International journal of cardiology最新文献

{"title":"Reply to \"Tertiary-centric data and AMI-CS care: Does it reflect real-world adherence?\"","authors":"Hong Wang, Yuwei Liu, Xiaotong Hou","doi":"10.1016/j.ijcard.2025.133868","DOIUrl":"10.1016/j.ijcard.2025.133868","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133868"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IPE eligibility post-ACS: Clarifying treatment gaps and refining lipid-based risk assessment.","authors":"Rui Lin, Mei Zhou","doi":"10.1016/j.ijcard.2025.133875","DOIUrl":"10.1016/j.ijcard.2025.133875","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133875"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor -commentary on \"relationship between coronary artery calcification and plaque vulnerability, a qualitative and quantitative optical coherence tomography study\".","authors":"Ruihang Luo, Zhehao Wu, Wei Zhong, Yutao Wu, Mingshan Liu","doi":"10.1016/j.ijcard.2025.133876","DOIUrl":"10.1016/j.ijcard.2025.133876","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133876"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mavacamten effectively reduces > 100 mmHg left ventricular outflow tract gradients as early as one week of treatment in obstructive hypertrophic cardiomyopathy","authors":"Viktória Nagy ,&nbsp;Gergely Rácz ,&nbsp;Hedvig Takács ,&nbsp;Krisztina Boda ,&nbsp;Bianka Polestyuk ,&nbsp;Noémi Schvartz ,&nbsp;László Dániel Vidács ,&nbsp;Jenő Antal Pintér ,&nbsp;Attila Pálinkás ,&nbsp;Árpád Kormányos ,&nbsp;Tamás Szűcsborus ,&nbsp;János Borbás ,&nbsp;Tamás Szili-Török ,&nbsp;Róbert Sepp","doi":"10.1016/j.ijcard.2025.133882","DOIUrl":"10.1016/j.ijcard.2025.133882","url":null,"abstract":"<div><h3>Background</h3><div>Real-world data on the efficacy of mavacamten, indicated for the treatment of obstructive hypertrophic cardiomyopathy (oHCM), are relatively scarce, particularly in patients with extreme left ventricular outflow tract (LVOT) gradients and concerning its short-term effects.</div></div><div><h3>Patients/Methods</h3><div>We investigated a cohort of twenty-five oHCM patients [15 men (60 %), mean age: 55 ± 11 years], with a resting or provoked LVOT gradient of &gt;100 mmHg, receiving mavacamten treatment. Patients underwent a complete standard and 2D-speckle tracking echocardiographic examination after one week (W1) of treatment initiation and at subsequent four-week intervals.</div></div><div><h3>Results</h3><div>After only one week of mavacamten therapy, both the resting peak LVOT gradient (from 121 to 87 mmHg) and the Valsalva gradient (from 167 to 129 mmHg) significantly decreased (all <em>p</em> &lt; 0.001), showing further decrease (resting gradient: to 67 mmHg at W4, and to 56 mmHg at W8; Valsalva gradient to 102 mmHg at W4, and to 80 mmHg at W8, all <em>p</em> &lt; 0.001). NTproBNP levels also significantly decreased already at W1 (−1467 pg/ml), showing further decrease during treatment (−1735 pg/ml at W4, and − 2048 pg/ml at W8; all <em>p</em> &lt; 0.001). NYHA functional class, 6-min walk distance, parameters of myocardial work and many of the assessed diastolic parameters showed significant improvements and no change in LV ejection fraction or global longitudinal strain was observed.</div></div><div><h3>Conclusions</h3><div>Mavacamten effectively reduced even &gt;100 mmHg LVOT gradients and led to significant gradient reduction already in one week. Besides favourable changes in LVOT obstruction, structural and functional echocardiographic parameters, functional capacity, and cardiac biomarkers, it also led to significant improvement in myocardial work parameters.