Infectious disorders drug targets最新文献_第5页

COVID-19 and Alzheimer's Disease: The Link Finally Established. COVID-19和阿尔茨海默病:最终建立的联系。

Infectious disorders drug targets Pub Date : 2023-01-01 DOI: 10.2174/1871526523666230529162633

Ziad Fajloun, Yingliang Wu, Zhijian Cao, Hervé Kovacic, Jean-Marc Sabatier

引用次数: 0

Acrophialophora fusispora as an Agent of Mycotic Keratitis: A Case Report and Review of Literature. fusispora acrophiophora作为真菌性角膜炎的病原体:1例报告及文献复习。

Infectious disorders drug targets Pub Date : 2023-01-01 DOI: 10.2174/1871526523666221026094300

Swati Sharma, Nidhi Singla, Neelam Gulati, Sudesh Kumar Arya, Jagdish Chander

{"title":"Acrophialophora fusispora as an Agent of Mycotic Keratitis: A Case Report and Review of Literature.","authors":"Swati Sharma, Nidhi Singla, Neelam Gulati, Sudesh Kumar Arya, Jagdish Chander","doi":"10.2174/1871526523666221026094300","DOIUrl":"https://doi.org/10.2174/1871526523666221026094300","url":null,"abstract":"Background: Acrophialophora species is an infrequent human opportunistic pathogen. It is widely distributed in temperate as well as tropical regions. Here, we present a rare case of fungal keratitis caused by A. fusispora.Case presentation: A 26-year male driver presented with pain, watering, redness, whitish discoloration, and blurring of vision in the left eye for the last 3-4 days. Upon examination, he had a dry-looking corneal ulcer with infiltration and satellite lesions. Corneal scrapings were positive for septate fungal hyphae by Gram staining and KOH mount. After five days, the growth observed was presumptively identified as genus Acrophialophora and finally identified as Acrophialophora fusispora by genetic sequencing. The patient failed to respond medically and was planned for therapeutic keratoplasty.Discussion: To date, four cases of ocular involvement due to Acrophialophora have been described. Amongst which one case was associated with an immunocompromised state. Three of the cases were resolved medically, while one required therapeutic keratoplasty, indicating possible strong pathogenicity to the eye.Conclusion: As Acrophialophora seems to have a predilection for eye infections, an early diagnosis with timely appropriate treatment is the best way to restore the normal vision of a patient.","PeriodicalId":13678,"journal":{"name":"Infectious disorders drug targets","volume":"23 3","pages":"e261022210377"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9774876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Outbreak of Monkeypox Virus Disease: An Update on Epidemiology, Pathophysiology and Available Treatment Options. 猴痘病毒疾病爆发：流行病学、病理生理学和现有治疗方案的最新进展。

Infectious disorders drug targets Pub Date : 2023-01-01 DOI: 10.2174/1871526523666230418121045

Akash Kumar, Neeti Angaria, Gurvinder Singh, Rajesh Kumar

{"title":"Outbreak of Monkeypox Virus Disease: An Update on Epidemiology, Pathophysiology and Available Treatment Options.","authors":"Akash Kumar, Neeti Angaria, Gurvinder Singh, Rajesh Kumar","doi":"10.2174/1871526523666230418121045","DOIUrl":"10.2174/1871526523666230418121045","url":null,"abstract":"The monkeypox virus is a zoonotic illness with a tropical distribution in Africa, and around the world. The disease is spread through contact with infected animals or humans, and can also be spread from person to person through close contact with respiratory or bodily fluids. Fever, swollen lymph nodes, blisters, and crusted rashes characterize the disease. The incubation period is five to twenty-one days. It is difficult to distinguish the rash caused by infection from varicella and smallpox. Laboratory investigations are essential aspects of illness diagnosis and surveillance, and novel tests are required for more accurate and faster diagnosis. Antiviral drugs are being used to treat monkeypox. Scarring as well as other comorbidities, are prevalent in survivors, with the case mortality rate varying from 1 to 11%. The virus was found in monkeys at a Danish research facility in 1958, from which the term 'monkeypox' is derived. The primary human case was found in a child in the Democratic Republic of the Congo (DRC) in 1970. The World Health Organisation (WHO) has recently declared monkeypox a public health emergency of international concern. This manuscript attempts to review the various aspects of monkeypox disease and its allopathic as well as alternative treatment options available and serves as a valuable resource for healthcare professionals, researchers, and the general public.","PeriodicalId":13678,"journal":{"name":"Infectious disorders drug targets","volume":"23 6","pages":"e180423216001"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10399820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Epidemiology and Recycling of Staphylococcus aureus Resistant to Methicillin Among the Staff, Patients, and Surfaces in University Hospital in West Iran, Ilam. 伊朗西部大学医院工作人员、患者和表面耐甲氧西林金黄色葡萄球菌的分子流行病学和循环利用

