International journal of cardiology最新文献

{"title":"Comment on: Cardiopulmonary remodeling following repetitive acute pulmonary emboli and inhibition of endogenous fibrinolysis in a porcine model.","authors":"Yan Yuehua, Miao Jia, Yang Yang","doi":"10.1016/j.ijcard.2025.133546","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133546","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133546"},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Letter to the editor: Prediction of adverse cardiovascular events in children using artificial intelligence-based electrocardiogram","authors":"Yoshitsugu Nogimori , Ryo Inuzuka","doi":"10.1016/j.ijcard.2025.133540","DOIUrl":"10.1016/j.ijcard.2025.133540","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133540"},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential role of Loganin in modulating JAK2/STAT3 signaling pathway in atherosclerosis","authors":"Sisi Li , Xiaogang Li , Yanmin Song","doi":"10.1016/j.ijcard.2025.133549","DOIUrl":"10.1016/j.ijcard.2025.133549","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133549"},"PeriodicalIF":3.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-cardioversion anticoagulation in atrial fibrillation with left atrial appendage occlusion: Necessary or not?","authors":"Sittinun Thangjui ,&nbsp;Angkawipa Trongtorsak ,&nbsp;Jakrin Kewcharoen ,&nbsp;Sudarshan Balla ,&nbsp;Sandeep Arora ,&nbsp;David Schwartzman","doi":"10.1016/j.ijcard.2025.133518","DOIUrl":"10.1016/j.ijcard.2025.133518","url":null,"abstract":"<div><h3>Background</h3><div>The role of post-cardioversion oral anticoagulation (OAC) in patients with atrial fibrillation (AF) and left atrial appendage occlusion (LAAO) remains unclear. Limited evidence exists regarding stroke, systemic thromboembolism (SSTEs), and bleeding risks in this population.</div></div><div><h3>Objective</h3><div>To evaluate the clinical outcomes following electrical cardioversion (eCVN) in patients with AF and prior LAAO.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study using the TriNetX Research Network to identify patients with prior surgical or percutaneous LAAO, no history of stroke, and no OAC use for at least 1 month prior to eCVN for AF between January 1, 2014, and November 1, 2024. Propensity score matching (PSM) was used to compare outcomes between those who received ≥1 month of OAC post-cardioversion (AC group) and those who did not (Non-AC group). Primary outcomes were SSTEs and significant bleeding.</div></div><div><h3>Results</h3><div>Among 1507 eligible patients, 583 (38.7 %) received post-cardioversion OAC. After PSM, 551 patients per group were analyzed. The AC group had a numerically lower but not statistically significant rate of SSTEs (OR 0.59, 95 % CI: 0.31–1.13) and ischemic stroke/transient ischemic attack (OR 0.69, 95 % CI: 0.35–1.92). Significant bleeding was similar between groups (6.0 % vs. 5.3 %; OR 1.15, 95 % CI: 0.67–1.92).</div></div><div><h3>Conclusion</h3><div>Among patients with AF and prior surgical and percutaneous LAAO undergoing cardioversion, post-procedure OAC use was not associated with significant differences in SSTEs or bleeding risk. Prospective studies are warranted to inform clinical guidelines.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133518"},"PeriodicalIF":3.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Growth differentiation factor 15 and empagliflozin in acute myocardial infarction: Correspondence”","authors":"Óscar M. Peiró ,&nbsp;Alfredo Bardají ,&nbsp;Anna Carrasquer ,&nbsp;German Cediel ,&nbsp;Isabel Serrano ,&nbsp;Gil Bonet ,&nbsp;María Ferrero ,&nbsp;Víctor Del-Moral-Ronda ,&nbsp;Mar Rocamora-Horrach ,&nbsp;José Luis Ferreiro","doi":"10.1016/j.ijcard.2025.133531","DOIUrl":"10.1016/j.ijcard.2025.133531","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133531"},"PeriodicalIF":3.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific response to cardiac resynchronization therapy: the BIO|WOMEN trial.","authors":"Jose Luis Zamorano, Gabor Vörös, Valeria Calvi, Joaquín Osca, Aurelio Quesada, Kevin Vernooy, Juan Gabriel Martinez, Alexander H Maass, Eyal Nof, Jose Maria Tolosana, Mónica Pardo, Craig Barr, Ignacio Fernández, Jose Luis Merino, Susan Ellery, Enrique Ricoy-Martínez, Giuseppina Belotti, Lea Seidlmayer, Santiago Garcia, Tobias Tönnis, Niall G Campbell, Paul Foley, Johannes Brockmeier, Michael Nürnberg, Ricardo Ruiz-Granell, Frits W Prinzen, Álvaro Lorente-Ros, Alicia Moreno, Mariona Pinart, Mark Ver Heyen, Lieselot Van Erven","doi":"10.1016/j.ijcard.2025.133526","DOIUrl":"10.1016/j.ijcard.2025.133526","url":null,"abstract":"<p><strong>Background: </strong>Variable evidence exists about the efficacy of Cardiac resynchronization therapy (CRT) in women vs. men with reduced left ventricular ejection fraction (LVEF) and wide QRS complex. Current guidelines, hindered by underrepresentation of women in clinical trials, lack definitive recommendations. The present study was designed to achieve an equal distribution of women and men to prospectively evaluate sex-specific response to CRT.