International journal of cardiology最新文献

{"title":"Safety and efficacy of catheter-directed thrombectomy without thrombolysis in acute pulmonary embolism: A systematic review and meta-analysis.","authors":"Omotayo Segun-Omosehin, Maya L Nasser, Joseph Nasr, Ao Shi, Natalie E Bourdakos, Suresh Seneviratne, Christian A Than, Victor F Tapson","doi":"10.1016/j.ijcard.2024.132707","DOIUrl":"https://doi.org/10.1016/j.ijcard.2024.132707","url":null,"abstract":"<p><strong>Background: </strong>This meta-analysis aims to investigate the safety and efficacy of catheter-directed thrombectomy (CDT) without using adjunct thrombolysis as reperfusion therapy to manage intermediate and high-risk pulmonary embolism (PE).</p><p><strong>Methods: </strong>A literature search of Ovid MEDLINE, Embase, CiNAHL, Cochrane Library, and Web of Science was conducted from inception to January 2024. Eligible studies reported more than 10 patients treated for acute PE with catheter-directed thrombectomy only, who were over 18 years of age. Primary endpoints were major bleeding, in-hospital mortality, and hemodynamic changes.</p><p><strong>Results: </strong>Eighteen studies (n = 803) were included for quantitative analysis. The pooled estimate of incidences of in-hospital mortality and major bleeding was 1.8 % (95 % CI 0.009, 0.027) and 2.1 % (95 % CI 0.011, 0.031) respectively. A pooled estimate reported a post-procedural increase in oxygen saturation and systolic blood pressure by 8.96 % (95 % CI: 3.54, 14.38) and 15.02 mmHg (95 % CI 6.35, 23.69) respectively. Post-procedural mean pulmonary artery pressure, right ventricle/left ventricle (RV/LV) ratio, and Miller score were reduced by 10.30 mmHg (95 % CI -14.94, -5.66), 0.29 (95 % CI -0.50, -0.08) and 8.09 (95 % CI -10.70, -5.47) respectively.</p><p><strong>Conclusion: </strong>CDT without adjunctive thrombolysis may lead to improvements in hemodynamic outcomes and appears to exhibit favorable safety profiles. This meta-analysis provides a rationale for further research comparing CDT alone against using adjunct thrombolysis to determine optimal management strategies for intermediate to high-risk acute PE.</p>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical training augmented with whole body electronic muscle stimulation favorably impacts cardiovascular biomarkers in healthy adults – A pilot randomized controlled trial","authors":"Jaskanwal Deep Singh Sara ,&nbsp;Nazanin Rajai ,&nbsp;Ali Ahmad ,&nbsp;Logan Breuer ,&nbsp;Thomas Olson ,&nbsp;Wolfgang Kemmler ,&nbsp;Takashi Nagai ,&nbsp;Nathan Schilaty ,&nbsp;Amir Lerman","doi":"10.1016/j.ijcard.2024.132706","DOIUrl":"10.1016/j.ijcard.2024.132706","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Physical activity is protective against cardiovascular disease (CVD) and favorably improves CVD risk profile. However, more than 25 % of American adults report no participation in physical activity. Whole body electronic muscle stimulation (WB-EMS) training is a novel FDA-cleared technology which offers a time-efficient and adaptable method for physical training by simultaneously stimulating the main muscle groups using percutaneous electrical impulse transmission. Studies have demonstrated increased muscle mass, reduced fat mass, and improved functional capacity in sedentary individuals after training with WB-EMS, but studies evaluating the role of WB-EMS training on CVD risk profile are lacking.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We performed a pilot randomized controlled trial in healthy adults randomized to physical training with versus without WB-EMS for one session of 20 min duration per week across 16-weeks. Study participants were asked to perform their usual activities but to abstain from any strength training during the study. During each training session, all study participants wore a specifically designed vest and arm and leg straps that were connected with electrical wires to the WB-EMS device (&lt;em&gt;Miha Bodytec&lt;/em&gt; Gersthofen, Germany). Biphasic electrical stimulation was delivered through the vest and straps (4 s on, 4 s off) at a frequency that elicited a score of 5 or 6 on the Borg rating of perceived exertion