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133882"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the puzzling speckle tracking echocardiography/clinical severity dissociation between patients with takotsubo syndrome and anterior ST-elevation myocardial infarction.","authors":"John E Madias","doi":"10.1016/j.ijcard.2025.133878","DOIUrl":"10.1016/j.ijcard.2025.133878","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133878"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Outcomes of mitral valve reoperation and first-time surgery for mitral regurgitation: A nationwide study.","authors":"Muhammad Huzaifa Zahid, Maria Saleem, Amir Murtaza","doi":"10.1016/j.ijcard.2025.133859","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133859","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133859"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of centre experience on complete clinical and haemodynamic response after alcohol septal ablation for hypertrophic obstructive cardiomyopathy","authors":"Josef Veselka ,&nbsp;Max Liebregts ,&nbsp;Robert Cooper ,&nbsp;Lothar Faber ,&nbsp;Jaroslav Januska ,&nbsp;Jan Krejci ,&nbsp;Maciej Dabrowski ,&nbsp;Peter Riis Hansen ,&nbsp;Hubert Seggewiss ,&nbsp;Jurriën ten Berg ,&nbsp;Rodney Hilton Stables ,&nbsp;Ladislav Dusek ,&nbsp;Klara Hulikova Tesarkova","doi":"10.1016/j.ijcard.2025.133865","DOIUrl":"10.1016/j.ijcard.2025.133865","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol septal ablation (ASA) is an established therapy for symptomatic hypertrophic obstructive cardiomyopathy (HOCM) in patients unresponsive to medical treatment. However, comprehensive assessment of ASA outcomes remains challenging. This study aimed to evaluate the impact of institutional experience and patient characteristics on achieving complete clinical and haemodynamic response (CCHR), a novel composite outcome integrating long-term symptomatic, haemodynamic, safety, and major clinical endpoints, including survival and resuscitation.</div></div><div><h3>Methods</h3><div>We retrospectively analysed 1206 symptomatic HOCM patients undergoing first-time ASA between 1996 and 2023 in seven European centres. CCHR was defined as residual left ventricular outflow tract (LVOT) gradient &lt;30 mmHg, NYHA class I/II, absence of new permanent pacemaker implantation, and absence of major adverse cardiovascular events at last follow-up.</div></div><div><h3>Results</h3><div>After a median follow-up of 4.9 (IQR 2.0–7.0) years, CCHR was achieved in 59 % of patients, with inter-centre variability ranging from 21.4 % to 69.3 %. Centres with higher procedural volumes showed significantly better outcomes. Patients treated within the first 50 procedures at a centre had significantly lower odds of achieving CCHR (OR 0.49; 95 % CI 0.34–0.71; <em>p</em> &lt; 0.001). Younger age, lower baseline LVOT gradient, and higher baseline ejection fraction were independent predictors of success.</div></div><div><h3>Conclusions</h3><div>CCHR, integrating both haemodynamic and hard clinical outcomes, was achieved in the majority of ASA-treated HOCM patients. Institutional experience and patient selection emerged as key determinants of success. These findings support centralisation of ASA in high-volume centres and may inform patient-tailored therapeutic strategies.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133865"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of early-onset atrial fibrillation and flutter: Population based study","authors":"Yifan Lu ,&nbsp;Yu Liu ,&nbsp;Yuji Zhang ,&nbsp;Huishan Wang ,&nbsp;Lin Xia","doi":"10.1016/j.ijcard.2025.133862","DOIUrl":"10.1016/j.ijcard.2025.133862","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation and flutter (AF/AFL) are traditionally regarded as diseases of ageing, with most research focused on elderly populations. In contrast, early-onset AF/AFL (&lt;65 years) is increasingly recognized as a potential marker of cardiomyopathy, yet its global burden remains poorly understood.</div></div><div><h3>Methods</h3><div>Using data from the Global Burden of Disease 2021 study, we analyzed trends in prevalence, incidence, disability-adjusted life years (DALYs), mortality, and average annual percentage change (AAPC) of AF/AFL among individuals aged 30–64 years from 1990 to 2021. Das Gupta decomposition quantified the contributions of population growth, ageing, and age-specific prevalence. Based on spatial co-occurrence with cardiomyopathy and myocarditis (CMP), we classified 204 countries and territories into consistent, AF/AFL-dominant, and CMP-dominant patterns.