Infectious disorders drug targets Pub Date : 2023-01-01 DOI: 10.2174/1871526522666220928145550

Fatemeh Ghanbari, Heshmatollah Nourmoradi, Ali Nazari, Nourkhoda Sadeghifard, Iraj Pakzad, Setareh Soroush, Behnam Ashrafi, Morovat Taherikalani

{"title":"Molecular Epidemiology and Recycling of Staphylococcus aureus Resistant to Methicillin Among the Staff, Patients, and Surfaces in University Hospital in West Iran, Ilam.","authors":"Fatemeh Ghanbari, Heshmatollah Nourmoradi, Ali Nazari, Nourkhoda Sadeghifard, Iraj Pakzad, Setareh Soroush, Behnam Ashrafi, Morovat Taherikalani","doi":"10.2174/1871526522666220928145550","DOIUrl":"https://doi.org/10.2174/1871526522666220928145550","url":null,"abstract":"Staphylococcus aureus is a human pathogen causing nosocomial infections and increased hospitalization and mortality among human communities. Methicillin-resistant S. aureus strains are considered a severe threat in nosocomial infections and cause complications in the remedy process of bacterial infections. In this study, 137 samples were collected from different departments, staff, and patients in Ilam hospital. Eighty-eight samples of these strains were examined to test antibiotic resistance and diffusion. MIC (minimum inhibitory concentration) and PCR (polymerase chain reaction) were performed on the samples resistant to oxacillin. 36 (40.9%) strains were MRSA, and 52 (59.1%) isolates were MSSA. 44.4% of MRSA strains with IV SCCmec type. Fourteen different spa types were found using spa typing, of which the most abundant types were t037, t030, and t701, and three new types, including t15471, t15474, and t17470, were identified among the strains. The molecular analysis by MLST showed that the strains are classified into 11 different sequence types. Sequence type 239 and clonal complexes of 329 and 22 were dominant. ST239-spat037-SCCmec III was also identified as the most frequent clone of MRSA. The most identified clones were MRSA ST239-spa t037-SCCmec III. The results show the spa-type distribution between samples of patients, personnel, and surfaces, demonstrating MRSA circulation between patients and the environment. The results show the need to control environmental health.","PeriodicalId":13678,"journal":{"name":"Infectious disorders drug targets","volume":"23 1","pages":"e280922209259"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9234278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cryptosporidiosis in Yellow Nail Syndrome - A Rare Case Report. 黄指甲综合征隐孢子虫病1例报道。

Infectious disorders drug targets Pub Date : 2023-01-01 DOI: 10.2174/1871526522666220920142423