scale from study participants when each of the following muscle groups was stimulated: thighs, buttocks, lower back, upper back, latissimus dorsi, abdomen, chest and arms. These frequencies were ‘titrated’ during the first 4 weeks and were then fixed at each muscle group for each participant. Individuals randomized to no WB-EMS wore the same equipment but received no electrical stimulation. Physical training sessions were provided by personal trainers certified for WB-EMS training and consisted of a fixed number of exercises and repetitions. We measured and compared several clinically important cardiovascular parameters at baseline and post-intervention.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Seventy-eight participants were recruited between January 2021 and March 2022 with a mean age of 35.9 ± 11.2, 61.3 % females, median BMI 24.3 (21.8, 28.1); &lt;em&gt;N&lt;/em&gt; = 46 were randomized to intervention group and &lt;em&gt;N&lt;/em&gt; = 32 were randomized to the control group. Eighteen (23 %) participants dropped out of the trial, including 9 participants from the EMS arm (19.6 %), and 9 participants in control arm (28.1 %). There was no significant differences in the rate of dropping out of the WB-EMS and control groups (&lt;em&gt;p&lt;/em&gt; = 0.27). Those in the intervention group compared to controls exhibited the following changes after 16-weeks of training: waist:hip ratio (∆ -0.03 ± 0.05, &lt;em&gt;p&lt;/em&gt; = 0.01 vs. -0.01 ± 0.0, &lt;em&gt;p&lt;/em&gt; = 0.1), peripheral endothelial function, measured using reactive hyperemia peripheral ar","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kounis syndrome: A natural paradigm for preventing mast cell activation-degranulation","authors":"Nicholas G. Kounis ,&nbsp;Virginia Mplani ,&nbsp;Ioanna Koniari","doi":"10.1016/j.ijcard.2024.132704","DOIUrl":"10.1016/j.ijcard.2024.132704","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoproteins and lipoprotein lipid composition are associated with stages of dysglycemia and subclinical coronary atherosclerosis","authors":"Bruna Gigante ,&nbsp;Qiaosen Chen ,&nbsp;Harry Björkbacka ,&nbsp;Elias Björnson ,&nbsp;Jonas Brinck ,&nbsp;Elin Chorell ,&nbsp;Demir Djekic ,&nbsp;Andreas Edsfeldt ,&nbsp;Gunnar Engström ,&nbsp;Jan W. Eriksson ,&nbsp;Anders Gottsäter ,&nbsp;Anders Gummesson ,&nbsp;Emil Hagström ,&nbsp;Ulf Hedin ,&nbsp;Tomas Jernberg ,&nbsp;Nina Johnston ,&nbsp;Lennart Nilsson ,&nbsp;Fredrik Nyström ,&nbsp;Julia Otten ,&nbsp;Annika Rosengren ,&nbsp;Carl Johan Östgren","doi":"10.1016/j.ijcard.2024.132698","DOIUrl":"10.1016/j.ijcard.2024.132698","url":null,"abstract":"<div><h3>Background</h3><div>Dyslipidaemia in patients with diabetes contributes to the risk of atherosclerotic cardiovascular disease. We aimed to identify a dyslipidemic profile associated with both dysglycemia and subclinical coronary atherosclerosis.</div></div><div><h3>Methods</h3><div>Study participants (<em>n</em> = 5050) were classified in three groups: normoglycemia, pre-diabetes, and diabetes. A coronary artery calcium score (CACS) &gt; 0 defined subclinical coronary atherosclerosis. Two independent methods were used to identify, among 225 lipid biomarkers, those that were associated with pre-diabetes and diabetes and were further tested for association by zero inflated Poisson regression with CACS and with CACS burden in study participants with CACS&gt;0. Estimates were adjusted for cardiovascular risk factors with an interaction term for dispensed lipid lowering drugs.</div></div><div><h3>Results</h3><div>Thirty-two biomarkers associated with prediabetes and diabetes were further investigated for association with CACS. HDL diameter [multi-adjusted OR of 0.85 and 95 %CI (0.78–0.92)] as well as free cholesterol, phospholipids and total lipids in extra large HDL were inversely associated with CACS. There was a borderline significant interaction between small HDL and dispensed lipid lowering drugs on the presence of CACS, with and multi-adjusted OR of 0.53 and 95 %CI (0.36–0.77). None of the 32 glycemic profile-related lipid biomarkers associated with the relative increase of CACS in those with CACS&gt;0. No consistent association was observed between non-HDL lipoproteins and CACS.