</p><p><strong>Methods: </strong>The primary endpoint was the absolute increase in core-lab-assessed LVEF 12 months after de novo implantation of a CRT device. Estimation was adjusted by several baseline confounders to correct sex-specific effect of CRT. Secondary endpoints were further echocardiographic changes including responder rate (LVEF increase ≥5 %); change in NYHA class, 6-min walk distance, quality of life, a clinical composite score (CCS) and the composite of death or HF hospitalization.</p><p><strong>Results: </strong>We enrolled 230 women and 244 men at 25 sites in eight countries. A larger improvement in LVEF (+14.7 % vs. +11.5 %, p ≤ 0.01) in women remained after adjustment for baseline variables (absolute increase attributed to female sex +2.53 %, P = 0.023). Furthermore, a better improvement was observed in reverse remodeling, responder rate (∆LVEF ≥5 %: 83.3 % vs. 70.6 %; p = 0.003), quality of life and HF symptoms in women compared to men. The CCS and the composite of death or HF hospitalization were better in women than in men after CRT.</p><p><strong>Conclusions: </strong>The effect of CRT remained superior in women regarding echocardiographic outcomes even after adjusting for baseline variables. Our results confirm the importance of recognizing sex-specific differences when screening patients for CRT.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133526"},"PeriodicalIF":3.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of CMR-derived extracellular volume in myocardial infarction with non-obstructive coronary arteries","authors":"Lei Chen ,&nbsp;Liqi Ge ,&nbsp;Fuad A. Abdu ,&nbsp;Xinjia Du ,&nbsp;Jiahua Liu ,&nbsp;Wensu Chen ,&nbsp;Yuan Lu ,&nbsp;Wenliang Che","doi":"10.1016/j.ijcard.2025.133528","DOIUrl":"10.1016/j.ijcard.2025.133528","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac magnetic resonance (CMR) is crucial for diagnosing myocardial infarction with non-obstructive coronary arteries (MINOCA) and is recommended by current guidelines for its diagnostic and prognostic capabilities. However, the prognostic value of CMR parameters, particularly extracellular volume (ECV), in predicting major adverse cardiovascular events (MACE) among MINOCA remains unclear. This study analyzes ECV distribution across different MINOCA etiologies and its predictive value for MACE in “true” MINOCA.</div></div><div><h3>Methods</h3><div>Consecutive patients with a working diagnosis of MINOCA who underwent CMR were included. We investigated the relationships between CMR parameters and MACE in “true” MINOCA. Cox regression and ROC curve analyses were used to assess ECV in predicting MACE. “True” MINOCA was defined by evidence of ischemia or infarction on CMR.</div></div><div><h3>Results</h3><div>Among 275 patients with a working diagnosis of MINOCA (median 4 days to CMR), 96 were diagnosed with “true” MINOCA, 66 with myocarditis, 31 with Takotsubo syndrome (TS), 34 with cardiomyopathies, and 48 had normal findings. “True” MINOCA had higher ECV compared to other etiologies (29.10 % vs. 26.00 %, <em>P</em> &lt; 0.001). During a median follow-up of 26.6 months, 29.2 % of “true” MINOCA patients experienced MACE. In the adjusted Cox model, ECV (HR 1.063, 95 % CI 1.019–1.108, <em>P</em> = 0.004) was an independent predictor of MACE in patients with “true” MINOCA. According to optimal cut-off values from ROC, patients with ECV &gt;28.94 % had a significantly higher MACE risk (log-rank <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>CMR-derived ECV varies by MINOCA etiology, with higher levels in “true” MINOCA. Elevated ECV independently predicts increased MACE risk in “true” MINOCA patients.</div><div>Trial registration number: <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> (ID: <span><span>NCT06502899</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"437 ","pages":"Article 133528"},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Target, track, treat: Evolving paradigms in cardiovascular molecular imaging.","authors":"Brijesh Sathian, Javed Iqbal, Syed Muhammad Ali, Khadija Said Hamood Al Shukaili","doi":"10.1016/j.ijcard.2025.133539","DOIUrl":"10.1016/j.ijcard.2025.133539","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133539"},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Outcomes of mitral valve reoperation and first-time surgery for mitral regurgitation: A nationwide study”","authors":"Aabir Imran ,&nbsp;Aaila Haider","doi":"10.1016/j.ijcard.2025.133534","DOIUrl":"10.1016/j.ijcard.2025.133534","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"438 ","pages":"Article 133534"},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"The efficacy and safety of dapagliflozin in pediatric heart failure\".","authors":"Yuting Song, Qiang Shi, Chengzhi Xu","doi":"10.1016/j.ijcard.2025.133537","DOIUrl":"10.1016/j.ijcard.2025.133537","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133537"},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}