Aditya Kundu, Saumya Srivastava, Vibhor Tak, Jagdish Prasad Goyal

{"title":"Cryptosporidiosis in Yellow Nail Syndrome - A Rare Case Report.","authors":"Aditya Kundu, Saumya Srivastava, Vibhor Tak, Jagdish Prasad Goyal","doi":"10.2174/1871526522666220920142423","DOIUrl":"https://doi.org/10.2174/1871526522666220920142423","url":null,"abstract":"Background: Cryptosporidium species infection causes malabsorption and severe diarrhea in immunocompromised hosts. Association of Yellow Nail Syndrome (YNS) and Cryptosporidiosis is rare and has not been reported till date. Immunity can also be affected in this case of YNS is associated with autoimmune disorders.Case presentation: Here, we describe a case of persistent diarrhea in an 8 month old YNS patient. Modified Ziehl-Neelsen staining and Saffranine-Methylene blue revealed oocyts of Cryptosporidium species. Following appropriate treatment, the patient's symptoms improved and the patient was discharged in a hemodynamically stable condition.Discussion: Cryptosporidiosis is a significant cause of morbidity and mortality in immunocompromised patients. YNS per se as well as treatment including steroids leads to immunosuppression in individuals making them susceptible host for opportunistic infections like Cryptosporidiosis.Conclusion: Clinicians should be aware of the condition and screen for Cryptosporidiosis in any immunocompromised patients with diarrheal symptoms, as parasitic infection like this are opportunistic in them.","PeriodicalId":13678,"journal":{"name":"Infectious disorders drug targets","volume":"23 2","pages":"e200922208989"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10133358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient Care and Treatment Strategies for Skin Diseases in Sub-Saharan Africa: Role of Traditional and Western Medicines. 撒哈拉以南非洲皮肤病患者护理和治疗战略:传统和西药的作用。

Infectious disorders drug targets Pub Date : 2023-01-01 DOI: 10.2174/1871526522666220919105643

Astha Sharma, Sonali Sundram, Rishabha Malviya, Swati Verma, Neeraj Kumar Fuloria, Shivkanya Fuloria, Mahendran Sekar, Neelesh Mishra, Dhanalekshmi Unnikrishnan Meenakshi

{"title":"Patient Care and Treatment Strategies for Skin Diseases in Sub-Saharan Africa: Role of Traditional and Western Medicines.","authors":"Astha Sharma, Sonali Sundram, Rishabha Malviya, Swati Verma, Neeraj Kumar Fuloria, Shivkanya Fuloria, Mahendran Sekar, Neelesh Mishra, Dhanalekshmi Unnikrishnan Meenakshi","doi":"10.2174/1871526522666220919105643","DOIUrl":"https://doi.org/10.2174/1871526522666220919105643","url":null,"abstract":"The perspective of the people of Sub-Saharan Africa (SSA) toward both traditional and western healthcare systems varies. The goal of the current study is to examine the SSA's unique skin disease health care system. This study comprises numerous research that sought to examine how the general public feels about the SSA's current healthcare system. In this review, common skin conditions, such as atopic dermatitis, buruli ulcers, dermatophytosis, and scabies, are addressed. According to this report, government agencies must pay particular attention to skin illnesses in SSA and raise public awareness. Availability of medical care, socioeconomic factors, degree of education, and other factors influence patients' attitudes toward traditional and western health care differently in different geographic areas. Facts suggest that self-medication is the preference of the majority of patients before seeking dermatological care. The present study concludes that the magnitude of skin diseases is neglected or underestimated in many regions of SSA. Also, western healthcare facilities of many regions of SSA are not up to the mark. The present study recommends that proper access to the health care system and awareness about skin diseases through various government programs can be helpful in the regulation of skin disorders among people of SSA.","PeriodicalId":13678,"journal":{"name":"Infectious disorders drug targets","volume":"23 3","pages":"e190922208916"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10151815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Management of Denture Infection with Phytomedicine. 假牙感染的植物药物治疗。

Infectious disorders drug targets Pub Date : 2023-01-01 DOI: 10.2174/1871526522666220829160234

