Acrophialophora fusispora as an Agent of Mycotic Keratitis: A Case Report and Review of Literature.

Q3 Pharmacology, Toxicology and Pharmaceutics

Infectious disorders drug targets Pub Date : 2023-01-01 DOI:10.2174/1871526523666221026094300

Swati Sharma, Nidhi Singla, Neelam Gulati, Sudesh Kumar Arya, Jagdish Chander

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引用次数: 2

Abstract

Background: Acrophialophora species is an infrequent human opportunistic pathogen. It is widely distributed in temperate as well as tropical regions. Here, we present a rare case of fungal keratitis caused by A. fusispora.

Case presentation: A 26-year male driver presented with pain, watering, redness, whitish discoloration, and blurring of vision in the left eye for the last 3-4 days. Upon examination, he had a dry-looking corneal ulcer with infiltration and satellite lesions. Corneal scrapings were positive for septate fungal hyphae by Gram staining and KOH mount. After five days, the growth observed was presumptively identified as genus Acrophialophora and finally identified as Acrophialophora fusispora by genetic sequencing. The patient failed to respond medically and was planned for therapeutic keratoplasty.

Discussion: To date, four cases of ocular involvement due to Acrophialophora have been described. Amongst which one case was associated with an immunocompromised state. Three of the cases were resolved medically, while one required therapeutic keratoplasty, indicating possible strong pathogenicity to the eye.

Conclusion: As Acrophialophora seems to have a predilection for eye infections, an early diagnosis with timely appropriate treatment is the best way to restore the normal vision of a patient.

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fusispora acrophiophora作为真菌性角膜炎的病原体:1例报告及文献复习。

背景:肩蝗是一种罕见的人类机会致病菌。它广泛分布于温带和热带地区。在此，我们报告一例罕见的由镰刀孢杆菌引起的真菌性角膜炎。病例介绍:一名26岁男性司机，最近3-4天左眼疼痛、流泪、发红、发白、视力模糊。经检查，他有干性角膜溃疡伴浸润和卫星病变。革兰氏染色和KOH涂片检测角膜刮屑中分离真菌菌丝阳性。5 d后，初步鉴定为Acrophialophora属，最终通过基因测序鉴定为fusispora Acrophialophora。该患者治疗无效，计划进行角膜移植术。讨论:迄今为止，四例眼部受累由于肩深斜视已被描述。其中一例与免疫功能低下有关。其中3例经医学治疗解决，1例需要角膜移植术治疗，表明可能对眼睛有很强的致病性。结论:该病易发生眼部感染，早期诊断并及时治疗是恢复患者正常视力的最佳途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious disorders drug targets Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.10

自引率

0.00%

发文量

123

期刊介绍： Infectious Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in infectious disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in infectious disorders. As the discovery, identification, characterization and validation of novel human drug targets for anti-infective drug discovery continues to grow, this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.