International journal of cardiology最新文献

{"title":"Invasive coronary function testing in clinical practice: Implementing the 2024 ESC guidelines on chronic coronary syndromes","authors":"Hanae F. Namba ,&nbsp;Coen K.M. Boerhout ,&nbsp;Peter Damman ,&nbsp;Vijay Kunadian ,&nbsp;Javier Escaned ,&nbsp;Peter Ong ,&nbsp;Divaka Perera ,&nbsp;Colin Berry ,&nbsp;Tim P. van de Hoef ,&nbsp;Jan J. Piek","doi":"10.1016/j.ijcard.2025.133176","DOIUrl":"10.1016/j.ijcard.2025.133176","url":null,"abstract":"<div><div>Angina with non-obstructive coronary arteries (ANOCA) is increasingly recognized as a significant aspect of chronic coronary syndromes. These patients frequently experience recurrent angina, resulting in high healthcare costs and impaired quality of life. Invasive coronary function testing (ICFT) is able to identify ANOCA endotypes, which can guide treatment and improve quality of life. Despite Class II recommendations for invasive microvascular assessments in the previous 2019 European Society of Cardiology (ESC) Guidelines, ICFT has yet to translate into widespread clinical practice. Patients with ANOCA experience poor quality of life and reduced functional capacity, highlighting the need for earlier ICFT implementation. The 2024 ESC Guidelines now strongly recommend ICFT (Class I, level of evidence B) for patients with non-obstructive coronary arteries and persistent angina despite optimal medical therapy, and for confirming or excluding ANOCA in patients with uncertain diagnoses on non-invasive testing (Class I, level of evidence B). Consequently, a standardized approach to optimize the management of ANOCA patients is warranted. Therefore, this review aims to provide interventional cardiologists with a contemporary review of the literature and a practical guideline on implementation of ICFT. It will discuss the following subjects: the definitions of the different endotypes, an example of an ICFT protocol, discontinuation of medication prior to ICFT, use of radial cocktail, target vessel for testing, acetylcholine injection techniques and rechallenge, adenosine injection techniques, the order of testing, the interpretation of ICFT, safety and feasibility, and the pharmacological treatment.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133176"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Age-related ten-year outcomes after percutaneous coronary intervention of in-stent restenosis","authors":"Faridun Rahimi,&nbsp;Dirk Westermann,&nbsp;Philipp Breitbart","doi":"10.1016/j.ijcard.2025.133183","DOIUrl":"10.1016/j.ijcard.2025.133183","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133183"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sjögren's syndrome and pulmonary hypertension: Exploring the intricate link with interstitial lung disease","authors":"F. Coppi ,&nbsp;G. Pagnoni ,&nbsp;C. Campani ,&nbsp;F. Grossule ,&nbsp;C. Vacchi ,&nbsp;D. Giuggioli ,&nbsp;A.V. Mattioli ,&nbsp;G. Boriani","doi":"10.1016/j.ijcard.2025.133185","DOIUrl":"10.1016/j.ijcard.2025.133185","url":null,"abstract":"<div><h3>Background</h3><div>Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease commonly presenting with sicca symptoms and, in approximately one-third of cases, extra-glandular manifestations, including pulmonary involvement. Pulmonary hypertension (pH) is a recognized, though less frequently studied, complication in pSS, particularly in patients with interstitial lung disease (ILD). This study evaluates the prevalence of PH in pSS and the relationship between ILD and cardiovascular risk in this population.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 63 patients with pSS, diagnosed according to ACR/EULAR criteria. Among them, 24 patients (38.1 %) had ILD, with 9 presenting pulmonary fibrosis. Comprehensive evaluations were conducted, including 2D/3D echocardiography, HRCT, and pulmonary function tests. Right heart catheterization confirmed PH when indicated. Patients were categorized into pSS-ILD and pSS-noILD groups for comparative analysis.