</div></div><div><h3>Results</h3><div>From 1990 to 2021, age standardised prevalence, incidence, and DALY rates of early-onset AF/AFL increased significantly (AAPC: 0.14 %, 0.11 %, and 0.07 %, respectively), unlike the stable trends observed in the late-onset or overall AF/AFL population. Population growth contributed 89 % of the increase in early-onset cases, followed by ageing (17 %) and rising age-specific prevalence (7 %). High systolic blood pressure was the leading risk factor, contributing 13.04 DALYs per 100,000 population (AAPC: 0.09 %). In 2021, 86 countries showed consistent patterns, 65 were CMP-dominant, and 53 were AF/AFL-dominant.</div></div><div><h3>Conclusions</h3><div>The global burden of early-onset AF/AFL has risen significantly over three decades, contrasting with stable trends in the late-onset or overall population. Driven mainly by population growth and high systolic blood pressure, and linked with cardiomyopathy, these findings underscore the need for age-specific strategies and targeted research.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133862"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the diagnostic value of pre-event intracardiac electrogram (pre-EGM) storage function in cardiac electronic implantable devices for arrhythmia diagnosis","authors":"Zeyu Niu ,&nbsp;Zimo Wei ,&nbsp;Jia Wang ,&nbsp;Xin Jin ,&nbsp;Junpeng Liu ,&nbsp;Zhilei Wang ,&nbsp;Ruijuan Yan ,&nbsp;You Lv ,&nbsp;Tong Zou","doi":"10.1016/j.ijcard.2025.133881","DOIUrl":"10.1016/j.ijcard.2025.133881","url":null,"abstract":"<div><h3>Background and aims</h3><div>Previous cardiac implantable electronic devices (CIEDs) automatically monitored, diagnosed, and stored atrial or ventricular tachyarrhythmias as intracardiac electrograms (EGMs). Abbott's new-generation CIEDs offer pre-event EGM storage (Pre-EGM), recording cardiac electrical activity before arrhythmic events. This study determines whether Pre-EGM provides additional diagnostic information for arrhythmic events.</div></div><div><h3>Methods</h3><div>We consecutively enrolled 92 patients with CIEDs featuring Pre-EGM functionality at Beijing Hospital (April 2015–July 2023). Devices reported 1543 events based on built-in algorithms. Three cardiac electrophysiology experts independently interpreted each event twice: first using only post-trigger EGMs, then incorporating Pre-EGM data for final classification.</div></div><div><h3>Results</h3><div>Among 1260 automatic mode switch (AMS) events, 994 (78.89 %) were diagnosed using EGM-only interpretation versus 1251 (99.29 %) with Pre-EGM incorporation, representing a 20.40 % improvement in diagnostic yield. Among 187 arrhythmic events including high ventricular rate, premature ventricular contractions, supraventricular tachycardia, and ventricular tachycardia, 124 (66.31 %) were diagnosed using EGM-only versus 183 (97.86 %) with Pre-EGM, representing 31.55 % improvement.</div></div><div><h3>Conclusions</h3><div>Relying solely on post-event EGMs for event determination is insufficiently precise. Pre-EGM functionality provides comprehensive information for definitive diagnosis of CIED-recorded events, representing superior post-implantation device analysis.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"442 ","pages":"Article 133881"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Commentary on \"Relationship between coronary artery calcification and plaque vulnerability, a qualitative and quantitative optical coherence tomography study\".","authors":"Chunwei Liu, Jingxia Zhang","doi":"10.1016/j.ijcard.2025.133867","DOIUrl":"10.1016/j.ijcard.2025.133867","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133867"},"PeriodicalIF":3.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}