50], 76 [71–80] and 70 [61–76], respectively; <em>p</em> &lt; 0.001) and had more autonomic dysfunction (50 %, 6.3 %, and 7.7 %, respectively; <em>p</em> &lt; 0.001) and similar cardiac symptom profiles. They had fewer conduction disorders (11.5 %) than early-onset Val30Met (76.9 %, p &lt; 0.001) and Ser77Tyr group, notably less cardiac pacemaker present on diagnosis: 3.8 % for Glu54Gln vs. 23.5 % for Ser77Tyr; <em>p</em> = 0.014. Glu54Gln, Val122Ile, late-onset Val30Met and Ser77Tyr patients had similar left ventricular mass and systolic function values. Median survival for Glu54Gln patients was 58.7 years (95 %CI 55.9 – upper bound indeterminable), significantly lower than that of Val122Ile (83.6 years 95 %CI 81.6–85.5, log-rank test <em>p</em> &lt; 0.001), late-onset Val30Met (83.4 years 95 %CI 81.9–84.9, log-rank test p &lt; 0.001) and Ser77Tyr (74.8 years 95 %CI 68.7–80.9, log-rank test <em>p</em> = 0.022). Median survival after diagnosis was 5.7 years for Glu54Gln patients (95 %CI 4.7–6.4).</div></div><div><h3>Conclusion</h3><div>We established that the Glu54Gln variant has an aggressive, mixed phenotype, with an early onset of autonomic dysfunction and heart failure symptoms. We emphasize the need for systematic genetic testing in patients with ATTR as understanding genotype-phenotype correlations is key for the management and the counseling of patients and their family members.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mild basal interventricular inflammation as a predictor of ventricular arrhythmia?","authors":"Thomas H. Schindler ,&nbsp;Azadeh Eslambolchi ,&nbsp;Elgin Ozkan","doi":"10.1016/j.ijcard.2024.132715","DOIUrl":"10.1016/j.ijcard.2024.132715","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The one-minute sit-to-stand test is an alternative to the 6-minute walk test in patients with atrial fibrillation: A cross-sectional study and ROC curve analysis.","authors":"Cemile Bozdemir Ozel, Hazal Yakut Ozdemir, Muhammet Dural, Aytug Al, Halit Emre Yalvac, Gurbet Ozge Mert, Selda Murat, Yuksel Cavusoglu","doi":"10.1016/j.ijcard.2024.132713","DOIUrl":"https://doi.org/10.1016/j.ijcard.2024.132713","url":null,"abstract":"<p><strong>Background: </strong>The one-minute sit-to-stand test (1STST) is an easy-to-administer, space and time-saving test for determining functional exercise capacity in cardiac disease. This study aimed to investigate the 1STSt-test-retest reliability and convergent validity and compare its physiological responses to the six-minute walk test (6MWT) in patients with Atrial fibrillation (AF).</p><p><strong>Methods: </strong>Forty-five patients with AF were included in this study. Functional exercise capacity was evaluated using the 1STST and 6MWT. For assessing test-retest reliability, the intraclass correlation coefficient and Bland-Altman plots were utilised. Convergent validity was determined by correlation analysis 1 STST and 6MWT, age, European Heart Rhythm Association score, ejection fraction, and quality of life. The cut-off point of 1STST was defined using ROC analysis.</p><p><strong>Results: </strong>With an intraclass correlation coefficient value of 0.975 [95 % confidence interval (CI) 0.954-0.986], the 1STST demonstrated excellent-test-retest reliability. Physiological responses after tests were similar in the 1STST and 6MWT (p > 0.05). The number of 1STST repetitions was strongly associated with 6MWT distance (r = 0.809; p < 0.001). A cut-off value of ≤13 repetitions in the number of 1STST repetitions was defined as functional impairment related to an increased risk of clinical events [sensitivity: 100 %, specificity: 84.6 %; AUC:0.94; 95 % CI 0.82 to 0.98; p < 0.001].</p><p><strong>Conclusions: </strong>The 1STST is a reliable and valid assessment tool that produced comparable hemodynamic responses to the 6MWT in patients with AF. Considering its feasibility and time efficiency, healthcare professionals can use the 1STST rather than the 6MWT test to measure functional exercise status in a constrained environment for this patient group.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The French hypertrophic cardiomyopathy gene register: A systematic large gene screening for hypertrophic cardiomyopathy” [International Journal of Cardiology Volume 417, 15 December 2024, 132542]","authors":"Albert Hagège ,&nbsp;Tania Puscas ,&nbsp;Mohamed El Hachmi ,&nbsp;Alessandro Parodi ,&nbsp;Anne Bacher ,&nbsp;Benoit Funalot ,&nbsp;Karim Wahbi ,&nbsp;Xavier Jeunemaître ,&nbsp;Thibaud Damy ,&nbsp;Clarisse Billon ,&nbsp;the GEREMY Working Group of the French Society of Cardiology","doi":"10.1016/j.ijcard.2024.132692","DOIUrl":"10.1016/j.ijcard.2024.132692","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial iron overload: the use of speckle-tracking echocardiography in patients with transfusion-dependent beta-thalassaemia","authors":"Shingo Ota","doi":"10.1016/j.ijcard.2024.132701","DOIUrl":"10.1016/j.ijcard.2024.132701","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative D-dimer and outcomes in obstructive hypertrophic cardiomyopathy after myectomy","authors":"Tao Lu ,&nbsp;Changsheng Zhu ,&nbsp;Hao Cui ,&nbsp;Yanhai Meng ,&nbsp;Qiulan Yang ,&nbsp;Zhengyang Lu ,&nbsp;Yunhu Song ,&nbsp;Shuiyun Wang","doi":"10.1016/j.ijcard.2024.132705","DOIUrl":"10.1016/j.ijcard.2024.132705","url":null,"abstract":"<div><h3>Background</h3><div>The prognostic significance of D-dimer in patients with hypertrophic cardiomyopathy undergoing septal myectomy has not been well established.