</div></div><div><h3>Conclusions</h3><div>Changes in composition and relative concentration of HDL associated with both dysglycemia and subclinical coronary atherosclerosis. Treatment with lipid lowering drugs may contribute to reduce the risk associated with high circulating levels of small HDL.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the risk factors of cardiomyopathy in pregnant mothers","authors":"Mehdi Norouzi ,&nbsp;Zahra Amiri ,&nbsp;Vahid Ghavami ,&nbsp;Mohammad Hossein Madahali ,&nbsp;Amin Moradi ,&nbsp;Ehsan Mosafarkhani","doi":"10.1016/j.ijcard.2024.132696","DOIUrl":"10.1016/j.ijcard.2024.132696","url":null,"abstract":"<div><h3>Background</h3><div>Cardiomyopathy during pregnancy significantly impacts maternal health, contributing to high morbidity and mortality. Identifying risk factors for this condition is crucial for enhancing prenatal care and preventing adverse outcomes.</div></div><div><h3>Study design</h3><div>This population-based case-control study investigates the risk factors associated with cardiomyopathy in pregnant women.</div></div><div><h3>Methods</h3><div>We analyzed data from 5133 pregnant women (1686 cases with cardiomyopathy and 3447 controls without cardiomyopathy) who received care at healthcare facilities affiliated with Mashhad University of Medical Sciences between March 1, 2017, and June 20, 2024. Risk factors were assessed through logistic regression models, which calculated adjusted odds ratios (AORs) with 95 % confidence intervals (CIs) for various demographic, medical, and pregnancy-related variables.</div></div><div><h3>Results</h3><div>Significant risk factors for cardiomyopathy in pregnancy included obesity (AOR = 2.11, 95 % CI: 1.43–2.02), higher education level (AOR = 1.84, 95 % CI: 1.25–1.86), mental health issues (AOR = 2.07, 95 % CI: 1.7–2.5), domestic violence (AOR = 2.02, 95 % CI: 1.08–3.6), twin pregnancy (AOR = 2.6, 95 % CI: 1.57–4.6), and preeclampsia (AOR = 6.9, 95 % CI: 2.78–17.4). Additional risk factors included lack of physical fitness (AOR = 1.5, 95 % CI: 1.13–2.007), history of infectious disease during pregnancy (AOR = 1.4, 95 % CI: 1.11–1.76), anemia (AOR = 1.57, 95 % CI: 1.15–2.09), and hypertension (AOR = 1.55, 95 % CI: 1.18–2.02). Smoking increased risk but was not statistically significant (AOR = 1.29, 95 % CI: 0.69–2.4).</div></div><div><h3>Conclusion</h3><div>Addressing modifiable and non-modifiable risk factors in prenatal care is crucial to reducing cardiomyopathy incidence and improving maternal cardiovascular health.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health behavior associated with cardiometabolic outcomes: A nationally representative cross-sectional study in Portugal","authors":"Maria Santos ,&nbsp;Carlos Matias Dias ,&nbsp;Vânia Gaio","doi":"10.1016/j.ijcard.2024.132702","DOIUrl":"10.1016/j.ijcard.2024.132702","url":null,"abstract":"<div><h3>Background</h3><div>Oral diseases are associated with the development of cardiometabolic diseases. This study aimed to evaluate the relationship between oral health behaviors (tooth brushing and oral health appointments) with cardiometabolic diseases.</div></div><div><h3>Methods</h3><div>Data from the First National Health Examination Survey were used. Participants aged 25–74 years and diagnosis of acute myocardial infarction (<em>n</em> = 4442), stroke (<em>n</em> = 4441), hypertension (<em>n</em> = 4450) and diabetes (<em>n</em> = 4327) were analyzed. A fifth subsample (<em>n</em> = 2555) included participants aged 40–69 for calculating cardiovascular risk. Poor oral health behavior was defined as brushing once a day or less and having the last oral health appointment at 12 months or more. Poisson regression models assessed the relationship between poor oral health behavior and these cardiometabolic outcomes.</div></div><div><h3>Results</h3><div>Among 4.450 participants, 20.5 % had poor oral health behavior. A statistically significant association was found between poor oral health behavior with diabetes (PR: 1.44 [95 % CI: 1.10–1.98], and high/very high cardiovascular risk (PR: 1.42 [95 % CI: 1.25–1.62]). In the sensitivity analysis the association with diabetes and high/very high cardiovascular risk persisted when considering only brushing behavior but not when considering only oral health appointments at 12 months or more.