K V Anitha, Rajkumar K

{"title":"Management of Denture Infection with Phytomedicine.","authors":"K V Anitha, Rajkumar K","doi":"10.2174/1871526522666220829160234","DOIUrl":"https://doi.org/10.2174/1871526522666220829160234","url":null,"abstract":"Natural teeth are an integral part of the masticatory system. Absence of dentition subjects the individual to compromised oral function, facial appearance and phonetics. Rehabilitation with dental prosthesis is imperative to restore form and masticatory activity. Currently, fabrication of removable and fixed prosthesis has become most predictable. Nonetheless, there is an increased prevalence of oral stomatitis observed over the years in edentulous individuals wearing removable dentures. Amongst the many pathogens that cause denture infections, Candida albicans is assumed to be the most virulent opportunistic agent. Different methods, such as mechanical, chemical, chemicmechanical, and pharmacological are tried to fight such infections. Regardless of various management strategies developed to treat denture stomatitis, the research continues to evolve the most optimal one. Improper oral and or denture hygiene maintenance, surface irregularities on denture, persistence of xerostomia and associated systemic illness pose risk for exaggeration of the disease. In extreme conditions, the development of aspiration pneumonia in geriatric patients is considered a threat to both dental and medical specialists. Therapeutic administration of synthetic anti-microbial drugs, along with meticulous oral hygiene maintenance are recommended protocols till date. However, limitations such as antibiotic resistance, side effects, counter drug reactions, cost of the medicaments predispose to origin of natural herbal products to treat denture stomatitis. Vast array of plant products are studied in previous literature, yet no definitive edge of one over the other is proven. This article intends to provide a mini-review on the different organic plant materials, also called as phytomedicines used for the treatment of candida associated denture stomatitis (CADS).","PeriodicalId":13678,"journal":{"name":"Infectious disorders drug targets","volume":"23 2","pages":"e290822208190"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9771904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interplay between SARS-CoV-2 and Cancer: Plausible Risk Factors, Cellular Immune Responses, Cancer Directed Therapy- Current Challenges. SARS-CoV-2与癌症之间的相互作用:可能的危险因素、细胞免疫反应、癌症定向治疗——当前的挑战。

Infectious disorders drug targets Pub Date : 2023-01-01 DOI: 10.2174/1871526523666221028162406

Suman Kumar Ray, Sukhes Mukherjee

{"title":"Interplay between SARS-CoV-2 and Cancer: Plausible Risk Factors, Cellular Immune Responses, Cancer Directed Therapy- Current Challenges.","authors":"Suman Kumar Ray, Sukhes Mukherjee","doi":"10.2174/1871526523666221028162406","DOIUrl":"https://doi.org/10.2174/1871526523666221028162406","url":null,"abstract":"COVID-19 has created tremendous societal upheaval, resulting in a global overhaul of healthcare systems. According to new evidence, the COVID-19 pandemic has the potential to aggravate pre-existing inequities, particularly among cancer patients. The COVID-19 pandemic has had a disproportionately negative impact on cancer patients. The unfavorable outcomes in cancer patients who contract COVID-19, the impact of the COVID-19 pandemic on cancer care delivery, and the significant disruption of cancer research are all examples of this consequence. On the other hand, patients with cancer are a diverse group, and new research has identified characteristics that allow for risk categorization of cancer patients to optimize care. Variable access to telemedicine, timely diagnosis, and treatment access are all possible drivers of unequal cancer survival as a result of the epidemic. Despite oncology associations presenting guidelines on cancer care during the pandemic, the magnitude of potential therapy advantages, therapeutic purpose, and access to care all play a role in prioritizing cancer medicines. This review focuses on evidence related to COVID-19 and cancer, such as the molecular interactions between the two diseases and practical therapeutic suggestions for cancer patients during the pandemic. We also explore the pandemic's possible long-term influence on cancer care due to its negative impact on cancer research, as well as biological discoveries from the cancer research community that could aid in the development of novel therapeutics for all COVID-19 patients.","PeriodicalId":13678,"journal":{"name":"Infectious disorders drug targets","volume":"23 2","pages":"e281022210459"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9774879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can the New BA.2.75 Sub-variant Lead To One More COVID-19 Wave? 新的BA.2.75亚变体会导致新一轮COVID-19浪潮吗?