</div></div><div><h3>Results</h3><div>The cohort comprised 7 males (11.1 %) and 56 females (88.9 %), with a mean age of 69.1 ± 12.5 years. The prevalence of PH was low (1.6 %), with only one confirmed case via right heart catheterization, significantly below previous reports. Notably, pSS-ILD patients were older (77.1 ± 10.7 years) and diagnosed with pSS later (68.5 ± 12.6 years; <em>p</em> = 0.001) than pSS-noILD patients. Cardiovascular comorbidities, including arterial hypertension (32.8 %) and dyslipidemia (24.2 %), were more prevalent in pSS-ILD patients (<em>p</em> = 0.003 and <em>p</em> = 0.001, respectively). Pulmonary function tests revealed lower FVC (2.23 ± 0.70 vs. 2.98 ± 0.56; <em>p</em> = 0.004) and DLCO-Sb (3.87 ± 1.52 vs. 5.31 ± 1.26; <em>p</em> = 0.017) in pSS-ILD patients, indicating reduced lung function. Echocardiographic findings showed higher sPA<em>P</em> values (&gt;35 mmHg) and reduced TAPSE/sPAP ratios in the pSS-ILD group (<em>p</em> = 0.028 and <em>p</em> = 0.026, respectively), suggesting early signs of right ventricular impairment.</div></div><div><h3>Conclusions</h3><div>PH prevalence in pSS is lower than previously reported, likely due to rigorous diagnostic criteria. Patients with pSS-ILD exhibit a higher risk of cardiovascular comorbidities and lung function decline. Echocardiographic monitoring of parameters like TAPSE/sPAP may aid in early PH detection, emphasizing the need for tailored management in pSS-ILD patients. Further studies are warranted to explore PH subtypes in diverse populations and to optimize follow-up protocols for at-risk patients.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133185"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGLT2 Inhibitors in atrial fibrillation: Ready for prime time?","authors":"Arturo Cesaro ,&nbsp;Vincenzo Acerbo ,&nbsp;Felice Gragnano ,&nbsp;Paolo Calabrò","doi":"10.1016/j.ijcard.2025.133186","DOIUrl":"10.1016/j.ijcard.2025.133186","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133186"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of fasting blood glucose with in-hospital mortality in acute coronary syndrome patients with different glycemic statuses: Findings from the CCC-ACS project","authors":"Chu Fan,&nbsp;Hangyu Yan,&nbsp;Kehang Lei,&nbsp;Dan Li,&nbsp;Shutong Dong,&nbsp;Yue Zhang,&nbsp;Yutong Cheng,&nbsp;Zhao Li,&nbsp;Zhizhong Li,&nbsp;Haiyan Qian,&nbsp;Ji Huang","doi":"10.1016/j.ijcard.2025.133184","DOIUrl":"10.1016/j.ijcard.2025.133184","url":null,"abstract":"<div><h3>Background</h3><div>Fasting blood glucose (FBG) is a significant risk factor for in-hospital mortality in acute coronary syndrome (ACS). This study examines the relationship between FBG levels and outcomes in ACS patients with different glycemic statuses.</div></div><div><h3>Methods and results</h3><div>Data from 50,365 ACS patients in the CCC-ACS Project (2014–2019) were analyzed in a prospective cohort study. Patients were categorized into three groups based on diabetes history and HbA1c levels: Group A (good), Group B (intermediate), and Group C (poor) glycemic status. A non-linear relationship between FBG and mortality was found. The lowest mortality risks were associated with FBG levels of 4.96 mmol/L (Group A), 5.71 mmol/L (Group B), and 7.44 mmol/L (Group C). Elevated FBG levels were linked to increased mortality risk in all groups: Group A (OR: 1.17), Group B (OR: 1.14), and Group C (OR: 1.10), all <em>p</em> &lt; 0.001. The model showed moderate accuracy (AUC: 0.78 for Groups A/B, 0.80 for Group C)·In Group A, each unit increase in FBG raised the mortality risk by 1.08 times compared to Group B (OR: 1.08, 95 % CI: 1.03–1.14, <em>p</em> = 0.002) and by 1.07 times compared to Group C (OR: 1.07, 95 % CI: 1.03–1.12, p = 0.002).</div></div><div><h3>Conclusions</h3><div>In ACS patients, elevated FBG is an independent risk factor for in-hospital mortality, regardless of glycemic status. Different glycemic statuses have varied optimal glycemic targets. The effect of FBG on mortality differs across glycemic groups, with patients in good glycemic status facing the highest mortality risk as FBG increases.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133184"},"PeriodicalIF":3.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking risk stratification for infective endocarditis in adults with congenital heart disease: Lessons for emergency medicine","authors":"Yalcin Golcuk","doi":"10.1016/j.ijcard.2025.133187","DOIUrl":"10.1016/j.ijcard.2025.133187","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133187"},"PeriodicalIF":3.