</div></div><div><h3>Conclusions</h3><div>Individuals with poor oral health behavior had a higher prevalence of diabetes and high/very high cardiovascular risk. Sensitivity analysis suggested that regular tooth brushing may be the main behavior for preventing diabetes and cardiovascular risk. The results suggest that regular tooth brushing may act in prevention for diabetes and cardiovascular risk.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of radial artery spasm prophylaxis on intracoronary vasomotor responses during acetylcholine spasm provocation testing","authors":"Tim Schäufele ,&nbsp;Miguel Nobre Menezes ,&nbsp;Benedict Schulte Steinberg ,&nbsp;Astrid Hubert ,&nbsp;Valeria Martínez Pereyra ,&nbsp;Helene Arndt ,&nbsp;Udo Sechtem ,&nbsp;Raffi Bekeredjian ,&nbsp;Peter Ong","doi":"10.1016/j.ijcard.2024.132703","DOIUrl":"10.1016/j.ijcard.2024.132703","url":null,"abstract":"<div><h3>Background</h3><div>Invasive coronary angiography via the radial approach is commonly performed following radial artery spasm prophylaxis (RASP). It is however unknown, whether RASP influences the results of coronary spasm provocation testing performed after diagnostic angiography. We aimed to investigate the effects of RASP on vasomotor responses during intracoronary acetylcholine (ACh) testing.</div></div><div><h3>Methods</h3><div>We retrospectively screened 372 consecutive patients (51 % female, mean age 61 ± 11 years) with angina and non-obstructive coronary arteries, who underwent intracoronary provocation with ACh according to a standardized protocol. During testing, dose-dependent clinical discomfort and concomitant ischemic electrocardiographic changes were recorded in addition to visual reductions of epicardial lumen diameters. Of these patients, 156 (42 %) received RASP (i.e. 200 μg nitroglycerin and 2.5 mg verapamil), while no RASP was administered in 216 (58 %) patients. Both groups were compared regarding age, sex, cardiovascular risk factors and ACh-test results.</div></div><div><h3>Results</h3><div>ACh provocation testing revealed a pathological test result in 71 patients (46 %) with RASP and 103 patients (48 %) without (<em>p</em> = 0.752) [epicardial spasm: in 20 patients (28 %) with RASP and 42 patients (41 %) without (<em>p</em> = 0.120); microvascular spasm: in 51 patients (72 %) with RASP and 61 patients (59 %) without (<em>p</em> = 0.362)]. Overall, RASP did not significantly alter coronary artery vasomotor responses, neither regarding the frequency (<em>p</em> = 0.752) or type of coronary spasm (microvascular vs. epicardial; <em>p</em> = 0.108) nor regarding the ACh dose leading to spasm (<em>p</em> = 0.151).</div></div><div><h3>Conclusions</h3><div>RASP does not significantly affect coronary vasomotor responses to ACh, suggesting that radial artery spasm prophylaxis can be routinely administered even in patients in whom intracoronary spasm testing is performed.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends (2003–2018) of in-hospital and 30-day mortality in patients hospitalized with acute heart failure","authors":"Giancarlo Marenzi ,&nbsp;Nicola Cosentino ,&nbsp;Livio Imparato ,&nbsp;Filippo Trombara ,&nbsp;Olivia Leoni ,&nbsp;Francesco Bortolan ,&nbsp;Matteo Franchi ,&nbsp;Erica Rurali ,&nbsp;Paolo Poggio ,&nbsp;Jeness Campodonico ,&nbsp;Fabrizio Oliva ,&nbsp;Alice Bonomi ,&nbsp;Piergiuseppe Agostoni","doi":"10.1016/j.ijcard.2024.132693","DOIUrl":"10.1016/j.ijcard.2024.132693","url":null,"abstract":"<div><h3>Background</h3><div>Limited temporal data on in-hospital mortality trends of patients hospitalized with acute heart failure (AHF) have been reported. We evaluated whether, in AHF hospitalized patients, the rate of in-hospital and 30-day mortality, and 30-day re-hospitalization for AHF have changed in the past 15 years.