International journal of cardiology最新文献

{"title":"Plasma proteomics and heart failure: A new frontier beyond ejection fraction","authors":"Takahiro Okumura , Hiroaki Hiraiwa , Satoshi Yanagisawa , Mikito Takefuji , Toyoaki Murohara","doi":"10.1016/j.ijcard.2025.133943","DOIUrl":"10.1016/j.ijcard.2025.133943","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133943"},"PeriodicalIF":3.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical impact of kidney function in patients with atrial fibrillation receiving oral anticoagulants","authors":"Yuki Matsuoka ,&nbsp;Daisuke Sakamoto ,&nbsp;Akihiro Sunaga ,&nbsp;Katsuki Okada ,&nbsp;Daisaku Nakatani ,&nbsp;Tetsuhisa Kitamura ,&nbsp;Takashi Kanda ,&nbsp;Hitoshi Minamiguchi ,&nbsp;Ryuta Watanabe ,&nbsp;Kouichi Nagashima ,&nbsp;Yoshiharu Higuchi ,&nbsp;Yasuo Okumura ,&nbsp;Yohei Sotomi ,&nbsp;Yasushi Sakata","doi":"10.1016/j.ijcard.2025.133942","DOIUrl":"10.1016/j.ijcard.2025.133942","url":null,"abstract":"<div><h3>Background</h3><div>Renal function influences the pharmacokinetics of oral anticoagulants in atrial fibrillation (AF), potentially affecting both efficacy and bleeding risk. However, its differential impact across specific agents remains unclear. In this study, we aimed to evaluate the association between renal function and ischemic and bleeding risks in patients with AF, with analyses stratified by anticoagulant type.</div></div><div><h3>Methods</h3><div>We analyzed 7239 patients with non-valvular AF from the DIRECT-Extend registry, a pooled dataset of three large-scale registries. Creatinine clearance (CrCl) was calculated using the Cockcroft-Gault formula and categorized into ≥50, 30 to &lt;50, and 15 to &lt;30 mL/min. The primary ischemic endpoint was stroke or systemic embolism, and the primary bleeding endpoint was major bleeding. Cox proportional hazard models and restricted cubic spline analyses assessed associations between CrCl and outcomes, with subgroup analyses by anticoagulant type.</div></div><div><h3>Results</h3><div>Lower CrCl was associated with older age, female sex, and greater comorbidity burden. Impaired renal function was significantly associated with higher ischemic and bleeding risks. Spline analysis demonstrated a continuous increase in both risks with declining CrCl, with a nonlinear relationship for bleeding. Subgroup analyses revealed significant associations between reduced CrCl and ischemic risk in patients on dabigatran, rivaroxaban, edoxaban, and warfarin. Increased bleeding risk was evident for edoxaban and warfarin at lower CrCl levels. No significant association was observed between CrCl and either endpoint in patients receiving apixaban.</div></div><div><h3>Conclusion</h3><div>In this large real-world cohort, declining renal function was associated with increased ischemic and bleeding risks, highlighting the importance of renal function–based risk assessment in the management of anticoagulation therapy.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133942"},"PeriodicalIF":3.2,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residual confounding by mental health: The blind spot in gender-specific alcohol-CIMT studies.","authors":"Jinyan Guo, Mengting Zhang","doi":"10.1016/j.ijcard.2025.133933","DOIUrl":"10.1016/j.ijcard.2025.133933","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133933"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"critical appraisal of early diagnosis and progression to heart failure with preserved ejection fraction among hypertensive patients with left ventricular hypertrophy\".","authors":"Vivian P Kassab, Leonardo G O Oldra, Gabriele S Milanesi, Francis R de Souza, Luiz A Bortolotto, Guilherme W P Fonseca, Maria-Janieire de N N Alves, Roberto Kalil-Filho","doi":"10.1016/j.ijcard.2025.133911","DOIUrl":"https://doi.org/10.1016/j.ijcard.2025.133911","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133911"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forty years of research have identified the best method of tilt testing for the diagnosis of syncope: Is the scientific community ready to accept it?","authors":"Michele Brignole","doi":"10.1016/j.ijcard.2025.133932","DOIUrl":"10.1016/j.ijcard.2025.133932","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133932"},"PeriodicalIF":3.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter to the editor: A critique on the association between non-classical monocytes and HFpEF pathophysiology.","authors":"Elise L Kessler, Elisa Dal Canto, Saskia C A de Jager","doi":"10.1016/j.ijcard.2025.133920","DOIUrl":"10.1016/j.ijcard.2025.133920","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":" ","pages":"133920"},"PeriodicalIF":3.2,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underrepresented patient populations in cardiovascular device trials: A transatlantic expert narrative on sex, age, demographic groups, and geographical background","authors":"Ernest Spitzer ,&nbsp;Francesco Costa ,&nbsp;Ingibjörg Jóna Guðmundsdóttir ,&nbsp;José M. de la Torre Hernández ,&nbsp;Luca Testa ,&nbsp;Eugene McFadden ,&nbsp;Claude Hanet ,&nbsp;Joost Daemen ,&nbsp;Eric Van Belle ,&nbsp;Juan F. Iglesias ,&nbsp;Dominic Allocco ,&nbsp;Sonja Dietzsch ,&nbsp;Anders Jönsson ,&nbsp;Tristan Slots ,&nbsp;Manuela Negoita ,&nbsp;Chananit S. Hutson ,&nbsp;Jose I. Larrubia-Valle ,&nbsp;Ximena S. Paredes ,&nbsp;David Erlinge ,&nbsp;David E. Kandzari ,&nbsp;Mitchell W. Krucoff","doi":"10.1016/j.ijcard.2025.133930","DOIUrl":"10.1016/j.ijcard.2025.133930","url":null,"abstract":"<div><div>External validity of clinical research can be optimized by an adequate representation of all patient groups within a disease spectrum. This emphasizes the need of enrolling patient groups who have been historically underrepresented on the basis of sex, age, demographic groups, or geographical background. Especially in countries with pronounced disparities, raising awareness regarding the existing gaps in future clinical studies continues to be a priority. Census-defined demographic minority groups have been reported to have less access to high-quality healthcare, are less studied in clinical trials, and have less group-specific high-quality data on outcomes after treatment. Additionally, efforts should continue towards enrolling a balanced or at least representative distribution of women and men in clinical trials; and, enrolling age ranges that are consistent with patients suffering from the index disease. Aiming for heterogeneity in study populations will undoubtedly contribute to advancements in medicine, the development of improved therapies, and better outcomes. Analyses on demographic groups have revealed significant disparities within some regions of the world, underlining the need to further investigate whether access to advanced therapies is consistently offered to all members of a nation. To foster international collaboration in cutting-edge clinical research with adequate patient representation, this document presents insights and consensus on fundamental issues, including available classifications of demographic groups in Europe and North America, and presents a standardized approach for collecting geographical background data.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133930"},"PeriodicalIF":3.2,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to reinforcing the prognostic role of angiographic microvascular resistance (AMR) in rotational atherectomy and chronic coronary syndrome: A prospective validation","authors":"Xi Zhang ,&nbsp;Zongqi Deng ,&nbsp;Jingyu Qu ,&nbsp;Qiang Xue ,&nbsp;Hailong Dai","doi":"10.1016/j.ijcard.2025.133919","DOIUrl":"10.1016/j.ijcard.2025.133919","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133919"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SAPIEN 3 in type 0 bicuspid aortic valves: Promising early results","authors":"Alberto Alperi ,&nbsp;Pablo Avanzas","doi":"10.1016/j.ijcard.2025.133918","DOIUrl":"10.1016/j.ijcard.2025.133918","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133918"},"PeriodicalIF":3.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-enabled electrocardiography for risk prediction in chronic liver disease: A systematic review","authors":"Christian Akem Dimala ,&nbsp;Yazan A. Al-Ajlouni ,&nbsp;Nso Nso ,&nbsp;Basile Njei","doi":"10.1016/j.ijcard.2025.133926","DOIUrl":"10.1016/j.ijcard.2025.133926","url":null,"abstract":"<div><h3>Background</h3><div>Artificial intelligence-enabled electrocardiography (AI-ECG) has emerged as a promising tool to improve risk stratification by leveraging machine learning algorithms to detect subtle ECG abnormalities. This systematic review evaluates the performance and clinical utility of AI-ECG in risk prediction among patients with chronic liver disease (CLD).</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted in PubMed, EMBASE, Cochrane Library, and Scopus databases for studies published through November 28th, 2024. Eligible studies assessed AI-enhanced ECG models for risk prediction of cirrhosis, esophageal varices and metabolic dysfunction-associated steatotic liver disease (MASLD) in patients with CLD. Relevant data on were extracted and synthesized.</div></div><div><h3>Results</h3><div>Four studies, encompassing 133,408 participants were included. The AI-ECG-Cirrhosis (ACE) 12‑lead ECG model was the highest performing model (AUC:0.908, sensitivity: 84.9 %, specificity: 83.2 %), followed by the convolutional neural network (CNN)-based deep learning algorithm for the detection of cirrhosis (AUC: 0.86, 95 %CI: 0.85–0.87, sensitivity: 79.5 %, specificity: 76.1 %). The Detection of Undiagnosed Liver Cirrhosis via ECG (DULCE) model in combination with platelet count for the detection of large esophageal varices (AUC: 0.636) and the ECG in combination with clinical parameters (age, sex, body mass index, diabetes mellitus, alanine aminotransferase) models for the detection of MASLD (AUC: 0.76, 95 %CI: 0.74–0.78), sensitivity: 71.9 %, specificity: 67.1 %), had lower performances. There was a positive correlation of the ACE score and MELD-Na score (Spearman's correlation coefficient <em>r</em> = 0.3267, <em>p</em> &lt; 0.001) for the grading of cirrhosis severity.</div></div><div><h3>Conclusions</h3><div>AI-enabled ECG models could offer a novel non-invasive approach to early subclinical disease detection and risk stratification in patients with CLD, however, their sensitivities and specificities remain to be improved prior to routine clinical use. Future research should therefore focus on optimizing, refining, prospectively validating and standardizing these models to facilitate clinical integration.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"443 ","pages":"Article 133926"},"PeriodicalIF":3.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}