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed D-dimer levels in 728 patients who underwent septal myectomy at our hospital between 2009 and 2018. Baseline D-dimer levels were categorized into tertiles (&lt;0.21, 0.21–0.3, ≥0.3 mg/L) The primary and secondary endpoints were all-cause mortality and cardiovascular mortality, respectively. Cox regression and competing risk models were used to evaluate risk factors for all-cause and cardiovascular mortality, respectively.</div></div><div><h3>Results</h3><div>Higher D-dimer levels were associated with older age, female sex, more severe mitral regurgitation, and elevated N-terminal pro B-type natriuretic peptide levels (<em>P</em> &lt; 0.05). Over a median follow-up of 4.2 years, 31 (4.3 %) patients reached the primary endpoint; 23 deaths were attributed to cardiovascular causes. The optimal cutoff D-dimer level for predicting 5-year mortality was 0.29 mg/L. After adjusting for covariates, D-dimer levels of &gt;0.29 mg/L were significantly associated with an increased risk of all-cause mortality (hazard ratio [HR], 3.12; 95 % confidence interval [CI], 1.42–6.86; <em>p</em> = 0.005) and cardiovascular mortality (HR, 3.29; 95 % CI, 1.12–9.62; <em>p</em> = 0.030). Body mass index and left atrial diameter were also independent predictors of both all-cause mortality (HR, 1.12; <em>p</em> = 0.026, and HR, 1.08; <em>p</em> = 0.006, respectively) and cardiovascular mortality (HR, 1.12; <em>p</em> = 0.043, and HR, 1.11; <em>p</em> = 0.004, respectively). The inclusion of D-dimer levels of &gt;0.29 mg/L improved the net reclassification index for all-cause mortality (<em>p</em> = 0.016).</div></div><div><h3>Conclusion</h3><div>D-dimer is a robust predictor of mid-to-long-term all-cause and cardiovascular mortality in patients undergoing septal myectomy.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late gadolinium enhancement on cardiac MRI: A systematic review and meta-analysis of prognosis across cardiomyopathies.","authors":"Joshua Helali, Karthik Ramesh, John Brown, Carlos Preciado-Ruiz, Thornton Nguyen, Livia Tavane, Austin Ficara, George Wesbey, Jorge A Gonzalez, Kenneth C Bilchick, Michael Salerno, Austin Robinson","doi":"10.1016/j.ijcard.2024.132711","DOIUrl":"https://doi.org/10.1016/j.ijcard.2024.132711","url":null,"abstract":"<p><strong>Background: </strong>Late gadolinium enhancement (LGE) on cardiac MRI has been shown to predict adverse outcomes in a range of cardiac diseases. However, no study has systematically reviewed and analyzed the literature across all cardiac pathologies including rare diseases.</p><p><strong>Methods: </strong>PubMed, EMBASE and Web of Science were searched for studies evaluating the relationship between LGE burden and cardiovascular outcomes. Outcomes included all-cause mortality, MACE, sudden cardiac death, sustained VT or VF, appropriate ICD shock, heart transplant, and heart failure hospitalization. Only studies reporting hazards ratios with LGE as a continuous variable were included.</p><p><strong>Results: </strong>Of the initial 8928 studies, 95 studies (23,313 patients) were included across 19 clinical entities. The studies included ischemic cardiomyopathy (7182 patients, 33 studies), hypertrophic cardiomyopathy (5080 patients, 17 studies), non-ischemic cardiomyopathy not otherwise specified (2627 patients, 11 studies), and dilated cardiomyopathy (2345 patients, 14 studies). Among 42 studies that quantified LGE by percent myocardium, a 1 % increase in LGE burden was associated with life-threatening ventricular arrhythmias (LTVA) with a pooled hazard ratio of 1.04 (CI 1.02-1.05), and MACE with a pooled hazard ratio of 1.06 (CI 1.04-1.07). The risk of these events was similar across disease types, with minimal heterogeneity.</p><p><strong>Conclusions: </strong>Despite mechanistic differences myocardial injury, LGE appears to have a fairly consistent, dose-dependent effect on risk of LTVA, MACE, and mortality. This data can be applied to derive a patient's absolute risk of LTVA, and therefore can be clinically useful in informing decisions on primary prevention ICD implantation irrespective of the disease etiology.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing prognostic Precision in dilated cardiomyopathy: The role of enhanced Cine CMR-based radiomics","authors":"Chunxiang Tang ,&nbsp;Xianghua Huang","doi":"10.1016/j.ijcard.2024.132700","DOIUrl":"10.1016/j.ijcard.2024.132700","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}