</div></div><div><h3>Methods and results</h3><div>We examined administrative data from the Lombardy region, Italy and analysed data of all adults hospitalized for AHF from 2003 to 2018. Patients were stratified according to the hospitalization period: 2003–2006; 2007–2010; 2011–2014; 2015–2018. Primary endpoint was the comparison of in-hospital mortality rates among periods. Secondary endpoints were 30-day mortality rates and temporal trends of re-hospitalization for AHF. During this period, 414,164 hospitalizations with a primary diagnosis of AHF were identified, involving 286,028 patients aged 18 and older. In-hospital and 30-day mortality in the entire cohort showed a progressive increase over time (from 6.7 % to 8.5 % and from 12.4 % to 14.5 %, respectively). Thirty-day re-hospitalization for AHF was 2 %, showing a progressive decrease over the years. However, patient’ age and complexity increased in the most recently hospitalized patients. After adjusting for major confounders, in-hospital and 30-day mortality risks were similar moving from one study period to the next (relative risk for trend 1.00 [95 % CI 0.99–1.01] and 1.00 [95 % CI 0.98–1.01], respectively), while that of 30-day AHF re-hospitalization decreased progressively (hazard ratio for trend 0.86 [95 % CI 0.84–0.88]).</div></div><div><h3>Conclusions</h3><div>In our study, the increasing age and complexity of patients largely accounted for the continued rise in early mortality observed in patients hospitalized with AHF.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut dysbiosis and neutrophil extracellular traps in chronic heart failure","authors":"Vibeke Bratseth ,&nbsp;Andraz Nendl ,&nbsp;Sajan C. Raju ,&nbsp;Kristian Holm ,&nbsp;Kaspar Broch ,&nbsp;Johannes R. Hov ,&nbsp;Ingebjørg Seljeflot ,&nbsp;Marius Trøseid ,&nbsp;Ayodeji Awoyemi","doi":"10.1016/j.ijcard.2024.132689","DOIUrl":"10.1016/j.ijcard.2024.132689","url":null,"abstract":"<div><h3>Background</h3><div>Chronic heart failure (HF) patients have reduced microbiota diversity. Leakage of microbes and their metabolites into the bloodstream may activate neutrophils. Neutrophil extracellular traps (NETs) consist of chromatin and proteases, and may contribute to HF pathogenesis. We assessed associations between circulating NETs and 1) cardiac function, 2) the degree of gut microbiota diversity and 3) gut leakage and microbial metabolites in HF patients.</div></div><div><h3>Methods</h3><div>A cross-sectional study including 124 patients with chronic HF and left ventricular ejection fraction ≤40 %. Severe HF was defined as N-terminal pro-B-type natriuretic peptide concentrations above median. We measured citrullinated histone H₃ (CitH₃), myeloperoxidase- and double-stranded-DNA in the blood. Gut leakage markers included bacterial lipopolysaccharides and soluble cluster of differentiation 14. The microbial metabolites included circulating trimethylamine N-oxide and butyrate producing capacity. We used the Shannon diversity-index and a dysbiosis-index based on bacteria with altered relative abundance to characterize the gut microbiota profile.</div></div><div><h3>Results</h3><div>Quartile 4 of CitH₃ was associated with more severe HF compared to quartiles 1–3, after adjustments for age, gender and hypertension (adjusted odds ratio [95 %CI] 3.21[1.18–8.69], <em>p</em> = 0.022). CitH₃ was moderately associated with hypertension (<em>p</em> = 0.04), higher CRP levels (<em>p</em> = 0.016) and lower Shannon diversity index_, (<em>p</em> = 0.039). No other NET marker associated with severe HF.</div></div><div><h3>Conclusions</h3><div>In chronic HF patients with reduced LVEF, high levels of CitH₃ were associated with disease severity, inflammation and reduced gut microbiota diversity. Our results suggest that enhanced release of NETs could be involved in progressive HF, although the contribution of the gut microbiota seems limited in this context.</div></div>","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and spontaneous coronary artery dissection: Navigating a high-risk condition","authors":"Giuseppe Ciliberti ,&nbsp;Luca Franchin ,&nbsp;Federico Fortuni ,&nbsp;Filippo Zilio","doi":"10.1016/j.ijcard.2024.132685","DOIUrl":"10.1016/j.ijcard.2024.132685","url":null,"abstract":"","PeriodicalId":13710,"journal":{"name":"International journal of cardiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}