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new predictive tool of ventricular arrhythmias and cardiac death in primary benign cardiac tumors in children","authors":"Juan Yang,&nbsp;Lijuan He,&nbsp;Dongwei Yuan","doi":"10.1016/j.ijcard.2025.133190","DOIUrl":"10.1016/j.ijcard.2025.133190","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133190"},"PeriodicalIF":3.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical appraisal of “Risk and Predictors of First-Time Infective endocarditis in adult patients with congenital heart disease—A Nationwide, register-based study”","authors":"Fathimathul Henna ,&nbsp;Zaryab Bacha ,&nbsp;Umama Alam ,&nbsp;Javed Iqbal","doi":"10.1016/j.ijcard.2025.133191","DOIUrl":"10.1016/j.ijcard.2025.133191","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133191"},"PeriodicalIF":3.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in pulmonary arterial hypertension: Insights from the FOCUS-PAH registry","authors":"Matteo Pagnesi ,&nbsp;Mauro Riccardi ,&nbsp;Giulio Savonitto ,&nbsp;Pietro Ameri ,&nbsp;Simonetta Monti ,&nbsp;Mauro Driussi ,&nbsp;Piero Gentile ,&nbsp;Claudia Specchia ,&nbsp;Chiara Oriecuia ,&nbsp;Marianna Adamo ,&nbsp;Matteo Toma ,&nbsp;Alberto Giannoni ,&nbsp;Emma Di Poi ,&nbsp;Luciana D'Angelo ,&nbsp;Valentina Colombo ,&nbsp;Veronica Vecchiato ,&nbsp;Edoardo Airo ,&nbsp;Massimo Imazio ,&nbsp;Andrea Garascia ,&nbsp;Gianfranco Sinagra ,&nbsp;Carlo Mario Lombardi","doi":"10.1016/j.ijcard.2025.133180","DOIUrl":"10.1016/j.ijcard.2025.133180","url":null,"abstract":"<div><h3>Background</h3><div>Despite the higher incidence of pulmonary arterial hypertension (PAH) in women, sex differences in terms of clinical presentation and prognosis are still uncertain. We assess the impact of sex in patients with PAH.</div></div><div><h3>Methods</h3><div>Sex differences were evaluated in the multicenter FOCUS-PAH registry, that included patients diagnosed with PAH at 7 tertiary care centers between 2001 and 2022. Patients' characteristics and outcomes were compared in men vs. women, and factors independently associated with long-term outcomes were assessed. The primary endpoint was overall survival.</div></div><div><h3>Results</h3><div>Among 410 included patients, 273 (66.6 %) were women and 137 (33.4 %) were men. Despite similar age, men had more cardio-renal-metabolic comorbidities and history of HIV infection, whereas women had more connective tissue disorders and scleroderma, and worse functional capacity. Dual therapy was more commonly prescribed in women (39.9 % vs. 27.0 %). At multivariable Cox regression analysis, female sex was independently associated with a lower risk of all-cause mortality (adjusted hazard ratio 0.60, 95 % confidence interval 0.38–0.95, <em>p</em> = 0.031). Age, European Society of Cardiology (ESC) / European Respiratory Society (ERS) risk score, glomerular filtration rate and scleroderma were independently associated with long-term mortality in women, whereas only age and ESC/ERS risk score independently predicted this endpoint in men.</div></div><div><h3>Conclusions</h3><div>In this real-world registry, women represented 2 out of 3 patients with PAH and female sex was independently associated with a lower risk of mortality. There were differences in the variables associated with long-term mortality between sexes, suggesting that individualized approach to risk stratification should also include sex.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133180"},"PeriodicalIF":3.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic glycemic monitoring and systemic inflammation assessment: New insights into plaque characteristics in acute myocardial infarction","authors":"Xiaoting Yang ,&nbsp;Hui Wu ,&nbsp;Di Liu ,&nbsp;Gang Zhou ,&nbsp;Dong Zhang ,&nbsp;Yanfang Liu ,&nbsp;Yi Li ,&nbsp;Tian Zhou ,&nbsp;Yan Xiong","doi":"10.1016/j.ijcard.2025.133189","DOIUrl":"10.1016/j.ijcard.2025.133189","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":"430 ","pages":"Article 133189"},"PeriodicalIF":3.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}