Infectious disorders drug targets Pub Date : 2023-01-01 DOI: 10.2174/1871526523666230302103609

Suman Kumar Ray, Sukhes Mukherjee

{"title":"Can the New BA.2.75 Sub-variant Lead To One More COVID-19 Wave?","authors":"Suman Kumar Ray, Sukhes Mukherjee","doi":"10.2174/1871526523666230302103609","DOIUrl":"https://doi.org/10.2174/1871526523666230302103609","url":null,"abstract":"The highly transmissible variation of COVID-19 has a new sub-variant known as a variant BA.2.75, which was initially discovered in India and is now found in at least 10 more countries. The World Health Organization (WHO) officials said that the new variant is actively being monitored. It has yet to be determined if the new variation is more clinically severe than its predecessors. It is known that the Omicron strain sub-variants are responsible for this rise in the worldwide COVID tally. It is too early to know if this sub-variant exhibits additional immune evasion characteristics, or is more clinically severe. The extremely contagious BA.2.75 sub-variant of Omicron has been documented in India, but there is no evidence yet that it has increased disease severity or dissemination. Many of the BA.2 lineage's sublineages form a unique collection of mutations as it evolves. A related branch of the BA.2 lineage is B.2.75. The size of genomic sequencing must be increased and maintained for the early detection of the variant strains of SARS-CoV-2. BA.2.75 is the second generation of BA.2 variations and has a high transmissibility level.","PeriodicalId":13678,"journal":{"name":"Infectious disorders drug targets","volume":"23 4","pages":"e020323214247"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9785455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Change in the Trend of Quality Reporting in Leprosy Trials: A Systematic Review. 麻风病试验质量报告趋势的变化:一项系统评价。

Infectious disorders drug targets Pub Date : 2023-01-01 DOI: 10.2174/1871526523666230224104113

Pugazhenthan Thangaraju, Pranav G Sheth, Hemasri Velmurugan, Sajitha Venkatesan, Aravind Kumar B

{"title":"A Change in the Trend of Quality Reporting in Leprosy Trials: A Systematic Review.","authors":"Pugazhenthan Thangaraju, Pranav G Sheth, Hemasri Velmurugan, Sajitha Venkatesan, Aravind Kumar B","doi":"10.2174/1871526523666230224104113","DOIUrl":"https://doi.org/10.2174/1871526523666230224104113","url":null,"abstract":"Background: Leprosy is a communicable disease caused by bacteria Mycobacterium leprae. Despite all attempts, it has not been eradicated in several underdeveloped nations since the start of the antibiotic age. It's a social issue as well as a stigmatised disease. Due to these restrictions, randomised controlled trials in leprosy confront numerous obstacles, which are reflected in the quality of study reporting.Objectives: The objective of this study is to use the Consolidated Standard for Reporting Trials (CONSORT) 2010 checklist to assess the quality of leprosy trial reporting.Methods: We assess the quality of reporting of randomised control trials on leprosy conducted after 2010 in the PubMed database, using the CONSORT checklist 2010. Second, we compare the quality of RCT reporting before and after the release of the CONSORT guidelines in 2010.Results: A total of 19 full-text eligible articles were examined and included in the final list of articles, which were then evaluated further. 4 out of 19 trials had a compliance percentage of more than 75%. 6 out of 19 trials had compliance percentage of 50% to 75%. 9 trials had a compliance percentage of below 50%. Highest compliance was 86.48% and the lowest compliance was 32.43%. When compared with trials before 2010, we could see an improvement in some criteria showing a statistically significant rise in comparison with trials conducted before 2010.Conclusion: Leprosy is still a concern in developing countries, which have failed to eradicate the disease despite their best efforts and resources. The compliance of leprosy related RCTs has improved since the introduction of the CONSORT guidelines, but the quality of reporting still remains on the lower side.","PeriodicalId":13678,"journal":{"name":"Infectious disorders drug targets","volume":"23 4","pages":"e240223214010"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9790787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0